Heat stable antigen (mouse CD24) supports myeloid cell binding to endothelial and platelet P-selectin.

abstract：:The immediate responses to aerosolized staphylococcal enterotoxin B (SEB) in respiratory toxic shock were studied in the circulation of rhesus monkeys with low antibody levels following immunization with SEB toxoid-containing microspheres. Both the surviving and dying monkeys had toxic shock syndrome 4-48 h after SEB ...

journal_title：International immunology

authors： Weng CF,Komisar JL,Hunt RE,Johnson AJ,Pitt ML,Ruble DL,Tseng J

更新日期：1997-12-01 00:00:00

abstract：:Exosomes are small vesicles (60-100 nm) secreted by various cell types upon the fusion of endosomal compartments with the plasma membrane. Exosomes from antigen-presenting cells (APC), such as B lymphocytes and dendritic cells (DC), bear MHC class II molecules. In addition, the injection of DC-derived exosomes was rep...

journal_title：International immunology

authors： Vincent-Schneider H,Stumptner-Cuvelette P,Lankar D,Pain S,Raposo G,Benaroch P,Bonnerot C

更新日期：2002-07-01 00:00:00

abstract：:IgE plus antigen-stimulated mast cells degranulate, synthesize leukotrienes and secrete cytokines. According to the coalescence model this process is initiated in specific membrane compartments termed rafts. There, enhanced levels of glycosphingolipids and cholesterol stabilize the interaction of FcepsilonRI and Lyn, ...

journal_title：International immunology

authors： Baumruker T,Csonga R,Pursch E,Pfeffer A,Urtz N,Sutton S,Bofill-Cardona E,Cooke M,Prieschl E

更新日期：2003-10-01 00:00:00

abstract：:T(h)17 cells, an inflammatory T helper cell subset, are involved in the pathogenesis of various inflammatory, autoimmune and allergic diseases. Recent evidence supports the idea that immune cell functions and the inflammatory response are finely regulated by various physiological substances. Calcitonin gene-related pe...

journal_title：International immunology

authors： Mikami N,Watanabe K,Hashimoto N,Miyagi Y,Sueda K,Fukada S,Yamamoto H,Tsujikawa K

更新日期：2012-11-01 00:00:00

abstract：:The transcription factor interferon regulatory factor-5 (IRF5) plays an important role in innate immune responses via the TLR-MyD88 (Toll-like receptor - myeloid differentiation primary response 88) pathway. IRF5 is also involved in the pathogenesis of the autoimmune disease systemic lupus erythematosus (SLE). Recent ...

journal_title：International immunology

authors： Ban T,Sato GR,Tamura T

更新日期：2018-10-29 00:00:00

abstract：:After a 3 week course (approximately), during which there is marked lymphoid hyperplasia, Trypanosoma musculi infections in young-adult mice are cured by an immune mechanism involving antibodies of the IgG2a isotype. Both the lymphoid hyperplasia and IgG2a antibody response are T-cell-dependent events and both process...

journal_title：International immunology

authors： Utsuyama M,Albright JW,Holmes KL,Hirokawa K,Albright JF

更新日期：1994-08-01 00:00:00

abstract：:Cross-linking of the IgM antigen receptor on an immature B cell lymphoma (BKS-2) induces growth arrest and apoptosis. This is accompanied by down-regulation of the immediate early genes, egr-1 and c-myc, and a reduction in NF-kappaB activity. Anti-IgM-induced growth arrest and apoptosis of this murine B cell lymphoma ...

journal_title：International immunology

authors： Han SS,Chung ST,Robertson DA,Chelvarajan RL,Bondada S

更新日期：1999-06-01 00:00:00

abstract：:CD45 is a receptor tyrosine phosphatase essential for TCR signaling. One isoform, CD45RB, is down-regulated in memory cells and targeting CD45RB with a specific antibody has been shown to inhibit graft rejection. Its role in immunity to infection, however, has not been tested. Here, we report the effect of anti-CD45RB...

journal_title：International immunology

authors： Lim B,Sutherland RM,Zhan Y,Deliyannis G,Brown LE,Lew AM

更新日期：2006-02-01 00:00:00

abstract：:Investigation of the process of Peyer's patch (PP) formation has been hampered by difficulties in identifying its initial step in the embryo. In this study, we overcame this problem by means of whole-mount immunohistochemistry using mAb against the molecules which were expressed in the cells accumulated at the site of...

journal_title：International immunology

authors： Adachi S,Yoshida H,Kataoka H,Nishikawa S

更新日期：1997-04-01 00:00:00

abstract：:CD4 T cells are not thought to play a significant role in generating an effective primary CD8 T cell response to most viral infections. We have challenged this view by demonstrating that antigen-specific CD4 T cells can indeed suppress the proliferation of antigen-specific naive CD8 T cells in response to low doses of...

