Abstract:
:Cytotoxic T lymphocyte (CTL) mediated killing has classically been associated with a high level of specificity for the target cell. However, when CTL clones and specific target cells were copelleted with innocent bystander cells for which the CTL was not specific, these bystander cells were also lysed. Bystander lysis did not depend on HLA compatibility between effector and bystander cell. Indeed bystander lysis was particularly efficient during cognate synthetic peptide induced CTL-CTL killing. Bystander lysis was species unrestricted. Lytic activity could not be transferred in supernatants nor could it be inhibited by anti-tumor necrosis factor antibodies. Perforin sensitive red blood cells were very inefficiently bystander lysed. Bystander cell death was characterized by DNA fragmentation indicative of apoptosis or programmed cell death. Bystander lysis thus appeared to be due to the apoptotic CTL lytic mediator(s). Importantly, CTL were not resistant to bystander lysis induced by other CTL; nor did they become resistant when they were actively killing target cells. Since it is well established that CTL survive the delivery of their own lytic mediators, these results suggest that CTL induced apoptosis is a membrane mediated event.
journal_name
Int Immunoljournal_title
International immunologyauthors
Burrows SR,Fernan A,Argaet V,Suhrbier Adoi
10.1093/intimm/5.9.1049subject
Has Abstractpub_date
1993-09-01 00:00:00pages
1049-58issue
9eissn
0953-8178issn
1460-2377journal_volume
5pub_type
杂志文章abstract::We have recently described the novel A6H antigen expressed on human peripheral blood T cells and on renal cell carcinoma cells. Cross-linking of the A6H antigen results in co-stimulation of human CD4(+) T cells, characterized by induction of the transcription factor activator protein-1 (AP-1), proliferation and promin...
journal_title:International immunology
pub_type: 杂志文章
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更新日期:2000-03-01 00:00:00
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journal_title:International immunology
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journal_title:International immunology
pub_type: 杂志文章
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pub_type: 杂志文章,评审
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journal_title:International immunology
pub_type: 杂志文章
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更新日期:1996-05-01 00:00:00
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journal_title:International immunology
pub_type: 杂志文章
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更新日期:1993-02-01 00:00:00
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journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/10.6.791
更新日期:1998-06-01 00:00:00
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journal_title:International immunology
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doi:10.1093/intimm/9.12.1825
更新日期:1997-12-01 00:00:00
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journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/dxg090
更新日期:2003-08-01 00:00:00
abstract:BACKGROUND:The pathogenesis of inflammatory skin disease involves the release of cytokines from keratinocytes, and one of these, IL-1β, has been previously implicated in inflammatory skin disease. T(h)17 cells, a subset of T(h) cells involved in autoimmunity and inflammation, possess IL-1β receptors and secrete cytokin...
journal_title:International immunology
pub_type: 杂志文章
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更新日期:2012-03-01 00:00:00
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pub_type: 杂志文章
doi:10.1093/intimm/11.8.1327
更新日期:1999-08-01 00:00:00
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journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/dxl006
更新日期:2006-05-01 00:00:00
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journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/dxm042
更新日期:2007-06-01 00:00:00
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journal_title:International immunology
pub_type: 杂志文章
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更新日期:2005-08-01 00:00:00
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更新日期:2008-06-01 00:00:00
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doi:10.1093/intimm/4.1.67
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journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/3.11.1157
更新日期:1991-11-01 00:00:00
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pub_type: 杂志文章
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更新日期:2014-10-01 00:00:00
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pub_type: 杂志文章
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更新日期:2008-02-01 00:00:00
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pub_type: 杂志文章
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更新日期:2003-10-01 00:00:00
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pub_type: 杂志文章
doi:10.1093/intimm/10.12.1891
更新日期:1998-12-01 00:00:00
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更新日期:1997-05-01 00:00:00
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journal_title:International immunology
pub_type: 杂志文章
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更新日期:2005-02-01 00:00:00
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pub_type: 杂志文章
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更新日期:2004-08-01 00:00:00