Ligand specificities of mouse complement receptor types 1 (CR1) and 2 (CR2) purified from spleen cells.

abstract：:Normal human sera contained 10-60 ng/ml of soluble membrane cofactor protein (MCP, CD46) whereas sera of > 50% of the cancer patients contained > 60 ng/ml. MCP purified by immunoaffinity chromatography from both normal and cancer patients' sera consisted of three bands of 56, 47 and 29 kDa on SDS-PAGE/immunoblotting. ...

journal_title：International immunology

authors： Seya T,Hara T,Iwata K,Kuriyama S,Hasegawa T,Nagase Y,Miyagawa S,Matsumoto M,Hatanaka M,Atkinson JP

更新日期：1995-05-01 00:00:00

abstract：:Intravenous sensitization of C57BL/6 (B6) mice with class II H-2-disparate B6-C-H-2bm12(bm12) resting B cells induced anti-bm12 CD4+ T cell tolerance as shown by hyporesponsiveness in the anti-bm12 mixed lymphocyte reaction (MLR). The present study investigated the mechanism(s) of the failure of bm12 B cells to stimul...

journal_title：International immunology

authors： Toyooka K,Maruo S,Iwahori T,Yamamoto N,Tai XG,Abe R,Takahama Y,Murakami M,Uede T,Hamaoka T,Fujiwara H

更新日期：1996-02-01 00:00:00

abstract：:Candida albicans is a commensal fungus that predominantly resides on mucosal surfaces and can cause lethal systemic infection when the host defense is compromised. Candidalysin is a cytolytic peptide toxin produced by C. albicans hyphae that is essential for mucosal tissue damage and is believed to contribute to the e...

journal_title：International immunology

authors： Hanaoka M,Domae E

更新日期：2020-10-10 00:00:00

abstract：:The chicken represents the best-characterized animal model for B cell development in the so-called gut-associated lymphoid tissue (GALT) and the molecular processes leading to B cell receptor diversification in this species are well investigated. However, the mechanisms regulating B cell development and homeostasis in...

journal_title：International immunology

authors： Kothlow S,Morgenroth I,Graef Y,Schneider K,Riehl I,Staeheli P,Schneider P,Kaspers B

更新日期：2007-02-01 00:00:00

abstract：:We have found that FOXP3 is an oligomeric component of a large supramolecular complex. Certain FOXP3 mutants with single amino acid deletions in the leucine zipper domain of FOXP3 are associated with the X-linked autoimmunity-allergic dysregulation (XLAAD) and immunodysregulation, polyendocrinopathy and enteropathy, X...

journal_title：International immunology

authors： Li B,Samanta A,Song X,Iacono KT,Brennan P,Chatila TA,Roncador G,Banham AH,Riley JL,Wang Q,Shen Y,Saouaf SJ,Greene MI

更新日期：2007-07-01 00:00:00

abstract：:In this study we investigated the role of the invariant chain (li) in the presentation of hen egg lysozyme (HEL) and measles virus hemagglutinin (HA) antigens to MHC class II-restricted T hybridoma cells. Fibroblastic cells transfected with Ed or Ak genes, and supertransfected or not with the li gene, were used as ant...

journal_title：International immunology

authors： Bertolino P,Forquet F,Pont S,Koch N,Gerlier D,Rabourdin-Combe C

更新日期：1991-05-01 00:00:00

abstract：:In an attempt to identify autoantigens of synovium in rheumatoid arthritis (RA), we constructed lambda phage expression cDNA libraries from synovium and screened them by IgG purified from synovial fluids, both of which were derived from RA patients. As a result of this unique combination of the libraries and probes, w...

journal_title：International immunology

authors： Tanaka M,Ozaki S,Osakada F,Mori K,Okubo M,Nakao K

更新日期：1998-09-01 00:00:00

abstract：:Lymphokine activity in seven myelin basic protein (MBP)-specific T cell clones was examined. All of the clones recognize MBP peptide 1-9 in the context of I-Au. A strong positive correlation was found between levels of lymphotoxin (LT) and tumor necrosis factor alpha (TNF-alpha) mRNA and biological activity on L929 ce...

journal_title：International immunology

authors： Powell MB,Mitchell D,Lederman J,Buckmeier J,Zamvil SS,Graham M,Ruddle NH,Steinman L

更新日期：1990-01-01 00:00:00

abstract：:Leptin, one of the typical adipokines, is reported to promote Th17 cell responses and to enhance production of proinflammatory cytokines. To clarify the role of leptin in the regulation of the IL-23/IL-17 axis and the development of kidney disease, we used a murine model of nephrotoxic serum (NTS) nephritis (NTN). She...

journal_title：International immunology

authors： Goto K,Kaneko Y,Sato Y,Otsuka T,Yamamoto S,Goto S,Yamamoto K,Yamamoto T,Kawachi H,Madaio MP,Narita I

