CCR6hiCD11c(int) B cells promote M-cell differentiation in Peyer's patch.

Abstract:

:M cells are responsible for uptake of mucosal antigens in Peyer's patches (PPs). Differentiation of M cells is thought to be induced by interactions between follicle-associated epithelium and PP cells; however, it remains elusive what types of immune cells function as M-cell inducers. Here, we attempted to identify the cells that serve as an M-cell inducer in PP. We found that a unique B-cell subset characterized by CCR6(hi)CD11c(int) resided in the subepithelial dome (SED) in mouse PP. CCR6(hi)CD11c(int) B cells showed chemotactic migration in response to CCL20. Furthermore, this unique B-cell subset substantially decreased in PP of CCR6-deficient mice, indicating that the SED localization of CCR6(hi)CD11c(int) B cells is most likely regulated by the CCL20-CCR6 system. Concomitantly, CCR6 deficiency caused remarkable decrement of M cells. Moreover, adoptive transfer of CCR6(hi)CD11c(int) B cells from wild-type mice restored the M-cell decrement in CCR6-deficient mice. Collectively, the spatial regulation of CCR6(hi)CD11c(int) B cells via the CCL20-CCR6 system may play a vital role in M-cell differentiation in mice.

journal_name

Int Immunol

journal_title

International immunology

authors

Ebisawa M,Hase K,Takahashi D,Kitamura H,Knoop KA,Williams IR,Ohno H

doi

10.1093/intimm/dxq478

subject

Has Abstract

pub_date

2011-04-01 00:00:00

pages

261-9

issue

4

eissn

0953-8178

issn

1460-2377

pii

dxq478

journal_volume

23

pub_type

杂志文章
  • Composition of TCR-CD3 complex in human intestinal intraepithelial lymphocytes: lack of Fc epsilon RI gamma chain.

    abstract::Human intestinal intraepithelial lymphocytes (iIEL) are a unique population of predominantly CD8 alpha beta+, TCR alpha beta+ lymphocytes and, to a lesser extent, TCP gamma delta+ lymphocytes that proliferate poorly to anti-CD3 mitogenic signals but display significant cytolytic activity. Studies in mouse model system...

    journal_title:International immunology

    pub_type: 杂志文章,评审

    doi:10.1093/intimm/7.8.1237

    authors: Balk SP,Polischuk JE,Probert C,Stevens C,Ebert E,She J,Terhorst C,Blumberg RS

    更新日期:1995-08-01 00:00:00

  • A study of peripheral tolerance through embryonic grafts of the bursal epithelial rudiment between MHC-distinct chick embryos.

    abstract::We report here that different organ grafts are not equally competent to induce tolerance of the host even if they are performed early in development, i.e. before the host's immune system has started to develop. We have grafted the epithelio-mesenchymal rudiment of the bursa of Fabricius between histoincompatible chick...

    journal_title:International immunology

    pub_type: 杂志文章

    doi:10.1093/intimm/6.6.795

    authors: Martin C,Belo M,Le Douarin NM,Corbel C

    更新日期:1994-06-01 00:00:00

  • Localization of intestinal intraepithelial T lymphocytes involves regulation of alphaEbeta7 expression by transforming growth factor-beta.

    abstract::Induction of alphaEbeta7 expression on T cells by transforming growth factor (TGF)-beta is thought to be important for intestinal intraepithelial T lymphocyte (IEL) entry into the epithelial compartment. However, there has been no in vivo evidence that up-regulation of alphaEbeta7 expression on T cells by TGF-beta is ...

    journal_title:International immunology

    pub_type: 杂志文章

    doi:10.1093/intimm/14.4.339

    authors: Suzuki R,Nakao A,Kanamaru Y,Okumura K,Ogawa H,Ra C

    更新日期:2002-04-01 00:00:00

  • Characterization of Fc epsilon RI gamma in human natural killer cells.

    abstract::We report the characterization of the Fc epsilon RI gamma chain which associates with the transmembrane form of CD16 to form the low affinity receptor for IgG (Fc gamma RIII) expressed on human natural killer (NK) cells. cDNA cloning and sequence analysis of Fc epsilon RI gamma from a polyclonal CD3-CD16+ NK line esta...

    journal_title:International immunology

    pub_type: 杂志文章

    doi:10.1093/intimm/4.8.955

    authors: Moingeon P,Lucich JL,Reinherz EL

    更新日期:1992-08-01 00:00:00

  • DNA vaccination with gp96-peptide fusion proteins induces protection against an intracellular bacterial pathogen.

