Regulation and role of the transcription factor IRF5 in innate immune responses and systemic lupus erythematosus.

abstract：:Mercury-induced autoimmunity is characterized by a T cell-dependent B cell activation (mainly of IgG1 and IgE isotypes), production of anti-nucleolar autoantibodies (ANolA) and the formation of renal IgG deposits. The autoimmunity is to a large extent controlled by genetic factors. We studied 15 different inbred mouse...

journal_title：International immunology

authors： Abedi-Valugerdi M,Möller G

更新日期：2000-10-01 00:00:00

abstract：:Leptin, one of the typical adipokines, is reported to promote Th17 cell responses and to enhance production of proinflammatory cytokines. To clarify the role of leptin in the regulation of the IL-23/IL-17 axis and the development of kidney disease, we used a murine model of nephrotoxic serum (NTS) nephritis (NTN). She...

journal_title：International immunology

authors： Goto K,Kaneko Y,Sato Y,Otsuka T,Yamamoto S,Goto S,Yamamoto K,Yamamoto T,Kawachi H,Madaio MP,Narita I

更新日期：2016-04-01 00:00:00

abstract：:Despite intense recent interest, the suppressive mechanisms of regulatory CD25+CD4 T cells remain poorly understood. One deficiency in the field is the lack of in vivo models where the effects of regulatory CD25+CD4 T cells on antigen-specific responder T cells can be measured quantitatively. We describe one such mode...

journal_title：International immunology

authors： Thorstenson KM,Herzovi L,Khoruts A

更新日期：2005-04-01 00:00:00

abstract：:The synthesis of antibodies of the IgE isotype in mice largely depends on IL-4, a cytokine that is released by T lymphocytes of the Th2 subtype. IL-12 is a cytokine considered to direct Th cell development into a Th1 direction and to suppress Th2 responses including the synthesis of IgE. Here we report about the influ...

journal_title：International immunology

authors： Germann T,Guckes S,Bongartz M,Dlugonska H,Schmitt E,Kolbe L,Kölsch E,Podlaski FJ,Gately MK,Rüde E

更新日期：1995-10-01 00:00:00

abstract：:Previously we examined the ability of the host's immune responses to regulate Ig production in an IgE-secreting murine plasma cell tumor (B53). In the present study we have examined the reverse phenomenon, in that we have investigated the effects of this and other plasma cell tumors on the immune responses of their ho...

journal_title：International immunology

authors： Ruzek MC,Mathur A

更新日期：1995-07-01 00:00:00

abstract：:The dynamic behaviour of isolated populations of peritoneal LPS-reactive (LPSr) B lymphocytes was studied upon transfer of peritoneal cells (PerC) from C57BL/6 LPS responder into C57BL/10ScCr LPS non-responder mice. We have followed the persistence and life-span of the transferred LPSr donor B cells in the spleen and ...

journal_title：International immunology

authors： Thomas-Vaslin V,Feitas AA

更新日期：1990-01-01 00:00:00

abstract：:Previously we observed elevation of the serum concentration of two acute-phase protein (AFP) complement components (C9 and C1-inhibitor) in patients with chronic hepatitis C who responded (R) to IFN-alpha therapy, but not in non-responders (NR). In the present study we investigated the effect of high-dose IFN-alpha th...

journal_title：International immunology

authors： Kalabay L,Nemesánszky E,Csepregi A,Pusztay M,Dávid K,Horváth G,Ibrányi E,Telegdy L,Pár A,Bíró A,Fekete B,Gervain J,Horányi M,Ribiczey P,Csöndes M,Kleiber M,Walentin S,Prohászka Z,Füst G

更新日期：2004-01-01 00:00:00

abstract：:Antigen-driven interaction of dendritic cells (DC) with CD4(+) T(h) cells results in the exchange of bidirectional activating signals. Cross-linking of TCR by MHC class II-bound antigen activates T(h) cells, resulting in their up-regulation of CD40 ligand. Here we show that MHC class II molecules, in addition to their...

journal_title：International immunology

authors： Lokshin AE,Kalinski P,Sassi RR,Mailliard RB,Müller-Berghaus J,Storkus WJ,Peng X,Marrangoni AM,Edwards RP,Gorelik E

更新日期：2002-09-01 00:00:00

abstract：:MicroRNAs 125a and 125b are predicted to be able to bind to the B lymphocyte-induced maturation protein-1 (BLIMP-1) and IFN regulatory protein-4 (IRF-4) transcription factors, which are essential for plasma cell differentiation. A computational survey of the human and mouse genomes revealed that miR-125a and miR-125b ...

journal_title：International immunology

authors： Gururajan M,Haga CL,Das S,Leu CM,Hodson D,Josson S,Turner M,Cooper MD

更新日期：2010-07-01 00:00:00

abstract：:To understand the nature of long-term Th immune responses, we investigated in the present study the TCRBV gene repertoire of CD4(+) T cells specific for the recall antigen tetanus toxoid (TT) in recipients of an allogeneic bone marrow transplantation (allo-BMT) at several time points after transplantation and in their...

