当前位置： SCI文献检索 > INTERNATIONAL IMMUNOLOGY期刊下所有文献 > Elevated non-specific immunity and normal Listeria clearance in young and old vitamin D receptor knockout mice.

Elevated non-specific immunity and normal Listeria clearance in young and old vitamin D receptor knockout mice.

Abstract：

:1,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)] and the vitamin D receptor (VDR) are important regulators of autoimmunity. The effect of the VDR on the ability of mice to fight a primary or secondary infection has not been determined. Young and old VDR knockout (KO) mice were able to clear both primary and secondary infections with Listeria monocytogenes. However, the kinetics of clearance was somewhat delayed in the absence of the VDR. Memory T cell development was not different in young VDR KO and wild-type (WT) mice; however, old VDR KO mice had significantly less memory T cells than their WT counterparts but still mounted an adequate immune response as determined by the complete clearance of L. monocytogenes. Although the primary and secondary immune responses were largely intact in the VDR KO mice, the old VDR KO mice had increased cytokines and antibody responses compared with the old WT mice. In particular, old VDR KO mice had elevated antigen non-specific antibodies; however, these magnified immune responses did not correspond to more effective Listeria clearance. The increased antibody and cytokine responses in the old VDR KO mice are consistent with the increased susceptibility of these mice to autoimmunity.

journal_name

Int Immunol

journal_title

International immunology

authors

Bruce D,Whitcomb JP,August A,McDowell MA,Cantorna MT

doi

10.1093/intimm/dxn129

subject

Has Abstract

pub_date

2009-02-01 00:00:00

pages

113-22

issue

2

eissn

0953-8178

issn

1460-2377

pii

dxn129

journal_volume

21

pub_type

杂志文章

相关文献

INTERNATIONAL IMMUNOLOGY文献大全
  • Protective cytotoxic T lymphocyte responses against paramyxoviruses induced by epitope-based DNA vaccines: involvement of IFN-gamma.

    abstract：:Plasmid DNA vectors have been constructed with minigenes encoding a single cytotoxic T lymphocyte (CTL) epitope from either the M2 protein of respiratory syncytial virus (RSV) or from the nucleoprotein of measles virus (MV) with or without a signal sequence (also called secretory or leader sequence). Following intrade...

    journal_title：International immunology

    pub_type： 杂志文章

    doi：10.1093/intimm/10.10.1441

    authors： Hsu SC,Obeid OE,Collins M,Iqbal M,Chargelegue D,Steward MW

    更新日期：1998-10-01 00:00:00

  • Mechanisms that limit the diversity of antibody: three sequentially acting mechanisms that favor the spontaneous production of germline encoded anti-phosphatidyl choline.

    abstract：:Antibody to phosphatidyl choline (PtC) is produced spontaneously in mice, by approximately 2-10% of naturally occurring CD5+ (B1) B cells in the peritoneum. Much of this antibody is encoded by the VH11 gene associated with a specific V kappa 9 gene. Constraints on the size and structure of the H chain CDR3 have been d...

    journal_title：International immunology

    pub_type： 杂志文章

    doi：10.1093/intimm/5.11.1365

    authors： Arnold LW,Spencer DH,Clarke SH,Haughton G

    更新日期：1993-11-01 00:00:00

  • CCR1 expression and signal transduction by murine BMMC results in secretion of TNF-alpha, TGFbeta-1 and IL-6.

    abstract：:Chemokine receptors (CCRs) are important co-stimulatory molecules found on many blood cells and associated with various diseases. The expression and function of CCRs on mast cells has been quite controversial. In this study, we report for the first time that murine bone marrow-derived mast cells (BMMC) express messeng...

    journal_title：International immunology

    pub_type： 杂志文章

    doi：10.1093/intimm/dxp066

    authors： Fifadara NH,Aye CC,Raghuwanshi SK,Richardson RM,Ono SJ

    更新日期：2009-08-01 00:00:00

  • Reconstitution of the intermediate-affinity interleukin-2 receptor by cell fusion.

    abstract：:Although IL-2 receptor beta chain (IL-2R beta) expressed in various lymphoid cell lines binds IL-2 with an intermediate affinity, IL-2R beta expressed in fibroblasts is unable to bind IL-2, suggesting that IL-2R beta is on its own not sufficient for generating the intermediate-affinity receptor and that lymphoid-speci...

    journal_title：International immunology

    pub_type： 杂志文章

    doi：10.1093/intimm/4.10.1123

    authors： Kuida K,Tanaka T,Kitamura F,Toyama-Sorimachi N,Miyasaka M

    更新日期：1992-10-01 00:00:00

  • On the role of the inhibitory receptor LAG-3 in acute and chronic LCMV infection.