    abstract::Effective vaccination using in vitro peptide-loaded heat-shock proteins (HSP), tumor-derived HSP and HSP fusion proteins has been shown in viral, parasite and tumor model systems. We demonstrate protective DNA vaccination using gp96-peptide fusion proteins against the intracellular bacterial pathogen Listeria monocyto...

    journal_title:International immunology

    pub_type: 杂志文章

    doi:10.1093/intimm/dxh064

    authors: Rapp UK,Kaufmann SH

    更新日期:2004-04-01 00:00:00

  • Partial rescue of B cells in microphthalmic osteopetrotic marrow by loss of response to type I IFNs.

    abstract::The microphthalmic (mi) mouse exhibits deficiencies in the development of osteoclasts, melanocytes, mast cells and marrow B cells. Previously, we demonstrated that the marrow of such mice over-express receptor activator of nuclear factor kappaB (RANK) ligand (RANKL). RANKL has been shown to induce the production of IF...

    journal_title:International immunology

    pub_type: 杂志文章

    doi:10.1093/intimm/dxh327

    authors: Roundy KM,Spangrude G,Weis JJ,Weis JH

    更新日期:2005-11-01 00:00:00

  • Activation-induced expression of murine CD83 on T cells and identification of a specific CD83 ligand on murine B cells.

    abstract::Human CD83 is a cell surface protein expressed predominantly by dendritic cells (DC) and lymphoid cells. So far, there exists no information on the function and distribution of mCD83. Here we demonstrate that mCD83 is moderately expressed on resting T cells and DC, but strongly increases in its expression on T cells f...

    journal_title:International immunology

    pub_type: 杂志文章

    doi:10.1093/intimm/12.9.1347

    authors: Cramer SO,Trumpfheller C,Mehlhoop U,Moré S,Fleischer B,von Bonin A

    更新日期:2000-09-01 00:00:00

  • Rapid acceleration of neutrophil apoptosis by tumor necrosis factor-alpha.

    abstract::We demonstrate here that human necrosis factor-alpha, a potent neutrophil activator, induces rapid (within 3 h) apoptosis of these cells, i.e. neutrophils treated with this cytokine exhibit (i) light and electron microscopic changes characteristic to apoptotic cells, (ii) reduced propidium iodide binding to DNA, and (...

    journal_title:International immunology

    pub_type: 杂志文章

    doi:10.1093/intimm/5.6.691

    authors: Takeda Y,Watanabe H,Yonehara S,Yamashita T,Saito S,Sendo F

    更新日期:1993-06-01 00:00:00

  • PD-1 and PD-1 ligands: from discovery to clinical application.

    abstract::Programmed cell death-1 (PD-1, Pdcd1), an immunoreceptor belonging to the CD28/CTLA-4 family negatively regulates antigen receptor signaling by recruiting protein tyrosine phosphatase, SHP-2 upon interacting with either of two ligands, PD-L1 or PD-L2. Because of the wide range of ligand distribution in the body, its b...

    journal_title:International immunology

    pub_type: 杂志文章,评审

    doi:10.1093/intimm/dxm057

    authors: Okazaki T,Honjo T

    更新日期:2007-07-01 00:00:00

  • Intestinal epithelial cell-derived IL-15 determines local maintenance and maturation of intra-epithelial lymphocytes in the intestine.

    abstract::Interleukin-15 (IL-15) is a cytokine critical for maintenance of intestinal intra-epithelial lymphocytes (IELs), especially CD8αα + IELs (CD8αα IELs). In the intestine, IL-15 is produced by intestinal epithelial cells (IECs), blood vascular endothelial cells (BECs) and hematopoietic cells. However, the precise role of...

    journal_title:International immunology

    pub_type: 杂志文章

    doi:10.1093/intimm/dxz082

    authors: Zhu Y,Cui G,Miyauchi E,Nakanishi Y,Mukohira H,Shimba A,Abe S,Tani-Ichi S,Hara T,Nakase H,Chiba T,Sehara-Fujisawa A,Seno H,Ohno H,Ikuta K

    更新日期:2020-05-08 00:00:00

  • Allorecognition of human neural stem cells by peripheral blood lymphocytes despite low expression of MHC molecules: role of TGF-beta in modulating proliferation.

    abstract::Neural stem cells (NSCs) transplantation has been proposed as a means of restoring damaged brain tissue, a possibility rendered more likely by reports of low NSCs immunogenicity in various experimental models because of low expression of MHC class I and II as well as co-stimulatory molecules. We investigated the immun...

