Abstract:
:Immune tolerance in the lung is important for preventing hypersensitivity, such as allergic asthma. Maintenance of tolerance in the lung is established by coordinated activities of poorly understood cellular and molecular mechanisms, including participation of dendritic cells (DCs). We have previously identified DC expression of the signaling molecule TRAF6 as a non-redundant requirement for the maintenance of immune tolerance in the small intestine of mice. Because mucosal tissues share similarities in how they interact with exogenous antigens, we examined the role of DC-expressed TRAF6 in the lung. As with the intestine, we found that the absence TRAF6 expression by DCs led to spontaneous generation of Th2-associated immune responses and increased susceptibility to model antigen-induced asthma. To examine the role of commensal microbiota, mice deficient in TRAF6 in DCs were treated with broad-spectrum antibiotics and/or re-derived on a germ-free (GF) background. Interestingly, we found that antibiotics-treated specific pathogen-free, but not GF, mice showed restored immune tolerance in the absence of DC-expressed TRAF6. We further found that antibiotics mediate microbiota-independent effects on lung T cells to promote immune tolerance in the lung. This work provides both a novel tool for studying immune tolerance in the lung and an advance in our conceptual understanding of potentially common molecular mechanisms of immune tolerance in both the intestine and the lung.
journal_name
Int Immunoljournal_title
International immunologyauthors
Han D,Walsh MC,Kim KS,Hong SW,Lee J,Yi J,Rivas G,Choi Y,Surh CDdoi
10.1093/intimm/dxx011subject
Has Abstractpub_date
2017-02-01 00:00:00pages
71-78issue
2eissn
0953-8178issn
1460-2377pii
3066061journal_volume
29pub_type
杂志文章abstract::The intestinal epithelium not only acts as the physical structure that separates the intestinal lumen from the body but also actively participates in intestinal barrier functions. In the past decade, significant progress has been made in the development of culture technologies to maintain intestinal epithelial cells (...
journal_title:International immunology
pub_type: 杂志文章,评审
doi:10.1093/intimm/dxy065
更新日期:2019-02-06 00:00:00
abstract::Three MHC class II-derived synthetic peptides (I-A beta (g7)1-16, I-A beta (g7)52-77 and I-A alpha (g7)63-82YC) were analyzed for their ability to bind to syngeneic and allogeneic MHC class II molecules using a whole cell, competitive peptide binding assay. These studies demonstrated that the A beta (g7)1-16 peptide w...
journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/8.12.1857
更新日期:1996-12-01 00:00:00
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journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/1.5.503
更新日期:1989-01-01 00:00:00
abstract::A small proportion of the sIg+ B lymphocytes in peripheral lymphoid organs [22% in spleen and 6% in lymph node (LN)] in rat carries the Thy-1 antigen. These Thy-1+ B cells represent newly formed bone marrow (BM) derived (or immature) B cells. In this study we investigated the kinetic behavior of Thy-1+ and Thy-1- B ce...
journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/5.7.735
更新日期:1993-07-01 00:00:00
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journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/2.9.803
更新日期:1990-01-01 00:00:00
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journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/1.6.631
更新日期:1989-01-01 00:00:00
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journal_title:International immunology
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更新日期:2003-08-01 00:00:00
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journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/3.4.305
更新日期:1991-04-01 00:00:00
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journal_title:International immunology
pub_type: 杂志文章,评审
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更新日期:2017-07-01 00:00:00
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journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/11.6.871
更新日期:1999-06-01 00:00:00
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journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/12.9.1255
更新日期:2000-09-01 00:00:00
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journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/dxh139
更新日期:2004-10-01 00:00:00
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journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/dxaa070
更新日期:2020-10-10 00:00:00
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journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/6.10.1585
更新日期:1994-10-01 00:00:00
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pub_type: 杂志文章
doi:10.1093/intimm/7.4.541
更新日期:1995-04-01 00:00:00
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pub_type: 杂志文章
doi:10.1093/intimm/dxl046
更新日期:2006-07-01 00:00:00
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journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/11.8.1327
更新日期:1999-08-01 00:00:00
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journal_title:International immunology
pub_type: 杂志文章
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更新日期:2000-03-01 00:00:00
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journal_title:International immunology
pub_type: 杂志文章
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更新日期:1997-10-01 00:00:00
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更新日期:2002-01-01 00:00:00
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更新日期:2000-02-01 00:00:00
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更新日期:1998-05-01 00:00:00
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pub_type: 杂志文章
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更新日期:1993-04-01 00:00:00
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更新日期:1993-12-01 00:00:00
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journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/5.2.231
更新日期:1993-02-01 00:00:00
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pub_type: 杂志文章
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更新日期:1996-12-01 00:00:00