Schnurri-2 regulates Th2-dependent airway inflammation and airway hyperresponsiveness.

abstract：:Immune tolerance in the lung is important for preventing hypersensitivity, such as allergic asthma. Maintenance of tolerance in the lung is established by coordinated activities of poorly understood cellular and molecular mechanisms, including participation of dendritic cells (DCs). We have previously identified DC ex...

journal_title：International immunology

authors： Han D,Walsh MC,Kim KS,Hong SW,Lee J,Yi J,Rivas G,Choi Y,Surh CD

更新日期：2017-02-01 00:00:00

abstract：:It has been demonstrated that in vivo T cell priming requires CD154-CD40 interaction, which is suggested to be critical in the induction of co-stimulatory activities on antigen-presenting cells (APC). In the current study, we demonstrate that in vivo administration of a high dose of a superantigen, staphylococcal ente...

journal_title：International immunology

authors： Eshima K,Choi Y,Flavell RA

更新日期：2003-07-01 00:00:00

abstract：:T lymphocytes (pivotal in many inflammatory pathologies) are targets for glucocorticoid hormone (GC). How TCR-mediated activation and GC signaling via glucocorticoid receptor (GR) impact on T-cell fates is not fully defined. We delineated here the expression of a recently identified glucocorticoid-induced TNF receptor...

journal_title：International immunology

authors： Zhan Y,Funda DP,Every AL,Fundova P,Purton JF,Liddicoat DR,Cole TJ,Godfrey DI,Brady JL,Mannering SI,Harrison LC,Lew AM

更新日期：2004-09-01 00:00:00

abstract：:The utilization of individual VH7183 genes in the autoimmune non-obese diabetic (NOD) mouse and the normal C57BL/6 mouse, both carrying the IgHb haplotype, was investigated. Nucleotide sequence analyses of a large number of VHDJH rearrangements utilizing VH7183 gene segments allowed us to identify 10 individual member...

journal_title：International immunology

authors： Andersson A,Ekstrand-Hammarström B,Eriksson B,Overmo C,Holmberg D

更新日期：1994-04-01 00:00:00

abstract：:HLA-B*0702 transgenic mice (expressing a chimeric heavy chain with a murine alpha 3 domain: HLA-B7(m alpha 3)) in which the H-2K(b) and H-2D(b) class I-a (Cl I-a(-/-)) genes have been inactivated were compared with H-2K(b)D(b) Cl I-a(+/+) positive controls. Expression of the HLA-B7(m alpha 3) molecules resulted in a 3...

journal_title：International immunology

authors： Rohrlich PS,Cardinaud S,Firat H,Lamari M,Briand P,Escriou N,Lemonnier FA

更新日期：2003-06-01 00:00:00

abstract：:CD9 is a member of the tetraspanin superfamily which is characterized by four transmembrane (TM) domains and associates with other surface molecules. This tetraspanin was recently found to be expressed on mature T cells. Here, we investigated which molecules associate with CD9 on T cells and which CD9 domains are requ...

journal_title：International immunology

authors： Toyo-oka K,Yashiro-Ohtani Y,Park CS,Tai XG,Miyake K,Hamaoka T,Fujiwara H

更新日期：1999-12-01 00:00:00

abstract：:CD100/Sema4D belongs to the semaphorin family, factors known to act as repulsive cues for axons during neuronal development. Mouse CD100 plays a crucial role in both humoral and cellular immunity through ligation of the lymphocyte receptor, CD72. It remains controversial, however, whether human CD100 can function thro...

journal_title：International immunology

authors： Ishida I,Kumanogoh A,Suzuki K,Akahani S,Noda K,Kikutani H

更新日期：2003-08-01 00:00:00

abstract：:In the final analysis, the self (S)-non-self (NS) discrimination is regulated by the sufficiency or insufficiency of effector T(h) (eT(h)) specific for the given antigen. We have described a model (Th genesis) for the origin of eT(h) based on an antigen-independent pathway from initial state T(h) (iT(h)) to eT(h), and...

journal_title：International immunology

authors： Langman RE,Mata JJ,Cohn M

更新日期：2003-05-01 00:00:00

abstract：:Monoclonal non-specific suppressor factor (MNSF), a lymphokine produced by a murine hybridoma, was originally found to inhibit the generation of lipopolysaccharide (LPS)-induced Ig-secreting cells. Most recently, we demonstrated the recombinant form of the ubiquitin-like segment (rUbi-L) or MNSF beta, an isoform of MN...

journal_title：International immunology

authors： Nakamura M,Nagata T,Xavier M,Tanigawa Y

更新日期：1996-11-01 00:00:00

abstract：:Fas/APO-1 is a member of the tumor necrosis factor (TNF)/nerve growth factor receptor family. This cell surface protein, when associated with the Fas/APO-1 ligand or specific mAb, elicits an apoptotic response in susceptible cells via an oligomerization of its intracellular domains, termed the'death domains'. We have ...

