Antibody therapy for the management of severe asthma with eosinophilic inflammation.

abstract：:Antibody-secreting cells (ASCs) in respiratory tract tissues provide a first line of defense against invading pathogens. These cells often secrete IgA that is efficiently transcytosed across epithelial barriers into the airway lumen where pathogens can be blocked at their point of entry. Previous literature has report...

journal_title：International immunology

authors： Sealy RE,Surman SL,Vogel P,Hurwitz JL

更新日期：2016-11-01 00:00:00

abstract：:We have determined the origin and cell surface phenotype of B cells producing antibody in response to immunization with the non-self TI-2 antigen polyvinyl pyrrolidinone (PVP). We report that the responding cells are derived from precursors in adult bone marrow and display the phenotype characteristic of B-1 cells. By...

journal_title：International immunology

authors： Whitmore AC,Haughton G,Arnold LW

更新日期：1996-04-01 00:00:00

abstract：:Oral administration of large doses of protein antigen generally induces a state of systemic unresponsiveness currently termed mucosally induced tolerance. In this study, we used human milk protein (HMP) without casein as a multi-protein antigen for the study of mucosally induced tolerance. The HMP utilized in this stu...

journal_title：International immunology

authors： Yuki Y,Fujihashi K,Yamamoto M,McGhee JR,Kiyono H

更新日期：1998-04-01 00:00:00

abstract：:We have searched the human genome for genes that predispose to rheumatoid arthritis (RA) using fluorescence-based microsatellite marker analysis and affected sib-pair linkage study. A panel of 41 Japanese families, each with at least two affected siblings, was typed for genome-wide 358 polymorphic microsatellite marke...

journal_title：International immunology

authors： Shiozawa S,Hayashi S,Tsukamoto Y,Goko H,Kawasaki H,Wada T,Shimizu K,Yasuda N,Kamatani N,Takasugi K,Tanaka Y,Shiozawa K,Imura S

更新日期：1998-12-01 00:00:00

abstract：:Interleukin 3 (IL-3) promotes the survival and proliferation of hematopoietic cells of various lineages in culture. Like most other hematopoietic colony stimulating factors, its mode of action is unknown. However, binding of the lymphokine induces protein tyrosine phosphorylation and enhanced glucose transport in some...

journal_title：International immunology

authors： Nefesh I,Bauskin AR,Alkalay I,Golembo M,Ben-Neriah Y

更新日期：1991-08-01 00:00:00

abstract：:T cell responses against complex antigens are often directed against a limited set of immunodominant determinants. We have studied this phenomenon at the level of cellularly processed peptides recognized by CTL in the B6 anti-BALB.B minor histocompatibility (H) barrier, comprising at least 29 antigen loci. B6 anti-BAL...

journal_title：International immunology

authors： Wolpert E,Franksson L,Kärre K

更新日期：1995-06-01 00:00:00

abstract：:The human IL-3 gene, located on chromosome 5, contains several cis-acting DNA sequences, i.e. CLE (conserved lymphokine element) and a GC-rich region, similar to the GM-CSF gene. To investigate the role of these elements, the 5' flanking region of the IL-3 gene was attached to a bacterial chloramphenicol acetyltransfe...

journal_title：International immunology

authors： Nishida J,Yoshida M,Arai K,Yokota T

更新日期：1991-03-01 00:00:00

abstract：:In this review, we propose that certain modifications in cellular metabolism might function as danger signals triggering inflammasome-mediated immune responses. We propose to call them danger-associated metabolic modifications (DAMMs). As intracellular bacteria can actively modulate macrophage metabolism for their ben...

journal_title：International immunology

authors： Dramé M,Buchrieser C,Escoll P

更新日期：2020-06-26 00:00:00

abstract：:In order to develop predictive markers for a beneficial humoral immune response, we evaluated the in vivo and in vitro response to the pandemic (p)H1N1 vaccine in young and elderly individuals. We measured serum antibody response and associated this with the in vitro B-cell response to the vaccine, measured by activat...

journal_title：International immunology

authors： Frasca D,Diaz A,Romero M,Phillips M,Mendez NV,Landin AM,Blomberg BB

更新日期：2012-03-01 00:00:00

abstract：:SCID mice are profoundly immunodeficient, resulting from an inability to carry out the V(D)J recombination reaction during both B cell and T cell development. Recently, however, it was revealed that normal rearrangement frequently did occur in the TCR delta and gamma chain loci in the SCID thymus. To evaluate whether ...

journal_title：International immunology

authors： Araki R,Itoh M,Hamatani K,Abe M

更新日期：1996-07-01 00:00:00

abstract：:Toll-like receptor 7 (TLR7) and TLR9 sense microbial single-stranded RNA (ssRNA) and ssDNA in endolysosomes. Nucleic acid (NA)-sensing in endolysosomes is thought to be important for avoiding TLR7/9 responses to self-derived NAs. Aberrant self-derived NA transportation to endolysosomes predisposes to autoimmune diseas...

