IL-2 production by myofibroblasts from post-radiation fibrosis in breast cancer patients.

abstract：:Toll-like receptors (TLRs) traffic to distinct membranes for signaling. TLR7 and TLR9 recognize viral nucleic acids in the endosomes and induce robust anti-viral program. Signaling from these TLRs bifurcate at the level of distinct endosomal compartments, namely VAMP3(+) and LAMP(+) endosomes, to mediate the induction...

journal_title：International immunology

authors： Hayashi K,Sasai M,Iwasaki A

更新日期：2015-09-01 00:00:00

abstract：:CD161(++)IL-18Rα(+)CD8(+) human T cells have recently been identified as a new subset of memory cells but their exact role remains unclear. CD161(++)IL-18Rα(+)CD8(+), mucosal-associated invariant T cells express a semi-invariant TCR Vα7.2-Jα33, which recognizes the MHC-related protein 1. On the basis of properties inc...

journal_title：International immunology

authors： Havenith SH,Yong SL,Henson SM,Piet B,Idu MM,Koch SD,Jonkers RE,Kragten NA,Akbar AN,van Lier RA,ten Berge IJ

更新日期：2012-10-01 00:00:00

abstract：:Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are among the major causes of death worldwide due to acute inflammation in the lung. AT-rich interactive domain-containing 5a (Arid5a) is an RNA-binding protein involved in inflammatory autoimmune disease through post-transcriptional control of Il6...

journal_title：International immunology

authors： Dubey PK,Masuda K,Nyati KK,-Uz Zaman MM,Chalise JP,Millrine D,Kai W,Ripley B,Kishimoto T

更新日期：2017-02-01 00:00:00

abstract：:A small proportion of the sIg+ B lymphocytes in peripheral lymphoid organs [22% in spleen and 6% in lymph node (LN)] in rat carries the Thy-1 antigen. These Thy-1+ B cells represent newly formed bone marrow (BM) derived (or immature) B cells. In this study we investigated the kinetic behavior of Thy-1+ and Thy-1- B ce...

journal_title：International immunology

authors： Deenen GJ,Kroese FG

更新日期：1993-07-01 00:00:00

abstract：:Under equilibrium conditions, the affinities of five anti-IgG2a mAb isolated from virus-infected mice were comparable to other high-affinity auto-antibodies. Similar to rheumatoid factors, these anti-IgG2a auto-antibodies bound to aggregated or complexed IgG2a with 50 to 1500-fold higher avidity than their monomeric c...

journal_title：International immunology

authors： Fazekas G,Pálfi G,Wolff-Winiski B,Rosenwirth B,Dukor P,Gergely J,Rajnavölgyi E

更新日期：1995-07-01 00:00:00

abstract：:Myelin proteolipid protein (PLP) 139-151 is an immunodominant peptide that induces experimental autoimmune encephalomyelitis (EAE) in H-2(s) SJL/J mice. While PLP 139-151-specific TCR transgenic (tg) 4E3 mice develop fulminant spontaneous disease on the susceptible SJL/J background, spontaneous EAE is dramatically red...

journal_title：International immunology

authors： Illés Z,Waldner H,Reddy J,Anderson AC,Sobel RA,Kuchroo VK

更新日期：2007-10-01 00:00:00

abstract：:The efficacy of cytotoxic T lymphocytes (CTL) has been shown to be highly dependent upon their functional avidity (the sensitivity of their cellular response to MHC-peptide complexes). To examine this relationship, we employed target cell lysis as a quantitative measure and established a set of four CTL clones that ex...

journal_title：International immunology

authors： Derby MA,Wang J,Margulies DH,Berzofsky JA

更新日期：2001-06-01 00:00:00

abstract：:Human dendritic cells (DC) generated from CD34+ hematopoietic progenitors cultured in the presence of granulocyte macrophage colony stimulating factor (GM-CSF) and tumor necrosis factor (TNF)-alpha are related to Langerhans cells (DLC) and have been shown to induce a strong proliferation of allogeneic CD4+ T cells. Th...

journal_title：International immunology

authors： Caux C,Massacrier C,Vanbervliet B,Barthelemy C,Liu YJ,Banchereau J

更新日期：1994-08-01 00:00:00

abstract：:Germline CH transcripts initiate from a non-coding I exon and terminate downstream of the associated CH exons. Ig heavy chain class switch recombination from the VDJ-C mu gene to particular downstream CH genes appears to be regulated by a process that involves mitogen and/or cytokine induction of germline CH transcrip...

journal_title：International immunology

authors： Li SC,Rothman PB,Zhang J,Chan C,Hirsh D,Alt FW

更新日期：1994-04-01 00:00:00

abstract：:In view of our recent report that T cell receptor (TCR) alpha chain restriction fragment length polymorphism (RFLP) is associated with multiple sclerosis (MS), we have assessed the possibility that HLA-DR2, HLA-DPw4, and TCR alpha chain RFLPs may interact to increase the risk of developing MS. Detection of TCR alpha c...