    abstract：:Chronic viral infections are often characterized by CD8 T-cell responses with poor cytokine secretion potential and limited expansion of the CD8 T-cell pool, collectively referred to as CD8 T-cell exhaustion. Exhaustion of lymphocytic choriomeningitis virus (LCMV)-specific CD8 T cells was shown to be partially regulat...

    journal_title：International immunology

    pub_type： 杂志文章

    doi：10.1093/intimm/dxp107

    authors： Richter K,Agnellini P,Oxenius A

    更新日期：2010-01-01 00:00:00

  • Translocation of tyrosine-phosphorylated TCRzeta chain to glycolipid-enriched membrane domains upon T cell activation.

    abstract：:Recent studies point to glycolipid-enriched membrane (GEM) microdomains as the critical sites for TCR-mediated signal transduction. However, whether the TCR complex is localized in the GEM domain is not well-defined. In the present study, we analyzed localization of the TCR-CD3 complex in the GEM domain by isolating t...

    journal_title：International immunology

    pub_type： 杂志文章

    doi：10.1093/intimm/11.9.1395

    authors： Kosugi A,Saitoh S,Noda S,Yasuda K,Hayashi F,Ogata M,Hamaoka T

    更新日期：1999-09-01 00:00:00

  • Anti-Semaphorin 3A neutralization monoclonal antibody prevents sepsis development in lipopolysaccharide-treated mice.

    abstract：:Semaphorin 3A (Sema3A), originally identified as a potent growth cone collapsing factor in developing sensory neurons, is now recognized as a key player in immune, cardiovascular, bone metabolism and neurological systems. Here we established an anti-Sema3A monoclonal antibody that neutralizes the effects of Sema3A bot...

    journal_title：International immunology

    pub_type： 杂志文章

    doi：10.1093/intimm/dxv014

    authors： Yamashita N,Jitsuki-Takahashi A,Ogawara M,Ohkubo W,Araki T,Hotta C,Tamura T,Hashimoto S,Yabuki T,Tsuji T,Sasakura Y,Okumura H,Takaiwa A,Koyama C,Murakami K,Goshima Y

    更新日期：2015-09-01 00:00:00

  • An indispensable role of type-1 IFNs for inducing CTL-mediated complete eradication of established tumor tissue by CpG-liposome co-encapsulated with model tumor antigen.

    abstract：:We have evaluated the capacity of a novel, nanoparticle-based tumor vaccine to eradicate established tumors in mice. C57BL/6 mice were intradermally (i.d.) inoculated with ovalbumin (OVA)-expressing EG-7 tumor cells. When the tumor size reached 7-8 mm, the tumor-bearing mice were i.d. injected near the tumor-draining ...

    journal_title：International immunology

    pub_type： 杂志文章

    doi：10.1093/intimm/dxh381

    authors： Wakita D,Chamoto K,Zhang Y,Narita Y,Noguchi D,Ohnishi H,Iguchi T,Sakai T,Ikeda H,Nishimura T

    更新日期：2006-03-01 00:00:00

  • Rapid acceleration of neutrophil apoptosis by tumor necrosis factor-alpha.

    abstract：:We demonstrate here that human necrosis factor-alpha, a potent neutrophil activator, induces rapid (within 3 h) apoptosis of these cells, i.e. neutrophils treated with this cytokine exhibit (i) light and electron microscopic changes characteristic to apoptotic cells, (ii) reduced propidium iodide binding to DNA, and (...

    journal_title：International immunology

    pub_type： 杂志文章

    doi：10.1093/intimm/5.6.691

    authors： Takeda Y,Watanabe H,Yonehara S,Yamashita T,Saito S,Sendo F

    更新日期：1993-06-01 00:00:00

  • Rag-1: a topoisomerase?

    abstract：:Recombination activating genes Rag-1 and Rag-2 were isolated on the basis of their ability to confer V(D)J recombination activity when co-expressed in fibroblasts. The mode of action of the confer V(D)J recombination activity when co-expressed in fibroblasts. The mode of action of the products of these genes is not kn...

    journal_title：International immunology

    pub_type： 杂志文章

    doi：10.1093/intimm/5.2.231

    authors： Kallenbach S,Brinkmann T,Rougeon F

    更新日期：1993-02-01 00:00:00

  • IL-12 transiently induces IFN-gamma transcription and protein synthesis in human CD4+ allergen-specific Th2 T cell clones.

    abstract：:IL-12 is a cytokine produced by monocytes and Epstein-Barr virus-transformed B cells which initiates Th1 responses by inducing the development of CD4+, IFN-gamma producing Th1 T cells in mouse and human. We have previously reported that allergen-specific CD4+ Th2 T cell clones produce IFN-gamma, following activation b...