journal_title：International immunology

authors： Fadeel B,Lindberg J,Achour A,Chiodi F

更新日期：1998-02-01 00:00:00

abstract：:Fas (CD95) is a cell surface death receptor belonging to the tumor necrosis factor receptor superfamily, which mediates apoptosis-inducing signaling when activated by Fas ligand or its agonistic antibody. lpr mice with a loss of apoptosis-inducing function mutation in the Fas gene develop systemic autoimmune disease a...

journal_title：International immunology

authors： Takahashi S,Futatsugi-Yumikura S,Fukuoka A,Yoshimoto T,Nakanishi K,Yonehara S

更新日期：2013-05-01 00:00:00

abstract：:IL-12 is a cytokine produced by monocytes and Epstein-Barr virus-transformed B cells which initiates Th1 responses by inducing the development of CD4+, IFN-gamma producing Th1 T cells in mouse and human. We have previously reported that allergen-specific CD4+ Th2 T cell clones produce IFN-gamma, following activation b...

journal_title：International immunology

authors： Yssel H,Fasler S,de Vries JE,de Waal Malefyt R

更新日期：1994-07-01 00:00:00

abstract：:To understand the nature of long-term Th immune responses, we investigated in the present study the TCRBV gene repertoire of CD4(+) T cells specific for the recall antigen tetanus toxoid (TT) in recipients of an allogeneic bone marrow transplantation (allo-BMT) at several time points after transplantation and in their...

journal_title：International immunology

authors： Godthelp BC,van Tol MJ,Vossen JM,van den Elsen PJ

更新日期：2001-04-01 00:00:00

abstract：:We have investigated the B cell response to Mycobacterium leprae in leprosy patients and healthy controls. A comparison of Western-blotted proteins separated by two-dimensional gel electrophoresis and probed with pooled sera from LL and BT patients revealed distinct antigen recognition patterns for the two classificat...

journal_title：International immunology

authors： Mahon AC,Gebre N,Nurlign A

更新日期：1990-01-01 00:00:00

abstract：:Whether astrocytes utilize B7:CD28 co-stimulation to activate T cells mediating CNS inflammatory disease is controversial. In this report, primary astrocytes and murine astrocyte lines, generated by immortalization at two different times, day 7 or 45 of culture, were examined for their capability to express B7 co-stim...

journal_title：International immunology

authors： Soos JM,Ashley TA,Morrow J,Patarroyo JC,Szente BE,Zamvil SS

更新日期：1999-07-01 00:00:00

abstract：:Recent data suggest that initiation of signal transduction via type 1 Fc epsilon receptor (Fc epsilon RI) and other immunoreceptors is spatially constrained to lipid rafts. In order to better understand the complexity and function of these structures, we prepared mAb against lipid rafts from the rat basophilic leukemi...

journal_title：International immunology

authors： Hálová I,Dráberová L,Dráber P

更新日期：2002-02-01 00:00:00

abstract：:CD4 and CD8 T cell subsets involved in primary allo-MLR responses were re-evaluated in the present study. The slope analysis of B6 allo-MLR responses to MHC class I-disparate bm1 and class II-disparate bm12 revealed the presence of a T-T cell interaction between CD4 and CD8 T cell subsets. The allo-MLR response of B6 ...

journal_title：International immunology

authors： Asano Y,Komuro T,Tada T

更新日期：1990-01-01 00:00:00

abstract：:Human CD83 is a cell surface protein expressed predominantly by dendritic cells (DC) and lymphoid cells. So far, there exists no information on the function and distribution of mCD83. Here we demonstrate that mCD83 is moderately expressed on resting T cells and DC, but strongly increases in its expression on T cells f...

journal_title：International immunology

authors： Cramer SO,Trumpfheller C,Mehlhoop U,Moré S,Fleischer B,von Bonin A

更新日期：2000-09-01 00:00:00

abstract：:Eye-derived antigen-presenting cells (APCs) are known to contribute to the immune privilege status of the eye by inducing a form of peripheral tolerance that deviates T(h)1 type of pro-inflammatory immune responses. Similar systemic tolerance can also be induced by non-ocular APCs exposed to transforming growth factor...

journal_title：International immunology

authors： Masli S,Turpie B,Streilein JW

更新日期：2006-05-01 00:00:00

abstract：:HIV-1 infection in CD4(+) T cells initiates a viral cytopathic effect (CPE) that is dependent on the activation of intracellular protein tyrosine kinases (PTK). PTK in T cells are also activated during the course of TCR or CD4 receptor engagement and the manner of receptor engagement may generate signals leading eithe...

