Immunomodulation by hepatitis C virus-derived proteins: targeting human dendritic cells by multiple mechanisms.

abstract：:Treatment of melanoma cell lines with IFN-gamma induces the switch from proteasome (PS) to immunoproteasome (iPS). This finding has profound implications for the immunobiology of melanoma cells since certain peptides (such as Melan-A(mart1)(27-35)) are cleaved differently by iPS, thus implying a different ability to b...

journal_title：International immunology

authors： Cangemi G,Morandi B,D'Agostino A,Peri C,Conte R,Damonte G,Ferlazzo G,Biassoni R,Melioli G

更新日期：2003-12-01 00:00:00

abstract：:Under equilibrium conditions, the affinities of five anti-IgG2a mAb isolated from virus-infected mice were comparable to other high-affinity auto-antibodies. Similar to rheumatoid factors, these anti-IgG2a auto-antibodies bound to aggregated or complexed IgG2a with 50 to 1500-fold higher avidity than their monomeric c...

journal_title：International immunology

authors： Fazekas G,Pálfi G,Wolff-Winiski B,Rosenwirth B,Dukor P,Gergely J,Rajnavölgyi E

更新日期：1995-07-01 00:00:00

abstract：:The mucosa is one of the initial sites of group A streptococcal (GAS) infection and salivary IgA (sIgA) is thought to be critical to immunity. However, the target epitopes of sIgA and the function of sIgA in GAS immunity, in particular the role of accessory cells and complement, is largely unknown. We studied the aqui...

journal_title：International immunology

authors： Brandt ER,Hayman WA,Currie B,Carapetis J,Jackson DC,Do KA,Good MF

更新日期：1999-04-01 00:00:00

abstract：:Using Ia antigen-containing lipid vesicles, we investigated by stopped-flow fluorometry the requirements for helper T cell recognition and activation. When azobenzenearsonate-L-tyrosine (ABA-L-Tyr)-specific, I-Ak-restricted helper T cell hybridomas 2-45-12 were mixed with ABA-L-Tyr and purified I-Ak molecules on lipid...

journal_title：International immunology

authors： Odaka C,Utsunomiya N,Nakanishi M,Arata Y,Manabe S,Yasuda T,Tadakuma T

更新日期：1990-01-01 00:00:00

abstract：:Malaria infection induces the production of serum antibodies to a variety of malaria antigens but the prevalence of antibodies to any particular antigen is typically much less than 100%. It has been assumed that non-responsiveness to defined antigens in malaria immune subjects is due to HLS-mediated restriction of the...

journal_title：International immunology

authors： Taylor RR,Egan A,McGuinness D,Jepson A,Adair R,Drakely C,Riley E

更新日期：1996-06-01 00:00:00

abstract：:The extracellular signal-regulated kinase (ERK) signaling pathway is strongly activated in response to TCR stimulation in normal T cells. However, the extent to which activation of the ERK pathway is necessary for TCR-stimulated cytokine production is not clear. We have addressed this question by use of two separate m...

journal_title：International immunology

authors： Egerton M,Fitzpatrick DR,Kelso A

更新日期：1998-02-01 00:00:00

abstract：:Metazoan species, from sponges to insects and mammals, possess successful defence systems against their pathogens and parasites. The evolutionary origins of these diverse systems are beginning to be more comprehensively investigated and mapped out. We have collected 1811 metazoan immunity genes from literature and gen...

journal_title：International immunology

authors： Rannikko K,Ortutay C,Vihinen M

更新日期：2007-12-01 00:00:00

abstract：:Mercury-induced autoimmunity is characterized by a T cell-dependent B cell activation (mainly of IgG1 and IgE isotypes), production of anti-nucleolar autoantibodies (ANolA) and the formation of renal IgG deposits. The autoimmunity is to a large extent controlled by genetic factors. We studied 15 different inbred mouse...

journal_title：International immunology

authors： Abedi-Valugerdi M,Möller G

更新日期：2000-10-01 00:00:00

abstract：:Type II collagen (CII) is of immunological interest because of its repetitive structure and properties as an autoantigen. The mouse gene has recently been cloned, thus enabling T cell-defined epitopes to be identified. Multiple novel epitopes on mouse CII are here detected in the autoreactive T cell response. The majo...

journal_title：International immunology

authors： Bayrak S,Holmdahl R,Travers P,Lauster R,Hesse M,Dölling R,Mitchison NA

更新日期：1997-11-01 00:00:00

abstract：:Peyer's patch (PP) organogenesis proceeds through three histologically distinct steps: formation of organizing centers expressing VCAM-1 and ICAM-1 in segregated regions of the intestine at 15.5 days post-coitus (d.p.c.) (step I), accumulation of blood cells expressing different sets of surface markers to this region ...

journal_title：International immunology

authors： Yoshida H,Honda K,Shinkura R,Adachi S,Nishikawa S,Maki K,Ikuta K,Nishikawa SI

更新日期：1999-05-01 00:00:00

abstract：:Streptococcus suis serotype 2 is an important porcine bacterial pathogen and a zoonotic agent responsible for sudden death, septic shock and meningitis, with exacerbated inflammation being a hallmark of the systemic and central nervous system (CNS) infections. However, S. suis serotype 2 strains are genetically and ph...

