Selective recognition of malaria antigens by human serum antibodies is not genetically determined but demonstrates some features of clonal imprinting.


:Malaria infection induces the production of serum antibodies to a variety of malaria antigens but the prevalence of antibodies to any particular antigen is typically much less than 100%. It has been assumed that non-responsiveness to defined antigens in malaria immune subjects is due to HLS-mediated restriction of the immune response. In this study we have investigated the role of HLA and non-HLA genes in the antibody response to two merozoite surface antigens (MSP1 and MSP2) and a sexual stage antigen (Ps260/230) of Plasmodium falciparum, and conclude that host genotype is not a major determinant of responsiveness. Although antibody levels vary in accordance with seasonal variations in malaria transmission in semi-immune children, antibody levels remain stable in clinically immune adults. Antigen recognition is selective with individual donors showing consistent high titre responses to some antigens/epitopes whilst consistently failing to recognize adjacent regions/epitopes of the same protein. An alternative explanation, consistent with the data presented here, is that selective antibody responses to malaria antigens in immune individuals result from a process akin to clonal imprinting (original antigenic sin).


Int Immunol


International immunology


Taylor RR,Egan A,McGuinness D,Jepson A,Adair R,Drakely C,Riley E




Has Abstract


1996-06-01 00:00:00












  • IL-12 transiently induces IFN-gamma transcription and protein synthesis in human CD4+ allergen-specific Th2 T cell clones.

    abstract::IL-12 is a cytokine produced by monocytes and Epstein-Barr virus-transformed B cells which initiates Th1 responses by inducing the development of CD4+, IFN-gamma producing Th1 T cells in mouse and human. We have previously reported that allergen-specific CD4+ Th2 T cell clones produce IFN-gamma, following activation b...

    journal_title:International immunology

    pub_type: 杂志文章


    authors: Yssel H,Fasler S,de Vries JE,de Waal Malefyt R

    更新日期:1994-07-01 00:00:00

  • Tyk2 deficiency protects joints against destruction in anti-type II collagen antibody-induced arthritis in mice.

    abstract::Tyrosine kinase-2 (Tyk2) participates in the signaling pathways of multiple cytokines in innate and acquired immunity. In the present study, we investigated the in vivo involvement of Tyk2 in anti-type II collagen antibody-induced arthritis (CAIA) using Tyk2-deficient mice. Hind paws of wild-type mice showed massive s...

    journal_title:International immunology

    pub_type: 杂志文章


    authors: Ishizaki M,Muromoto R,Akimoto T,Ohshiro Y,Takahashi M,Sekine Y,Maeda H,Shimoda K,Oritani K,Matsuda T

    更新日期:2011-09-01 00:00:00

  • Influenza A virus elevates active cathepsin B in primary murine DC.

    abstract::Dendritic cells (DCs) act as a first-line recognition system for invading pathogens, such as influenza A. The interaction of DC with influenza A virus results in DC activation via endosomal Toll-like receptors and also leads to presentation of viral peptides on MHC class II molecules. Prior work demonstrated that infl...

    journal_title:International immunology

    pub_type: 杂志文章


    authors: Burster T,Giffon T,Dahl ME,Björck P,Bogyo M,Weber E,Mahmood K,Lewis DB,Mellins ED

    更新日期:2007-05-01 00:00:00

  • Self-reactive T cells are present in the peripheral lymphoid tissues of cyclosporin A-treated mice.

    abstract::Cyclosporin A (CsA) prevents most immature thymocytes from progressing to a mature phenotype and blocks the deletion of T cells that express self-specific TCR in the small population of cells that achieve maturity. The latter effect may explain the paradoxical observation that this immunosuppressive drug can induce au...

    journal_title:International immunology

    pub_type: 杂志文章


    authors: Urdahl KB,Pardoll DM,Jenkins MK

    更新日期:1992-12-01 00:00:00

  • Characterization of an active, non-myristylated, cytoplasmic form of the lymphoid protein tyrosine kinase pp56lck.

