Potentiation of NK cell-mediated cytotoxicity in human lung adenocarcinoma: role of NKG2D-dependent pathway.

abstract：:Experiments in transgenic mice have demonstrated that thymocyte differentiation into the mature CD4+ helper or CD8+ cytotoxic T cell lineage is ultimately dependent upon the specificity of the TCR for class II or class I MHC molecules respectively. However, the initial mechanistic events involved in this process remai...

journal_title：International immunology

authors： DeKoning J,Carbone FR,Kaye J

更新日期：1995-04-01 00:00:00

abstract：:A central tenet of vaccine development is to identify immune correlates of protection. Both plasmid-encoded gD as well as recombinant protein gD can protect mice from lethal herpes simplex virus (HSV) challenge. It is known that different vaccine modalities should induce different immune phenotypes. Yet, paradoxically...

journal_title：International immunology

authors： Sin JI,Ayyavoo V,Boyer J,Kim J,Ciccarelli RB,Weiner DB

更新日期：1999-11-01 00:00:00

abstract：:NOD mice spontaneously develop type I diabetes resulting from autoimmune destruction of their insulin-producing beta cells. Among the self-antigens targeted by NOD autoimmune T cells is a peptide, p277, from the sequence of the 60 kDa heat shock protein (hsp60). Common to the anti-p277 T cell populations of NOD mice i...

journal_title：International immunology

authors： Elias D,Tikochinski Y,Frankel G,Cohen IR

更新日期：1999-06-01 00:00:00

abstract：:Lymphocytes circulate in a quiescent (G(0)) state until they encounter specific antigens. In T cells, quiescence is programmed by transcription factors of the forkhead box O (FOXO) and Krüppel-like factor (KLF) families. However, the transcription factors that regulate B cell quiescence are not known. KLF4 is a candid...

journal_title：International immunology

authors： Yusuf I,Kharas MG,Chen J,Peralta RQ,Maruniak A,Sareen P,Yang VW,Kaestner KH,Fruman DA

更新日期：2008-05-01 00:00:00

abstract：:Defects of early complement components (C1, C4 and C2) are associated with the development of systemic lupus erythematosus (SLE). The availability of complement knockout mice has increased our knowledge on the role of complement in the regulation of adaptive immunity. An impaired removal of apoptotic bodies, a disturb...

journal_title：International immunology

authors： Zachrau B,Finke D,Kropf K,Gosink HJ,Kirchner H,Goerg S

更新日期：2004-12-01 00:00:00

abstract：:The mechanism underlying selective IgG subclass deficiency is largely unknown in humans. We have previously reported the acquisition of a complete IgG2 deficiency in a leukemia patient after bone marrow transplantation. Southern blot analysis showed a deletion including the Cgamma2 and Cgamma4 genes on one chromosome ...

journal_title：International immunology

authors： Zhao Y,Pan-Hammarström Q,Zhao Z,Wen S,Hammarström L

更新日期：2005-01-01 00:00:00

abstract：:Candida albicans is a commensal fungus that predominantly resides on mucosal surfaces and can cause lethal systemic infection when the host defense is compromised. Candidalysin is a cytolytic peptide toxin produced by C. albicans hyphae that is essential for mucosal tissue damage and is believed to contribute to the e...

journal_title：International immunology

authors： Hanaoka M,Domae E

更新日期：2020-10-10 00:00:00

abstract：:LPS-binding protein (LBP) can facilitate the transfer of cell wall components of both Gram-negative bacteria (LPS) and Gram-positive bacteria (lipoteichoic acid) to inflammatory cells. Although LBP is predominantly produced in the liver, recent studies have indicated that this protein is also synthesized locally in th...

journal_title：International immunology

authors： Branger J,Florquin S,Knapp S,Leemans JC,Pater JM,Speelman P,Golenbock DT,van der Poll T

更新日期：2004-11-01 00:00:00

abstract：:The T cell Ig domain and mucin domain (TIM) proteins form a conserved family of transmembrane cell-surface glycoproteins expressed by a variety of tissues. Each TIM protein contains a single V-type Ig domain, a glycosylated mucin-like domain, a transmembrane domain and a cytoplasmic domain. TIM proteins recognize a di...

journal_title：International immunology

authors： Wilker PR,Sedy JR,Grigura V,Murphy TL,Murphy KM

更新日期：2007-06-01 00:00:00

abstract：:Interleukin-15 (IL-15) is a cytokine critical for maintenance of intestinal intra-epithelial lymphocytes (IELs), especially CD8αα + IELs (CD8αα IELs). In the intestine, IL-15 is produced by intestinal epithelial cells (IECs), blood vascular endothelial cells (BECs) and hematopoietic cells. However, the precise role of...

