Abstract:
:Cells bearing the gamma delta form of the TCR make up only 1-3% of T cells in the adult murine thymus and peripheral lymphoid organs. Evidence from studies of nude mice suggests that the development of at least some gamma delta T cells is thymus dependent; however, until now it has not been directly demonstrated that gamma delta cells are exported from the thymus. In this paper we have used the technique of labelling thymocytes in vivo with FITC, followed by flow cytometric analysis to trace cells emigrating from the thymus to the spleen. Using this approach we have been able to demonstrate for the first time that gamma delta T cells are exported from the adult murine thymus to the spleen. We also demonstrate that the cells emigrating to the spleen are a selected subset of gamma delta thymocytes being heat stable antigen positive, Thy-1+, and expressing low levels of CD44 (Pgp-1). In addition, investigation of TCR V gamma gene usage among adult gamma delta + thymocytes, recent emigrants, and spleen cells, indicated a selective emigration of gamma delta cells expressing certain V gamma genes.
journal_name
Int Immunoljournal_title
International immunologyauthors
Kelly KA,Pearse M,Lefrancois L,Scollay Rdoi
10.1093/intimm/5.4.331subject
Has Abstractpub_date
1993-04-01 00:00:00pages
331-5issue
4eissn
0953-8178issn
1460-2377journal_volume
5pub_type
杂志文章abstract::In vivo administration of NKT cell ligand, alpha-galactosylceramide (alpha-GalCer), caused the activation of NKT cells to induce a strong NK activity and cytokine production by CD1d-restricted mechanisms. Surprisingly, we also found that alpha-GalCer induced the activation of immunoregulatory cells involved in acquire...
journal_title:International immunology
pub_type: 杂志文章
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pub_type: 临床试验,杂志文章
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更新日期:2006-10-01 00:00:00
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更新日期:1999-02-01 00:00:00
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pub_type: 杂志文章
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更新日期:1990-01-01 00:00:00
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journal_title:International immunology
pub_type: 杂志文章
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更新日期:1992-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2015-05-01 00:00:00
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pub_type: 杂志文章
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更新日期:2001-05-01 00:00:00
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pub_type: 杂志文章
doi:10.1093/intimm/5.9.1139
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2003-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1093/intimm/10.11.1613
更新日期:1998-11-01 00:00:00
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pub_type: 杂志文章
doi:10.1093/intimm/10.1.1
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pub_type: 杂志文章
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更新日期:1990-01-01 00:00:00
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pub_type: 杂志文章
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journal_title:International immunology
pub_type: 杂志文章
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journal_title:International immunology
pub_type: 杂志文章
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更新日期:2005-08-01 00:00:00
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更新日期:1998-02-01 00:00:00
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journal_title:International immunology
pub_type: 杂志文章
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更新日期:1995-04-01 00:00:00
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更新日期:1999-07-01 00:00:00