journal_title：International immunology

authors： Godthelp BC,van Tol MJ,Vossen JM,van den Elsen PJ

更新日期：2001-04-01 00:00:00

abstract：:Dendritic cells (DCs) are specialized antigen-presenting cells that play pivotal roles in initiating immune responses. However, DC maturation is usually strongly restricted by the stromal microenvironment, especially in non-lymphoid tissues, such as skin and mucosa. Although suppression of DC maturation by stromal cel...

journal_title：International immunology

authors： Shiraishi H,Yoshida H,Saeki K,Miura Y,Watanabe S,Ishizaki T,Hashimoto M,Takaesu G,Kobayashi T,Yoshimura A

更新日期：2008-09-01 00:00:00

abstract：:Our aim was to investigate the quantitative relationship between inoculation doses and physiological responses to infection by Salmonella enterica serovar Enteritidis. Rats were orally inoculated with 10-10(9) c.f.u. of S. Enteritidis and monitored for 6 days. Neutrophil and delayed-type hypersensitivity (DTH) respons...

journal_title：International immunology

authors： Takumi K,Garssen J,Havelaar A

更新日期：2002-02-01 00:00:00

abstract：:CD25(+)CD4(+) regulatory T cells inhibit the activation of autoreactive T cells in vitro and in vivo, and suppress organ-specific autoimmune diseases. The mechanism of CD25(+)CD4(+) T cells in the regulation of experimental autoimmune encephalomyelitis (EAE) is poorly understood. To assess the role of CD25(+)CD4(+) T ...

journal_title：International immunology

authors： Zhang X,Koldzic DN,Izikson L,Reddy J,Nazareno RF,Sakaguchi S,Kuchroo VK,Weiner HL

更新日期：2004-02-01 00:00:00

abstract：:Blocking T cell co-stimulatory signals by anti-B7-1/B7-2 mAb is an attractive approach to treat autoimmune diseases. However, anti-B7-1/B7-2 mAb treatment is known to exacerbate autoimmune diseases through mechanisms not fully understood. Tumor necrosis factor alpha (TNF-alpha) and reactive oxygen species (ROS) also p...

journal_title：International immunology

authors： Khan N,Ghousunnissa S,Jegadeeswaran SM,Thiagarajan D,Hasnain SE,Mukhopadhyay S

更新日期：2007-04-01 00:00:00

abstract：:T-cell immune responses are critical for protection of the host and for disease pathogenesis during infection with Plasmodium species. We examined the regulation of CD4(+) T-cell cytokine responses during infection with Plasmodium berghei ANKA (PbA). CD4(+) T cells from PbA-infected mice produced IFN-γ, IL-4 and IL-10...

journal_title：International immunology

authors： Kimura D,Miyakoda M,Honma K,Shibata Y,Yuda M,Chinzei Y,Yui K

更新日期：2010-12-01 00:00:00

abstract：:An alloreactive CTL clone, 27.B2, produced in the mouse strain combination B6.C-H-2bm1 (bm1) against C57BL/6 (B6) and nominally directed against the Kb molecule has been shown to be peptide dependent. The clone recognizes intact B6, but not intact bm1 or bm3 target cells. However, peptides recognized by 27.B2 CTL can ...

journal_title：International immunology

authors： Falk K,Rötzschke O,Rammensee HG

更新日期：1992-03-01 00:00:00

abstract：:Sera of patients suffering from systemic lupus erythematosus (SLE) frequently contain oligoclonal IgG autoantibodies with high affinity for the ribosomal protein L7 (rpL7). The humoral autoimmune response to rpL7 apparently is driven by antigen and T cell dependent. In order to analyze the T cell response to rpL7 we c...

journal_title：International immunology

authors： Donauer J,Wochner M,Witte E,Peter HH,Schlesier M,Krawinkel U

更新日期：1999-02-01 00:00:00

abstract：:We established an experimental system in vitro to examine the developmental capacity of individual hematopoietic progenitors to generate T, B and myeloid (M) cells. By using this system we analyzed the process of lineage commitment of hematopoietic progenitors in murine fetal liver (FL). It is known that small numbers...

journal_title：International immunology

authors： Kawamoto H,Ohmura K,Katsura Y

更新日期：1997-07-01 00:00:00

abstract：:The integrins have been grouped into three subfamilies based on the utilization of three distinct beta chain subunits, beta 1, beta 2, and beta 3. The recent discovery of beta 4 and beta 5 subunits, and the sharing of alpha subunits between beta subfamilies reflects a greater structural and functional diversity of the...

journal_title：International immunology

authors： Yuan QA,Jiang WM,Krissansen GW,Watson JD

更新日期：1990-01-01 00:00:00

abstract：:Dendritic cells (DC) are highly potent activators of the immune response. The precise mechanisms that give rise to the DC phenotype are not known. To investigate the mechanisms that contribute to the generation of the DC phenotype, precursor DC were freshly isolated from human blood and allowed to mature in vitro. The...