journal_title：International immunology

authors： Zhu Y,Cui G,Miyauchi E,Nakanishi Y,Mukohira H,Shimba A,Abe S,Tani-Ichi S,Hara T,Nakase H,Chiba T,Sehara-Fujisawa A,Seno H,Ohno H,Ikuta K

更新日期：2020-05-08 00:00:00

abstract：:P-selectin is a Ca(2+)-dependent lectin that participates in leukocyte adhesion to vascular endothelium and platelets. Myeloid cells and a subset of T lymphocytes express carbohydrate ligands at the cell surface. Previously, we suggested that heat stable antigen (HSA/mouse CD24), an extensively glycosylated cell surfa...

journal_title：International immunology

authors： Aigner S,Ruppert M,Hubbe M,Sammar M,Sthoeger Z,Butcher EC,Vestweber D,Altevogt P

更新日期：1995-10-01 00:00:00

abstract：:CD9 is a member of the tetraspanin superfamily which is characterized by four transmembrane (TM) domains and associates with other surface molecules. This tetraspanin was recently found to be expressed on mature T cells. Here, we investigated which molecules associate with CD9 on T cells and which CD9 domains are requ...

journal_title：International immunology

authors： Toyo-oka K,Yashiro-Ohtani Y,Park CS,Tai XG,Miyake K,Hamaoka T,Fujiwara H

更新日期：1999-12-01 00:00:00

abstract：:Impaired lymphocyte function is a common feature of human diabetes. Nucleoside transport across the plasma membrane is an essential step during lymphocyte growth and activation. In our study, we evaluated the impact of diabetic conditions on nucleoside transport system in B lymphocytes. Examination of the nucleoside t...

journal_title：International immunology

authors： Sakowicz M,Szutowicz A,Pawelczyk T

更新日期：2005-02-01 00:00:00

abstract：:Previously we examined the ability of the host's immune responses to regulate Ig production in an IgE-secreting murine plasma cell tumor (B53). In the present study we have examined the reverse phenomenon, in that we have investigated the effects of this and other plasma cell tumors on the immune responses of their ho...

journal_title：International immunology

authors： Ruzek MC,Mathur A

更新日期：1995-07-01 00:00:00

abstract：:We have used a set of single-chain variable fragment antibodies (sc) genetically fused with an influenza hemagglutinin-derived peptide as a means to investigate the role of CR1 and CR2 in antigen presentation by B cells. When incubated with the B cell lymphoma 2PK3, peptide-containing sc specific for either CR1 or CR1...

journal_title：International immunology

authors： Prechl J,Baiu DC,Horváth A,Erdei A

更新日期：2002-03-01 00:00:00

abstract：:It is now generally recognized that bone marrow is the survival niche for antigen-specific plasma cells with long-term immunological memory. These cells release antibodies into the circulation, needed to prime effector cells in the secondary immune response. These antibodies participate in the surveillance for antigen...

journal_title：International immunology

authors： Gould HJ,Wu YB

更新日期：2018-08-30 00:00:00

abstract：:CD70 and CD80 are co-stimulatory molecules which belong to the tumor necrosis factor family and the B7 family respectively. When they are co-expressed by gene-modified TS/A tumor cells, they provide an efficient protective and long-lasting T-dependent antitumor response. We first showed that when CD70 and CD80 were de...

journal_title：International immunology

authors： Douin-Echinard V,Péron JM,Lauwers-Cancès V,Favre G,Couderc B

更新日期：2003-03-01 00:00:00

abstract：:In vascularized organ transplantation, vascular endothelial cells (EC) confronting recipient T cells are potentially significant APC initiating cellular immune responses that lead to rejection. In the present study, we studied the ability of human EC to stimulate allogeneic T cells and the co-stimulatory molecules inv...

journal_title：International immunology

authors： Seino K,Azuma M,Bashuda H,Fukao K,Yagita H,Okumura K

更新日期：1995-08-01 00:00:00

abstract：:We have searched the human genome for genes that predispose to rheumatoid arthritis (RA) using fluorescence-based microsatellite marker analysis and affected sib-pair linkage study. A panel of 41 Japanese families, each with at least two affected siblings, was typed for genome-wide 358 polymorphic microsatellite marke...

journal_title：International immunology

authors： Shiozawa S,Hayashi S,Tsukamoto Y,Goko H,Kawasaki H,Wada T,Shimizu K,Yasuda N,Kamatani N,Takasugi K,Tanaka Y,Shiozawa K,Imura S

更新日期：1998-12-01 00:00:00

abstract：:The extracellular signal-regulated kinase (ERK) signaling pathway is strongly activated in response to TCR stimulation in normal T cells. However, the extent to which activation of the ERK pathway is necessary for TCR-stimulated cytokine production is not clear. We have addressed this question by use of two separate m...