更新日期：2016-04-01 00:00:00

abstract：:BALB/c mice injected at birth with 10(8) semi-allogeneic (C57BL/6 x BALB.IgHb)F1 spleen cells develop a lupus-like syndrome in which autoantibodies bear exclusively the donor allotype. We have analyzed the evolution of donor B cell chimerism and the autoimmune manifestations during the first year of life in these mice...

journal_title：International immunology

authors： de la Hera M,de la Hera A,Ramos A,Buelta L,Alonso JL,Rodriguez-Valverde V,Merino J

更新日期：1992-01-01 00:00:00

abstract：:Antigen engagement of the TCR may lead to activation of mature T cells while inducing deletion or positive selection of immature thymocytes. Using thymocytes from TCR transgenic mice recognizing the allo-antigen H-2Kb we investigated whether double-positive CD4+CD8+ (DP) thymocytes constitute a particular developmenta...

journal_title：International immunology

authors： Simon AK,Auphan N,Schmitt-Verhulst AM

更新日期：1996-09-01 00:00:00

abstract：:LPS-binding protein (LBP) can facilitate the transfer of cell wall components of both Gram-negative bacteria (LPS) and Gram-positive bacteria (lipoteichoic acid) to inflammatory cells. Although LBP is predominantly produced in the liver, recent studies have indicated that this protein is also synthesized locally in th...

journal_title：International immunology

authors： Branger J,Florquin S,Knapp S,Leemans JC,Pater JM,Speelman P,Golenbock DT,van der Poll T

更新日期：2004-11-01 00:00:00

abstract：:In this paper we describe a monoclonal antibody, JR9-318, which was obtained from a wild-derived mouse immunized with the M14T cell line (CD3+CD4-CD8-) in order to describe antigenic molecules expressed during T cell differentiation. This mAb precipitated a protein from the M14T cell line or subclones that migrates li...

journal_title：International immunology

authors： Roland J,Cazenave PA

更新日期：1992-06-01 00:00:00

abstract：:The intestinal epithelium not only acts as the physical structure that separates the intestinal lumen from the body but also actively participates in intestinal barrier functions. In the past decade, significant progress has been made in the development of culture technologies to maintain intestinal epithelial cells (...

journal_title：International immunology

authors： Nakamura T

更新日期：2019-02-06 00:00:00

abstract：:In this study, we show that IFNalpha increases the chemotaxis of human B cells to CCL20, CCL21 and CXCL12 in a dose- and time-dependent manner. The effect was maximal with 2000 IU ml(-1) IFNalpha. It peaked at 24 h and decreased thereafter. At 24 h, IFNalpha had increased B-cell chemotaxis to CCL20 by 20 +/- 6.2% (n =...

journal_title：International immunology

authors： Badr G,Borhis G,Treton D,Richard Y

更新日期：2005-04-01 00:00:00

abstract：:HLA-B*0702 transgenic mice (expressing a chimeric heavy chain with a murine alpha 3 domain: HLA-B7(m alpha 3)) in which the H-2K(b) and H-2D(b) class I-a (Cl I-a(-/-)) genes have been inactivated were compared with H-2K(b)D(b) Cl I-a(+/+) positive controls. Expression of the HLA-B7(m alpha 3) molecules resulted in a 3...

journal_title：International immunology

authors： Rohrlich PS,Cardinaud S,Firat H,Lamari M,Briand P,Escriou N,Lemonnier FA

更新日期：2003-06-01 00:00:00

abstract：:The non-obese diabetic (NOD) mouse spontaneously develops T-cell-mediated autoimmune insulitis. We analyzed the clonotypes of T cell infiltrates of the NOD mouse islets using a new method we have developed recently, which consists of RT-PCR amplification of the CDR3 region of the TCR beta chain mRNA and subsequent sin...

journal_title：International immunology

authors： Komagata Y,Masuko K,Tashiro F,Kato T,Ikuta K,Nishioka K,Ito K,Miyazaki J,Yamamoto K

更新日期：1996-06-01 00:00:00

abstract：:We asked herein whether functional dendritic-like cells could be generated from t(9;22) acute lymphoblastic leukemia (ALL) blasts. We first determined that the combination of interleukin (IL)-1beta, IL-3, IL-7, tumor necrosis factor-alpha, stem cell factor and CD40 ligand was optimal for generating dendritic-like cell...

journal_title：International immunology

authors： Lee J,Sait SN,Wetzler M

更新日期：2004-10-01 00:00:00

abstract：:NOD mice spontaneously develop type I diabetes resulting from autoimmune destruction of their insulin-producing beta cells. Among the self-antigens targeted by NOD autoimmune T cells is a peptide, p277, from the sequence of the 60 kDa heat shock protein (hsp60). Common to the anti-p277 T cell populations of NOD mice i...

journal_title：International immunology

authors： Elias D,Tikochinski Y,Frankel G,Cohen IR

更新日期：1999-06-01 00:00:00

abstract：:Experiments in transgenic mice have demonstrated that thymocyte differentiation into the mature CD4+ helper or CD8+ cytotoxic T cell lineage is ultimately dependent upon the specificity of the TCR for class II or class I MHC molecules respectively. However, the initial mechanistic events involved in this process remai...

