Suppression of MHC class II expression by human class II trans-activator constructs lacking the N-terminal domain.

abstract：:Based on the similarity in primary structure between the newly characterized ligand for CD40 (CD40L) and the tumor necrosis factors (TNFs), we have modeled a detailed 3-D structure for CD40L. We used the known structure of TNF alpha as a template for the generation of the CD40L model. The soundness of the model-buildi...

journal_title：International immunology

authors： Peitsch MC,Jongeneel CV

更新日期：1993-02-01 00:00:00

abstract：:Lymphocyte homing to lymph nodes is regulated by transient but specific interactions between lymphocytes and high endothelial venules (HEVs), the initial phase of which is mainly governed by the leukocyte adhesion molecule L-selectin, which recognizes sulfated and sialylated O-linked oligosaccharides displayed on sial...

journal_title：International immunology

authors： Kanda H,Tanaka T,Matsumoto M,Umemoto E,Ebisuno Y,Kinoshita M,Noda M,Kannagi R,Hirata T,Murai T,Fukuda M,Miyasaka M

更新日期：2004-09-01 00:00:00

abstract：:Intestinal intraepithelial lymphocytes (i-IEL) of aged rats comprise CD4+CD8alphaalpha+ and CD4-CD8alphaalpha+ T cells expressing TCR alphabeta. In the present study, we compared characteristics between CD4+CD8alphaalpha+ and CD4-CD8alphaalpha+ i-IEL, which were purified by a cell sorter from the i-IEL of 6-month-old ...

journal_title：International immunology

authors： Yamada K,Kimura Y,Nishimura H,Namii Y,Murase M,Yoshikai Y

更新日期：1999-01-01 00:00:00

abstract：:Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are among the major causes of death worldwide due to acute inflammation in the lung. AT-rich interactive domain-containing 5a (Arid5a) is an RNA-binding protein involved in inflammatory autoimmune disease through post-transcriptional control of Il6...

journal_title：International immunology

authors： Dubey PK,Masuda K,Nyati KK,-Uz Zaman MM,Chalise JP,Millrine D,Kai W,Ripley B,Kishimoto T

更新日期：2017-02-01 00:00:00

abstract：:The Lewis rat, an inbred rat strain susceptible to several well-characterized experimental autoimmune diseases, provides a good model to study peptide-mediated immunotherapy. Peptide immunotherapy focussing on the modulation of T cell responses by interfering with TCR-peptide-MHC complex formation requires the elucida...

journal_title：International immunology

authors： Wauben MH,van der Kraan M,Grosfeld-Stulemeyer MC,Joosten I

更新日期：1997-02-01 00:00:00

abstract：:The profile of cytokines produced by CD4 T cells is profoundly influenced by the presence of IL-12. Here we demonstrate that during re-stimulation of antigen-specific immune responses in vitro, antigen-primed lymph node cells from DBA/2 mice produced 3- to 30-fold more IL-12 than did cells from BALB/c mice, which are ...

journal_title：International immunology

authors： Gieni RS,Fang Y,Trinchieri G,Umetsu DT,DeKruyff RH

更新日期：1996-10-01 00:00:00

abstract：:Immune tolerance in the lung is important for preventing hypersensitivity, such as allergic asthma. Maintenance of tolerance in the lung is established by coordinated activities of poorly understood cellular and molecular mechanisms, including participation of dendritic cells (DCs). We have previously identified DC ex...

journal_title：International immunology

authors： Han D,Walsh MC,Kim KS,Hong SW,Lee J,Yi J,Rivas G,Choi Y,Surh CD

更新日期：2017-02-01 00:00:00

abstract：:Synovial tissues are frequent sites of inflammatory disorders in which dendritic cells (DCs) may play an important role. This study examines potential antigen-presenting cells obtained from synovium-rich tissues (SRTs) by vascular perfusion of rat hind limbs with collagenase and further enzymatic digestion of the disa...

journal_title：International immunology

authors： Moghaddami M,Cleland LG,Mayrhofer G

更新日期：2005-08-01 00:00:00

abstract：:The TCR is responsible for the specificity of cytotoxic T lymphocytes (CTL) by recognizing peptides presented in the context of MHC. By producing recombinant soluble TCR, it is possible to study this interaction at the molecular level. We generated single-chain TCR (scTCR) from tumor infiltrating lymphocytes (TIL) and...

journal_title：International immunology

authors： Lake DF,Salgaller ML,van der Bruggen P,Bernstein RM,Marchalonis JJ

更新日期：1999-05-01 00:00:00

abstract：:T-cell immune responses are critical for protection of the host and for disease pathogenesis during infection with Plasmodium species. We examined the regulation of CD4(+) T-cell cytokine responses during infection with Plasmodium berghei ANKA (PbA). CD4(+) T cells from PbA-infected mice produced IFN-γ, IL-4 and IL-10...

