The exploitation of distinct recognition receptors in dendritic cells determines the full range of host immune relationships with Candida albicans.


:Dendritic cells (DC) sense saprophytic yeast and pathogenic, filamentous forms of Candida albicans in a specific way, resulting in disparate patterns of DC and T(h) cell activation. Using human and murine DC, such disparate patterns could be traced to the exploitation of distinct recognition receptors. Although usage of mannose receptors led to protective type 1 responses in mice, entry through Fcgamma receptors was responsible for suppression of mannose receptor-dependent reactivity, onset of type 2 responses and associated pathology. As the usage of distinct receptors selectively occurred with yeast or hyphal forms of the fungus, these findings suggest that the responsibility for pathogenicity of C. albicans is shared by the organism and DC, with implications for fungal virulence, immunity and vaccine development.


Int Immunol


International immunology


Romani L,Montagnoli C,Bozza S,Perruccio K,Spreca A,Allavena P,Verbeek S,Calderone RA,Bistoni F,Puccetti P




Has Abstract


2004-01-01 00:00:00












  • Influenza A virus elevates active cathepsin B in primary murine DC.

    abstract::Dendritic cells (DCs) act as a first-line recognition system for invading pathogens, such as influenza A. The interaction of DC with influenza A virus results in DC activation via endosomal Toll-like receptors and also leads to presentation of viral peptides on MHC class II molecules. Prior work demonstrated that infl...

    journal_title:International immunology

    pub_type: 杂志文章


    authors: Burster T,Giffon T,Dahl ME,Björck P,Bogyo M,Weber E,Mahmood K,Lewis DB,Mellins ED

    更新日期:2007-05-01 00:00:00

  • Cellular selection leads to age-dependent and reversible down-regulation of transgenic immunoglobulin light chain genes.

    abstract::Analysis of immunoglobulin expression in mice transgenic for either a kappa light chain (driven by the kappa enhancer) or lambda light chain (driven by the IgH enhancer) revealed that the transgenic light chains are expressed by the majority of B lymphocytes in the neonatal mice. However, the proportion of B cells tha...

    journal_title:International immunology

    pub_type: 杂志文章


    authors: Pettersson S,Sharpe MJ,Gilmore DR,Surani MA,Neuberger MS

    更新日期:1989-01-01 00:00:00

  • Allorecognition of human neural stem cells by peripheral blood lymphocytes despite low expression of MHC molecules: role of TGF-beta in modulating proliferation.

    abstract::Neural stem cells (NSCs) transplantation has been proposed as a means of restoring damaged brain tissue, a possibility rendered more likely by reports of low NSCs immunogenicity in various experimental models because of low expression of MHC class I and II as well as co-stimulatory molecules. We investigated the immun...

    journal_title:International immunology

    pub_type: 杂志文章


    authors: Ubiali F,Nava S,Nessi V,Frigerio S,Parati E,Bernasconi P,Mantegazza R,Baggi F

    更新日期:2007-09-01 00:00:00

  • Molecular genetic features reflecting the preference for isotype switching to IgA expression by Peyer's patch germinal center B cells.

    abstract::It has proven difficult to evaluate the functional potential of germinal center (GC) B cells, including those from Peyer's patches (PP), by either in vivo or in vitro methods. Thus, rather than assess secreted Ig product as an indicator of functional potential we have instead sought to detect mRNAs related to the vari...

    journal_title:International immunology

    pub_type: 杂志文章


    authors: Weinstein PD,Schweitzer PA,Cebra-Thomas JA,Cebra JJ

    更新日期:1991-12-01 00:00:00

  • Exposure of resting peripheral blood T cells to HIV-1 particles generates CD25+ killer cells in a small subset, leading to induction of apoptosis in bystander cells.

    abstract::Apoptosis is a major mechanism whereby HIV-1 depletes uninfected CD4+ and CD8+ T cells. We previously showed that resting peripheral blood T cells derived from healthy donors were killed by an apoptotic mechanism after adsorption to gp120-containing, protease-defective HIV-1 (L-2) particles, more effectively than pare...