    journal_title:International immunology

    pub_type: 杂志文章

    doi:10.1093/intimm/dxm079

    authors: Ubiali F,Nava S,Nessi V,Frigerio S,Parati E,Bernasconi P,Mantegazza R,Baggi F

    更新日期:2007-09-01 00:00:00

  • Cell adhesion by membrane-bound paf-acether.

    abstract::It was recently shown that paf-acether (paf) synthesized in different cell types remains partly cell-associated. In the present work, we tested the hypothesis that cell-associated paf might in fact remain exposed on the external plasma membrane and be able to exert its biological functions. Human polymorphonuclear neu...

    journal_title:International immunology

    pub_type: 杂志文章

    doi:10.1093/intimm/3.11.1157

    authors: Ninio E,Leyravaud S,Bidault J,Jurgens P,Benveniste J

    更新日期:1991-11-01 00:00:00

  • Deficient surface expression of glycosylphosphatidylinositol-anchored proteins in B cell lines established from patients with paroxysmal nocturnal hemoglobinuria.

    abstract::Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired type hemolytic disorder. Hematopoietic cells of patients with PNH are deficient in glycosylphosphatidylinositol (GPI) anchored membrane proteins. Since some membrane-bound complement inhibitors, such as CD59 and decay accelerating factor (DAF), are GPI anchored ...

    journal_title:International immunology

    pub_type: 杂志文章

    doi:10.1093/intimm/4.11.1263

    authors: Ueda E,Nishimura J,Kitani T,Nasu K,Kageyama T,Kim YU,Takeda J,Kinoshita T

    更新日期:1992-11-01 00:00:00

  • Changes in the subsets of CD4+ T cells in Trypanosoma musculi infection: delay of immunological cure in young mice and the weak ability of aged mice to control the infection.

    abstract::After a 3 week course (approximately), during which there is marked lymphoid hyperplasia, Trypanosoma musculi infections in young-adult mice are cured by an immune mechanism involving antibodies of the IgG2a isotype. Both the lymphoid hyperplasia and IgG2a antibody response are T-cell-dependent events and both process...

    journal_title:International immunology

    pub_type: 杂志文章

    doi:10.1093/intimm/6.8.1107

    authors: Utsuyama M,Albright JW,Holmes KL,Hirokawa K,Albright JF

    更新日期:1994-08-01 00:00:00

  • Loss of SDF-1 receptor expression during positive selection in the thymus.

    abstract::SDF-1 is a member of the CXC chemokines. In contrast to other chemokines that are induced by inflammation, SDF-1 is constitutively produced by stromal cells. In order to investigate the physiological roles of SDF-1, we constructed a fusion protein, SDF-1-Cgamma1, composed from murine SDF-1alpha and the constant region...

    journal_title:International immunology

    pub_type: 杂志文章

    doi:10.1093/intimm/10.8.1049

    authors: Suzuki G,Nakata Y,Dan Y,Uzawa A,Nakagawa K,Saito T,Mita K,Shirasawa T

    更新日期:1998-08-01 00:00:00

  • Administration of IL-12 during ongoing immune responses fails to permanently suppress and can even enhance the synthesis of antigen-specific IgE.

    abstract::The synthesis of antibodies of the IgE isotype in mice largely depends on IL-4, a cytokine that is released by T lymphocytes of the Th2 subtype. IL-12 is a cytokine considered to direct Th cell development into a Th1 direction and to suppress Th2 responses including the synthesis of IgE. Here we report about the influ...

    journal_title:International immunology

    pub_type: 杂志文章

    doi:10.1093/intimm/7.10.1649

    authors: Germann T,Guckes S,Bongartz M,Dlugonska H,Schmitt E,Kolbe L,Kölsch E,Podlaski FJ,Gately MK,Rüde E

    更新日期:1995-10-01 00:00:00

  • Different cytoplasmic structure of the CD3 zeta family dimer modulates the activation signal and function of T cells.

    abstract::The TCR complex transduces the antigen recognition signal through common activation motifs present in both CD3 gamma delta epsilon chains and zeta dimers within the complex. We have investigated functional roles of the cytoplasmic domain in zeta and CD3 gamma delta epsilon for T cell activation in early and late respo...

    journal_title:International immunology

    pub_type: 杂志文章

    doi:10.1093/intimm/6.11.1671

    authors: Aoe T,Goto S,Ohno H,Saito T

    更新日期:1994-11-01 00:00:00

  • Immediate responses of leukocytes, cytokines and glucocorticoid hormones in the blood circulation of monkeys following challenge with aerosolized staphylococcal enterotoxin B.

