Abstract:
:Unlike splenic B cells from normal BALB/c mice, those from autoimmune-prone NZB x NZW (B/W) F1 young mice were hyperresponsive to interleukin 2 (IL2) and proliferated even in the absence of prior stimulation signals. We found that the B cell subpopulation responsible for this event belongs to that with 6B2 (B220)-dull, Ly1(CD5)-positive phenotypes. Cell cycle analysis revealed that the 6B2-dull, Ly1 B cell subpopulation contains a significant number of cells at stages of G1A and G1B, while the majority of 6B2-bright B cells belongs to GO. Therefore, it appears that most of the 6B2-dull, Ly1 B cells in young B/W F1 mice are already stimulated in vivo to the stage of early activation, so that they respond to IL2 without prior stimuli. Unlike other strains of mice, including parental NZB and NZW, the B/W F1 mice showed a rapid decrease in the proportion of splenic Ly1 B cells, beginning at about 6 months of age. This was associated with the hyporesponsiveness to IL2 of 6B2-dull splenic B cell population in the old B/W F1 mice. This phenomenon seems to relate to further activation and differentiation, which occur in Ly1 B cells with aging.
journal_name
Int Immunoljournal_title
International immunologyauthors
Hasegawa K,Abe M,Okada T,Hirose S,Sato H,Shirai Tdoi
10.1093/intimm/1.1.99subject
Has Abstractpub_date
1989-01-01 00:00:00pages
99-103issue
1eissn
0953-8178issn
1460-2377journal_volume
1pub_type
杂志文章abstract::CD161(++)IL-18Rα(+)CD8(+) human T cells have recently been identified as a new subset of memory cells but their exact role remains unclear. CD161(++)IL-18Rα(+)CD8(+), mucosal-associated invariant T cells express a semi-invariant TCR Vα7.2-Jα33, which recognizes the MHC-related protein 1. On the basis of properties inc...
journal_title:International immunology
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journal_title:International immunology
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journal_title:International immunology
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pub_type: 杂志文章
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更新日期:1997-12-01 00:00:00
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pub_type: 杂志文章
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更新日期:1998-05-01 00:00:00
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pub_type: 杂志文章
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journal_title:International immunology
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journal_title:International immunology
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doi:10.1093/intimm/5.8.965
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pub_type: 杂志文章
doi:10.1093/intimm/dxh028
更新日期:2004-02-01 00:00:00
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journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/13.1.13
更新日期:2001-01-01 00:00:00
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journal_title:International immunology
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pub_type: 杂志文章
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更新日期:1996-11-01 00:00:00
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journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/8.1.65
更新日期:1996-01-01 00:00:00
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journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/6.3.355
更新日期:1994-03-01 00:00:00
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journal_title:International immunology
pub_type: 杂志文章
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更新日期:2009-01-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2002-01-01 00:00:00
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journal_title:International immunology
pub_type: 杂志文章
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更新日期:1996-07-01 00:00:00
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更新日期:1996-04-01 00:00:00