    journal_title:International immunology

    pub_type: 杂志文章


    authors: Kameoka M,Suzuki S,Kimura T,Fujinaga K,Auwanit W,Luftig RB,Ikuta K

    更新日期:1997-10-01 00:00:00

  • Neutrophil activation and survival are modulated by interaction with NK cells.

    abstract::It is increasingly evident that neutrophils are able to cross-talk with other leukocytes to shape ongoing inflammatory and immune responses. In this study, we analyzed whether human NK cells may influence the survival and activation of neutrophils under co-culture conditions. We report that NK cells exposed to either ...

    journal_title:International immunology

    pub_type: 杂志文章


    authors: Costantini C,Micheletti A,Calzetti F,Perbellini O,Pizzolo G,Cassatella MA

    更新日期:2010-10-01 00:00:00

  • Identification of the gene loci that predispose to rheumatoid arthritis.

    abstract::We have searched the human genome for genes that predispose to rheumatoid arthritis (RA) using fluorescence-based microsatellite marker analysis and affected sib-pair linkage study. A panel of 41 Japanese families, each with at least two affected siblings, was typed for genome-wide 358 polymorphic microsatellite marke...

    journal_title:International immunology

    pub_type: 杂志文章


    authors: Shiozawa S,Hayashi S,Tsukamoto Y,Goko H,Kawasaki H,Wada T,Shimizu K,Yasuda N,Kamatani N,Takasugi K,Tanaka Y,Shiozawa K,Imura S

    更新日期:1998-12-01 00:00:00

  • Partial rescue of B cells in microphthalmic osteopetrotic marrow by loss of response to type I IFNs.

    abstract::The microphthalmic (mi) mouse exhibits deficiencies in the development of osteoclasts, melanocytes, mast cells and marrow B cells. Previously, we demonstrated that the marrow of such mice over-express receptor activator of nuclear factor kappaB (RANK) ligand (RANKL). RANKL has been shown to induce the production of IF...

    journal_title:International immunology

    pub_type: 杂志文章


    authors: Roundy KM,Spangrude G,Weis JJ,Weis JH

    更新日期:2005-11-01 00:00:00

  • HIV envelope-directed signaling aberrancies and cell death of CD4+ T cells in the absence of TCR co-stimulation.

    abstract::HIV-1 infection in CD4(+) T cells initiates a viral cytopathic effect (CPE) that is dependent on the activation of intracellular protein tyrosine kinases (PTK). PTK in T cells are also activated during the course of TCR or CD4 receptor engagement and the manner of receptor engagement may generate signals leading eithe...

    journal_title:International immunology

    pub_type: 杂志文章


    authors: Tian H,Lempicki R,King L,Donoghue E,Samelson LE,Cohen DI

    更新日期:1996-01-01 00:00:00

  • IL-7 receptor alpha+ CD3(-) cells in the embryonic intestine induces the organizing center of Peyer's patches.

    abstract::Peyer's patch (PP) organogenesis proceeds through three histologically distinct steps: formation of organizing centers expressing VCAM-1 and ICAM-1 in segregated regions of the intestine at 15.5 days post-coitus (d.p.c.) (step I), accumulation of blood cells expressing different sets of surface markers to this region ...

    journal_title:International immunology

    pub_type: 杂志文章


    authors: Yoshida H,Honda K,Shinkura R,Adachi S,Nishikawa S,Maki K,Ikuta K,Nishikawa SI

    更新日期:1999-05-01 00:00:00

  • Commercial rodent diets differentially regulate autoimmune glomerulonephritis, epigenetics and microbiota in MRL/lpr mice.

    abstract::The course and severity of lupus in spontaneous murine lupus models varies among laboratories, which may be due to variations in diet, housing and/or local environmental conditions. In this study, we investigated the influence of common rodent diets while keeping other factors constant. Female lupus-prone MRL/lpr (MRL...

    journal_title:International immunology

    pub_type: 杂志文章


    authors: Edwards MR,Dai R,Heid B,Cecere TE,Khan D,Mu Q,Cowan C,Luo XM,Ahmed SA

    更新日期:2017-06-01 00:00:00

  • TGF-beta signaling regulates CD8+ T cell responses to high- and low-affinity TCR interactions.

