HIV envelope-directed signaling aberrancies and cell death of CD4+ T cells in the absence of TCR co-stimulation.

abstract：:We asked herein whether functional dendritic-like cells could be generated from t(9;22) acute lymphoblastic leukemia (ALL) blasts. We first determined that the combination of interleukin (IL)-1beta, IL-3, IL-7, tumor necrosis factor-alpha, stem cell factor and CD40 ligand was optimal for generating dendritic-like cell...

journal_title：International immunology

authors： Lee J,Sait SN,Wetzler M

更新日期：2004-10-01 00:00:00

abstract：:Experimental autoimmune encephalomyelitis (EAE) is a CD4(+) T cell-mediated, inflammatory disease with similarities to multiple sclerosis in humans. Intranasal (i.n.) administration of a myelin basic protein (MBP)-derived peptide can protect susceptible mice from EAE. The mechanisms underlying this phenomenon, however...

journal_title：International immunology

authors： Burkhart C,Liu GY,Anderton SM,Metzler B,Wraith DC

更新日期：1999-10-01 00:00:00

abstract：:CD100/Sema4D belongs to the semaphorin family, factors known to act as repulsive cues for axons during neuronal development. Mouse CD100 plays a crucial role in both humoral and cellular immunity through ligation of the lymphocyte receptor, CD72. It remains controversial, however, whether human CD100 can function thro...

journal_title：International immunology

authors： Ishida I,Kumanogoh A,Suzuki K,Akahani S,Noda K,Kikutani H

更新日期：2003-08-01 00:00:00

abstract：:Susceptibility and resistance to type 1 diabetes are associated with MHC class II alleles that carry non-Asp and Asp at residue 57 of their beta chain respectively. The effect of Asp or non-Aspbeta57 may relate to a differential ability of distinct class II molecules to bind specific immuno-pathogenic peptides. Recent...

journal_title：International immunology

authors： Quarsten H,Paulsen G,Johansen BH,Thorpe CJ,Holm A,Buus S,Sollid LM

更新日期：1998-08-01 00:00:00

abstract：:Impaired lymphocyte function is a common feature of human diabetes. Nucleoside transport across the plasma membrane is an essential step during lymphocyte growth and activation. In our study, we evaluated the impact of diabetic conditions on nucleoside transport system in B lymphocytes. Examination of the nucleoside t...

journal_title：International immunology

authors： Sakowicz M,Szutowicz A,Pawelczyk T

更新日期：2005-02-01 00:00:00

abstract：:The microphthalmic (mi) mouse exhibits deficiencies in the development of osteoclasts, melanocytes, mast cells and marrow B cells. Previously, we demonstrated that the marrow of such mice over-express receptor activator of nuclear factor kappaB (RANK) ligand (RANKL). RANKL has been shown to induce the production of IF...

journal_title：International immunology

authors： Roundy KM,Spangrude G,Weis JJ,Weis JH

更新日期：2005-11-01 00:00:00

abstract：:CD9 is a member of the tetraspanin superfamily which is characterized by four transmembrane (TM) domains and associates with other surface molecules. This tetraspanin was recently found to be expressed on mature T cells. Here, we investigated which molecules associate with CD9 on T cells and which CD9 domains are requ...

journal_title：International immunology

authors： Toyo-oka K,Yashiro-Ohtani Y,Park CS,Tai XG,Miyake K,Hamaoka T,Fujiwara H

更新日期：1999-12-01 00:00:00

abstract：:Macrophages are heterogeneous and plastic, and play several diverse functions in immune responses. Emerging data provide evidence of multiple roles for metabolic pathways in the control of macrophage effector functions. The diverse functions of macrophages are categorized into two main subsets: classical activated mac...

journal_title：International immunology

authors： Kang S,Kumanogoh A

更新日期：2020-06-26 00:00:00

abstract：:Natural cytotoxicity receptors and NKG2D correspond to major activating receptors involved in triggering of tumor cell lysis by human NK cells. In this report, we investigated the expression of NKG2D ligands (NKG2DLs), MHC class I-related chain (MIC) A, MICB and UL16-binding proteins 1, 2 and 3, on a panel of human no...

journal_title：International immunology

authors： Le Maux Chansac B,Missé D,Richon C,Vergnon I,Kubin M,Soria JC,Moretta A,Chouaib S,Mami-Chouaib F

更新日期：2008-07-01 00:00:00

abstract：:Cytotoxic T lymphocyte (CTL) mediated killing has classically been associated with a high level of specificity for the target cell. However, when CTL clones and specific target cells were copelleted with innocent bystander cells for which the CTL was not specific, these bystander cells were also lysed. Bystander lysis...

journal_title：International immunology

authors： Burrows SR,Fernan A,Argaet V,Suhrbier A

更新日期：1993-09-01 00:00:00

abstract：:It was recently shown that paf-acether (paf) synthesized in different cell types remains partly cell-associated. In the present work, we tested the hypothesis that cell-associated paf might in fact remain exposed on the external plasma membrane and be able to exert its biological functions. Human polymorphonuclear neu...