journal_title：International immunology

authors： Engering AJ,Richters CD,Fluitsma DM,van Pelt AM,Kamperdijk EW,Hoefsmit EC,Pieters J

更新日期：1998-11-01 00:00:00

abstract：:Murine complement receptor type 2 (MCR2) is homologous to human CR2, whereas murine CR1 (MCR1) is structurally and evolutionary different from human CR1. Since ligand specificities of MCR1 and MCR2 are not completely clarified, we analyzed their functional characteristics to correlate them with structural information ...

journal_title：International immunology

authors： Pramoonjago P,Takeda J,Kim YU,Inoue K,Kinoshita T

更新日期：1993-04-01 00:00:00

abstract：:The lectin complement pathway is initiated by binding of mannose-binding lectin (MBL) and MBL-associated serine protease (MASP) to carbohydrates. In the human lectin pathway, MASP-1 and MASP-2 are involved in the proteolysis of C4, C2 and C3. Here we report that the human MBL-MASP complex contains a new 22 kDa protein...

journal_title：International immunology

authors： Takahashi M,Endo Y,Fujita T,Matsushita M

更新日期：1999-05-01 00:00:00

abstract：:Lymphokine activity in seven myelin basic protein (MBP)-specific T cell clones was examined. All of the clones recognize MBP peptide 1-9 in the context of I-Au. A strong positive correlation was found between levels of lymphotoxin (LT) and tumor necrosis factor alpha (TNF-alpha) mRNA and biological activity on L929 ce...

journal_title：International immunology

authors： Powell MB,Mitchell D,Lederman J,Buckmeier J,Zamvil SS,Graham M,Ruddle NH,Steinman L

更新日期：1990-01-01 00:00:00

abstract：:Based on the evidence that CD8+ cytotoxic T cells (CTL) precursors do not appear to distinguish between virus-infected cells and viral peptide-pulsed syngeneic cells, we have developed methods for priming class I MHC molecule restricted CD8+ CTL with such peptides without using any adjuvant. We were able to prime in v...

journal_title：International immunology

authors： Takahashi H,Nakagawa Y,Yokomuro K,Berzofsky JA

更新日期：1993-08-01 00:00:00

abstract：:In this paper we describe a monoclonal antibody, JR9-318, which was obtained from a wild-derived mouse immunized with the M14T cell line (CD3+CD4-CD8-) in order to describe antigenic molecules expressed during T cell differentiation. This mAb precipitated a protein from the M14T cell line or subclones that migrates li...

journal_title：International immunology

authors： Roland J,Cazenave PA

更新日期：1992-06-01 00:00:00

abstract：:Activation of T cells leads to the induction of many cytokine genes that are required for appropriate immune responses, including IL-2, a key cytokine for T cell proliferation and homeostasis. The activating transcription factors such as nuclear factor of activated T cells, nuclear factor kappaB/Rel and activated prot...

journal_title：International immunology

authors： Wang J,Lee S,Teh CE,Bunting K,Ma L,Shannon MF

更新日期：2009-03-01 00:00:00

abstract：:BALB/c mice are susceptible to cutaneous leishmaniasis upon infection with Leishmania major while C57BL/6 are not. There is a major promastigote surface protease (PSP or gp63) which is available in both native and recombinant forms, and for which the primary amino acid sequence is known. Immunization with PSP has been...

journal_title：International immunology

authors： Soares LR,Sercarz EE,Miller A

更新日期：1994-05-01 00:00:00

abstract：:Infection by protozoan parasites of the genus Leishmania results in the development of leishmaniasis, an increasingly prevalent group of diseases affecting over 12 million people worldwide. Leishmaniasis can have very different outcomes ranging from cutaneous lesions, mucosal lesions to visceralization depending on th...

journal_title：International immunology

authors： Rossi M,Fasel N

更新日期：2018-03-10 00:00:00

abstract：:In this study, a B cell growth stimulatory factor, constitutively secreted by a human CD4+ T cell hybridoma clone, MP6, has been purified and characterized. Serum-free 24 h culture media from MP6 cells were collected, concentrated by ultrafiltration and separated by gel chromatography. Fractions were analyzed for stim...

journal_title：International immunology

authors： Rosen A,Lundman P,Carlsson M,Bhavani K,Srinivasa BR,Kjellström G,Nilsson K,Holmgren A

更新日期：1995-04-01 00:00:00

abstract：:HLA-G, a human MHC class I molecule expressed on the trophoblast during pregnancy, was expressed in transgenic mice by recombining the HLA-G gene with a transcriptional promoter from a murine H-2 MHC class I gene. Skin grafts from HLA-G transgenic mice were rejected by non-transgenic mice showing that HLA-G behaves as...

journal_title：International immunology

authors： Horuzsko A,Antoniou J,Tomlinson P,Portik-Dobos V,Mellor AL

更新日期：1997-05-01 00:00:00