    abstract::Absence of transforming growth factor-beta (TGF-beta) signaling to T cells in mice results in an increase in T cell numbers, an activated CD44 high, CD69-, CD25- T cell phenotype and a T cell-mediated injury to many organs. It is not known if such T cell activation in the absence of TGF-beta signaling is spontaneous o...

    journal_title:International immunology

    pub_type: 杂志文章


    authors: Mehal WZ,Sheikh SZ,Gorelik L,Flavell RA

    更新日期:2005-05-01 00:00:00

  • Human MD-2 confers on mouse Toll-like receptor 4 species-specific lipopolysaccharide recognition.

    abstract::Toll-like receptor 4 (TLR4) recognizes lipopolysaccharide (LPS). MD-2 is associated with TLR4 and imparts LPS responsiveness to it. Little is known, however, as to whether MD-2 directly regulates LPS recognition by TLR4. To address the issue, we took advantage of a species-specific pharmacology of lipid IVa, an analog...

    journal_title:International immunology

    pub_type: 杂志文章


    authors: Akashi S,Nagai Y,Ogata H,Oikawa M,Fukase K,Kusumoto S,Kawasaki K,Nishijima M,Hayashi S,Kimoto M,Miyake K

    更新日期:2001-12-01 00:00:00

  • Prostanoids and leukotrienes in the pathophysiology of atopic dermatitis and psoriasis.

    abstract::Lipid mediators, such as prostanoids and leukotrienes (LTs), exert a range of actions through their own receptors on cell surfaces in various pathophysiological conditions. It has been reported that the production of prostanoids and LTs is significantly elevated in the skin lesions of some chronic inflammatory skin di...

    journal_title:International immunology

    pub_type: 杂志文章,评审


    authors: Honda T,Kabashima K

    更新日期:2019-08-23 00:00:00

  • Analysis of stem-cell-like properties of human CD161++IL-18Rα+ memory CD8+ T cells.

    abstract::CD161(++)IL-18Rα(+)CD8(+) human T cells have recently been identified as a new subset of memory cells but their exact role remains unclear. CD161(++)IL-18Rα(+)CD8(+), mucosal-associated invariant T cells express a semi-invariant TCR Vα7.2-Jα33, which recognizes the MHC-related protein 1. On the basis of properties inc...

    journal_title:International immunology

    pub_type: 杂志文章


    authors: Havenith SH,Yong SL,Henson SM,Piet B,Idu MM,Koch SD,Jonkers RE,Kragten NA,Akbar AN,van Lier RA,ten Berge IJ

    更新日期:2012-10-01 00:00:00

  • Schnurri-2 regulates Th2-dependent airway inflammation and airway hyperresponsiveness.

    abstract::Schnurri (Shn)-2 is a large zinc finger-containing protein, which plays a critical role in cell growth, signal transduction and lymphocyte development. In Shn-2-deficient (Shn-2(-/-)) CD4 T cells, the activation of nuclear factor-kappaB is up-regulated and their ability to differentiate into Th2 is enhanced. Here, we ...

    journal_title:International immunology

    pub_type: 杂志文章


    authors: Iwamura C,Kimura MY,Shinoda K,Endo Y,Hasegawa A,Yamashita M,Nakayama T

    更新日期:2007-06-01 00:00:00

  • A 3-D model for the CD40 ligand predicts that it is a compact trimer similar to the tumor necrosis factors.

    abstract::Based on the similarity in primary structure between the newly characterized ligand for CD40 (CD40L) and the tumor necrosis factors (TNFs), we have modeled a detailed 3-D structure for CD40L. We used the known structure of TNF alpha as a template for the generation of the CD40L model. The soundness of the model-buildi...

    journal_title:International immunology

    pub_type: 杂志文章


    authors: Peitsch MC,Jongeneel CV

    更新日期:1993-02-01 00:00:00

  • Molecular analysis of TCR junctional variability in individual infiltrated islets of non-obese diabetic mice: evidence for the constitution of largely autonomous T cell foci within the same pancreas.