journal_title：International immunology

authors： Tian H,Lempicki R,King L,Donoghue E,Samelson LE,Cohen DI

更新日期：1996-01-01 00:00:00

abstract：:We have shown that the dominance of CD8+ T cells expressing TCR Vbeta17 in the adult HLA-A*0201-restricted influenza A/M1(58-66)-specific response is acquired following first antigen exposure. Despite the acquired dominance of Vbeta17+ cells, subdominant M1(58-66)-specific clones expressing non-Vbeta17+ TCR persist in...

journal_title：International immunology

authors： Lawson TM,Man S,Wang EC,Williams S,Amos N,Gillespie GM,Moss PA,Borysiewicz LK

更新日期：2001-11-01 00:00:00

abstract：:Notch2 and Delta-like 1 (Dll1) have been implicated in the development of marginal zone B (MZB) cells. In the present study, we characterized the expression and function of mouse Notch receptors and ligands in the spleen by using newly generated mAbs. Although Notch2 was expressed on both B and T cells in the spleen, ...

journal_title：International immunology

authors： Moriyama Y,Sekine C,Koyanagi A,Koyama N,Ogata H,Chiba S,Hirose S,Okumura K,Yagita H

更新日期：2008-06-01 00:00:00

abstract：:The immunomodulator FTY720 inhibits lymph node (LN) and thymic egress, thereby constraining T cell circulation and reducing peripheral T cell numbers. Here, we analyzed in mouse models the as yet scarcely characterized impact of long-term (up to 6 months) FTY720 exposure on T cell homeostasis and possible consequences...

journal_title：International immunology

authors： Metzler B,Gfeller P,Wieczorek G,Li J,Nuesslein-Hildesheim B,Katopodis A,Mueller M,Brinkmann V

更新日期：2008-05-01 00:00:00

abstract：:To develop a comprehensive catalogue of phenotypic and functional parameters of human CD4(+) T cell differentiation stages, we have performed microarray gene expression profiling on subpopulations of human thymocytes and circulating naive CD4(+) T cells, including CD3(-)CD4(+)CD8(-) intrathymic T progenitor cells, CD3...

journal_title：International immunology

authors： Lee MS,Hanspers K,Barker CS,Korn AP,McCune JM

更新日期：2004-08-01 00:00:00

abstract：:NOD mice spontaneously develop type I diabetes resulting from autoimmune destruction of their insulin-producing beta cells. Among the self-antigens targeted by NOD autoimmune T cells is a peptide, p277, from the sequence of the 60 kDa heat shock protein (hsp60). Common to the anti-p277 T cell populations of NOD mice i...

journal_title：International immunology

authors： Elias D,Tikochinski Y,Frankel G,Cohen IR

更新日期：1999-06-01 00:00:00

abstract：:It is well established that the bacterial superantigens bind to both TCR beta-chain and, with moderate affinity, to MHC class II molecules. Class II-bearing cells bind the superantigen and present the superantigen to T cells expressing certain TCR beta-chain variable region alleles. We have observed that the superanti...

journal_title：International immunology

authors： Rogers TJ,Guan L,Zhang L

更新日期：1995-11-01 00:00:00

abstract：:We have analyzed transcripts encoding the variable regions of Ig heavy chains from adult and fetal bovine splenocytes and bovine x mouse heterohybridomas. The 13 adult, seven fetal and two heterohybridomas transcripts as well as the six genes that were sequenced had > 83% identity to each other in the VH-encoded regio...

journal_title：International immunology

authors： Berens SJ,Wylie DE,Lopez OJ

更新日期：1997-01-01 00:00:00

abstract：:In order to better understand the role of intestinal CD1d, we sought to define the cellular localization and further characterize the biochemical structure of CD1d in human intestinal epithelial cells (IEC). Using a CD1d-specific rabbit anti-gst-CD1d antibody, immunoprecipitation of radiolabeled cell surface proteins ...

journal_title：International immunology

authors： Somnay-Wadgaonkar K,Nusrat A,Kim HS,Canchis WP,Balk SP,Colgan SP,Blumberg RS

更新日期：1999-03-01 00:00:00

abstract：:Antibody to phosphatidyl choline (PtC) is produced spontaneously in mice, by approximately 2-10% of naturally occurring CD5+ (B1) B cells in the peritoneum. Much of this antibody is encoded by the VH11 gene associated with a specific V kappa 9 gene. Constraints on the size and structure of the H chain CDR3 have been d...

journal_title：International immunology

authors： Arnold LW,Spencer DH,Clarke SH,Haughton G

更新日期：1993-11-01 00:00:00

abstract：:The intestinal epithelium not only acts as the physical structure that separates the intestinal lumen from the body but also actively participates in intestinal barrier functions. In the past decade, significant progress has been made in the development of culture technologies to maintain intestinal epithelial cells (...

journal_title：International immunology

authors： Nakamura T

更新日期：2019-02-06 00:00:00