    abstract::pp56lck is a member of the src family of tyrosine kinases mainly expressed in T lymphocytes. Src tyrosine kinases have been implicated in the control of cell growth and differentiation in different cell types, but the mechanism of regulation of these enzymes is poorly understood. In order to characterize the distinct ...

    journal_title:International immunology

    pub_type: 杂志文章


    authors: Carrera AC,Li P,Roberts TM

    更新日期:1991-07-01 00:00:00

  • Dominant and cryptic antigens in the MHC class I restricted T cell response across a complex minor histocompatibility barrier: analysis and mapping by elution of cellular peptides.

    abstract::T cell responses against complex antigens are often directed against a limited set of immunodominant determinants. We have studied this phenomenon at the level of cellularly processed peptides recognized by CTL in the B6 anti-BALB.B minor histocompatibility (H) barrier, comprising at least 29 antigen loci. B6 anti-BAL...

    journal_title:International immunology

    pub_type: 杂志文章


    authors: Wolpert E,Franksson L,Kärre K

    更新日期:1995-06-01 00:00:00

  • IL-1α released from oral epithelial cells upon candidalysin exposure initiates an early innate epithelial response.

    abstract::Candida albicans is a commensal fungus that predominantly resides on mucosal surfaces and can cause lethal systemic infection when the host defense is compromised. Candidalysin is a cytolytic peptide toxin produced by C. albicans hyphae that is essential for mucosal tissue damage and is believed to contribute to the e...

    journal_title:International immunology

    pub_type: 杂志文章


    authors: Hanaoka M,Domae E

    更新日期:2020-10-10 00:00:00

  • Rapid acceleration of neutrophil apoptosis by tumor necrosis factor-alpha.

    abstract::We demonstrate here that human necrosis factor-alpha, a potent neutrophil activator, induces rapid (within 3 h) apoptosis of these cells, i.e. neutrophils treated with this cytokine exhibit (i) light and electron microscopic changes characteristic to apoptotic cells, (ii) reduced propidium iodide binding to DNA, and (...

    journal_title:International immunology

    pub_type: 杂志文章


    authors: Takeda Y,Watanabe H,Yonehara S,Yamashita T,Saito S,Sendo F

    更新日期:1993-06-01 00:00:00

  • Glycosyltransferase regulation mediated by pre-TCR signaling in early thymocyte development.

    abstract::CT1 is a carbohydrate moiety of CD45 that is expressed on fetal thymocytes in vivo. Examination of CT1 expression on thymocyte subsets revealed that primarily pro-T cells (CD44+ CD25+) and pre-T cells (CD44- CD25+) expressed CT1. Interestingly, non-T-lineage committed lymphoid progenitors (CD44+ CD25-) lacked CT1 indi...

    journal_title:International immunology

    pub_type: 杂志文章


    authors: Reed DS,Olson S,Lefrançois L

    更新日期:1998-04-01 00:00:00

  • Immediate responses of leukocytes, cytokines and glucocorticoid hormones in the blood circulation of monkeys following challenge with aerosolized staphylococcal enterotoxin B.

    abstract::The immediate responses to aerosolized staphylococcal enterotoxin B (SEB) in respiratory toxic shock were studied in the circulation of rhesus monkeys with low antibody levels following immunization with SEB toxoid-containing microspheres. Both the surviving and dying monkeys had toxic shock syndrome 4-48 h after SEB ...

    journal_title:International immunology

    pub_type: 杂志文章


    authors: Weng CF,Komisar JL,Hunt RE,Johnson AJ,Pitt ML,Ruble DL,Tseng J

    更新日期:1997-12-01 00:00:00

  • Modeling the presentation of C3d-coated antigen by B lymphocytes: enhancement by CR1/2-BCR co-ligation is selective for the co-ligating antigen.

    abstract::We have used a set of single-chain variable fragment antibodies (sc) genetically fused with an influenza hemagglutinin-derived peptide as a means to investigate the role of CR1 and CR2 in antigen presentation by B cells. When incubated with the B cell lymphoma 2PK3, peptide-containing sc specific for either CR1 or CR1...