journal_title：International immunology

authors： Auger JP,Benoit-Biancamano MO,Bédard C,Segura M,Gottschalk M

更新日期：2019-10-16 00:00:00

abstract：:Ig are multifunctional molecules with distinct properties assigned to individual domains. To assess the importance of IgM domain assembly in B cell development we generated two transgenic mouse lines with truncated muH chains by homologous integration of the neomycin resistance gene (neo(r)) into exons C(mu)1 and C(mu...

journal_title：International immunology

authors： Zou X,Ayling C,Xian J,Piper TA,Barker PJ,Brüggemann M

更新日期：2001-12-01 00:00:00

abstract：:HLA-G, a human MHC class I molecule expressed on the trophoblast during pregnancy, was expressed in transgenic mice by recombining the HLA-G gene with a transcriptional promoter from a murine H-2 MHC class I gene. Skin grafts from HLA-G transgenic mice were rejected by non-transgenic mice showing that HLA-G behaves as...

journal_title：International immunology

authors： Horuzsko A,Antoniou J,Tomlinson P,Portik-Dobos V,Mellor AL

更新日期：1997-05-01 00:00:00

abstract：:IL-18 is a proinflammatory cytokine that plays an important role in NK cell activation and T(h)1 response. IL-18 has a structural homology to IL-1, particularly IL-1beta. IL-18R, composed of IL-1R-related protein (IL-18Ralpha) and IL-1R accessory protein-like (IL-18Rbeta), belongs to the IL-1R family. Furthermore, IL-...

journal_title：International immunology

authors： Tominaga K,Yoshimoto T,Torigoe K,Kurimoto M,Matsui K,Hada T,Okamura H,Nakanishi K

更新日期：2000-02-01 00:00:00

abstract：:Recent studies have suggested that Fas-mediated apoptosis is involved in the pathogenesis of intestinal injury. In this study, we determined the role of Fas/Fas ligand (FasL) interactions in different T cell compartments using a murine model of small intestinal injury. An intraperitoneal injection of 145-2C11 (anti-CD...

journal_title：International immunology

authors： Miura N,Yamamoto M,Fukutake M,Ohtake N,Iizuka S,Ishige A,Sasaki H,Fukuda K,Yamamoto T,Hayakawa S

更新日期：2005-05-01 00:00:00

abstract：:Dendritic cells (DCs) are responsible for the initiation of immune responses. Our study demonstrates a new pathway for generating a large quantity of stimulatory monocyte-derived DCs (Mo-DCs) from human monocytes using anti-4-1BB ligand (4-1BBL) mAb to trigger reverse signaling. The anti-4-1BBL-driven Mo-DCs (DCs(alph...

journal_title：International immunology

authors： Ju S,Ju S,Ge Y,Qiu H,Lu B,Qiu Y,Fu J,Liu G,Wang Q,Hu Y,Shu Y,Zhang X

更新日期：2009-10-01 00:00:00

abstract：:IgE plus antigen-stimulated mast cells degranulate, synthesize leukotrienes and secrete cytokines. According to the coalescence model this process is initiated in specific membrane compartments termed rafts. There, enhanced levels of glycosphingolipids and cholesterol stabilize the interaction of FcepsilonRI and Lyn, ...

journal_title：International immunology

authors： Baumruker T,Csonga R,Pursch E,Pfeffer A,Urtz N,Sutton S,Bofill-Cardona E,Cooke M,Prieschl E

更新日期：2003-10-01 00:00:00

abstract：:Novel biomarkers of rheumatoid arthritis (RA), in addition to antibodies against cyclic citrullinated peptides, are required. Metabolome analysis is a promising approach to identify metabolite biomarkers for clinical diagnosis. We adopted a comprehensive nontargeted metabolomics approach combining capillary electropho...

journal_title：International immunology

authors： Kishikawa T,Maeda Y,Nii T,Arase N,Hirata J,Suzuki K,Yamamoto K,Masuda T,Ogawa K,Tsuji S,Matsushita M,Matsuoka H,Yoshimura M,Tsunoda S,Ohshima S,Narazaki M,Ogata A,Saeki Y,Inohara H,Kumanogoh A,Takeda K,Okada Y

更新日期：2020-08-31 00:00:00

abstract：:Dendritic cells (DCs) act as a first-line recognition system for invading pathogens, such as influenza A. The interaction of DC with influenza A virus results in DC activation via endosomal Toll-like receptors and also leads to presentation of viral peptides on MHC class II molecules. Prior work demonstrated that infl...

journal_title：International immunology

authors： Burster T,Giffon T,Dahl ME,Björck P,Bogyo M,Weber E,Mahmood K,Lewis DB,Mellins ED

更新日期：2007-05-01 00:00:00

abstract：:Neutrophils and lymphocytes are recruited to sites of inflammation and require the adhesion molecule L-selectin (CD62L) for adherence to endothelial cells. Nucleotides released from activated or dying cells at sites of inflammation can mediate signaling through purinergic receptor family II, resulting in CD62L sheddin...

