HLA-G functions as a restriction element and a transplantation antigen in mice.

abstract：:Under physiological conditions immune complexes (IC) are efficiently cleared from the circulation and meanwhile provide important feedback signals for the immune system via Fc gamma Rs and complement receptors. Dysregulation of these mechanisms have been implicated in conditions where IC concentrations reach pathologi...

journal_title：International immunology

authors： Isaák A,Gergely P Jr,Szekeres Z,Prechl J,Poór G,Erdei A,Gergely J

更新日期：2008-02-01 00:00:00

abstract：:Using Ia antigen-containing lipid vesicles, we investigated by stopped-flow fluorometry the requirements for helper T cell recognition and activation. When azobenzenearsonate-L-tyrosine (ABA-L-Tyr)-specific, I-Ak-restricted helper T cell hybridomas 2-45-12 were mixed with ABA-L-Tyr and purified I-Ak molecules on lipid...

journal_title：International immunology

authors： Odaka C,Utsunomiya N,Nakanishi M,Arata Y,Manabe S,Yasuda T,Tadakuma T

更新日期：1990-01-01 00:00:00

abstract：:Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are among the major causes of death worldwide due to acute inflammation in the lung. AT-rich interactive domain-containing 5a (Arid5a) is an RNA-binding protein involved in inflammatory autoimmune disease through post-transcriptional control of Il6...

journal_title：International immunology

authors： Dubey PK,Masuda K,Nyati KK,-Uz Zaman MM,Chalise JP,Millrine D,Kai W,Ripley B,Kishimoto T

更新日期：2017-02-01 00:00:00

abstract：:The endocytic and phagocytic activities of a population of MHC IIhi CD11c+ dendritic cell (DC)-like cells in synovium-rich tissues (SRTs) of normal rat paws were compared with CD163+ cells (putative macrophages) from the same tissues and pseudo-afferent lymph DCs, peritoneal macrophages and blood monocytes. Fifty perc...

journal_title：International immunology

authors： Moghaddami M,Mayrhofer G,Cleland LG

更新日期：2005-08-01 00:00:00

abstract：:Southern blot analysis of genomic DNA of normal mouse thymocytes with a JH4 probe, a probe for JH4 of Igh genes, consistently showed a second band in addition to a germline band. The same band was also observed in analysis with a 5' DQ probe, a 5'-flanking sequence of DQ52, thus suggesting the use of DQ52. By analyzin...

journal_title：International immunology

authors： Suzuki H,Abe M,Nishikawa S,Nakayama E,Shiku H

更新日期：1989-01-01 00:00:00

abstract：:In this review, we propose that certain modifications in cellular metabolism might function as danger signals triggering inflammasome-mediated immune responses. We propose to call them danger-associated metabolic modifications (DAMMs). As intracellular bacteria can actively modulate macrophage metabolism for their ben...

journal_title：International immunology

authors： Dramé M,Buchrieser C,Escoll P

更新日期：2020-06-26 00:00:00

abstract：:A gelatin sponge model of concomitant tumor immunity was employed in order to examine the clonality of T cells associated with progressing and rejected tumor sites. Here we show that freshly isolated T cells bearing TCR V(beta)1, CDR3 RPGTGN, J(beta)1.1 and TCR V(beta)8, CDR3 GD, J(beta)1.6 predominated progressing an...

journal_title：International immunology

authors： Kurt RA,Park JA,Schluter SF,Marchalonis JJ,Akporiaye ET

更新日期：2000-05-01 00:00:00

abstract：:We investigated the role of IL-7 receptor alpha (IL-7Ralpha) signal in the formation of Peyer's patch (PP) anlage. Although pan-lymphopenia is a common phenotype of rag2-/- and il7ralpha-/- mice, a close inspection revealed nodules corresponding to PP in the adult rag2-/- but not in the il7ralpha-/- mouse. In our prev...

journal_title：International immunology

authors： Adachi S,Yoshida H,Honda K,Maki K,Saijo K,Ikuta K,Saito T,Nishikawa SI

更新日期：1998-01-01 00:00:00

abstract：:It is increasingly evident that neutrophils are able to cross-talk with other leukocytes to shape ongoing inflammatory and immune responses. In this study, we analyzed whether human NK cells may influence the survival and activation of neutrophils under co-culture conditions. We report that NK cells exposed to either ...

journal_title：International immunology

authors： Costantini C,Micheletti A,Calzetti F,Perbellini O,Pizzolo G,Cassatella MA

更新日期：2010-10-01 00:00:00

abstract：:The thymus leukemia antigens (TL) belong to the MHC class Ib family and can be recognized by CD8-dependent or -independent cytotoxic T lymphocytes (CTL) showing TL, but not H-2, restriction. We previously reported that the CTL epitope is TAP independent and in the present study we further characterize the recognition ...

