Abstract:
:During brain development, the generation of neurons and glial cells is rigorously regulated by diverse mechanisms including the immune system. Dysfunction of the developing system results in the onset of neurodevelopmental disorders and psychological disorders. Recent studies have demonstrated that the immune system is implicated in brain development. As the central nervous system is physically separated from the circulatory system by the blood-brain barrier, circulating immune cells are unable to infiltrate into the brain parenchyma. However, several studies have demonstrated that immune cells, such as B cells, T cells and macrophages, are observed in the meningeal space, perivascular space and choroid plexus and have crucial roles in brain function. Moreover, genome-wide association studies have revealed that the immune system is implicated in neurodevelopmental disorders and psychological disorders. Here, we discuss the role of each of these immune cell types in brain development and the association with neurodevelopmental disorders.
journal_name
Int Immunoljournal_title
International immunologyauthors
Tanabe S,Yamashita Tdoi
10.1093/intimm/dxy041subject
Has Abstractpub_date
2018-09-25 00:00:00pages
437-444issue
10eissn
0953-8178issn
1460-2377pii
5038904journal_volume
30pub_type
杂志文章,评审abstract::Impaired lymphocyte function is a common feature of human diabetes. Nucleoside transport across the plasma membrane is an essential step during lymphocyte growth and activation. In our study, we evaluated the impact of diabetic conditions on nucleoside transport system in B lymphocytes. Examination of the nucleoside t...
journal_title:International immunology
pub_type: 杂志文章
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abstract::We have investigated the B cell response to Mycobacterium leprae in leprosy patients and healthy controls. A comparison of Western-blotted proteins separated by two-dimensional gel electrophoresis and probed with pooled sera from LL and BT patients revealed distinct antigen recognition patterns for the two classificat...
journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/2.9.803
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abstract::CD4 T cells are not thought to play a significant role in generating an effective primary CD8 T cell response to most viral infections. We have challenged this view by demonstrating that antigen-specific CD4 T cells can indeed suppress the proliferation of antigen-specific naive CD8 T cells in response to low doses of...
journal_title:International immunology
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abstract::Whether astrocytes utilize B7:CD28 co-stimulation to activate T cells mediating CNS inflammatory disease is controversial. In this report, primary astrocytes and murine astrocyte lines, generated by immortalization at two different times, day 7 or 45 of culture, were examined for their capability to express B7 co-stim...
journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/11.7.1169
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abstract::Type II collagen (CII) is of immunological interest because of its repetitive structure and properties as an autoantigen. The mouse gene has recently been cloned, thus enabling T cell-defined epitopes to be identified. Multiple novel epitopes on mouse CII are here detected in the autoreactive T cell response. The majo...
journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/9.11.1687
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journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/dxq033
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journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/dxn024
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journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/dxp082
更新日期:2009-10-01 00:00:00
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journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/2.6.539
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journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/3.7.691
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journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/dxf047
更新日期:2002-07-01 00:00:00
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journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/9.9.1271
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journal_title:International immunology
pub_type: 杂志文章
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更新日期:2000-02-01 00:00:00
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journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/6.8.1235
更新日期:1994-08-01 00:00:00
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journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/dxh149
更新日期:2004-10-01 00:00:00
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pub_type: 杂志文章
doi:10.1093/intimm/5.8.849
更新日期:1993-08-01 00:00:00
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journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/7.12.1905
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pub_type: 杂志文章
doi:10.1093/intimm/dxn091
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pub_type: 杂志文章
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journal_title:International immunology
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pub_type: 杂志文章
doi:10.1093/intimm/4.11.1303
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pub_type: 杂志文章
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doi:10.1093/intimm/12.12.1705
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journal_title:International immunology
pub_type: 杂志文章
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doi:10.1093/intimm/5.6.591
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