journal_title：International immunology

authors： Ninio E,Leyravaud S,Bidault J,Jurgens P,Benveniste J

更新日期：1991-11-01 00:00:00

abstract：:Candida albicans is a commensal fungus that predominantly resides on mucosal surfaces and can cause lethal systemic infection when the host defense is compromised. Candidalysin is a cytolytic peptide toxin produced by C. albicans hyphae that is essential for mucosal tissue damage and is believed to contribute to the e...

journal_title：International immunology

authors： Hanaoka M,Domae E

更新日期：2020-10-10 00:00:00

abstract：:Using anti-Tac (anti-alpha chain) and 2R-B (anti-beta chain) antibodies, we studied the roles of IL-2 receptor subunits (alpha and beta chains) in the formation of IL-2 and high-affinity IL-2 receptor complex, which is the initial event of IL-2 induced T cell growth. High-affinity IL-2 binding which was undetectable i...

journal_title：International immunology

authors： Kamio M,Uchiyama T,Arima N,Itoh K,Ishikawa T,Hori T,Uchino H

更新日期：1990-01-01 00:00:00

abstract：:The Lewis rat, an inbred rat strain susceptible to several well-characterized experimental autoimmune diseases, provides a good model to study peptide-mediated immunotherapy. Peptide immunotherapy focussing on the modulation of T cell responses by interfering with TCR-peptide-MHC complex formation requires the elucida...

journal_title：International immunology

authors： Wauben MH,van der Kraan M,Grosfeld-Stulemeyer MC,Joosten I

更新日期：1997-02-01 00:00:00

abstract：:CD45 is a receptor tyrosine phosphatase essential for TCR signaling. One isoform, CD45RB, is down-regulated in memory cells and targeting CD45RB with a specific antibody has been shown to inhibit graft rejection. Its role in immunity to infection, however, has not been tested. Here, we report the effect of anti-CD45RB...

journal_title：International immunology

authors： Lim B,Sutherland RM,Zhan Y,Deliyannis G,Brown LE,Lew AM

更新日期：2006-02-01 00:00:00

abstract：:At birth, virtually all peripheral CD8(+) T cells express the CD28 co-stimulatory molecule, but healthy human adults accumulate CD28(-)CD8(+) T cells that often express the CD57 marker. While these CD28(-) subpopulations are known to exert effector-type functions, the generation, maintenance and regulation of CD28(-) ...

journal_title：International immunology

authors： Labalette M,Leteurtre E,Thumerelle C,Grutzmacher C,Tourvieille B,Dessaint JP

更新日期：1999-08-01 00:00:00

abstract：:Naive and primed alpha beta T cells can be distinguished on the basis of their differential expression of CD45RA and CD45RO, respectively. The present study indicates that these CD45-isoforms also identify naive and primed maturational stages of gamma delta T cells and natural killer (NK) cells. In peripheral blood, a...

journal_title：International immunology

authors： Braakman E,Sturm E,Vijverberg K,van Krimpen BA,Gratama JW,Bolhuis RL

更新日期：1991-07-01 00:00:00

abstract：:The A6H mAb raised primarily against human renal cell carcinoma (RCC) has previously been shown to bind strongly to RCC, to some degree to colon carcinoma but only marginally to a variety of normal tissues. Immunohistochemical analysis or RCC tissues containing tumor-infiltrating lymphocytes revealed that A6H stained ...

journal_title：International immunology

authors： Labuda T,Lando P,Björkdahl O,Kalland T,Vessella R,Hedlund G,Eriksson H,Sjögren HO,Dohlsten M

更新日期：1995-09-01 00:00:00

abstract：:STAT6, NF-kappaB (p50) and C/EBPbeta transcription factors (TF) were examined with respect to CD23 regulation. Electrophoretic mobility shift assay (EMSA), competition and supershift analysis demonstrated that STAT6 binds the CD23a promoter but with a lower affinity than the consensus site. STAT6-/- mice were analyzed...

journal_title：International immunology

authors： Tinnell SB,Jacobs-Helber SM,Sterneck E,Sawyer ST,Conrad DH

更新日期：1998-10-01 00:00:00

abstract：:The endocytic and phagocytic activities of a population of MHC IIhi CD11c+ dendritic cell (DC)-like cells in synovium-rich tissues (SRTs) of normal rat paws were compared with CD163+ cells (putative macrophages) from the same tissues and pseudo-afferent lymph DCs, peritoneal macrophages and blood monocytes. Fifty perc...