    journal_title：International immunology

    pub_type： 杂志文章

    doi：10.1093/intimm/6.7.1091

    authors： Yssel H,Fasler S,de Vries JE,de Waal Malefyt R

    更新日期：1994-07-01 00:00:00

  • Structure of celiac disease-associated HLA-DQ8 and non-associated HLA-DQ9 alleles in complex with two disease-specific epitopes.

    abstract：:The association of celiac disease (CD) with HLA-DQ2 and HLA-DQ8 is indicative of preferential mucosal T cell recognition of gluten fragments bound to either DQ allele. We have recently identified two gluten-derived, HLA-DQ8-restricted T cell stimulatory peptides, one each from gliadin and glutenin, recognized by speci...

    journal_title：International immunology

    pub_type： 杂志文章

    doi：10.1093/intimm/12.8.1157

    authors： Moustakas AK,van de Wal Y,Routsias J,Kooy YM,van Veelen P,Drijfhout JW,Koning F,Papadopoulos GK

    更新日期：2000-08-01 00:00:00

  • Interleukin 12 alters the isotype-restricted antibody response of mice to hen eggwhite lysozyme.

    abstract：:Protein antigens elicit humoral responses in mice that consist predominantly of IgG1 antibodies. We have now investigated the ability of IL-12, a cytokine reported to augment IgG2a anti-hapten responses through activation of Th1 cells, to alter antibody responses to hen eggwhite lysozyme (HEL). The normal response of ...

    journal_title：International immunology

    pub_type： 杂志文章

    doi：10.1093/intimm/7.9.1519

    authors： Buchanan JM,Vogel LA,Van Cleave VH,Metzger DW

    更新日期：1995-09-01 00:00:00

  • Definition of a GC-rich motif as regulatory sequence of the human IL-3 gene: coordinate regulation of the IL-3 gene by CLE2/GC box of the GM-CSF gene in T cell activation.

    abstract：:The human IL-3 gene, located on chromosome 5, contains several cis-acting DNA sequences, i.e. CLE (conserved lymphokine element) and a GC-rich region, similar to the GM-CSF gene. To investigate the role of these elements, the 5' flanking region of the IL-3 gene was attached to a bacterial chloramphenicol acetyltransfe...

    journal_title：International immunology

    pub_type： 杂志文章

    doi：10.1093/intimm/3.3.245

    authors： Nishida J,Yoshida M,Arai K,Yokota T

    更新日期：1991-03-01 00:00:00

  • A novel co-stimulatory T cell antigen co-expressed on renal cell carcinoma.

    abstract：:The A6H mAb raised primarily against human renal cell carcinoma (RCC) has previously been shown to bind strongly to RCC, to some degree to colon carcinoma but only marginally to a variety of normal tissues. Immunohistochemical analysis or RCC tissues containing tumor-infiltrating lymphocytes revealed that A6H stained ...

    journal_title：International immunology

    pub_type： 杂志文章

    doi：10.1093/intimm/7.9.1425

    authors： Labuda T,Lando P,Björkdahl O,Kalland T,Vessella R,Hedlund G,Eriksson H,Sjögren HO,Dohlsten M

    更新日期：1995-09-01 00:00:00

  • IL-1α released from oral epithelial cells upon candidalysin exposure initiates an early innate epithelial response.

    abstract：:Candida albicans is a commensal fungus that predominantly resides on mucosal surfaces and can cause lethal systemic infection when the host defense is compromised. Candidalysin is a cytolytic peptide toxin produced by C. albicans hyphae that is essential for mucosal tissue damage and is believed to contribute to the e...

    journal_title：International immunology

    pub_type： 杂志文章

    doi：10.1093/intimm/dxaa070

    authors： Hanaoka M,Domae E

    更新日期：2020-10-10 00:00:00

  • TGF-beta signaling regulates CD8+ T cell responses to high- and low-affinity TCR interactions.

    abstract：:Absence of transforming growth factor-beta (TGF-beta) signaling to T cells in mice results in an increase in T cell numbers, an activated CD44 high, CD69-, CD25- T cell phenotype and a T cell-mediated injury to many organs. It is not known if such T cell activation in the absence of TGF-beta signaling is spontaneous o...

    journal_title：International immunology

    pub_type： 杂志文章

    doi：10.1093/intimm/dxh233

    authors： Mehal WZ,Sheikh SZ,Gorelik L,Flavell RA

    更新日期：2005-05-01 00:00:00

  • Analysis of stem-cell-like properties of human CD161++IL-18Rα+ memory CD8+ T cells.

