Protective cytotoxic T lymphocyte responses against paramyxoviruses induced by epitope-based DNA vaccines: involvement of IFN-gamma.

abstract：:Intestinal intraepithelial lymphocytes (i-IEL) of aged rats comprise CD4+CD8alphaalpha+ and CD4-CD8alphaalpha+ T cells expressing TCR alphabeta. In the present study, we compared characteristics between CD4+CD8alphaalpha+ and CD4-CD8alphaalpha+ i-IEL, which were purified by a cell sorter from the i-IEL of 6-month-old ...

journal_title：International immunology

authors： Yamada K,Kimura Y,Nishimura H,Namii Y,Murase M,Yoshikai Y

更新日期：1999-01-01 00:00:00

abstract：:In the genetic disorder ataxia telangiectasia (AT), humoral (B) and cellular (T) immunological abnormalities are frequently observed. As a consequence, AT patients are predisposed to life-threatening sinopulmonary infections. The pathogenic mechanisms remain unknown, but a role for ATM in signal transduction from memb...

journal_title：International immunology

authors： Rivero-Carmena M,Porras O,Pelaez B,Pacheco-Castro A,Gatti RA,Regueiro JR

更新日期：2000-06-01 00:00:00

abstract：:Antigen engagement of the TCR may lead to activation of mature T cells while inducing deletion or positive selection of immature thymocytes. Using thymocytes from TCR transgenic mice recognizing the allo-antigen H-2Kb we investigated whether double-positive CD4+CD8+ (DP) thymocytes constitute a particular developmenta...

journal_title：International immunology

authors： Simon AK,Auphan N,Schmitt-Verhulst AM

更新日期：1996-09-01 00:00:00

abstract：:Naive and primed alpha beta T cells can be distinguished on the basis of their differential expression of CD45RA and CD45RO, respectively. The present study indicates that these CD45-isoforms also identify naive and primed maturational stages of gamma delta T cells and natural killer (NK) cells. In peripheral blood, a...

journal_title：International immunology

authors： Braakman E,Sturm E,Vijverberg K,van Krimpen BA,Gratama JW,Bolhuis RL

更新日期：1991-07-01 00:00:00

abstract：:Leishmania donovani resides within the host macrophages by dampening host defence mechanisms and thereby it modulates the host cell functions for its survival. Multiple host cell factors compete during the interplay between the host and the parasite. Roles for dual-specificity phosphatases (DUSPs) are implicated in va...

journal_title：International immunology

authors： Parveen S,Bandhyopadhyay S,Das S,Majumdar SB,Jawed JJ,Chowdhury BP,Saha B,Majumdar S

更新日期：2016-12-01 00:00:00

abstract：:It is now generally recognized that bone marrow is the survival niche for antigen-specific plasma cells with long-term immunological memory. These cells release antibodies into the circulation, needed to prime effector cells in the secondary immune response. These antibodies participate in the surveillance for antigen...

journal_title：International immunology

authors： Gould HJ,Wu YB

更新日期：2018-08-30 00:00:00

abstract：:We have followed CD4 and CD8 TCR V beta repertoires during the acute phase of Trypanosoma cruzi infection in a resistant mouse strain (C57BL/6). No major changes were found in the V beta TCR distributions analyzed (covering roughly 40% of the TCR repertoire) in peripheral CD4 T lymphocytes, confirming the polyclonal n...

journal_title：International immunology

authors： Leite-de-Moraes MC,Coutinho A,Hontebeyrie-Joskowicz M,Minoprio P,Eisen H,Bandeira A

更新日期：1994-03-01 00:00:00

abstract：:The peptide motifs of two HLA molecules, B8 and DR3(17), which are associated with autoimmune diseases including myasthenia gravis, were determined from natural peptide pools using Edman degradation. The majority of HLA-B8 ligands are nonamers preferentially terminated by leucine. As a characteristic feature of the HL...

journal_title：International immunology

authors： Malcherek G,Falk K,Rötzschke O,Rammensee HG,Stevanović S,Gnau V,Jung G,Melms A

更新日期：1993-10-01 00:00:00

abstract：:Although IL-2 receptor beta chain (IL-2R beta) expressed in various lymphoid cell lines binds IL-2 with an intermediate affinity, IL-2R beta expressed in fibroblasts is unable to bind IL-2, suggesting that IL-2R beta is on its own not sufficient for generating the intermediate-affinity receptor and that lymphoid-speci...

journal_title：International immunology

authors： Kuida K,Tanaka T,Kitamura F,Toyama-Sorimachi N,Miyasaka M

更新日期：1992-10-01 00:00:00

abstract：:Interleukin 3 (IL-3) promotes the survival and proliferation of hematopoietic cells of various lineages in culture. Like most other hematopoietic colony stimulating factors, its mode of action is unknown. However, binding of the lymphokine induces protein tyrosine phosphorylation and enhanced glucose transport in some...