journal_title：International immunology

authors： Li X,Saitoh S,Shibata T,Tanimura N,Fukui R,Miyake K

更新日期：2015-02-01 00:00:00

abstract：:A recipient who received a renal graft from a living related donor showed good renal function for as long as 15 years after the withdrawal of azathioprine. The patient's creatinine clearance was maintained at 60 ml/min in spite of the administration of only 10 mg of predonisolon per day. Anti-idiotypic antibodies in t...

journal_title：International immunology

authors： Miyajima T,Shimizu R,Kuzuhara H,Fujimoto S

更新日期：1989-01-01 00:00:00

abstract：:The co-existence of tumor specific immunity with a progressing tumor is observed in a variety of experimental systems and remains one of the major paradoxes of tumor immunology. We now report that a human melanoma cell line (SMC) expressing MHC class II was able to induce clonal anergy in a specific, MHC-restricted CD...

journal_title：International immunology

authors： Becker JC,Brabletz T,Czerny C,Termeer C,Bröcker EB

更新日期：1993-12-01 00:00:00

abstract：:Two peptides based on the complementarity-determining regions (CDR) 1 and 3 (pCDR1 and pCDR3) of a murine monoclonal anti-DNA autoantibody that expresses the common idiotype 16/6Id were shown to down-regulate systemic lupus erythematosus (SLE)-associated T cell responses and to prevent the development of clinical symp...

journal_title：International immunology

authors： Zinger H,Eilat E,Meshorer A,Mozes E

更新日期：2003-02-01 00:00:00

abstract：:It is increasingly evident that neutrophils are able to cross-talk with other leukocytes to shape ongoing inflammatory and immune responses. In this study, we analyzed whether human NK cells may influence the survival and activation of neutrophils under co-culture conditions. We report that NK cells exposed to either ...

journal_title：International immunology

authors： Costantini C,Micheletti A,Calzetti F,Perbellini O,Pizzolo G,Cassatella MA

更新日期：2010-10-01 00:00:00

abstract：:Analyses of bone marrow (BM) lymphocytes in C57BL/6 mice homozygous for the lpr mutation (B6.lpr) disclosed low numbers of pre-B and B cells, as compared with age-matched control B6 mice. BM depletion in B6.lpr mice was selective for B-lineage cells, appeared in young adults, and developed markedly with age and diseas...

journal_title：International immunology

authors： Sundblad A,Coutinho A

更新日期：1996-02-01 00:00:00

abstract：:The intestinal epithelium not only acts as the physical structure that separates the intestinal lumen from the body but also actively participates in intestinal barrier functions. In the past decade, significant progress has been made in the development of culture technologies to maintain intestinal epithelial cells (...

journal_title：International immunology

authors： Nakamura T

更新日期：2019-02-06 00:00:00

abstract：:Dendritic cells (DC) are key players in the initiation and modulation of adaptive immune responses due to their ability to acquire and present antigen and stimulate T cells. For the induction of effector T cell functions, antigen must be presented by activated DC. In this study, we have compared uptake of antigen by m...

journal_title：International immunology

authors： Tirapu I,Giquel B,Alexopoulou L,Uematsu S,Flavell R,Akira S,Diebold SS

更新日期：2009-07-01 00:00:00

abstract：:The role of B7 co-stimulatory signaling in in vivo tumor rejection remains incompletely characterized. In particular, the relative competence of B7-1 (CD80) and B7-2 (CD86) to provide effective co-stimulus is not well defined, and the identification of the T cell co-stimulatory receptor that mediates B7 co-stimulation...

journal_title：International immunology

authors： Yu X,Abe R,Hodes RJ

更新日期：1998-06-01 00:00:00

abstract：:Dendritic cells (DC) are professional antigen-presenting cells that play a central role in the control of immunity. Mature DC are characterized by high expression levels of MHC and co-stimulatory molecules, and by the secretion of IL-12, a key cytokine for the priming of cytotoxic T lymphocytes. Here, we have compared...

journal_title：International immunology

authors： Rouas R,Lewalle P,El Ouriaghli F,Nowak B,Duvillier H,Martiat P

更新日期：2004-05-01 00:00:00

abstract：:Schnurri (Shn)-2 is a large zinc finger-containing protein, which plays a critical role in cell growth, signal transduction and lymphocyte development. In Shn-2-deficient (Shn-2(-/-)) CD4 T cells, the activation of nuclear factor-kappaB is up-regulated and their ability to differentiate into Th2 is enhanced. Here, we ...