journal_title：International immunology

authors： Sengstake S,Boneberg EM,Illges H

更新日期：2006-07-01 00:00:00

abstract：:Autoimmune gastritis is a CD4+ T cell-mediated disease induced in genetically susceptible mice by thymectomy on the third day after birth. Previous linkage analysis indicated that Gasa1 and Gasa2, the major susceptibility loci for gastritis, are located on mouse chromosome 4. Here we verified these linkage data by sho...

journal_title：International immunology

authors： Ang DK,Brodnicki TC,Jordan MA,Wilson WE,Silveira P,Gliddon BL,Baxter AG,van Driel IR

更新日期：2007-09-01 00:00:00

abstract：:In this study, we report that the release of IL-1 receptor antagonist (IL-1ra) from IL-4-stimulated neutrophils is markedly enhanced in the presence of IL-10. We also show that up-regulation of IL-1ra release by IL-10 in IL-4-stimulated neutrophils takes place through IL-1ra mRNA stabilization and enhancement of IL-1r...

journal_title：International immunology

authors： Crepaldi L,Silveri L,Calzetti F,Pinardi C,Cassatella MA

更新日期：2002-10-01 00:00:00

abstract：:Cytotoxic T lymphocyte (CTL) mediated killing has classically been associated with a high level of specificity for the target cell. However, when CTL clones and specific target cells were copelleted with innocent bystander cells for which the CTL was not specific, these bystander cells were also lysed. Bystander lysis...

journal_title：International immunology

authors： Burrows SR,Fernan A,Argaet V,Suhrbier A

更新日期：1993-09-01 00:00:00

abstract：:Incomplete T cell antigen receptor-mediated signaling induces an unresponsive state known as anergy. Previously, we had shown that anergy can be induced in antigen-primed but not naive T cells. In this report, we found that in vitro primed T cells from IL-2R alpha-deficient mice were resistant to anergy induction in c...

journal_title：International immunology

authors： Hayashi RJ,Kanagawa O

更新日期：2006-05-01 00:00:00

abstract：:Naturally arising CD25(+)CD4(+) regulatory T (T(R)) cells can be exploited to establish immunologic tolerance to non-self antigens. In vivo exposure of CD25(+)CD4(+) T cells from normal naive mice to alloantigen in a T cell-deficient environment elicited spontaneous expansion of alloantigen-specific CD25(+)CD4(+) T(R)...

journal_title：International immunology

authors： Nishimura E,Sakihama T,Setoguchi R,Tanaka K,Sakaguchi S

更新日期：2004-08-01 00:00:00

abstract：:The interleukin 2 receptor (IL-2R) is composed of at least two polypeptides--a 55 kd protein (the L chain, p55, or alpha chain) and a 75 kd protein (the H chain, p75 or beta chain). The high-affinity binding of IL-2 results in the formation of a ternary complex consisting of IL-2 and the L and H chains. We found that ...

journal_title：International immunology

authors： Saito Y,Ogura T,Kamio M,Sabe H,Uchiyama T,Honjo T

更新日期：1990-01-01 00:00:00

abstract：:IL-7 is a required factor for T-cell homeostasis. Because of low expression levels and poor reagent availability, the cellular sources of IL-7 have proven challenging to characterize. In this study, we describe a reporter mouse in which enhanced GFP is expressed from the endogenous Il7 locus. We show that IL-7 is prod...

journal_title：International immunology

authors： Miller CN,Hartigan-O'Connor DJ,Lee MS,Laidlaw G,Cornelissen IP,Matloubian M,Coughlin SR,McDonald DM,McCune JM

更新日期：2013-08-01 00:00:00

abstract：:NK cells are functionally controlled by the killer immunoglobulin-like receptor (KIR) family that comprises inhibitory (iKIR) and activating (aKIR) members. Genetic association studies suggest that donors expressing aKIRs next to iKIRs will be superior donors in the setting of hematopoietic stem cell transplantation o...

journal_title：International immunology

authors： Baltner K,Kübler A,Pal M,Balvociute M,Mezger M,Handgretinger R,André MC

更新日期：2017-11-01 00:00:00

abstract：:Although CD4(+) T cells form a major subset of TCRalphabeta T cells, only a small number of TCRgammadelta T cells express CD4. Factors contributing to the down-regulation of CD4(+) TCRgammadelta T cells have not been identified. The CD5 molecule is expressed on most TCRgammadelta T cells in the spleen, whereas only a ...

journal_title：International immunology

authors： Mizoguchi A,Mizoguchi E,de Jong YP,Takedatsu H,Preffer FI,Terhorst C,Bhan AK

更新日期：2003-01-01 00:00:00

abstract：:Dendritic cells (DC) are highly potent activators of the immune response. The precise mechanisms that give rise to the DC phenotype are not known. To investigate the mechanisms that contribute to the generation of the DC phenotype, precursor DC were freshly isolated from human blood and allowed to mature in vitro. The...

journal_title：International immunology

authors： Engering AJ,Richters CD,Fluitsma DM,van Pelt AM,Kamperdijk EW,Hoefsmit EC,Pieters J

更新日期：1998-11-01 00:00:00