journal_title：International immunology

authors： Tsujimura K,Obata Y,Kondo E,Nishida K,Matsudaira Y,Akatsuka Y,Kuzushima K,Takahashi T

更新日期：2003-11-01 00:00:00

abstract：:The extracellular signal-regulated kinase (ERK) signaling pathway is strongly activated in response to TCR stimulation in normal T cells. However, the extent to which activation of the ERK pathway is necessary for TCR-stimulated cytokine production is not clear. We have addressed this question by use of two separate m...

journal_title：International immunology

authors： Egerton M,Fitzpatrick DR,Kelso A

更新日期：1998-02-01 00:00:00

abstract：:A canonical pre-TCR/TCR signaling pathway critical for thymic T cell development involves sequential phosphorylation and signaling through Lck, Zap70, Lat and Slp76. However, we and others have previously reported that genomic deletion of c-Cbl (Cbl) partially or completely reverses the defects in thymic development i...

journal_title：International immunology

authors： Chiang YJ,Hodes RJ

更新日期：2015-05-01 00:00:00

abstract：:J11d is expressed on a variety of hemopoietic cells, including B cells. In previous studies, we have shown that B cells are heterogeneous with respect to their levels of J11d expression and that memory B cells are contained within the J11dlo B cell population. In this report, we have further examined the relationship ...

journal_title：International immunology

authors： Yin XM,Vitetta ES

更新日期：1992-06-01 00:00:00

abstract：:Rheumatic fever (RF) follows a throat infection with different M-serotypes of beta-hemolytic group A streptococci (GAS) and can affect different tissues, predominantly the heart. It is thought to be an autoimmune illness. Although histological examination of affected heart shows an infiltrate consisting mainly of T ce...

journal_title：International immunology

authors： Pruksakorn S,Currie B,Brandt E,Phornphutkul C,Hunsakunachai S,Manmontri A,Robinson JH,Kehoe MA,Galbraith A,Good MF

更新日期：1994-08-01 00:00:00

abstract：:Dendritic cells (DC) are professional antigen-presenting cells that play a central role in the control of immunity. Mature DC are characterized by high expression levels of MHC and co-stimulatory molecules, and by the secretion of IL-12, a key cytokine for the priming of cytotoxic T lymphocytes. Here, we have compared...

journal_title：International immunology

authors： Rouas R,Lewalle P,El Ouriaghli F,Nowak B,Duvillier H,Martiat P

更新日期：2004-05-01 00:00:00

abstract：:HLA class II molecules present superantigens more efficiently than their murine counterpart. Therefore, transgenic mice expressing HLA-DQ8 with and without CD28 were used to address the role of CD28 in staphylococcal enterotoxin B (SEB)-driven immune responses. SEB-induced in vitro proliferation of naive DQ8.CD28(-/-)...

journal_title：International immunology

authors： Rajagopalan G,Smart MK,Marietta EV,David CS

更新日期：2002-07-01 00:00:00

abstract：:Virus-like particles are a highly effective type of subunit vaccine that mimics the overall structure of virus particles without containing infectious genetic material. In this work, a particulate form of the recombinant capsid protein from dengue-2 was evaluated in mice to determine the level of protection against vi...

journal_title：International immunology

authors： Gil L,López C,Lazo L,Valdés I,Marcos E,Alonso R,Gambe A,Martín J,Romero Y,Guzmán MG,Guillén G,Hermida L

更新日期：2009-10-01 00:00:00

abstract：:Using anti-Tac (anti-alpha chain) and 2R-B (anti-beta chain) antibodies, we studied the roles of IL-2 receptor subunits (alpha and beta chains) in the formation of IL-2 and high-affinity IL-2 receptor complex, which is the initial event of IL-2 induced T cell growth. High-affinity IL-2 binding which was undetectable i...

journal_title：International immunology

authors： Kamio M,Uchiyama T,Arima N,Itoh K,Ishikawa T,Hori T,Uchino H

更新日期：1990-01-01 00:00:00

abstract：:Non-obese diabetic (NOD) mice that are genetically deficient in either IFN-gamma or beta chain of the IFN-gammaR develop diabetes with similar kinetics to wild-type NOD mice. In the current study, we demonstrated that treatment of IFN-gamma signaling-deficient NOD mice with cyclophosphamide (CY) not only fails to indu...

journal_title：International immunology

authors： Mori Y,Kato T,Kodaka T,Kanagawa EM,Hori S,Kanagawa O

更新日期：2008-09-01 00:00:00

abstract：:IL-12 has been shown to play a central role in cell-mediated inflammatory reactions through direct activation of T cells and NK cells. IL-12 also strongly influences humoral immunity but these effects have been thought to be indirect and caused by intermediary cytokines. Using flow cytometry, we now show that IL-12 di...

