Transmembrane polar residues of TCR beta chain are required for signal transduction.

abstract：:CD100/Sema4D belongs to the semaphorin family, factors known to act as repulsive cues for axons during neuronal development. Mouse CD100 plays a crucial role in both humoral and cellular immunity through ligation of the lymphocyte receptor, CD72. It remains controversial, however, whether human CD100 can function thro...

journal_title：International immunology

authors： Ishida I,Kumanogoh A,Suzuki K,Akahani S,Noda K,Kikutani H

更新日期：2003-08-01 00:00:00

abstract：:Quantitative expression of class I genes varies widely in different tissues, during development and in some neoplastic cells. Regulatory DNA sequences controlling levels of transcription of class I genes have been characterized in the murine and swine promoters. Although some regulatory features appear to be retained ...

journal_title：International immunology

authors： Blanchet O,Gazin C,L'Haridon M,Tatari Z,Degos L,Sigaux F,Paul P

更新日期：1994-10-01 00:00:00

abstract：:Toll-like receptors (TLRs) traffic to distinct membranes for signaling. TLR7 and TLR9 recognize viral nucleic acids in the endosomes and induce robust anti-viral program. Signaling from these TLRs bifurcate at the level of distinct endosomal compartments, namely VAMP3(+) and LAMP(+) endosomes, to mediate the induction...

journal_title：International immunology

authors： Hayashi K,Sasai M,Iwasaki A

更新日期：2015-09-01 00:00:00

abstract：:Leishmania donovani resides within the host macrophages by dampening host defence mechanisms and thereby it modulates the host cell functions for its survival. Multiple host cell factors compete during the interplay between the host and the parasite. Roles for dual-specificity phosphatases (DUSPs) are implicated in va...

journal_title：International immunology

authors： Parveen S,Bandhyopadhyay S,Das S,Majumdar SB,Jawed JJ,Chowdhury BP,Saha B,Majumdar S

更新日期：2016-12-01 00:00:00

abstract：:Induction of alphaEbeta7 expression on T cells by transforming growth factor (TGF)-beta is thought to be important for intestinal intraepithelial T lymphocyte (IEL) entry into the epithelial compartment. However, there has been no in vivo evidence that up-regulation of alphaEbeta7 expression on T cells by TGF-beta is ...

journal_title：International immunology

authors： Suzuki R,Nakao A,Kanamaru Y,Okumura K,Ogawa H,Ra C

更新日期：2002-04-01 00:00:00

abstract：:Amongst CD4-CD8- (double negative) thymocytes there is a sizeable population (variable from strain to strain) of cells expressing surface T cell receptor (TCR). These TCR+ double negatives are predominantly non-cycling, have very little precursor activity, and, unlike the TCR-CD4-CD8- thymocytes, appear not to be part...

journal_title：International immunology

authors： Wu L,Pearse M,Egerton M,Petrie H,Scollay R

更新日期：1990-01-01 00:00:00

abstract：:Dendritic cells (DC) are professional antigen-presenting cells that play a central role in the control of immunity. Mature DC are characterized by high expression levels of MHC and co-stimulatory molecules, and by the secretion of IL-12, a key cytokine for the priming of cytotoxic T lymphocytes. Here, we have compared...

journal_title：International immunology

authors： Rouas R,Lewalle P,El Ouriaghli F,Nowak B,Duvillier H,Martiat P

更新日期：2004-05-01 00:00:00

abstract：:T lymphocyte responses to the MHC of an evolutionarily distant species are known to be weak compared with responses against allogeneic MHC products within a species. This fact was used to examine the regions of human MHC class II molecules required for the stimulation of strong primary immune responses against MHC all...

journal_title：International immunology

authors： Ramesh P,Barber L,Batchelor JR,Lechler RI

更新日期：1992-08-01 00:00:00

abstract：:LPS-binding protein (LBP) can facilitate the transfer of cell wall components of both Gram-negative bacteria (LPS) and Gram-positive bacteria (lipoteichoic acid) to inflammatory cells. Although LBP is predominantly produced in the liver, recent studies have indicated that this protein is also synthesized locally in th...

journal_title：International immunology

authors： Branger J,Florquin S,Knapp S,Leemans JC,Pater JM,Speelman P,Golenbock DT,van der Poll T

更新日期：2004-11-01 00:00:00

abstract：:Treatment of melanoma cell lines with IFN-gamma induces the switch from proteasome (PS) to immunoproteasome (iPS). This finding has profound implications for the immunobiology of melanoma cells since certain peptides (such as Melan-A(mart1)(27-35)) are cleaved differently by iPS, thus implying a different ability to b...

journal_title：International immunology

authors： Cangemi G,Morandi B,D'Agostino A,Peri C,Conte R,Damonte G,Ferlazzo G,Biassoni R,Melioli G