journal_title：International immunology

authors： Moghaddami M,Mayrhofer G,Cleland LG

更新日期：2005-08-01 00:00:00

abstract：:Based on the evidence that CD8+ cytotoxic T cells (CTL) precursors do not appear to distinguish between virus-infected cells and viral peptide-pulsed syngeneic cells, we have developed methods for priming class I MHC molecule restricted CD8+ CTL with such peptides without using any adjuvant. We were able to prime in v...

journal_title：International immunology

authors： Takahashi H,Nakagawa Y,Yokomuro K,Berzofsky JA

更新日期：1993-08-01 00:00:00

abstract：:Dendritic cells (DC) sense saprophytic yeast and pathogenic, filamentous forms of Candida albicans in a specific way, resulting in disparate patterns of DC and T(h) cell activation. Using human and murine DC, such disparate patterns could be traced to the exploitation of distinct recognition receptors. Although usage ...

journal_title：International immunology

authors： Romani L,Montagnoli C,Bozza S,Perruccio K,Spreca A,Allavena P,Verbeek S,Calderone RA,Bistoni F,Puccetti P

更新日期：2004-01-01 00:00:00

abstract：:Kit/CD117 plays a crucial role in the cell-cell and cell-matrix adhesion of mammalian mast cells (MCs); however, it is unclear whether other adhesion molecule(s) perform important roles in the adhesion of MCs. In the present study, we show a novel Kit-independent adhesion mechanism of mouse cultured MCs mediated by No...

journal_title：International immunology

authors： Murata A,Hikosaka M,Yoshino M,Zhou L,Hayashi SI

更新日期：2019-02-15 00:00:00

abstract：:IgE plus antigen-stimulated mast cells degranulate, synthesize leukotrienes and secrete cytokines. According to the coalescence model this process is initiated in specific membrane compartments termed rafts. There, enhanced levels of glycosphingolipids and cholesterol stabilize the interaction of FcepsilonRI and Lyn, ...

journal_title：International immunology

authors： Baumruker T,Csonga R,Pursch E,Pfeffer A,Urtz N,Sutton S,Bofill-Cardona E,Cooke M,Prieschl E

更新日期：2003-10-01 00:00:00

abstract：:Immunoglobulin affinity maturation depends on somatic hypermutation (SHM) in immunoglobulin variable (IgV) regions initiated by activation-induced cytidine deaminase (AID). AID induces transition mutations by C→U deamination on both strands, causing C:G→T:A. Error-prone repairs of U by base excision and mismatch repai...

journal_title：International immunology

authors： Eid MMA,Shimoda M,Singh SK,Almofty SA,Pham P,Goodman MF,Maeda K,Sakaguchi N

更新日期：2017-05-01 00:00:00

abstract：:Cells bearing the gamma delta form of the TCR make up only 1-3% of T cells in the adult murine thymus and peripheral lymphoid organs. Evidence from studies of nude mice suggests that the development of at least some gamma delta T cells is thymus dependent; however, until now it has not been directly demonstrated that ...

journal_title：International immunology

authors： Kelly KA,Pearse M,Lefrancois L,Scollay R

更新日期：1993-04-01 00:00:00

abstract：:Type II collagen (CII) is of immunological interest because of its repetitive structure and properties as an autoantigen. The mouse gene has recently been cloned, thus enabling T cell-defined epitopes to be identified. Multiple novel epitopes on mouse CII are here detected in the autoreactive T cell response. The majo...

journal_title：International immunology

authors： Bayrak S,Holmdahl R,Travers P,Lauster R,Hesse M,Dölling R,Mitchison NA

更新日期：1997-11-01 00:00:00

abstract：:Cross-linking of the IgM antigen receptor on an immature B cell lymphoma (BKS-2) induces growth arrest and apoptosis. This is accompanied by down-regulation of the immediate early genes, egr-1 and c-myc, and a reduction in NF-kappaB activity. Anti-IgM-induced growth arrest and apoptosis of this murine B cell lymphoma ...

journal_title：International immunology

authors： Han SS,Chung ST,Robertson DA,Chelvarajan RL,Bondada S

更新日期：1999-06-01 00:00:00

abstract：:Investigation of the process of Peyer's patch (PP) formation has been hampered by difficulties in identifying its initial step in the embryo. In this study, we overcame this problem by means of whole-mount immunohistochemistry using mAb against the molecules which were expressed in the cells accumulated at the site of...

journal_title：International immunology

authors： Adachi S,Yoshida H,Kataoka H,Nishikawa S

更新日期：1997-04-01 00:00:00

abstract：:Lymphocytes circulate in a quiescent (G(0)) state until they encounter specific antigens. In T cells, quiescence is programmed by transcription factors of the forkhead box O (FOXO) and Krüppel-like factor (KLF) families. However, the transcription factors that regulate B cell quiescence are not known. KLF4 is a candid...

journal_title：International immunology

authors： Yusuf I,Kharas MG,Chen J,Peralta RQ,Maruniak A,Sareen P,Yang VW,Kaestner KH,Fruman DA

更新日期：2008-05-01 00:00:00