journal_title：International immunology

authors： Egerton M,Fitzpatrick DR,Kelso A

更新日期：1998-02-01 00:00:00

abstract：:The profile of cytokines produced by CD4 T cells is profoundly influenced by the presence of IL-12. Here we demonstrate that during re-stimulation of antigen-specific immune responses in vitro, antigen-primed lymph node cells from DBA/2 mice produced 3- to 30-fold more IL-12 than did cells from BALB/c mice, which are ...

journal_title：International immunology

authors： Gieni RS,Fang Y,Trinchieri G,Umetsu DT,DeKruyff RH

更新日期：1996-10-01 00:00:00

abstract：:The chicken represents the best-characterized animal model for B cell development in the so-called gut-associated lymphoid tissue (GALT) and the molecular processes leading to B cell receptor diversification in this species are well investigated. However, the mechanisms regulating B cell development and homeostasis in...

journal_title：International immunology

authors： Kothlow S,Morgenroth I,Graef Y,Schneider K,Riehl I,Staeheli P,Schneider P,Kaspers B

更新日期：2007-02-01 00:00:00

abstract：:The integrins have been grouped into three subfamilies based on the utilization of three distinct beta chain subunits, beta 1, beta 2, and beta 3. The recent discovery of beta 4 and beta 5 subunits, and the sharing of alpha subunits between beta subfamilies reflects a greater structural and functional diversity of the...

journal_title：International immunology

authors： Yuan QA,Jiang WM,Krissansen GW,Watson JD

更新日期：1990-01-01 00:00:00

abstract：:The granulocyte macrophage colony stimulating factor (GM-CSF) promoter contains a 10 bp element known as CK-1 or CD28RE that specifically responds to the co-stimulatory signal delivered to T cells via the CD28 surface receptor. This element is a variant NFkappaB site that does not function alone but requires an adjace...

journal_title：International immunology

authors： Shang C,Attema J,Cakouros D,Cockerill PN,Shannon MF

更新日期：1999-12-01 00:00:00

abstract：:Toll-like receptor 3 (TLR3) recognizes double-stranded RNA and transmits signals to activate NF-kappaB and the interferon (IFN)-beta promoter via the newly identified adaptor, TICAM-1. The extracellular LRR domain of TLR3 is engaged in the ligand recognition, while the intracellular TIR domain is crucial for the adapt...

journal_title：International immunology

authors： Funami K,Matsumoto M,Oshiumi H,Akazawa T,Yamamoto A,Seya T

更新日期：2004-08-01 00:00:00

abstract：:Recent studies have shown that tumor cells acquire escape mechanisms to evade host immunity in the tumor microenvironment. Two key immune checkpoint pathways mediated by immunosuppressive co-signaling, the first via programmed cell death 1 (PD-1) and PD-1 ligand 1 (PD-1/PD-L1) and the second via CTLA-4 and B7 (CTLA-4/...

journal_title：International immunology

authors： Hamanishi J,Mandai M,Konishi I

更新日期：2016-07-01 00:00:00

abstract：:In this study, a B cell growth stimulatory factor, constitutively secreted by a human CD4+ T cell hybridoma clone, MP6, has been purified and characterized. Serum-free 24 h culture media from MP6 cells were collected, concentrated by ultrafiltration and separated by gel chromatography. Fractions were analyzed for stim...

journal_title：International immunology

authors： Rosen A,Lundman P,Carlsson M,Bhavani K,Srinivasa BR,Kjellström G,Nilsson K,Holmgren A

更新日期：1995-04-01 00:00:00

abstract：:A canonical pre-TCR/TCR signaling pathway critical for thymic T cell development involves sequential phosphorylation and signaling through Lck, Zap70, Lat and Slp76. However, we and others have previously reported that genomic deletion of c-Cbl (Cbl) partially or completely reverses the defects in thymic development i...

journal_title：International immunology

authors： Chiang YJ,Hodes RJ

更新日期：2015-05-01 00:00:00

abstract：:Treatment of melanoma cell lines with IFN-gamma induces the switch from proteasome (PS) to immunoproteasome (iPS). This finding has profound implications for the immunobiology of melanoma cells since certain peptides (such as Melan-A(mart1)(27-35)) are cleaved differently by iPS, thus implying a different ability to b...

journal_title：International immunology

authors： Cangemi G,Morandi B,D'Agostino A,Peri C,Conte R,Damonte G,Ferlazzo G,Biassoni R,Melioli G

更新日期：2003-12-01 00:00:00

abstract：:Heat shock protein (Hsp) 60 is thought to function as endogenous danger signal by activating professional antigen-presenting cells (APC) through toll-like receptor (TLR) 4 and CD14, a mechanism that is also used by bacterial LPS. We recently showed that Hsp60 binds LPS and enhances LPS-induced immune stimulation. On t...

journal_title：International immunology

authors： Osterloh A,Veit A,Gessner A,Fleischer B,Breloer M

更新日期：2008-03-01 00:00:00