    journal_title:International immunology

    pub_type: 杂志文章


    authors: Prechl J,Baiu DC,Horváth A,Erdei A

    更新日期:2002-03-01 00:00:00

  • CD4+CD25-mTGFbeta+ T cells induced by nasal application of ovalbumin transfer tolerance in a therapeutic model of asthma.

    abstract:BACKGROUND:Intranasal administration of high amount of allergen was shown to induce tolerance and to reverse the allergic phenotype. However, mechanisms of tolerance induction via the mucosal route are still unclear. OBJECTIVES:To characterize the therapeutic effects of intranasal application of ovalbumin (OVA) in a m...

    journal_title:International immunology

    pub_type: 杂志文章


    authors: Pellaton-Longaretti C,Boudousquié C,Barbier N,Barbey C,Argiroffo CB,Donati Y,Sauty A,Spertini F

    更新日期:2011-01-01 00:00:00

  • The role of B7-CD28 co-stimulation in tumor rejection.

    abstract::The role of B7 co-stimulatory signaling in in vivo tumor rejection remains incompletely characterized. In particular, the relative competence of B7-1 (CD80) and B7-2 (CD86) to provide effective co-stimulus is not well defined, and the identification of the T cell co-stimulatory receptor that mediates B7 co-stimulation...

    journal_title:International immunology

    pub_type: 杂志文章


    authors: Yu X,Abe R,Hodes RJ

    更新日期:1998-06-01 00:00:00

  • Pyroptotic cells externalize eat-me and release find-me signals and are efficiently engulfed by macrophages.

    abstract::Pathogenic intracellular bacteria often hijack macrophages for their propagation. The infected macrophages release IL-1β and IL-18 and simultaneously commit suicide, which is called pyroptosis; both responses require caspase-1. Here, we found that pyroptotic cells induced by microbial infection were efficiently engulf...

    journal_title:International immunology

    pub_type: 杂志文章


    authors: Wang Q,Imamura R,Motani K,Kushiyama H,Nagata S,Suda T

    更新日期:2013-06-01 00:00:00

  • Bystander apoptosis induced by CD8+ cytotoxic T cell (CTL) clones: implications for CTL lytic mechanisms.

    abstract::Cytotoxic T lymphocyte (CTL) mediated killing has classically been associated with a high level of specificity for the target cell. However, when CTL clones and specific target cells were copelleted with innocent bystander cells for which the CTL was not specific, these bystander cells were also lysed. Bystander lysis...

    journal_title:International immunology

    pub_type: 杂志文章


    authors: Burrows SR,Fernan A,Argaet V,Suhrbier A

    更新日期:1993-09-01 00:00:00

  • A computerized model for the self-non-self discrimination at the level of the T(h) (Th genesis). II. The behavior of the system upon encounter with non-self antigens.

    abstract::In the final analysis, the self (S)-non-self (NS) discrimination is regulated by the sufficiency or insufficiency of effector T(h) (eT(h)) specific for the given antigen. We have described a model (Th genesis) for the origin of eT(h) based on an antigen-independent pathway from initial state T(h) (iT(h)) to eT(h), and...

    journal_title:International immunology

    pub_type: 杂志文章


    authors: Langman RE,Mata JJ,Cohn M

    更新日期:2003-05-01 00:00:00

  • p40 molecule regulates NK cell activation mediated by NK receptors for HLA class I antigens and TCR-mediated triggering of T lymphocytes.

    abstract::p40 was previously described as a regulatory molecule capable of inhibiting both the natural and the CD16-mediated cytotoxicity of NK cells. In this study, we analyze the effect of p40 molecule engagement on the NK cell triggering induced by activating HLA class I-specific NK receptors (NKR) or on TCR alpha beta-media...

    journal_title:International immunology

    pub_type: 杂志文章


    authors: Poggi A,Tomasello E,Revello V,Nanni L,Costa P,Moretta L

    更新日期:1997-09-01 00:00:00

  • The P9 pocket of HLA-DQ2 (non-Aspbeta57) has no particular preference for negatively charged anchor residues found in other type 1 diabetes-predisposing non-Aspbeta57 MHC class II molecules.