更新日期：2003-12-01 00:00:00

abstract：:Antigen-driven interaction of dendritic cells (DC) with CD4(+) T(h) cells results in the exchange of bidirectional activating signals. Cross-linking of TCR by MHC class II-bound antigen activates T(h) cells, resulting in their up-regulation of CD40 ligand. Here we show that MHC class II molecules, in addition to their...

journal_title：International immunology

authors： Lokshin AE,Kalinski P,Sassi RR,Mailliard RB,Müller-Berghaus J,Storkus WJ,Peng X,Marrangoni AM,Edwards RP,Gorelik E

更新日期：2002-09-01 00:00:00

abstract：:We have previously reported that tumor necrosis factor receptor-associated factor 1 (TRAF1), an intracellular protein, which binds to a range of molecules, including tumor necrosis factor (TNF) receptor family members, regulates TNF-induced NF-kappaB and AP-1 signaling as well as TCR-triggered proliferative responses ...

journal_title：International immunology

authors： Bryce PJ,Oyoshi MK,Kawamoto S,Oettgen HC,Tsitsikov EN

更新日期：2006-01-01 00:00:00

abstract：:Human dendritic cells (DC) generated from CD34+ hematopoietic progenitors cultured in the presence of granulocyte macrophage colony stimulating factor (GM-CSF) and tumor necrosis factor (TNF)-alpha are related to Langerhans cells (DLC) and have been shown to induce a strong proliferation of allogeneic CD4+ T cells. Th...

journal_title：International immunology

authors： Caux C,Massacrier C,Vanbervliet B,Barthelemy C,Liu YJ,Banchereau J

更新日期：1994-08-01 00:00:00

abstract：:Induction of mucosal tolerance by inhalation of soluble peptides with defined T cell epitopes is receiving much attention as a means of specifically down-regulating pathogenic T cell reactivities in autoimmune and allergic disorders. Experimental autoimmune encephalomyelitis (EAE) induced in the Lewis rat by immunizat...

journal_title：International immunology

authors： Liu JQ,Bai XF,Shi FD,Xiao BG,Li HL,Levi M,Mustafa M,Wahren B,Link H

更新日期：1998-08-01 00:00:00

abstract：:Murine complement receptor type 2 (MCR2) is homologous to human CR2, whereas murine CR1 (MCR1) is structurally and evolutionary different from human CR1. Since ligand specificities of MCR1 and MCR2 are not completely clarified, we analyzed their functional characteristics to correlate them with structural information ...

journal_title：International immunology

authors： Pramoonjago P,Takeda J,Kim YU,Inoue K,Kinoshita T

更新日期：1993-04-01 00:00:00

abstract：:The alternative complement pathway (ACP) in vertebrates is known to be important in inflammatory reactions, and to be activated by foreign substances such as bacterial lipopolysaccharide (LPS) and zymosan, although to date no intrinsic activators have been identified except complement receptor type 2. From the point o...

journal_title：International immunology

authors： Oshima H,Soma G,Mizuno D

更新日期：1993-10-01 00:00:00

abstract：:Deletion of alpha i2 subunit of heterotrimeric G proteins induces a 2-4-fold increase in the proportions of CD4 and CD8 single-positive (SP) thymocytes as compared with wild-type littermates, but how G alpha i2 is involved in thymocyte development is unknown. To determine a role for G alpha i2 in a specific developmen...

journal_title：International immunology

authors： Zhang Y,Finegold MJ,Jin Y,Wu MX

更新日期：2005-03-01 00:00:00

abstract：:T cell apoptosis has been proposed as an important contributor to the functional defects and depletion of T cells in HIV-infected individuals. However, the mechanisms involved in this apoptosis have not been elucidated. We recently showed that peripheral blood T cells from HIV-infected individuals are especially susce...

journal_title：International immunology

authors： Katsikis PD,García-Ojeda ME,Wunderlich ES,Smith CA,Yagita H,Okumura K,Kayagaki N,Alderson M,Herzenberg LA,Herzenberg LA

更新日期：1996-08-01 00:00:00

abstract：:The chicken represents the best-characterized animal model for B cell development in the so-called gut-associated lymphoid tissue (GALT) and the molecular processes leading to B cell receptor diversification in this species are well investigated. However, the mechanisms regulating B cell development and homeostasis in...

journal_title：International immunology

authors： Kothlow S,Morgenroth I,Graef Y,Schneider K,Riehl I,Staeheli P,Schneider P,Kaspers B

更新日期：2007-02-01 00:00:00

abstract：:The integrins have been grouped into three subfamilies based on the utilization of three distinct beta chain subunits, beta 1, beta 2, and beta 3. The recent discovery of beta 4 and beta 5 subunits, and the sharing of alpha subunits between beta subfamilies reflects a greater structural and functional diversity of the...

journal_title：International immunology

authors： Yuan QA,Jiang WM,Krissansen GW,Watson JD

更新日期：1990-01-01 00:00:00

abstract：:Dendritic cells (DC) sense saprophytic yeast and pathogenic, filamentous forms of Candida albicans in a specific way, resulting in disparate patterns of DC and T(h) cell activation. Using human and murine DC, such disparate patterns could be traced to the exploitation of distinct recognition receptors. Although usage ...