journal_title：International immunology

authors： Cose S,Brammer C,Zammit DJ,Blair DA,Lefrançois L

更新日期：2006-08-01 00:00:00

abstract：:A human neoplastic B cell line SSK41 that expresses IgM on its surface switches spontaneously to IgG-producing cells. The SSK41 line contains a single immunoglobulin heavy-chain locus, the constant region (C) genes of which retain the germline configuration. The IgG-producing SSK41 line was purified by sorting, and sh...

journal_title：International immunology

authors： Sideras P,Mizuta TR,Kanamori H,Suzuki N,Okamoto M,Kuze K,Ohno H,Doi S,Fukuhara S,Hassan MS

更新日期：1989-01-01 00:00:00

abstract：:1,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)] and the vitamin D receptor (VDR) are important regulators of autoimmunity. The effect of the VDR on the ability of mice to fight a primary or secondary infection has not been determined. Young and old VDR knockout (KO) mice were able to clear both primary and secondary infe...

journal_title：International immunology

authors： Bruce D,Whitcomb JP,August A,McDowell MA,Cantorna MT

更新日期：2009-02-01 00:00:00

abstract：:cDNA clones which strongly hybridized with a 3.1 kb mRNA from mouse macrophages and macrophage cell lines and weakly with mRNA from P815 but not from a variety of other cell lines and tissues were isolated from cDNA libraries constructed using mRNA from murine macrophage cell lines and peritoneal macrophages. Treatmen...

journal_title：International immunology

authors： Yoshida S,Setoguchi M,Higuchi Y,Akizuki S,Yamamoto S

更新日期：1990-01-01 00:00:00

abstract：:NK cells are functionally controlled by the killer immunoglobulin-like receptor (KIR) family that comprises inhibitory (iKIR) and activating (aKIR) members. Genetic association studies suggest that donors expressing aKIRs next to iKIRs will be superior donors in the setting of hematopoietic stem cell transplantation o...

journal_title：International immunology

authors： Baltner K,Kübler A,Pal M,Balvociute M,Mezger M,Handgretinger R,André MC

更新日期：2017-11-01 00:00:00

abstract：:Natural killer (NK) cells are a major FcγRIIIA-expressing lymphocyte population that mediate antibody-dependent cellular cytotoxicity. Although NK cells are critical for immunity against viruses and tumors, they are also activated in the joints of patients with rheumatoid arthritis (RA) and may be involved in disease ...

journal_title：International immunology

authors： Shimizu Y,Kohyama M,Yorifuji H,Jin H,Arase N,Suenaga T,Arase H

更新日期：2019-04-26 00:00:00

abstract：:CD100/Sema4D belongs to the semaphorin family, factors known to act as repulsive cues for axons during neuronal development. Mouse CD100 plays a crucial role in both humoral and cellular immunity through ligation of the lymphocyte receptor, CD72. It remains controversial, however, whether human CD100 can function thro...

journal_title：International immunology

authors： Ishida I,Kumanogoh A,Suzuki K,Akahani S,Noda K,Kikutani H

更新日期：2003-08-01 00:00:00

abstract：:Adhesion molecules of the integrin family are implicated not only in leukocyte migration but also in leukocyte activation. Here we characterize the expression and function of fibronectin receptor integrins on rat mast cells. A rat basophilic leukemia cell line (RBL-2H3) and phorbol ester-stimulated rat peritoneal mast...

journal_title：International immunology

authors： Yasuda M,Hasunuma Y,Adachi H,Sekine C,Sakanishi T,Hashimoto H,Ra C,Yagita H,Okumura K

更新日期：1995-02-01 00:00:00

abstract：:The contribution of the HLA-DRB1, -B3, and -B5 gene products in the recognition of Dermatophagoides spp. (house dust mite) by helper T cells isolated from an atopic individual (HLA-DRw12, DR7; DRw52b) with perennial rhinitis was investigated. Using a panel of histocompatible and histoincompatible accessory cells, the ...

journal_title：International immunology

authors： O'Hehir RE,Mach B,Berte C,Greenlaw R,Tiercy JM,Bal V,Lechler RI,Trowsdale J,Lamb JR

更新日期：1990-01-01 00:00:00

abstract：:SKG mice, a newly established model of rheumatoid arthritis (RA), spontaneously develop autoimmune arthritis accompanying extra-articular manifestations, such as interstitial pneumonitis. To examine possible roles of T cells for mediating this systemic autoimmunity, we generated T cell clones from arthritic joints of ...

journal_title：International immunology

authors： Wakasa-Morimoto C,Toyosaki-Maeda T,Matsutani T,Yoshida R,Nakamura-Kikuoka S,Maeda-Tanimura M,Yoshitomi H,Hirota K,Hashimoto M,Masaki H,Fujii Y,Sakata T,Tsuruta Y,Suzuki R,Sakaguchi N,Sakaguchi S