    abstract：:CD161(++)IL-18Rα(+)CD8(+) human T cells have recently been identified as a new subset of memory cells but their exact role remains unclear. CD161(++)IL-18Rα(+)CD8(+), mucosal-associated invariant T cells express a semi-invariant TCR Vα7.2-Jα33, which recognizes the MHC-related protein 1. On the basis of properties inc...

    journal_title：International immunology

    pub_type： 杂志文章

    doi：10.1093/intimm/dxs069

    authors： Havenith SH,Yong SL,Henson SM,Piet B,Idu MM,Koch SD,Jonkers RE,Kragten NA,Akbar AN,van Lier RA,ten Berge IJ

    更新日期：2012-10-01 00:00:00

  • Normal D-JH rearranged products of the IgH gene in SCID mouse bone marrow.

    abstract：:SCID mice are profoundly immunodeficient, resulting from an inability to carry out the V(D)J recombination reaction during both B cell and T cell development. Recently, however, it was revealed that normal rearrangement frequently did occur in the TCR delta and gamma chain loci in the SCID thymus. To evaluate whether ...

    journal_title：International immunology

    pub_type： 杂志文章

    doi：10.1093/intimm/8.7.1045

    authors： Araki R,Itoh M,Hamatani K,Abe M

    更新日期：1996-07-01 00:00:00

  • Increased levels of plasma nucleotides in patients with rheumatoid arthritis.

    abstract：:Novel biomarkers of rheumatoid arthritis (RA), in addition to antibodies against cyclic citrullinated peptides, are required. Metabolome analysis is a promising approach to identify metabolite biomarkers for clinical diagnosis. We adopted a comprehensive nontargeted metabolomics approach combining capillary electropho...

    journal_title：International immunology

    pub_type： 杂志文章

    doi：10.1093/intimm/dxaa059

    authors： Kishikawa T,Maeda Y,Nii T,Arase N,Hirata J,Suzuki K,Yamamoto K,Masuda T,Ogawa K,Tsuji S,Matsushita M,Matsuoka H,Yoshimura M,Tsunoda S,Ohshima S,Narazaki M,Ogata A,Saeki Y,Inohara H,Kumanogoh A,Takeda K,Okada Y

    更新日期：2020-08-31 00:00:00

  • IL-10 is involved in the suppression of experimental autoimmune encephalomyelitis by CD25+CD4+ regulatory T cells.

    abstract：:CD25(+)CD4(+) regulatory T cells inhibit the activation of autoreactive T cells in vitro and in vivo, and suppress organ-specific autoimmune diseases. The mechanism of CD25(+)CD4(+) T cells in the regulation of experimental autoimmune encephalomyelitis (EAE) is poorly understood. To assess the role of CD25(+)CD4(+) T ...

    journal_title：International immunology

    pub_type： 杂志文章

    doi：10.1093/intimm/dxh029

    authors： Zhang X,Koldzic DN,Izikson L,Reddy J,Nazareno RF,Sakaguchi S,Kuchroo VK,Weiner HL

    更新日期：2004-02-01 00:00:00

  • Prostaglandin E2 is a major soluble factor produced by stromal cells for preventing inflammatory cytokine production from dendritic cells.

    abstract：:Dendritic cells (DCs) are specialized antigen-presenting cells that play pivotal roles in initiating immune responses. However, DC maturation is usually strongly restricted by the stromal microenvironment, especially in non-lymphoid tissues, such as skin and mucosa. Although suppression of DC maturation by stromal cel...

    journal_title：International immunology

    pub_type： 杂志文章

    doi：10.1093/intimm/dxn078

    authors： Shiraishi H,Yoshida H,Saeki K,Miura Y,Watanabe S,Ishizaki T,Hashimoto M,Takaesu G,Kobayashi T,Yoshimura A

    更新日期：2008-09-01 00:00:00

  • HIV envelope-directed signaling aberrancies and cell death of CD4+ T cells in the absence of TCR co-stimulation.

    abstract：:HIV-1 infection in CD4(+) T cells initiates a viral cytopathic effect (CPE) that is dependent on the activation of intracellular protein tyrosine kinases (PTK). PTK in T cells are also activated during the course of TCR or CD4 receptor engagement and the manner of receptor engagement may generate signals leading eithe...

    journal_title：International immunology

    pub_type： 杂志文章

    doi：10.1093/intimm/8.1.65

    authors： Tian H,Lempicki R,King L,Donoghue E,Samelson LE,Cohen DI

    更新日期：1996-01-01 00:00:00

  • Expression of a type II collagen-specific TCR transgene accelerates the onset of arthritis in mice.