    abstract::The immediate responses to aerosolized staphylococcal enterotoxin B (SEB) in respiratory toxic shock were studied in the circulation of rhesus monkeys with low antibody levels following immunization with SEB toxoid-containing microspheres. Both the surviving and dying monkeys had toxic shock syndrome 4-48 h after SEB ...

    journal_title:International immunology

    pub_type: 杂志文章

    doi:10.1093/intimm/9.12.1825

    authors: Weng CF,Komisar JL,Hunt RE,Johnson AJ,Pitt ML,Ruble DL,Tseng J

    更新日期:1997-12-01 00:00:00

  • Isolation of human minor histocompatibility peptides.

    abstract::Incompatibility of human minor histocompatibility (hmH) antigens induces rejection of grafts in organ transplantation and graft versus host disease in bone marrow transplantation if donor and recipient are matched for human leukocyte antigen (HLA) genes. These antigens are recognized only by T cells. We describe here ...

    journal_title:International immunology

    pub_type: 杂志文章

    doi:10.1093/intimm/4.2.301

    authors: Sekimata M,Griem P,Egawa K,Rammensee HG,Takiguchi M

    更新日期:1992-02-01 00:00:00

  • Negative autoregulation of Src homology region 2-domain-containing phosphatase-1 in rat basophilic leukemia-2H3 cells.

    abstract::Src homology region 2-domain-containing phosphatase-1 (SHP-1) plays an important role in the regulation of signaling from various receptors in hematopoietic cells. In mast cells, SHP-1 has been shown to negatively regulate the initial signaling triggered by high-affinity receptor for IgE (FcepsilonRI) and positively r...

    journal_title:International immunology

    pub_type: 杂志文章

    doi:10.1093/intimm/dxm070

    authors: Ozawa T,Nakata K,Mizuno K,Yakura H

    更新日期:2007-09-01 00:00:00

  • CCR1 expression and signal transduction by murine BMMC results in secretion of TNF-alpha, TGFbeta-1 and IL-6.

    abstract::Chemokine receptors (CCRs) are important co-stimulatory molecules found on many blood cells and associated with various diseases. The expression and function of CCRs on mast cells has been quite controversial. In this study, we report for the first time that murine bone marrow-derived mast cells (BMMC) express messeng...

    journal_title:International immunology

    pub_type: 杂志文章

    doi:10.1093/intimm/dxp066

    authors: Fifadara NH,Aye CC,Raghuwanshi SK,Richardson RM,Ono SJ

    更新日期:2009-08-01 00:00:00

  • MicroRNA 125b inhibition of B cell differentiation in germinal centers.

    abstract::MicroRNAs 125a and 125b are predicted to be able to bind to the B lymphocyte-induced maturation protein-1 (BLIMP-1) and IFN regulatory protein-4 (IRF-4) transcription factors, which are essential for plasma cell differentiation. A computational survey of the human and mouse genomes revealed that miR-125a and miR-125b ...

    journal_title:International immunology

    pub_type: 杂志文章

    doi:10.1093/intimm/dxq042

    authors: Gururajan M,Haga CL,Das S,Leu CM,Hodson D,Josson S,Turner M,Cooper MD

    更新日期:2010-07-01 00:00:00

  • Are Ly1 B cells responsible for the IL2-hyperresponsiveness of B cells in autoimmune-prone NZB x NZW F1 mice?

    abstract::Unlike splenic B cells from normal BALB/c mice, those from autoimmune-prone NZB x NZW (B/W) F1 young mice were hyperresponsive to interleukin 2 (IL2) and proliferated even in the absence of prior stimulation signals. We found that the B cell subpopulation responsible for this event belongs to that with 6B2 (B220)-dull...

    journal_title:International immunology

    pub_type: 杂志文章

    doi:10.1093/intimm/1.1.99

    authors: Hasegawa K,Abe M,Okada T,Hirose S,Sato H,Shirai T

    更新日期:1989-01-01 00:00:00

  • STAT6, NF-kappaB and C/EBP in CD23 expression and IgE production.

    abstract::STAT6, NF-kappaB (p50) and C/EBPbeta transcription factors (TF) were examined with respect to CD23 regulation. Electrophoretic mobility shift assay (EMSA), competition and supershift analysis demonstrated that STAT6 binds the CD23a promoter but with a lower affinity than the consensus site. STAT6-/- mice were analyzed...