journal_title：International immunology

authors： DeKoning J,Carbone FR,Kaye J

更新日期：1995-04-01 00:00:00

abstract：:The TCR is responsible for the specificity of cytotoxic T lymphocytes (CTL) by recognizing peptides presented in the context of MHC. By producing recombinant soluble TCR, it is possible to study this interaction at the molecular level. We generated single-chain TCR (scTCR) from tumor infiltrating lymphocytes (TIL) and...

journal_title：International immunology

authors： Lake DF,Salgaller ML,van der Bruggen P,Bernstein RM,Marchalonis JJ

更新日期：1999-05-01 00:00:00

abstract：:Neural stem cells (NSCs) transplantation has been proposed as a means of restoring damaged brain tissue, a possibility rendered more likely by reports of low NSCs immunogenicity in various experimental models because of low expression of MHC class I and II as well as co-stimulatory molecules. We investigated the immun...

journal_title：International immunology

authors： Ubiali F,Nava S,Nessi V,Frigerio S,Parati E,Bernasconi P,Mantegazza R,Baggi F

更新日期：2007-09-01 00:00:00

abstract：:We examined effects of c-fos overexpression on the development and property of peritoneal B-1 cells using transgenic (H2-c-fos) mice carrying the c-fos gene under the control of the constitutive H-2Kb promoter. The number of B-1b cells in the peritoneal cavity of H2-c-fos mice was 4-fold larger than that in control li...

journal_title：International immunology

authors： Mori S,Sakamoto A,Yamashita K,Fujimura L,Arima M,Hatano M,Miyazaki M,Tokuhisa T

更新日期：2004-10-01 00:00:00

abstract：:In this study, we analyzed peripheral blood CD4+CD8+ double-positive (DP) lymphocytes in adult cynomolgus monkeys (Macaca fascicularis). Forty of 55 monkeys had > 5% of the peripheral blood DP subpopulation (9.3 +/- 5.9%; mean +/- SD) in peripheral blood lymphocytes (PBL) in contrast to a low percentage of peripheral ...

journal_title：International immunology

authors： Akari H,Terao K,Murayama Y,Nam KH,Yoshikawa Y

更新日期：1997-04-01 00:00:00

abstract：:NK cells are functionally controlled by the killer immunoglobulin-like receptor (KIR) family that comprises inhibitory (iKIR) and activating (aKIR) members. Genetic association studies suggest that donors expressing aKIRs next to iKIRs will be superior donors in the setting of hematopoietic stem cell transplantation o...

journal_title：International immunology

authors： Baltner K,Kübler A,Pal M,Balvociute M,Mezger M,Handgretinger R,André MC

更新日期：2017-11-01 00:00:00

abstract：:Murine bone marrow-derived macrophages (BMM) are able to inhibit the intracellular growth of Mycobacterium bovis and Mycobacterium tuberculosis H37Rv after activation with recombinant (r) IFN and growth inhibition is mediated by reactive nitrogen intermediates (RNI) derived from L-arginine. We now demonstrate that tum...

journal_title：International immunology

authors： Flesch IE,Hess JH,Oswald IP,Kaufmann SH

更新日期：1994-05-01 00:00:00

abstract：:We have generated a high copy number transgenic mouse line in which expression of mouse IL-7 cDNA is under the control of the mouse MHC class II E alpha promoter. These mice were generated in order to see if IL-7 over-production in the thymus altered either thymocyte differentiation or the process of negative selectio...

journal_title：International immunology

authors： Mertsching E,Burdet C,Ceredig R

更新日期：1995-03-01 00:00:00

abstract：:It is well established that the bacterial superantigens bind to both TCR beta-chain and, with moderate affinity, to MHC class II molecules. Class II-bearing cells bind the superantigen and present the superantigen to T cells expressing certain TCR beta-chain variable region alleles. We have observed that the superanti...

journal_title：International immunology

authors： Rogers TJ,Guan L,Zhang L

更新日期：1995-11-01 00:00:00

abstract：:Signal transducer and activator of transcription-1 (STAT1) signaling mediate most biological functions of IFNalpha, IFNbeta and IFNgamma although recent studies indicate that IFNgamma can alter expression of several genes via a STAT1-independent pathway. STAT1 is critical for immunity against a variety of intracellula...

journal_title：International immunology

authors： Roth KM,Gunn JS,Lafuse W,Satoskar AR

更新日期：2009-01-01 00:00:00

abstract：:A Plasmodium falciparum schizont lysate has been previously described as being a powerful inducer of proliferation for human peripheral T lymphocytes. In this report we study the phenotype of cycling T cells from unexposed donors and examine how the P. falciparum lysate compares with the conventional T cell mitogen ph...

journal_title：International immunology

authors： Behr C,Dubois P

更新日期：1992-03-01 00:00:00