journal_title：International immunology

authors： Nefesh I,Bauskin AR,Alkalay I,Golembo M,Ben-Neriah Y

更新日期：1991-08-01 00:00:00

abstract：:Unlike splenic B cells from normal BALB/c mice, those from autoimmune-prone NZB x NZW (B/W) F1 young mice were hyperresponsive to interleukin 2 (IL2) and proliferated even in the absence of prior stimulation signals. We found that the B cell subpopulation responsible for this event belongs to that with 6B2 (B220)-dull...

journal_title：International immunology

authors： Hasegawa K,Abe M,Okada T,Hirose S,Sato H,Shirai T

更新日期：1989-01-01 00:00:00

abstract：:BALB/c mice are susceptible to cutaneous leishmaniasis upon infection with Leishmania major while C57BL/6 are not. There is a major promastigote surface protease (PSP or gp63) which is available in both native and recombinant forms, and for which the primary amino acid sequence is known. Immunization with PSP has been...

journal_title：International immunology

authors： Soares LR,Sercarz EE,Miller A

更新日期：1994-05-01 00:00:00

abstract：:Earlier studies have demonstrated an over-expression of 9-O-acetylated sialoglycoconjugates (9-OAcSGs) on lymphoblasts, concomitant with high titers of anti-9-OAcSGs in childhood acute lymphoblastic leukemia (ALL). The present study was aimed to evaluate whether this high induction of anti-9-OAcSGs at disease presenta...

journal_title：International immunology

authors： Bandyopadhyay S,Bhattacharyya A,Mallick A,Sen AK,Tripathi G,Das T,Sa G,Bhattacharya DK,Mandal C

更新日期：2005-02-01 00:00:00

abstract：:Myasthenia gravis (MG) is an autoimmune disease, caused by autoantibodies against the muscle acetylcholine receptor (AChR), an oligomeric transmembrane glycoprotein composed of alpha(2)beta gamma delta subunits. The alpha subunit carries in its N-terminal extracellular domain the main immunogenic region (MIR), a group...

journal_title：International immunology

authors： Tsouloufis T,Mamalaki A,Remoundos M,Tzartos SJ

更新日期：2000-09-01 00:00:00

abstract：:Behçet's syndrome (BS) is a systemic inflammatory disorder with unknown etiology. Features of both innate and adaptive immunity have been claimed in the pathogenesis of BS. To test the possible dysregulation of the NLRP3/cryopyrin (Nod-like receptor with a pyrin domain 3) inflammasome, as a result of mutation(s), we p...

journal_title：International immunology

authors： Yüksel Ş,Eren E,Hatemi G,Sahillioğlu AC,Gültekin Y,Demiröz D,Akdiş C,Fresko İ,Özören N

更新日期：2014-02-01 00:00:00

abstract：:In humans, the thymus is the primary lymphoid organ able to support the development of T cells through its three-dimensional (3D) organization of the thymic stromal cells. Since a remarkable number of similarities are shared between the thymic epithelial cells (TECs) and skin-derived keratinocytes and fibroblasts, in ...

journal_title：International immunology

authors： Palamaro L,Guarino V,Scalia G,Antonini D,De Falco L,Bianchino G,Fusco A,Romano R,Grieco V,Missero C,Del Vecchio L,Ambrosio L,Pignata C

更新日期：2013-12-01 00:00:00

abstract：:Src homology region 2-domain-containing phosphatase-1 (SHP-1) plays an important role in the regulation of signaling from various receptors in hematopoietic cells. In mast cells, SHP-1 has been shown to negatively regulate the initial signaling triggered by high-affinity receptor for IgE (FcepsilonRI) and positively r...

journal_title：International immunology

authors： Ozawa T,Nakata K,Mizuno K,Yakura H

更新日期：2007-09-01 00:00:00

abstract：:Structural and functional aspects of the accessory molecule lymphocyte function associated antigen (LFA)-3 (CD58) have been examined following the transfection of DAP.3 and P815 cells with a cDNA clone encoding the glycosyl phosphatidylinositol (GPI)-linked form of human LFA-3. Despite earlier observations that DAP.3 ...

journal_title：International immunology

authors： Greenlaw R,Robinson P,Heaton T,Lombardi G,Lechler R

更新日期：1992-06-01 00:00:00

abstract：:The alternative complement pathway (ACP) in vertebrates is known to be important in inflammatory reactions, and to be activated by foreign substances such as bacterial lipopolysaccharide (LPS) and zymosan, although to date no intrinsic activators have been identified except complement receptor type 2. From the point o...

journal_title：International immunology

authors： Oshima H,Soma G,Mizuno D

更新日期：1993-10-01 00:00:00

abstract：:Amongst CD4-CD8- (double negative) thymocytes there is a sizeable population (variable from strain to strain) of cells expressing surface T cell receptor (TCR). These TCR+ double negatives are predominantly non-cycling, have very little precursor activity, and, unlike the TCR-CD4-CD8- thymocytes, appear not to be part...