journal_title：International immunology

authors： Kimura D,Miyakoda M,Honma K,Shibata Y,Yuda M,Chinzei Y,Yui K

更新日期：2010-12-01 00:00:00

abstract：:Naive and primed alpha beta T cells can be distinguished on the basis of their differential expression of CD45RA and CD45RO, respectively. The present study indicates that these CD45-isoforms also identify naive and primed maturational stages of gamma delta T cells and natural killer (NK) cells. In peripheral blood, a...

journal_title：International immunology

authors： Braakman E,Sturm E,Vijverberg K,van Krimpen BA,Gratama JW,Bolhuis RL

更新日期：1991-07-01 00:00:00

abstract：:Analyses of bone marrow (BM) lymphocytes in C57BL/6 mice homozygous for the lpr mutation (B6.lpr) disclosed low numbers of pre-B and B cells, as compared with age-matched control B6 mice. BM depletion in B6.lpr mice was selective for B-lineage cells, appeared in young adults, and developed markedly with age and diseas...

journal_title：International immunology

authors： Sundblad A,Coutinho A

更新日期：1996-02-01 00:00:00

abstract：:Cells bearing the gamma delta form of the TCR make up only 1-3% of T cells in the adult murine thymus and peripheral lymphoid organs. Evidence from studies of nude mice suggests that the development of at least some gamma delta T cells is thymus dependent; however, until now it has not been directly demonstrated that ...

journal_title：International immunology

authors： Kelly KA,Pearse M,Lefrancois L,Scollay R

更新日期：1993-04-01 00:00:00

abstract：:P-selectin is a Ca(2+)-dependent lectin that participates in leukocyte adhesion to vascular endothelium and platelets. Myeloid cells and a subset of T lymphocytes express carbohydrate ligands at the cell surface. Previously, we suggested that heat stable antigen (HSA/mouse CD24), an extensively glycosylated cell surfa...

journal_title：International immunology

authors： Aigner S,Ruppert M,Hubbe M,Sammar M,Sthoeger Z,Butcher EC,Vestweber D,Altevogt P

更新日期：1995-10-01 00:00:00

abstract：:Dendritic cells (DCs) are specialized antigen-presenting cells that play pivotal roles in initiating immune responses. However, DC maturation is usually strongly restricted by the stromal microenvironment, especially in non-lymphoid tissues, such as skin and mucosa. Although suppression of DC maturation by stromal cel...

journal_title：International immunology

authors： Shiraishi H,Yoshida H,Saeki K,Miura Y,Watanabe S,Ishizaki T,Hashimoto M,Takaesu G,Kobayashi T,Yoshimura A

更新日期：2008-09-01 00:00:00

abstract：:The TCR complex transduces the antigen recognition signal through common activation motifs present in both CD3 gamma delta epsilon chains and zeta dimers within the complex. We have investigated functional roles of the cytoplasmic domain in zeta and CD3 gamma delta epsilon for T cell activation in early and late respo...

journal_title：International immunology

authors： Aoe T,Goto S,Ohno H,Saito T

更新日期：1994-11-01 00:00:00

abstract：:The mature dendritic cell (DC) is considered to be the most potent antigen-presenting cell. Regulation of the DC, particularly its survival, is therefore critical. Mature DC are markedly more sensitive to HLA-DR-mediated apoptosis than immature DC. To further characterize this key survival difference, we compared the ...

journal_title：International immunology

authors： Bertho N,Blancheteau VM,Setterblad N,Laupeze B,Lord JM,Drénou B,Amiot L,Charron DJ,Fauchet R,Mooney N

更新日期：2002-08-01 00:00:00

abstract：:Protein antigens elicit humoral responses in mice that consist predominantly of IgG1 antibodies. We have now investigated the ability of IL-12, a cytokine reported to augment IgG2a anti-hapten responses through activation of Th1 cells, to alter antibody responses to hen eggwhite lysozyme (HEL). The normal response of ...

journal_title：International immunology

authors： Buchanan JM,Vogel LA,Van Cleave VH,Metzger DW

更新日期：1995-09-01 00:00:00

abstract：:Structural and functional aspects of the accessory molecule lymphocyte function associated antigen (LFA)-3 (CD58) have been examined following the transfection of DAP.3 and P815 cells with a cDNA clone encoding the glycosyl phosphatidylinositol (GPI)-linked form of human LFA-3. Despite earlier observations that DAP.3 ...

journal_title：International immunology

authors： Greenlaw R,Robinson P,Heaton T,Lombardi G,Lechler R

更新日期：1992-06-01 00:00:00

abstract：:NK cells were first identified in 1975 and represent the prototypical group 1 innate lymphoid cell (ILC). More recently, the discovery of new members of the ILC family has highlighted the complexity of this innate lymphoid lineage. Importantly, it has been recognized that different subsets exist within the group 1 ILC...