    abstract：:Animal models of autoimmune diseases have been instrumental in advancing our understanding of autoimmunity in humans. Collagen-induced arthritis in mice is an autoimmune disease model of rheumatoid arthritis, which is MHC class II restricted and CD4 T cell dependent. To better understand the fundamental role of T cell...

    journal_title：International immunology

    pub_type： 杂志文章

    doi：10.1093/intimm/10.11.1613

    authors： Osman GE,Cheunsuk S,Allen SE,Chi E,Liggitt HD,Hood LE,Ladiges WC

    更新日期：1998-11-01 00:00:00

  • Immunofluorescence analysis of B-1 cell ontogeny in the mouse.

    abstract：:In order to further understand the developmental aspects of B-1 cells, we characterized the ontogeny of this B cell population in the spleen and peritoneal cavity of BALB/c mice. Although there are B-1 cells in the spleen within the first 1-3 weeks after birth, they do not at any stage represent the majority of spleni...

    journal_title：International immunology

    pub_type： 杂志文章

    doi：10.1093/intimm/6.3.355

    authors： Hamilton AM,Lehuen A,Kearney JF

    更新日期：1994-03-01 00:00:00

  • TRAF1 regulates Th2 differentiation, allergic inflammation and nuclear localization of the Th2 transcription factor, NIP45.

    abstract：:We have previously reported that tumor necrosis factor receptor-associated factor 1 (TRAF1), an intracellular protein, which binds to a range of molecules, including tumor necrosis factor (TNF) receptor family members, regulates TNF-induced NF-kappaB and AP-1 signaling as well as TCR-triggered proliferative responses ...

    journal_title：International immunology

    pub_type： 杂志文章

    doi：10.1093/intimm/dxh354

    authors： Bryce PJ,Oyoshi MK,Kawamoto S,Oettgen HC,Tsitsikov EN

    更新日期：2006-01-01 00:00:00

  • MHC class I H-2Kd-restricted antigenic peptides: additional constraints for the binding motif.

    abstract：:The previously defined binding motif of MHC class I H-2Kd-restricted antigenic peptides consists of a Y residue in position P2 and a hydrophobic residue with a large aliphatic side chain (L, I, or V) in position P9/P10 of optimal 9- or 10-mer peptides. We show now that the presence of a charged or a F residue in posit...

    journal_title：International immunology

    pub_type： 杂志文章

    doi：10.1093/intimm/5.11.1489

    authors： Eberl G,Sabbatini A,Servis C,Romero P,Maryanski JL,Corradin G

    更新日期：1993-11-01 00:00:00

  • A quantitative model for neutrophil response and delayed-type hypersensitivity reaction in rats orally inoculated with various doses of Salmonella Enteritidis.

    abstract：:Our aim was to investigate the quantitative relationship between inoculation doses and physiological responses to infection by Salmonella enterica serovar Enteritidis. Rats were orally inoculated with 10-10(9) c.f.u. of S. Enteritidis and monitored for 6 days. Neutrophil and delayed-type hypersensitivity (DTH) respons...

    journal_title：International immunology

    pub_type： 杂志文章

    doi：10.1093/intimm/14.2.111

    authors： Takumi K,Garssen J,Havelaar A

    更新日期：2002-02-01 00:00:00

  • Characterization of the developmental landscape of murine RORγt+ iNKT cells.

    abstract：:Invariant natural killer T (iNKT) cells expressing the retinoic acid receptor-related orphan receptor γt (RORγt) and producing IL-17 represent a minor subset of CD1d-restricted iNKT cells (iNKT17) in C57BL/6J (B6) mice. We aimed in this study to define the reasons for their low distribution and the sequence of events ...

    journal_title：International immunology

    pub_type： 杂志文章

    doi：10.1093/intimm/dxz064

    authors： Klibi J,Li S,Amable L,Joseph C,Brunet S,Delord M,Parietti V,Jaubert J,Marie J,Karray S,Eberl G,Lucas B,Toubert A,Benlagha K

    更新日期：2020-02-07 00:00:00

  • Interleukin 6 in inflammation, autoimmunity and cancer.

    abstract：:Interleukin 6 (IL-6) is involved both in immune responses and in inflammation, hematopoiesis, bone metabolism and embryonic development. IL-6 plays roles in chronic inflammation (closely related to chronic inflammatory diseases, autoimmune diseases and cancer) and even in the cytokine storm of corona virus disease 201...

    journal_title：International immunology

    pub_type： 杂志文章

    doi：10.1093/intimm/dxaa078

    authors： Hirano T

    更新日期：2020-12-18 00:00:00