更新日期：2008-10-01 00:00:00

abstract：:CD70 and CD80 are co-stimulatory molecules which belong to the tumor necrosis factor family and the B7 family respectively. When they are co-expressed by gene-modified TS/A tumor cells, they provide an efficient protective and long-lasting T-dependent antitumor response. We first showed that when CD70 and CD80 were de...

journal_title：International immunology

authors： Douin-Echinard V,Péron JM,Lauwers-Cancès V,Favre G,Couderc B

更新日期：2003-03-01 00:00:00

abstract：:We have determined the origin and cell surface phenotype of B cells producing antibody in response to immunization with the non-self TI-2 antigen polyvinyl pyrrolidinone (PVP). We report that the responding cells are derived from precursors in adult bone marrow and display the phenotype characteristic of B-1 cells. By...

journal_title：International immunology

authors： Whitmore AC,Haughton G,Arnold LW

更新日期：1996-04-01 00:00:00

abstract：:Lymphocyte homing to lymph nodes is regulated by transient but specific interactions between lymphocytes and high endothelial venules (HEVs), the initial phase of which is mainly governed by the leukocyte adhesion molecule L-selectin, which recognizes sulfated and sialylated O-linked oligosaccharides displayed on sial...

journal_title：International immunology

authors： Kanda H,Tanaka T,Matsumoto M,Umemoto E,Ebisuno Y,Kinoshita M,Noda M,Kannagi R,Hirata T,Murai T,Fukuda M,Miyasaka M

更新日期：2004-09-01 00:00:00

abstract：:Human monocytes isolated from peripheral blood of healthy donors show a time-dependent differentiation into macrophages upon in vitro cultivation, closely mimicking their in vivo migration and maturation into extravascular tissues. The mediator(s) of this maturation process has not been yet defined. We investigated th...

journal_title：International immunology

authors： Coccia EM,Del Russo N,Stellacci E,Testa U,Marziali G,Battistini A

更新日期：1999-07-01 00:00:00

abstract：:Based on the similarity in primary structure between the newly characterized ligand for CD40 (CD40L) and the tumor necrosis factors (TNFs), we have modeled a detailed 3-D structure for CD40L. We used the known structure of TNF alpha as a template for the generation of the CD40L model. The soundness of the model-buildi...

journal_title：International immunology

authors： Peitsch MC,Jongeneel CV

更新日期：1993-02-01 00:00:00

abstract：:Immune tolerance in the lung is important for preventing hypersensitivity, such as allergic asthma. Maintenance of tolerance in the lung is established by coordinated activities of poorly understood cellular and molecular mechanisms, including participation of dendritic cells (DCs). We have previously identified DC ex...

journal_title：International immunology

authors： Han D,Walsh MC,Kim KS,Hong SW,Lee J,Yi J,Rivas G,Choi Y,Surh CD

更新日期：2017-02-01 00:00:00

abstract：:The alternative complement pathway (ACP) in vertebrates is known to be important in inflammatory reactions, and to be activated by foreign substances such as bacterial lipopolysaccharide (LPS) and zymosan, although to date no intrinsic activators have been identified except complement receptor type 2. From the point o...

journal_title：International immunology

authors： Oshima H,Soma G,Mizuno D

更新日期：1993-10-01 00:00:00

abstract：:STAT6, NF-kappaB (p50) and C/EBPbeta transcription factors (TF) were examined with respect to CD23 regulation. Electrophoretic mobility shift assay (EMSA), competition and supershift analysis demonstrated that STAT6 binds the CD23a promoter but with a lower affinity than the consensus site. STAT6-/- mice were analyzed...

journal_title：International immunology

authors： Tinnell SB,Jacobs-Helber SM,Sterneck E,Sawyer ST,Conrad DH

更新日期：1998-10-01 00:00:00

abstract：:Infection by protozoan parasites of the genus Leishmania results in the development of leishmaniasis, an increasingly prevalent group of diseases affecting over 12 million people worldwide. Leishmaniasis can have very different outcomes ranging from cutaneous lesions, mucosal lesions to visceralization depending on th...

journal_title：International immunology

authors： Rossi M,Fasel N

更新日期：2018-03-10 00:00:00

abstract：:CD4 and CD8 T cell subsets involved in primary allo-MLR responses were re-evaluated in the present study. The slope analysis of B6 allo-MLR responses to MHC class I-disparate bm1 and class II-disparate bm12 revealed the presence of a T-T cell interaction between CD4 and CD8 T cell subsets. The allo-MLR response of B6 ...

journal_title：International immunology

authors： Asano Y,Komuro T,Tada T

更新日期：1990-01-01 00:00:00

abstract：:IL-12 has been shown to play a central role in cell-mediated inflammatory reactions through direct activation of T cells and NK cells. IL-12 also strongly influences humoral immunity but these effects have been thought to be indirect and caused by intermediary cytokines. Using flow cytometry, we now show that IL-12 di...

journal_title：International immunology

authors： Vogel LA,Showe LC,Lester TL,McNutt RM,Van Cleave VH,Metzger DW

更新日期：1996-12-01 00:00:00