    abstract::Susceptibility and resistance to type 1 diabetes are associated with MHC class II alleles that carry non-Asp and Asp at residue 57 of their beta chain respectively. The effect of Asp or non-Aspbeta57 may relate to a differential ability of distinct class II molecules to bind specific immuno-pathogenic peptides. Recent...

    journal_title:International immunology

    pub_type: 杂志文章


    authors: Quarsten H,Paulsen G,Johansen BH,Thorpe CJ,Holm A,Buus S,Sollid LM

    更新日期:1998-08-01 00:00:00

  • Structure of celiac disease-associated HLA-DQ8 and non-associated HLA-DQ9 alleles in complex with two disease-specific epitopes.

    abstract::The association of celiac disease (CD) with HLA-DQ2 and HLA-DQ8 is indicative of preferential mucosal T cell recognition of gluten fragments bound to either DQ allele. We have recently identified two gluten-derived, HLA-DQ8-restricted T cell stimulatory peptides, one each from gliadin and glutenin, recognized by speci...

    journal_title:International immunology

    pub_type: 杂志文章


    authors: Moustakas AK,van de Wal Y,Routsias J,Kooy YM,van Veelen P,Drijfhout JW,Koning F,Papadopoulos GK

    更新日期:2000-08-01 00:00:00

  • Differential effect of insulin and elevated glucose level on adenosine transport in rat B lymphocytes.

    abstract::Impaired lymphocyte function is a common feature of human diabetes. Nucleoside transport across the plasma membrane is an essential step during lymphocyte growth and activation. In our study, we evaluated the impact of diabetic conditions on nucleoside transport system in B lymphocytes. Examination of the nucleoside t...

    journal_title:International immunology

    pub_type: 杂志文章


    authors: Sakowicz M,Szutowicz A,Pawelczyk T

    更新日期:2005-02-01 00:00:00

  • The extended substrate specificity of the human mast cell chymase reveals a serine protease with well-defined substrate recognition profile.

    abstract::The human chymase (HC) is a major granule constituent of mast cells (MCs) residing in the connective tissue and the sub-mucosa. Although many potential substrates have been described for this important MC enzyme, its full range of in vivo substrates has most likely not yet been identified. A major step toward a better...

    journal_title:International immunology

    pub_type: 杂志文章


    authors: Andersson MK,Enoksson M,Gallwitz M,Hellman L

    更新日期:2009-01-01 00:00:00

  • Structural analysis of human anti-mouse H-2E xenorecognition: T cell receptor bias and impaired CD4 interaction contribute to weak xenoresponses.

    abstract::T lymphocyte responses to the MHC of an evolutionarily distant species are known to be weak compared with responses against allogeneic MHC products within a species. This fact was used to examine the regions of human MHC class II molecules required for the stimulation of strong primary immune responses against MHC all...

    journal_title:International immunology

    pub_type: 杂志文章


    authors: Ramesh P,Barber L,Batchelor JR,Lechler RI

    更新日期:1992-08-01 00:00:00

  • Basophils as T(h)2-inducing antigen-presenting cells.

    abstract::Recent studies have revealed a role for basophils as antigen-presenting cells that preferentially induce T(h)2 cells in response to complexes of antigen plus antigen-specific IgE, to protease allergens or to helminthic parasites in vitro and in vivo through the production of 'early IL-4' and the presentation to CD4(+)...

    journal_title:International immunology

    pub_type: 杂志文章,评审


    authors: Yoshimoto T

    更新日期:2010-07-01 00:00:00

  • Production of sterile transcripts of C gamma genes in an IgM-producing human neoplastic B cell line that switches to IgG-producing cells.

    abstract::A human neoplastic B cell line SSK41 that expresses IgM on its surface switches spontaneously to IgG-producing cells. The SSK41 line contains a single immunoglobulin heavy-chain locus, the constant region (C) genes of which retain the germline configuration. The IgG-producing SSK41 line was purified by sorting, and sh...