journal_title：International immunology

authors： Romani L,Montagnoli C,Bozza S,Perruccio K,Spreca A,Allavena P,Verbeek S,Calderone RA,Bistoni F,Puccetti P

更新日期：2004-01-01 00:00:00

abstract：:The invertebrate pattern-recognition protein named coelomic cytolytic factor (CCF) and the mammalian cytokine tumor necrosis factor (TNF) share functional analogies that are based on a similar saccharide recognition specificity. In particular, CCF and TNF have been shown to interact with ion channels on the surface of...

journal_title：International immunology

authors： Bilej M,Josková R,Van den Bergh R,Procházková P,Silerová M,Ameloot P,De Baetselier P,Beschin A

更新日期：2006-12-01 00:00:00

abstract：:We have followed CD4 and CD8 TCR V beta repertoires during the acute phase of Trypanosoma cruzi infection in a resistant mouse strain (C57BL/6). No major changes were found in the V beta TCR distributions analyzed (covering roughly 40% of the TCR repertoire) in peripheral CD4 T lymphocytes, confirming the polyclonal n...

journal_title：International immunology

authors： Leite-de-Moraes MC,Coutinho A,Hontebeyrie-Joskowicz M,Minoprio P,Eisen H,Bandeira A

更新日期：1994-03-01 00:00:00

abstract：:Members of protein kinase D (PKD) family serine/threonine kinases (PKD1, PKD2 and PKD3) are expressed in wide range of cells and regulate various cellular responses including immune responses. We have previously shown that PKD is involved in the signaling pathways of a human CD4(+) T cell clone stimulated with its cog...

journal_title：International immunology

authors： Irie A,Harada K,Tsukamoto H,Kim JR,Araki N,Nishimura Y

更新日期：2006-12-01 00:00:00

abstract：:Adhesion molecules of the integrin family are implicated not only in leukocyte migration but also in leukocyte activation. Here we characterize the expression and function of fibronectin receptor integrins on rat mast cells. A rat basophilic leukemia cell line (RBL-2H3) and phorbol ester-stimulated rat peritoneal mast...

journal_title：International immunology

authors： Yasuda M,Hasunuma Y,Adachi H,Sekine C,Sakanishi T,Hashimoto H,Ra C,Yagita H,Okumura K

更新日期：1995-02-01 00:00:00

abstract：:CD45 is a receptor tyrosine phosphatase essential for TCR signaling. One isoform, CD45RB, is down-regulated in memory cells and targeting CD45RB with a specific antibody has been shown to inhibit graft rejection. Its role in immunity to infection, however, has not been tested. Here, we report the effect of anti-CD45RB...

journal_title：International immunology

authors： Lim B,Sutherland RM,Zhan Y,Deliyannis G,Brown LE,Lew AM

更新日期：2006-02-01 00:00:00

abstract：:The two-signal model states that activation of naive T cells requires a signal 1 stimulus through the TCR and a co-stimulatory signal 2. By contrast, signal 1 alone is sufficient for pre-activated T cells. Recently, however, it has been shown that under certain conditions T cells can bypass the requirement for co-stim...

journal_title：International immunology

authors： Pardigon N,Bercovici N,Calbo S,Santos-Lima EC,Liblau R,Kourilsky P,Abastado JP

更新日期：1998-05-01 00:00:00

abstract：:Exosomes are small vesicles (60-100 nm) secreted by various cell types upon the fusion of endosomal compartments with the plasma membrane. Exosomes from antigen-presenting cells (APC), such as B lymphocytes and dendritic cells (DC), bear MHC class II molecules. In addition, the injection of DC-derived exosomes was rep...

journal_title：International immunology

authors： Vincent-Schneider H,Stumptner-Cuvelette P,Lankar D,Pain S,Raposo G,Benaroch P,Bonnerot C

更新日期：2002-07-01 00:00:00

abstract：:Human CD83 is a cell surface protein expressed predominantly by dendritic cells (DC) and lymphoid cells. So far, there exists no information on the function and distribution of mCD83. Here we demonstrate that mCD83 is moderately expressed on resting T cells and DC, but strongly increases in its expression on T cells f...

journal_title：International immunology

authors： Cramer SO,Trumpfheller C,Mehlhoop U,Moré S,Fleischer B,von Bonin A

更新日期：2000-09-01 00:00:00

abstract：:Auto-antibodies against heat shock proteins (HSPs) are frequently found in the sera of patients with rheumatic and other autoimmune diseases. However, it is unclear whether these auto-antibodies play a role in the pathophysiology and etiology of these diseases. We found that a murine anti-HSP60 mAb enhanced the produc...

journal_title：International immunology

authors： Yokota S,Minota S,Fujii N

更新日期：2006-04-01 00:00:00