journal_title：International immunology

authors： Sherritt MA,Oksenberg J,de Rosbo NK,Bernard CC

更新日期：1992-02-01 00:00:00

abstract：:T cells of an unique phenotype (CD3+CD4-CD8- alpha beta TCR+) develop in vitro from the hematopoietic progenitors, the majority of which carry homologous alpha beta TCR (V alpha 4J alpha 28/V beta 2D beta 1.1J beta 2.6). In the present study, antigen corresponding to the particular alpha beta TCR was investigated, tak...

journal_title：International immunology

authors： Kubota H,Sato M,Ogawa Y,Iwai K,Hattori M,Yoshida T,Minato N

更新日期：1994-09-01 00:00:00

abstract：:Chemokine receptors (CCRs) are important co-stimulatory molecules found on many blood cells and associated with various diseases. The expression and function of CCRs on mast cells has been quite controversial. In this study, we report for the first time that murine bone marrow-derived mast cells (BMMC) express messeng...

journal_title：International immunology

authors： Fifadara NH,Aye CC,Raghuwanshi SK,Richardson RM,Ono SJ

更新日期：2009-08-01 00:00:00

abstract：:SKG mice, a newly established model of rheumatoid arthritis (RA), spontaneously develop autoimmune arthritis accompanying extra-articular manifestations, such as interstitial pneumonitis. To examine possible roles of T cells for mediating this systemic autoimmunity, we generated T cell clones from arthritic joints of ...

journal_title：International immunology

authors： Wakasa-Morimoto C,Toyosaki-Maeda T,Matsutani T,Yoshida R,Nakamura-Kikuoka S,Maeda-Tanimura M,Yoshitomi H,Hirota K,Hashimoto M,Masaki H,Fujii Y,Sakata T,Tsuruta Y,Suzuki R,Sakaguchi N,Sakaguchi S

更新日期：2008-10-01 00:00:00

abstract：:It has been demonstrated that in vivo T cell priming requires CD154-CD40 interaction, which is suggested to be critical in the induction of co-stimulatory activities on antigen-presenting cells (APC). In the current study, we demonstrate that in vivo administration of a high dose of a superantigen, staphylococcal ente...

journal_title：International immunology

authors： Eshima K,Choi Y,Flavell RA

更新日期：2003-07-01 00:00:00

abstract：:The invertebrate pattern-recognition protein named coelomic cytolytic factor (CCF) and the mammalian cytokine tumor necrosis factor (TNF) share functional analogies that are based on a similar saccharide recognition specificity. In particular, CCF and TNF have been shown to interact with ion channels on the surface of...

journal_title：International immunology

authors： Bilej M,Josková R,Van den Bergh R,Procházková P,Silerová M,Ameloot P,De Baetselier P,Beschin A

更新日期：2006-12-01 00:00:00

abstract：:To investigate the involvement of retinoic acid receptor (RAR)-alpha in allograft rejection, we investigated the effect of a novel selective agonist to the receptor, ER-38925, in a mouse cardiac allograft model. Prophylactic treatment with ER-38925 inhibited the acute rejection of the mouse cardiac allograft (BALB/c -...

journal_title：International immunology

authors： Seino K,Yamauchi T,Shikata K,Kobayashi S,Nagai M,Taniguchi M,Fukao K

更新日期：2004-05-01 00:00:00

abstract：:T lymphocyte responses to the MHC of an evolutionarily distant species are known to be weak compared with responses against allogeneic MHC products within a species. This fact was used to examine the regions of human MHC class II molecules required for the stimulation of strong primary immune responses against MHC all...

journal_title：International immunology

authors： Ramesh P,Barber L,Batchelor JR,Lechler RI

更新日期：1992-08-01 00:00:00

abstract：:The endocytic and phagocytic activities of a population of MHC IIhi CD11c+ dendritic cell (DC)-like cells in synovium-rich tissues (SRTs) of normal rat paws were compared with CD163+ cells (putative macrophages) from the same tissues and pseudo-afferent lymph DCs, peritoneal macrophages and blood monocytes. Fifty perc...

journal_title：International immunology

authors： Moghaddami M,Mayrhofer G,Cleland LG

更新日期：2005-08-01 00:00:00

abstract：:We have determined the origin and cell surface phenotype of B cells producing antibody in response to immunization with the non-self TI-2 antigen polyvinyl pyrrolidinone (PVP). We report that the responding cells are derived from precursors in adult bone marrow and display the phenotype characteristic of B-1 cells. By...

journal_title：International immunology

authors： Whitmore AC,Haughton G,Arnold LW

更新日期：1996-04-01 00:00:00

abstract：:Nitric oxide (NO) is formed constitutively in neurons by the constitutive enzyme NO synthase (cNOS) and acts as a neurotransmitter. It has already been shown that cNOS-containing neurons are identical to neurons staining for NADPH diaphorase and vice versa. Effector cells of the immune response produce high NO levels ...