    abstract::Insulitis develops in non-obese diabetic (NOD) mice as a multicentric and asynchronous process. In an effort to understand how this T cell mediated process expands within each islet and propagates between the islets of the same pancreas, we have analyzed the junctional diversity of TCR V beta 6 and V beta 8.2 transcri...

    journal_title:International immunology

    pub_type: 杂志文章


    authors: Sarukhan A,Bedossa P,Garchon HJ,Bach JF,Carnaud C

    更新日期:1995-01-01 00:00:00

  • A thymic epithelial cell line induces both positive and negative selection in the thymus.

    abstract::TCR engagement in the thymus results in both survival and elimination signals for developing thymocytes. To examine whether both signals can be provided by the same cell type, we investigated the ability of a thymic epithelial cell (TEC) line 427.1, previously shown to allow positive selection in the thymus, to induce...

    journal_title:International immunology

    pub_type: 杂志文章


    authors: Vukmanović S,Jameson SC,Bevan MJ

    更新日期:1994-02-01 00:00:00

  • The involvement of the proto-oncogene p120 c-Cbl and ZAP-70 in CD2-mediated T cell activation.

    abstract::The CD2 co-receptor expressed on the surface of T lymphocytes is able to stimulate T cell activation, proliferation and cytokine production in the absence of direct engagement of the antigen-specific TCR. Engagement of human CD2 by mitogenic pairs of anti-CD2 mAb induces tyrosine phosphorylation of a number of intrace...

    journal_title:International immunology

    pub_type: 杂志文章


    authors: Lin H,Martelli MP,Bierer BE

    更新日期:2001-01-01 00:00:00

  • Leptin deficiency down-regulates IL-23 production in glomerular podocytes resulting in an attenuated immune response in nephrotoxic serum nephritis.

    abstract::Leptin, one of the typical adipokines, is reported to promote Th17 cell responses and to enhance production of proinflammatory cytokines. To clarify the role of leptin in the regulation of the IL-23/IL-17 axis and the development of kidney disease, we used a murine model of nephrotoxic serum (NTS) nephritis (NTN). She...

    journal_title:International immunology

    pub_type: 杂志文章


    authors: Goto K,Kaneko Y,Sato Y,Otsuka T,Yamamoto S,Goto S,Yamamoto K,Yamamoto T,Kawachi H,Madaio MP,Narita I

    更新日期:2016-04-01 00:00:00

  • On the mechanism of human T cell suppression.

    abstract::Previous evidence from several laboratories suggests that CD8+ T suppressor cells may be important regulatory elements governing specific unresponsiveness of lepromatous lepromatous leprosy patients to M.leprae. To analyse the mechanism of suppression, CD8+ Ts clones were established from lesions and peripheral blood ...

    journal_title:International immunology

    pub_type: 杂志文章


    authors: Salgame P,Modlin R,Bloom BR

    更新日期:1989-01-01 00:00:00

  • Selective recognition of malaria antigens by human serum antibodies is not genetically determined but demonstrates some features of clonal imprinting.

    abstract::Malaria infection induces the production of serum antibodies to a variety of malaria antigens but the prevalence of antibodies to any particular antigen is typically much less than 100%. It has been assumed that non-responsiveness to defined antigens in malaria immune subjects is due to HLS-mediated restriction of the...

    journal_title:International immunology

    pub_type: 杂志文章


    authors: Taylor RR,Egan A,McGuinness D,Jepson A,Adair R,Drakely C,Riley E

    更新日期:1996-06-01 00:00:00

  • Adjuvant-dependent modulation of Th1 and Th2 responses to immunization with beta-amyloid.

    abstract::The role of adjuvant on the T(h)1 and T(h)2 immune responses to Abeta-immunotherapy (Abeta(42 )peptide) was examined in wild-type mice. Fine epitope analysis with overlapping oligomers of the Abeta(42) sequence identified the 1-15 region as a dominant B cell epitope. The 6-20 peptide was recognized only weakly by anti...

