IL-12 transiently induces IFN-gamma transcription and protein synthesis in human CD4+ allergen-specific Th2 T cell clones.

abstract：:Cytotoxic T lymphocytes (CTL) confer protection against intracellular pathogens, yet the mechanism by which some escape activation induced cell death (AICD) and give rise to long-lived memory cells is unclear. We studied the differentiation of transgenic TCR CD8(+) cells into CTL and memory cells using a novel system ...

journal_title：International immunology

authors： Opferman JT,Ober BT,Narayanan R,Ashton-Rickardt PG

更新日期：2001-04-01 00:00:00

abstract：:Peptide-MHC class II complexes (pMHC II) are degraded by MARCH-I-mediated ubiquitination, and the stabilization of pMHC II by loss of its ubiquitination is one phenotype defining the activation of conventional dendritic cells (cDCs). However, the role of such stabilization of pMHC II in the context of T-cell activatio...

journal_title：International immunology

authors： Ishikawa R,Kajikawa M,Ishido S

更新日期：2014-05-01 00:00:00

abstract：:Recent studies have revealed a role for basophils as antigen-presenting cells that preferentially induce T(h)2 cells in response to complexes of antigen plus antigen-specific IgE, to protease allergens or to helminthic parasites in vitro and in vivo through the production of 'early IL-4' and the presentation to CD4(+)...

journal_title：International immunology

authors： Yoshimoto T

更新日期：2010-07-01 00:00:00

abstract：:In vivo administration of NKT cell ligand, alpha-galactosylceramide (alpha-GalCer), caused the activation of NKT cells to induce a strong NK activity and cytokine production by CD1d-restricted mechanisms. Surprisingly, we also found that alpha-GalCer induced the activation of immunoregulatory cells involved in acquire...

journal_title：International immunology

authors： Nishimura T,Kitamura H,Iwakabe K,Yahata T,Ohta A,Sato M,Takeda K,Okumura K,Van Kaer L,Kawano T,Taniguchi M,Nakui M,Sekimoto M,Koda T

更新日期：2000-07-01 00:00:00

abstract：:p40 was previously described as a regulatory molecule capable of inhibiting both the natural and the CD16-mediated cytotoxicity of NK cells. In this study, we analyze the effect of p40 molecule engagement on the NK cell triggering induced by activating HLA class I-specific NK receptors (NKR) or on TCR alpha beta-media...

journal_title：International immunology

authors： Poggi A,Tomasello E,Revello V,Nanni L,Costa P,Moretta L

更新日期：1997-09-01 00:00:00

abstract：:Myasthenia gravis (MG) is an autoimmune disease, caused by autoantibodies against the muscle acetylcholine receptor (AChR), an oligomeric transmembrane glycoprotein composed of alpha(2)beta gamma delta subunits. The alpha subunit carries in its N-terminal extracellular domain the main immunogenic region (MIR), a group...

journal_title：International immunology

authors： Tsouloufis T,Mamalaki A,Remoundos M,Tzartos SJ

更新日期：2000-09-01 00:00:00

abstract：:A Plasmodium falciparum schizont lysate has been previously described as being a powerful inducer of proliferation for human peripheral T lymphocytes. In this report we study the phenotype of cycling T cells from unexposed donors and examine how the P. falciparum lysate compares with the conventional T cell mitogen ph...

journal_title：International immunology

authors： Behr C,Dubois P

更新日期：1992-03-01 00:00:00

abstract：:To investigate the involvement of retinoic acid receptor (RAR)-alpha in allograft rejection, we investigated the effect of a novel selective agonist to the receptor, ER-38925, in a mouse cardiac allograft model. Prophylactic treatment with ER-38925 inhibited the acute rejection of the mouse cardiac allograft (BALB/c -...

journal_title：International immunology

authors： Seino K,Yamauchi T,Shikata K,Kobayashi S,Nagai M,Taniguchi M,Fukao K

更新日期：2004-05-01 00:00:00

abstract：:The class II trans-activator (CIITA) is a bi- or multi-functional domain protein which plays a critical role in the expression of MHC class II genes. We report that removal of the N-terminal 151 amino acids, encompassing all of the acidic domain but leaving intact the proline/serine/threonine-rich domain, results in a...

journal_title：International immunology

authors： Yun S,Gustafsson K,Fabre JW

更新日期：1997-10-01 00:00:00

abstract：:To delineate the role of the IgH 3' enhancer in the regulation of Ig heavy (IgH) chain gene expression, mice harbouring rearranged IgH transgenes, with (PSVmu3) and without (PSVmu1) this element, were produced. RNA and protein analysis from the different transgenic lines revealed a 5- to 7-fold increase in the express...

journal_title：International immunology

authors： Arulampalam V,Furebring C,Samuelsson A,Lendahl U,Borrebaeck C,Lundkvist I,Pettersson S