journal_title：International immunology

authors： Flesch IE,Hess JH,Kaufmann SH

更新日期：1994-11-01 00:00:00

abstract：:Neural stem cells (NSCs) transplantation has been proposed as a means of restoring damaged brain tissue, a possibility rendered more likely by reports of low NSCs immunogenicity in various experimental models because of low expression of MHC class I and II as well as co-stimulatory molecules. We investigated the immun...

journal_title：International immunology

authors： Ubiali F,Nava S,Nessi V,Frigerio S,Parati E,Bernasconi P,Mantegazza R,Baggi F

更新日期：2007-09-01 00:00:00

abstract：:Linomide (LS-2616, quinoline-3-carboxamide) has strong immunomodulating effects in animal models, inhibiting toxic shock, progressive autoimmune disease and cancer. In humans, linomide strongly reduced the appearance of new lesions in multiple sclerosis yet enhanced immune responses after bone marrow transplantation. ...

journal_title：International immunology

authors： Arad G,Katzenellenbogen M,Levy R,Slavin S,Kaempfer R

更新日期：1996-10-01 00:00:00

abstract：:It is now generally recognized that bone marrow is the survival niche for antigen-specific plasma cells with long-term immunological memory. These cells release antibodies into the circulation, needed to prime effector cells in the secondary immune response. These antibodies participate in the surveillance for antigen...

journal_title：International immunology

authors： Gould HJ,Wu YB

更新日期：2018-08-30 00:00:00

abstract：:To understand the nature of long-term Th immune responses, we investigated in the present study the TCRBV gene repertoire of CD4(+) T cells specific for the recall antigen tetanus toxoid (TT) in recipients of an allogeneic bone marrow transplantation (allo-BMT) at several time points after transplantation and in their...

journal_title：International immunology

authors： Godthelp BC,van Tol MJ,Vossen JM,van den Elsen PJ

更新日期：2001-04-01 00:00:00

abstract：:Constitutive expression of p35 and p40 IL-12 mRNA was detected in splenic macrophages isolated from aged mice. Macrophages were also implicated as the cell type responsible for the dysregulated IL-6 and tumor necrosis factor (TNF)-alpha commonly observed to be constitutively produced by lymphoid cells from aged donors...

journal_title：International immunology

authors： Spencer NF,Daynes RA

更新日期：1997-05-01 00:00:00

abstract：:Naive CD4(+) T cells rapidly proliferate to generate effector cells after encountering an antigen and small numbers survive as memory T cells in preparation for future immunological events. In the present work, adoptive transfer of naive CD4(+) T cells into RAG2(-/-) mice caused the generation of memory-type effector ...

journal_title：International immunology

authors： Noguchi D,Wakita D,Tajima M,Ashino S,Iwakura Y,Zhang Y,Chamoto K,Kitamura H,Nishimura T

更新日期：2007-12-01 00:00:00

abstract：:Incomplete T cell antigen receptor-mediated signaling induces an unresponsive state known as anergy. Previously, we had shown that anergy can be induced in antigen-primed but not naive T cells. In this report, we found that in vitro primed T cells from IL-2R alpha-deficient mice were resistant to anergy induction in c...

journal_title：International immunology

authors： Hayashi RJ,Kanagawa O

更新日期：2006-05-01 00:00:00

abstract：:We examined effects of c-fos overexpression on the development and property of peritoneal B-1 cells using transgenic (H2-c-fos) mice carrying the c-fos gene under the control of the constitutive H-2Kb promoter. The number of B-1b cells in the peritoneal cavity of H2-c-fos mice was 4-fold larger than that in control li...

journal_title：International immunology

authors： Mori S,Sakamoto A,Yamashita K,Fujimura L,Arima M,Hatano M,Miyazaki M,Tokuhisa T

更新日期：2004-10-01 00:00:00

abstract：:The ability of cytokines to steer CD4(+) T(h) cell responses toward a T(h)1 or T(h)2 phenotype and enhance the magnitude of both CD8(+) cytotoxic T lymphocytes (CTL) and antibody responses has clearly been demonstrated by our lab and others, but the influence of cytokines on protective immune responses is much less cl...

journal_title：International immunology

authors： Ahlers JD,Belyakov IM,Matsui S,Berzofsky JA

更新日期：2001-07-01 00:00:00

abstract：:MicroRNAs 125a and 125b are predicted to be able to bind to the B lymphocyte-induced maturation protein-1 (BLIMP-1) and IFN regulatory protein-4 (IRF-4) transcription factors, which are essential for plasma cell differentiation. A computational survey of the human and mouse genomes revealed that miR-125a and miR-125b ...

journal_title：International immunology

authors： Gururajan M,Haga CL,Das S,Leu CM,Hodson D,Josson S,Turner M,Cooper MD

更新日期：2010-07-01 00:00:00