journal_title：International immunology

authors： Vogel LA,Showe LC,Lester TL,McNutt RM,Van Cleave VH,Metzger DW

更新日期：1996-12-01 00:00:00

abstract：:We have analyzed transcripts encoding the variable regions of Ig heavy chains from adult and fetal bovine splenocytes and bovine x mouse heterohybridomas. The 13 adult, seven fetal and two heterohybridomas transcripts as well as the six genes that were sequenced had > 83% identity to each other in the VH-encoded regio...

journal_title：International immunology

authors： Berens SJ,Wylie DE,Lopez OJ

更新日期：1997-01-01 00:00:00

abstract：:Heat shock protein (Hsp) 60 is thought to function as endogenous danger signal by activating professional antigen-presenting cells (APC) through toll-like receptor (TLR) 4 and CD14, a mechanism that is also used by bacterial LPS. We recently showed that Hsp60 binds LPS and enhances LPS-induced immune stimulation. On t...

journal_title：International immunology

authors： Osterloh A,Veit A,Gessner A,Fleischer B,Breloer M

更新日期：2008-03-01 00:00:00

abstract：:We have followed CD4 and CD8 TCR V beta repertoires during the acute phase of Trypanosoma cruzi infection in a resistant mouse strain (C57BL/6). No major changes were found in the V beta TCR distributions analyzed (covering roughly 40% of the TCR repertoire) in peripheral CD4 T lymphocytes, confirming the polyclonal n...

journal_title：International immunology

authors： Leite-de-Moraes MC,Coutinho A,Hontebeyrie-Joskowicz M,Minoprio P,Eisen H,Bandeira A

更新日期：1994-03-01 00:00:00

abstract：:CD4 and CD8 T cell subsets involved in primary allo-MLR responses were re-evaluated in the present study. The slope analysis of B6 allo-MLR responses to MHC class I-disparate bm1 and class II-disparate bm12 revealed the presence of a T-T cell interaction between CD4 and CD8 T cell subsets. The allo-MLR response of B6 ...

journal_title：International immunology

authors： Asano Y,Komuro T,Tada T

更新日期：1990-01-01 00:00:00

abstract：:CD69, an 'activation marker' that is rapidly induced on mature T cells after stimulation through the T cell antigen receptor (TCR) was found to be expressed on approximately 10% of normal thymocytes. All of these CD69+ thymocytes express alpha beta TCR, and they include both TCRlowCD4+CD8+ and TCRhighCD4+CD8- or CD4-C...

journal_title：International immunology

authors： Yamashita I,Nagata T,Tada T,Nakayama T

更新日期：1993-09-01 00:00:00

abstract：:Lymphocyte homing to lymph nodes is regulated by transient but specific interactions between lymphocytes and high endothelial venules (HEVs), the initial phase of which is mainly governed by the leukocyte adhesion molecule L-selectin, which recognizes sulfated and sialylated O-linked oligosaccharides displayed on sial...

journal_title：International immunology

authors： Kanda H,Tanaka T,Matsumoto M,Umemoto E,Ebisuno Y,Kinoshita M,Noda M,Kannagi R,Hirata T,Murai T,Fukuda M,Miyasaka M

更新日期：2004-09-01 00:00:00

abstract：:We have determined the origin and cell surface phenotype of B cells producing antibody in response to immunization with the non-self TI-2 antigen polyvinyl pyrrolidinone (PVP). We report that the responding cells are derived from precursors in adult bone marrow and display the phenotype characteristic of B-1 cells. By...

journal_title：International immunology

authors： Whitmore AC,Haughton G,Arnold LW

更新日期：1996-04-01 00:00:00

abstract：:Dendritic cells (DC) sense saprophytic yeast and pathogenic, filamentous forms of Candida albicans in a specific way, resulting in disparate patterns of DC and T(h) cell activation. Using human and murine DC, such disparate patterns could be traced to the exploitation of distinct recognition receptors. Although usage ...

journal_title：International immunology

authors： Romani L,Montagnoli C,Bozza S,Perruccio K,Spreca A,Allavena P,Verbeek S,Calderone RA,Bistoni F,Puccetti P

更新日期：2004-01-01 00:00:00

abstract：:The previously defined binding motif of MHC class I H-2Kd-restricted antigenic peptides consists of a Y residue in position P2 and a hydrophobic residue with a large aliphatic side chain (L, I, or V) in position P9/P10 of optimal 9- or 10-mer peptides. We show now that the presence of a charged or a F residue in posit...

journal_title：International immunology

authors： Eberl G,Sabbatini A,Servis C,Romero P,Maryanski JL,Corradin G

更新日期：1993-11-01 00:00:00

abstract：:The role of B7 co-stimulatory signaling in in vivo tumor rejection remains incompletely characterized. In particular, the relative competence of B7-1 (CD80) and B7-2 (CD86) to provide effective co-stimulus is not well defined, and the identification of the T cell co-stimulatory receptor that mediates B7 co-stimulation...

journal_title：International immunology

authors： Yu X,Abe R,Hodes RJ

更新日期：1998-06-01 00:00:00