journal_title：International immunology

authors： Seillet C,Belz GT

更新日期：2016-01-01 00:00:00

abstract：:We have previously reported that tumor necrosis factor receptor-associated factor 1 (TRAF1), an intracellular protein, which binds to a range of molecules, including tumor necrosis factor (TNF) receptor family members, regulates TNF-induced NF-kappaB and AP-1 signaling as well as TCR-triggered proliferative responses ...

journal_title：International immunology

authors： Bryce PJ,Oyoshi MK,Kawamoto S,Oettgen HC,Tsitsikov EN

更新日期：2006-01-01 00:00:00

abstract：:Several cis-acting elements regulate the expression of germline transcripts of heavy chain constant region genes and their subsequent switch recombination. To study such elements in the murine gamma1 gene, we have utilized a transgenic approach. In this study we focused on a DNase I hypersensitive site (termed 'Site I...

journal_title：International immunology

authors： Adams K,Ackerly H,Cunningham K,Dunnick W

更新日期：2000-12-01 00:00:00

abstract：:CD4 T cells are not thought to play a significant role in generating an effective primary CD8 T cell response to most viral infections. We have challenged this view by demonstrating that antigen-specific CD4 T cells can indeed suppress the proliferation of antigen-specific naive CD8 T cells in response to low doses of...

journal_title：International immunology

authors： Cose S,Brammer C,Zammit DJ,Blair DA,Lefrançois L

更新日期：2006-08-01 00:00:00

abstract：:CD4 and CD8 T cell subsets involved in primary allo-MLR responses were re-evaluated in the present study. The slope analysis of B6 allo-MLR responses to MHC class I-disparate bm1 and class II-disparate bm12 revealed the presence of a T-T cell interaction between CD4 and CD8 T cell subsets. The allo-MLR response of B6 ...

journal_title：International immunology

authors： Asano Y,Komuro T,Tada T

更新日期：1990-01-01 00:00:00

abstract：:Earlier studies have suggested that in adults the n-positive allele of the human IgG2 gene is more productive than the n-negative allele. This superiority was seen to be manifested in IgG2 antibody responses to polysaccharides, in the higher serum concentration of total IgG2 in the n/n than in -/- individuals, and in ...

journal_title：International immunology

authors： Sarvas H,Rautonen N,Käyhty H,Kallio M,Mäkelä O

更新日期：1990-01-01 00:00:00

abstract：:Type II collagen (CII) is of immunological interest because of its repetitive structure and properties as an autoantigen. The mouse gene has recently been cloned, thus enabling T cell-defined epitopes to be identified. Multiple novel epitopes on mouse CII are here detected in the autoreactive T cell response. The majo...

journal_title：International immunology

authors： Bayrak S,Holmdahl R,Travers P,Lauster R,Hesse M,Dölling R,Mitchison NA

更新日期：1997-11-01 00:00:00

abstract：:We have recently described the novel A6H antigen expressed on human peripheral blood T cells and on renal cell carcinoma cells. Cross-linking of the A6H antigen results in co-stimulation of human CD4(+) T cells, characterized by induction of the transcription factor activator protein-1 (AP-1), proliferation and promin...

journal_title：International immunology

authors： Labuda T,Sundstedt A,Dohlsten M

更新日期：2000-03-01 00:00:00

abstract：:We have previously shown that the occurrence of CD45RA+ adult mouse thymocytes is strain-dependent, e.g. constituting approximately 0.6% in C57BL/Icrf and approximately 2.5% in BALB/c (Huby, R. and Goff, L., 1992. Eur. J. Immunol. 22:1659). Here we show that irrespective of strain, the thymus contains approximately 0....

journal_title：International immunology

authors： Goff LK,Huby RD

更新日期：1992-11-01 00:00:00

abstract：:Pathogenic intracellular bacteria often hijack macrophages for their propagation. The infected macrophages release IL-1β and IL-18 and simultaneously commit suicide, which is called pyroptosis; both responses require caspase-1. Here, we found that pyroptotic cells induced by microbial infection were efficiently engulf...

journal_title：International immunology

authors： Wang Q,Imamura R,Motani K,Kushiyama H,Nagata S,Suda T

更新日期：2013-06-01 00:00:00

abstract：:To investigate the role of the Toll-like receptor (TLR) family in host defense against Toxoplasma gondii, we infected TLR2-, TLR4- and MyD88-deficient mice with the avirulent cyst-forming Fukaya strain of T. gondii. All TLR2- and MyD88-deficient mice died within 8 days, whereas all TLR4-deficient and wild-type mice su...

journal_title：International immunology

authors： Mun HS,Aosai F,Norose K,Chen M,Piao LX,Takeuchi O,Akira S,Ishikura H,Yano A

更新日期：2003-09-01 00:00:00