    journal_title:International immunology

    pub_type: 杂志文章


    authors: Sideras P,Mizuta TR,Kanamori H,Suzuki N,Okamoto M,Kuze K,Ohno H,Doi S,Fukuhara S,Hassan MS

    更新日期:1989-01-01 00:00:00

  • Phenotypic and functional heterogeneity of the IgD- B cell compartment: identification of two major tonsillar B cell subsets.

    abstract::Two major B cell subpopulations were identified in the IgD- compartment of tonsils and subsequently isolated. They displayed the following phenotypes: CD10+CD38+CD44- (CD38+ B cells) and CD10-CD38-CD44+ (CD38- B cells). Of the CD38- B cells, 70% also expressed CD24 and CD39, whereas CD77 was specifically distributed o...

    journal_title:International immunology

    pub_type: 杂志文章


    authors: Lagresle C,Bella C,Defrance T

    更新日期:1993-10-01 00:00:00

  • IL-18-independent cytotoxic T lymphocyte activation and IFN-gamma production during experimental acute graft-versus-host disease.

    abstract::Acute graft-versus-host disease (GvHD) is a serious complication after allogeneic bone marrow transplantation. Donor-derived T cells infiltrate recipient target organs and cause severe tissue damage, often leading to death of the affected patient. Tissue destruction is a direct result of donor CD8+ T cell activation a...

    journal_title:International immunology

    pub_type: 杂志文章


    authors: Arnold D,Wasem C,Juillard P,Graber P,Cima I,Frutschi C,Herren S,Jakob S,Alouani S,Mueller C,Chvatchko Y,Brunner T

    更新日期:2002-05-01 00:00:00

  • Differential recognition of a retinal autoantigen peptide and its variants by rat T cells in vitro and in vivo.

    abstract::Previously we have described the role of two 14mer peptides in autoimmune uveitis, PDSAg from the retinal autoantigen S-antigen (S-Ag) and B27PD from the sequence of disease-associated HLA-B molecules, which show antigenic mimicry. The retinal peptide gave rise to severe uveitis in the Lewis rat model of experimental ...

    journal_title:International immunology

    pub_type: 杂志文章


    authors: Wildner G,Diedrichs-Möhring M

    更新日期:2003-08-01 00:00:00

  • Hsp60-mediated T cell stimulation is independent of TLR4 and IL-12.

    abstract::Heat shock protein (Hsp) 60 is thought to function as endogenous danger signal by activating professional antigen-presenting cells (APC) through toll-like receptor (TLR) 4 and CD14, a mechanism that is also used by bacterial LPS. We recently showed that Hsp60 binds LPS and enhances LPS-induced immune stimulation. On t...

    journal_title:International immunology

    pub_type: 杂志文章


    authors: Osterloh A,Veit A,Gessner A,Fleischer B,Breloer M

    更新日期:2008-03-01 00:00:00

  • Immunolocalization of CD1d in human intestinal epithelial cells and identification of a beta2-microglobulin-associated form.

    abstract::In order to better understand the role of intestinal CD1d, we sought to define the cellular localization and further characterize the biochemical structure of CD1d in human intestinal epithelial cells (IEC). Using a CD1d-specific rabbit anti-gst-CD1d antibody, immunoprecipitation of radiolabeled cell surface proteins ...

    journal_title:International immunology

    pub_type: 杂志文章


    authors: Somnay-Wadgaonkar K,Nusrat A,Kim HS,Canchis WP,Balk SP,Colgan SP,Blumberg RS

    更新日期:1999-03-01 00:00:00

  • Mechanisms of cytokine synergy essential for vaccine protection against viral challenge.

    abstract::The ability of cytokines to steer CD4(+) T(h) cell responses toward a T(h)1 or T(h)2 phenotype and enhance the magnitude of both CD8(+) cytotoxic T lymphocytes (CTL) and antibody responses has clearly been demonstrated by our lab and others, but the influence of cytokines on protective immune responses is much less cl...

    journal_title:International immunology

    pub_type: 杂志文章


    authors: Ahlers JD,Belyakov IM,Matsui S,Berzofsky JA

    更新日期:2001-07-01 00:00:00