journal_title：International immunology

authors： Iwamura C,Kimura MY,Shinoda K,Endo Y,Hasegawa A,Yamashita M,Nakayama T

更新日期：2007-06-01 00:00:00

abstract：:The origin of anti-DNA antibodies remains speculative. We argue that some of these antibodies may arise inadvertently in nature during the course of a normal immune response due to their induction by antibodies which bear structures (mimotopes) that mimic DNA. These antibodies are not necessarily DNA specific but, lik...

journal_title：International immunology

authors： Wun HL,Leung DT,Wong KC,Chui YL,Lim PL

更新日期：2001-09-01 00:00:00

abstract：:The origin of cell activation in post-radiation fibrosis and its chronic extension are still poorly understood. Since local IL-2 cancer treatment sometimes triggers intraperitoneal fibrosis we have analyzed three myofibroblastic cell strains from post-radiation skin fibrosis (FPR7, FPR10 and FPR15) for their interacti...

journal_title：International immunology

authors： Alileche A,Han D,Plaisance S,Assier E,Sahraoui Y,Clemanceau C,Metivier D,Brouty-Boyer D,Jasmin C,Azzarone B

更新日期：1994-10-01 00:00:00

abstract：:The mucosa is one of the initial sites of group A streptococcal (GAS) infection and salivary IgA (sIgA) is thought to be critical to immunity. However, the target epitopes of sIgA and the function of sIgA in GAS immunity, in particular the role of accessory cells and complement, is largely unknown. We studied the aqui...

journal_title：International immunology

authors： Brandt ER,Hayman WA,Currie B,Carapetis J,Jackson DC,Do KA,Good MF

更新日期：1999-04-01 00:00:00

abstract：:The product of the LAG-3 gene is a cell surface protein with significant homology to CD4. It has been suggested that it can serve as a functional equivalent of CD4 and account for the MHC class II-restricted responses which persist in CD4-deficient mice. To test this hypothesis, we have created CD4/LAG-3 double-defici...

journal_title：International immunology

authors： Miyazaki T,Dierich A,Benoist C,Mathis D

更新日期：1996-05-01 00:00:00

abstract：:Invariant natural killer T (iNKT) cells expressing the retinoic acid receptor-related orphan receptor γt (RORγt) and producing IL-17 represent a minor subset of CD1d-restricted iNKT cells (iNKT17) in C57BL/6J (B6) mice. We aimed in this study to define the reasons for their low distribution and the sequence of events ...

journal_title：International immunology

authors： Klibi J,Li S,Amable L,Joseph C,Brunet S,Delord M,Parietti V,Jaubert J,Marie J,Karray S,Eberl G,Lucas B,Toubert A,Benlagha K

更新日期：2020-02-07 00:00:00

abstract：:SDF-1 is a member of the CXC chemokines. In contrast to other chemokines that are induced by inflammation, SDF-1 is constitutively produced by stromal cells. In order to investigate the physiological roles of SDF-1, we constructed a fusion protein, SDF-1-Cgamma1, composed from murine SDF-1alpha and the constant region...

journal_title：International immunology

authors： Suzuki G,Nakata Y,Dan Y,Uzawa A,Nakagawa K,Saito T,Mita K,Shirasawa T

更新日期：1998-08-01 00:00:00

abstract：:Sequestration of neutrophils and release of histotoxic mediators are considered important for the development of pathologic alterations of the lung defined as adult respiratory distress syndrome. Mechanisms of inflammatory lung injury caused by abdominal sepsis were investigated using the colon ascendens stent periton...

journal_title：International immunology

authors： Neumann B,Zantl N,Veihelmann A,Emmanuilidis K,Pfeffer K,Heidecke CD,Holzmann B

更新日期：1999-02-01 00:00:00

abstract：:Lymphocyte homing to lymph nodes is regulated by transient but specific interactions between lymphocytes and high endothelial venules (HEVs), the initial phase of which is mainly governed by the leukocyte adhesion molecule L-selectin, which recognizes sulfated and sialylated O-linked oligosaccharides displayed on sial...

journal_title：International immunology

authors： Kanda H,Tanaka T,Matsumoto M,Umemoto E,Ebisuno Y,Kinoshita M,Noda M,Kannagi R,Hirata T,Murai T,Fukuda M,Miyasaka M

更新日期：2004-09-01 00:00:00

abstract：:In this study, we show that IFNalpha increases the chemotaxis of human B cells to CCL20, CCL21 and CXCL12 in a dose- and time-dependent manner. The effect was maximal with 2000 IU ml(-1) IFNalpha. It peaked at 24 h and decreased thereafter. At 24 h, IFNalpha had increased B-cell chemotaxis to CCL20 by 20 +/- 6.2% (n =...

journal_title：International immunology

authors： Badr G,Borhis G,Treton D,Richard Y

更新日期：2005-04-01 00:00:00