    journal_title:International immunology

    pub_type: 杂志文章

    doi:10.1093/intimm/10.10.1529

    authors: Tinnell SB,Jacobs-Helber SM,Sterneck E,Sawyer ST,Conrad DH

    更新日期:1998-10-01 00:00:00

  • A high frequency of hybridomas from M54 mu heavy chain transgenic mice initially co-express transgenic and rearranged endogenous mu genes.

    abstract::The M54 transgenic mouse line, which carries the 17.2.25 Ig mu heavy chain gene, rearranges Ig heavy chains and expresses both transgenic and endogenous mu. B cell lineage development is selectively impaired in these mice and cells that simultaneously express transgenic and endogenous mu ('double-producers') are commo...

    journal_title:International immunology

    pub_type: 杂志文章

    doi:10.1093/intimm/5.9.1011

    authors: Lam KP,Herzenberg LA,Stall AM

    更新日期:1993-09-01 00:00:00

  • CD4-CD8- thymocytes that express the T cell receptor may have previously expressed CD8.

    abstract::Amongst CD4-CD8- (double negative) thymocytes there is a sizeable population (variable from strain to strain) of cells expressing surface T cell receptor (TCR). These TCR+ double negatives are predominantly non-cycling, have very little precursor activity, and, unlike the TCR-CD4-CD8- thymocytes, appear not to be part...

    journal_title:International immunology

    pub_type: 杂志文章

    doi:10.1093/intimm/2.1.51

    authors: Wu L,Pearse M,Egerton M,Petrie H,Scollay R

    更新日期:1990-01-01 00:00:00

  • Preferential expansion of V gamma 9 V delta 2 T cells following stimulation of peripheral blood lymphocytes with extracts of Plasmodium falciparum.

    abstract::A Plasmodium falciparum schizont lysate has been previously described as being a powerful inducer of proliferation for human peripheral T lymphocytes. In this report we study the phenotype of cycling T cells from unexposed donors and examine how the P. falciparum lysate compares with the conventional T cell mitogen ph...

    journal_title:International immunology

    pub_type: 杂志文章

    doi:10.1093/intimm/4.3.361

    authors: Behr C,Dubois P

    更新日期:1992-03-01 00:00:00

  • Production of sterile transcripts of C gamma genes in an IgM-producing human neoplastic B cell line that switches to IgG-producing cells.

    abstract::A human neoplastic B cell line SSK41 that expresses IgM on its surface switches spontaneously to IgG-producing cells. The SSK41 line contains a single immunoglobulin heavy-chain locus, the constant region (C) genes of which retain the germline configuration. The IgG-producing SSK41 line was purified by sorting, and sh...

    journal_title:International immunology

    pub_type: 杂志文章

    doi:10.1093/intimm/1.6.631

    authors: Sideras P,Mizuta TR,Kanamori H,Suzuki N,Okamoto M,Kuze K,Ohno H,Doi S,Fukuhara S,Hassan MS

    更新日期:1989-01-01 00:00:00

  • Potentiation of NK cell-mediated cytotoxicity in human lung adenocarcinoma: role of NKG2D-dependent pathway.

    abstract::Natural cytotoxicity receptors and NKG2D correspond to major activating receptors involved in triggering of tumor cell lysis by human NK cells. In this report, we investigated the expression of NKG2D ligands (NKG2DLs), MHC class I-related chain (MIC) A, MICB and UL16-binding proteins 1, 2 and 3, on a panel of human no...

    journal_title:International immunology

    pub_type: 杂志文章

    doi:10.1093/intimm/dxn038

    authors: Le Maux Chansac B,Missé D,Richon C,Vergnon I,Kubin M,Soria JC,Moretta A,Chouaib S,Mami-Chouaib F

    更新日期:2008-07-01 00:00:00

  • Normal thymic selection, superantigen-induced deletion and Fas-mediated apoptosis of T cells in IL-2 receptor beta chain-deficient mice.

    abstract::Mice lacking the IL-2 receptor beta chain (IL-2R beta) exhibit an autoimmune reaction characterized by generalized T cell activation, production of autoantibodies, myeloproliferation and severe anemia. T cells of IL-2R beta-/- mice were examined to elucidate the mechanism responsible for their abnormal activation and ...

    journal_title:International immunology

    pub_type: 杂志文章

    doi:10.1093/intimm/9.9.1367

    authors: Suzuki H,Hayakawa A,Bouchard D,Nakashima I,Mak TW

    更新日期:1997-09-01 00:00:00