    journal_title:International immunology

    pub_type: 杂志文章


    authors: Cribbs DH,Ghochikyan A,Vasilevko V,Tran M,Petrushina I,Sadzikava N,Babikyan D,Kesslak P,Kieber-Emmons T,Cotman CW,Agadjanyan MG

    更新日期:2003-04-01 00:00:00

  • Translocation of tyrosine-phosphorylated TCRzeta chain to glycolipid-enriched membrane domains upon T cell activation.

    abstract::Recent studies point to glycolipid-enriched membrane (GEM) microdomains as the critical sites for TCR-mediated signal transduction. However, whether the TCR complex is localized in the GEM domain is not well-defined. In the present study, we analyzed localization of the TCR-CD3 complex in the GEM domain by isolating t...

    journal_title:International immunology

    pub_type: 杂志文章


    authors: Kosugi A,Saitoh S,Noda S,Yasuda K,Hayashi F,Ogata M,Hamaoka T

    更新日期:1999-09-01 00:00:00

  • Expression of I mu-C gamma hybrid germline transcripts subsequent to immunoglobulin heavy chain class switching.

    abstract::Germline CH transcripts initiate from a non-coding I exon and terminate downstream of the associated CH exons. Ig heavy chain class switch recombination from the VDJ-C mu gene to particular downstream CH genes appears to be regulated by a process that involves mitogen and/or cytokine induction of germline CH transcrip...

    journal_title:International immunology

    pub_type: 杂志文章


    authors: Li SC,Rothman PB,Zhang J,Chan C,Hirsh D,Alt FW

    更新日期:1994-04-01 00:00:00

  • Hsp60-mediated T cell stimulation is independent of TLR4 and IL-12.

    abstract::Heat shock protein (Hsp) 60 is thought to function as endogenous danger signal by activating professional antigen-presenting cells (APC) through toll-like receptor (TLR) 4 and CD14, a mechanism that is also used by bacterial LPS. We recently showed that Hsp60 binds LPS and enhances LPS-induced immune stimulation. On t...

    journal_title:International immunology

    pub_type: 杂志文章


    authors: Osterloh A,Veit A,Gessner A,Fleischer B,Breloer M

    更新日期:2008-03-01 00:00:00

  • TRAF6 is a critical regulator of LMP1 functions in vivo.

    abstract::EBV-encoded latent membrane protein 1 (LMP1) is critical for EBV-driven B-cell transformation and most EBV-associated malignancies and is also implicated in exacerbation of autoimmunity. LMP1 functionally mimics the TNFR superfamily member CD40, but LMP1-induced signals and downstream B-cell functions are amplified an...

    journal_title:International immunology

    pub_type: 杂志文章


    authors: Arcipowski KM,Stunz LL,Bishop GA

    更新日期:2014-03-01 00:00:00

  • Rearrangement and expression of kappa light chain genes can occur without mu heavy chain expression during differentiation of pre-B cells.

    abstract::The kinetics of kappa light (kappa L) chain gene rearrangement and expression on mRNA and protein level has been studied with four stromal cell/IL-7 reactive, long-term in vitro proliferating pre-B cell lines and clones, two from fetal liver of normal mice and two from fetal liver of E microH-bcl-2 transgenic (bcl-2-t...

    journal_title:International immunology

    pub_type: 杂志文章


    authors: Grawunder U,Haasner D,Melchers F,Rolink A

    更新日期:1993-12-01 00:00:00

  • House dust mite allergen Der p 1 elevates the release of inflammatory cytokines and expression of adhesion molecules in co-culture of human eosinophils and bronchial epithelial cells.

    abstract::House dust mite (HDM) is a common allergen of allergic asthma. Eosinophils are principal effector cells of allergic inflammation and their adhesion onto human bronchial epithelial cells is mediated by a CD18-intracellular adhesion molecule-1 (ICAM-1)-dependent interaction. We studied the effects of HDM Dermatophagoide...

    journal_title:International immunology

    pub_type: 杂志文章


    authors: Wong CK,Li ML,Wang CB,Ip WK,Tian YP,Lam CW

    更新日期:2006-08-01 00:00:00