journal_title：International immunology

authors： Wu L,Pearse M,Egerton M,Petrie H,Scollay R

更新日期：1990-01-01 00:00:00

abstract：:Sequestration of neutrophils and release of histotoxic mediators are considered important for the development of pathologic alterations of the lung defined as adult respiratory distress syndrome. Mechanisms of inflammatory lung injury caused by abdominal sepsis were investigated using the colon ascendens stent periton...

journal_title：International immunology

authors： Neumann B,Zantl N,Veihelmann A,Emmanuilidis K,Pfeffer K,Heidecke CD,Holzmann B

更新日期：1999-02-01 00:00:00

abstract：:Long-term side effects may represent a relevant burden of antiretroviral treatment (ART) in HIV-infected patients with good CD4 immune reconstitution over extended time spans. CD4-guided treatment interruption (TI) has been evaluated to address this point and may result in a wide spectrum of time off ART in different ...

journal_title：International immunology

authors： Bozzano F,Nasi M,Bertoncelli L,Nemes E,Prati F,Marras F,Mussini C,Moretta L,Cossarizza A,De Maria A

更新日期：2011-02-01 00:00:00

abstract：:IL-7 is a required factor for T-cell homeostasis. Because of low expression levels and poor reagent availability, the cellular sources of IL-7 have proven challenging to characterize. In this study, we describe a reporter mouse in which enhanced GFP is expressed from the endogenous Il7 locus. We show that IL-7 is prod...

journal_title：International immunology

authors： Miller CN,Hartigan-O'Connor DJ,Lee MS,Laidlaw G,Cornelissen IP,Matloubian M,Coughlin SR,McDonald DM,McCune JM

更新日期：2013-08-01 00:00:00

abstract：:Normal human sera contained 10-60 ng/ml of soluble membrane cofactor protein (MCP, CD46) whereas sera of > 50% of the cancer patients contained > 60 ng/ml. MCP purified by immunoaffinity chromatography from both normal and cancer patients' sera consisted of three bands of 56, 47 and 29 kDa on SDS-PAGE/immunoblotting. ...

journal_title：International immunology

authors： Seya T,Hara T,Iwata K,Kuriyama S,Hasegawa T,Nagase Y,Miyagawa S,Matsumoto M,Hatanaka M,Atkinson JP

更新日期：1995-05-01 00:00:00

abstract：:The B cell-activating factor from the tumor necrosis factor family (BAFF) is an important regulator of B cell immunity. Recently, we demonstrated that recombinant BAFF also provides a co-stimulatory signal to T cells. Here, we studied expression of BAFF in peripheral blood leukocytes and correlated this expression wit...

journal_title：International immunology

authors： Huard B,Arlettaz L,Ambrose C,Kindler V,Mauri D,Roosnek E,Tschopp J,Schneider P,French LE

更新日期：2004-03-01 00:00:00

abstract：:Interleukin 6 (IL-6) is involved both in immune responses and in inflammation, hematopoiesis, bone metabolism and embryonic development. IL-6 plays roles in chronic inflammation (closely related to chronic inflammatory diseases, autoimmune diseases and cancer) and even in the cytokine storm of corona virus disease 201...

journal_title：International immunology

authors： Hirano T

更新日期：2020-12-18 00:00:00

abstract：:The intestinal epithelium not only acts as the physical structure that separates the intestinal lumen from the body but also actively participates in intestinal barrier functions. In the past decade, significant progress has been made in the development of culture technologies to maintain intestinal epithelial cells (...

journal_title：International immunology

authors： Nakamura T

更新日期：2019-02-06 00:00:00

abstract：:Organs of transgenic pigs that express human complement regulatory proteins are under assessment as an alternative to transplantation. A major barrier to the transplantation of pig organs is the hyperacute rejection caused by pre-existing antibodies and complement. Pig cells are very susceptible to human complement, p...

journal_title：International immunology

authors： Toyomura K,Fujimura T,Murakami H,Natsume T,Shigehisa T,Inoue N,Takeda J,Kinoshita T

更新日期：1997-06-01 00:00:00

abstract：:The profile of cytokines produced by CD4 T cells is profoundly influenced by the presence of IL-12. Here we demonstrate that during re-stimulation of antigen-specific immune responses in vitro, antigen-primed lymph node cells from DBA/2 mice produced 3- to 30-fold more IL-12 than did cells from BALB/c mice, which are ...

journal_title：International immunology

authors： Gieni RS,Fang Y,Trinchieri G,Umetsu DT,DeKruyff RH

更新日期：1996-10-01 00:00:00

abstract：:The ability of cytokines to steer CD4(+) T(h) cell responses toward a T(h)1 or T(h)2 phenotype and enhance the magnitude of both CD8(+) cytotoxic T lymphocytes (CTL) and antibody responses has clearly been demonstrated by our lab and others, but the influence of cytokines on protective immune responses is much less cl...

journal_title：International immunology

authors： Ahlers JD,Belyakov IM,Matsui S,Berzofsky JA

更新日期：2001-07-01 00:00:00