更新日期：1996-07-01 00:00:00

abstract：:bcl-2 transgenic mice develop anti-double-stranded (ds) DNA antibodies similar to those present in systemic lupus erythematosus. To begin to understand where a breakdown in the regulation of autoreactive lymphocytes is occurring, we have used a bcl-2 transgene (Tg) in conjunction with an Ig Tg that allows us to identi...

journal_title：International immunology

authors： Mandik-Nayak L,Nayak S,Sokol C,Eaton-Bassiri A,Madaio MP,Caton AJ,Erikson J

更新日期：2000-03-01 00:00:00

abstract：:Mice with a targeted deletion of the T-bet gene exhibit spontaneous airway hyperresponsiveness (AHR), airway inflammation, enhanced recovery of T(h)2 cytokines from bronchoalveolar lavage fluid, sub-epithelial collagen deposition and myofibroblast transformation. Here we analyze the mechanisms responsible for the chro...

journal_title：International immunology

authors： Finotto S,Hausding M,Doganci A,Maxeiner JH,Lehr HA,Luft C,Galle PR,Glimcher LH

更新日期：2005-08-01 00:00:00

abstract：:Liver fibrosis is commonly observed in chronic liver disease. However, the immunological mechanisms underlying hepatic fibrosis due to chronic inflammation are not well defined, mainly because suitable experimental models have not been established. We have found that weekly i.v. administration of concanavalin A (Con A...

journal_title：International immunology

authors： Kimura K,Ando K,Ohnishi H,Ishikawa T,Kakumu S,Takemura M,Muto Y,Moriwaki H

更新日期：1999-09-01 00:00:00

abstract：:Organs of transgenic pigs that express human complement regulatory proteins are under assessment as an alternative to transplantation. A major barrier to the transplantation of pig organs is the hyperacute rejection caused by pre-existing antibodies and complement. Pig cells are very susceptible to human complement, p...

journal_title：International immunology

authors： Toyomura K,Fujimura T,Murakami H,Natsume T,Shigehisa T,Inoue N,Takeda J,Kinoshita T

更新日期：1997-06-01 00:00:00

abstract：:To understand the nature of long-term Th immune responses, we investigated in the present study the TCRBV gene repertoire of CD4(+) T cells specific for the recall antigen tetanus toxoid (TT) in recipients of an allogeneic bone marrow transplantation (allo-BMT) at several time points after transplantation and in their...

journal_title：International immunology

authors： Godthelp BC,van Tol MJ,Vossen JM,van den Elsen PJ

更新日期：2001-04-01 00:00:00

abstract：:Whether astrocytes utilize B7:CD28 co-stimulation to activate T cells mediating CNS inflammatory disease is controversial. In this report, primary astrocytes and murine astrocyte lines, generated by immortalization at two different times, day 7 or 45 of culture, were examined for their capability to express B7 co-stim...

journal_title：International immunology

authors： Soos JM,Ashley TA,Morrow J,Patarroyo JC,Szente BE,Zamvil SS

更新日期：1999-07-01 00:00:00

abstract：:The class II transactivator (CIITA) controls both the constitutive and IFN-gamma inducible expression of HLA-D genes. In addition, through the squelching of another transactivator CREB-binding protein, CIITA was more recently shown to have a wider cellular function, including cell cycle control or cellular response to...

journal_title：International immunology

authors： Barbieri G,Deffrennes V,Prod'homme T,Vedrenne J,Baton F,Cortes C,Fischer A,Bono MR,Lisowska-Grospierre B,Charron D,Alcaïde-Loridan C

更新日期：2002-08-01 00:00:00

abstract：:The TCR complex transduces the antigen recognition signal through common activation motifs present in both CD3 gamma delta epsilon chains and zeta dimers within the complex. We have investigated functional roles of the cytoplasmic domain in zeta and CD3 gamma delta epsilon for T cell activation in early and late respo...

journal_title：International immunology

authors： Aoe T,Goto S,Ohno H,Saito T

更新日期：1994-11-01 00:00:00

abstract：:Three MHC class II-derived synthetic peptides (I-A beta (g7)1-16, I-A beta (g7)52-77 and I-A alpha (g7)63-82YC) were analyzed for their ability to bind to syngeneic and allogeneic MHC class II molecules using a whole cell, competitive peptide binding assay. These studies demonstrated that the A beta (g7)1-16 peptide w...

journal_title：International immunology

authors： Feili-Hariri M,Kao H,Mietzner TA,Morel PA

更新日期：1996-12-01 00:00:00

abstract：:Virus-like particles are a highly effective type of subunit vaccine that mimics the overall structure of virus particles without containing infectious genetic material. In this work, a particulate form of the recombinant capsid protein from dengue-2 was evaluated in mice to determine the level of protection against vi...

journal_title：International immunology

authors： Gil L,López C,Lazo L,Valdés I,Marcos E,Alonso R,Gambe A,Martín J,Romero Y,Guzmán MG,Guillén G,Hermida L

更新日期：2009-10-01 00:00:00

abstract：:The immunomodulator FTY720 inhibits lymph node (LN) and thymic egress, thereby constraining T cell circulation and reducing peripheral T cell numbers. Here, we analyzed in mouse models the as yet scarcely characterized impact of long-term (up to 6 months) FTY720 exposure on T cell homeostasis and possible consequences...

journal_title：International immunology

authors： Metzler B,Gfeller P,Wieczorek G,Li J,Nuesslein-Hildesheim B,Katopodis A,Mueller M,Brinkmann V

更新日期：2008-05-01 00:00:00

abstract：:The Ig heavy chain (IgH) locus is controlled by multiple regulatory sequences mapping both within the IgH transcription unit (E mu) and downstream (3') of IgH coding sequences (hs3a, hs1,2, hs3b and hs4). Enhancer knockout studies in mice have implicated E mu in the control of IgH variable region gene assembly, but si...

journal_title：International immunology

authors： Shi X,Eckhardt LA

更新日期：2001-08-01 00:00:00

abstract：:Macrophages are heterogeneous and plastic, and play several diverse functions in immune responses. Emerging data provide evidence of multiple roles for metabolic pathways in the control of macrophage effector functions. The diverse functions of macrophages are categorized into two main subsets: classical activated mac...

journal_title：International immunology

authors： Kang S,Kumanogoh A

更新日期：2020-06-26 00:00:00

abstract：:AbstractImmune homeostasis is critically regulated by the balance between activating and inhibitory receptors expressed on various immune cells such as T and B lymphocytes, and myeloid cells. The inhibitory receptors play a fundamental role in the immune checkpoint pathway, thus maintaining peripheral tolerance. We re...

journal_title：International immunology

authors： Wong YL,Su MT,Sugahara-Tobinai A,Itoi S,Kezuka D,Endo S,Inui M,Takai T

更新日期：2019-05-21 00:00:00

abstract：:In view of our recent report that T cell receptor (TCR) alpha chain restriction fragment length polymorphism (RFLP) is associated with multiple sclerosis (MS), we have assessed the possibility that HLA-DR2, HLA-DPw4, and TCR alpha chain RFLPs may interact to increase the risk of developing MS. Detection of TCR alpha c...

journal_title：International immunology

authors： Sherritt MA,Oksenberg J,de Rosbo NK,Bernard CC

更新日期：1992-02-01 00:00:00

abstract：:STAT6, NF-kappaB (p50) and C/EBPbeta transcription factors (TF) were examined with respect to CD23 regulation. Electrophoretic mobility shift assay (EMSA), competition and supershift analysis demonstrated that STAT6 binds the CD23a promoter but with a lower affinity than the consensus site. STAT6-/- mice were analyzed...

journal_title：International immunology

authors： Tinnell SB,Jacobs-Helber SM,Sterneck E,Sawyer ST,Conrad DH

更新日期：1998-10-01 00:00:00

abstract：:The course and severity of lupus in spontaneous murine lupus models varies among laboratories, which may be due to variations in diet, housing and/or local environmental conditions. In this study, we investigated the influence of common rodent diets while keeping other factors constant. Female lupus-prone MRL/lpr (MRL...

journal_title：International immunology

authors： Edwards MR,Dai R,Heid B,Cecere TE,Khan D,Mu Q,Cowan C,Luo XM,Ahmed SA

更新日期：2017-06-01 00:00:00

abstract：:The extracellular signal-regulated kinase (ERK) signaling pathway is strongly activated in response to TCR stimulation in normal T cells. However, the extent to which activation of the ERK pathway is necessary for TCR-stimulated cytokine production is not clear. We have addressed this question by use of two separate m...

journal_title：International immunology

authors： Egerton M,Fitzpatrick DR,Kelso A

更新日期：1998-02-01 00:00:00

abstract：:The mechanism underlying selective IgG subclass deficiency is largely unknown in humans. We have previously reported the acquisition of a complete IgG2 deficiency in a leukemia patient after bone marrow transplantation. Southern blot analysis showed a deletion including the Cgamma2 and Cgamma4 genes on one chromosome ...

journal_title：International immunology

authors： Zhao Y,Pan-Hammarström Q,Zhao Z,Wen S,Hammarström L

更新日期：2005-01-01 00:00:00

abstract：:Novel biomarkers of rheumatoid arthritis (RA), in addition to antibodies against cyclic citrullinated peptides, are required. Metabolome analysis is a promising approach to identify metabolite biomarkers for clinical diagnosis. We adopted a comprehensive nontargeted metabolomics approach combining capillary electropho...

journal_title：International immunology

authors： Kishikawa T,Maeda Y,Nii T,Arase N,Hirata J,Suzuki K,Yamamoto K,Masuda T,Ogawa K,Tsuji S,Matsushita M,Matsuoka H,Yoshimura M,Tsunoda S,Ohshima S,Narazaki M,Ogata A,Saeki Y,Inohara H,Kumanogoh A,Takeda K,Okada Y

更新日期：2020-08-31 00:00:00