Mechanisms of cytokine synergy essential for vaccine protection against viral challenge.

abstract：:Ig are multifunctional molecules with distinct properties assigned to individual domains. To assess the importance of IgM domain assembly in B cell development we generated two transgenic mouse lines with truncated muH chains by homologous integration of the neomycin resistance gene (neo(r)) into exons C(mu)1 and C(mu...

journal_title：International immunology

authors： Zou X,Ayling C,Xian J,Piper TA,Barker PJ,Brüggemann M

更新日期：2001-12-01 00:00:00

abstract：:After a 3 week course (approximately), during which there is marked lymphoid hyperplasia, Trypanosoma musculi infections in young-adult mice are cured by an immune mechanism involving antibodies of the IgG2a isotype. Both the lymphoid hyperplasia and IgG2a antibody response are T-cell-dependent events and both process...

journal_title：International immunology

authors： Utsuyama M,Albright JW,Holmes KL,Hirokawa K,Albright JF

更新日期：1994-08-01 00:00:00

abstract：:Previous evidence from several laboratories suggests that CD8+ T suppressor cells may be important regulatory elements governing specific unresponsiveness of lepromatous lepromatous leprosy patients to M.leprae. To analyse the mechanism of suppression, CD8+ Ts clones were established from lesions and peripheral blood ...

journal_title：International immunology

authors： Salgame P,Modlin R,Bloom BR

更新日期：1989-01-01 00:00:00

abstract：:Linomide (LS-2616, quinoline-3-carboxamide) has strong immunomodulating effects in animal models, inhibiting toxic shock, progressive autoimmune disease and cancer. In humans, linomide strongly reduced the appearance of new lesions in multiple sclerosis yet enhanced immune responses after bone marrow transplantation. ...

journal_title：International immunology

authors： Arad G,Katzenellenbogen M,Levy R,Slavin S,Kaempfer R

更新日期：1996-10-01 00:00:00

abstract：:The contribution of the HLA-DRB1, -B3, and -B5 gene products in the recognition of Dermatophagoides spp. (house dust mite) by helper T cells isolated from an atopic individual (HLA-DRw12, DR7; DRw52b) with perennial rhinitis was investigated. Using a panel of histocompatible and histoincompatible accessory cells, the ...

journal_title：International immunology

authors： O'Hehir RE,Mach B,Berte C,Greenlaw R,Tiercy JM,Bal V,Lechler RI,Trowsdale J,Lamb JR

更新日期：1990-01-01 00:00:00

abstract：:IL-12 is a cytokine produced by monocytes and Epstein-Barr virus-transformed B cells which initiates Th1 responses by inducing the development of CD4+, IFN-gamma producing Th1 T cells in mouse and human. We have previously reported that allergen-specific CD4+ Th2 T cell clones produce IFN-gamma, following activation b...

journal_title：International immunology

authors： Yssel H,Fasler S,de Vries JE,de Waal Malefyt R

更新日期：1994-07-01 00:00:00

abstract：:The origin of cell activation in post-radiation fibrosis and its chronic extension are still poorly understood. Since local IL-2 cancer treatment sometimes triggers intraperitoneal fibrosis we have analyzed three myofibroblastic cell strains from post-radiation skin fibrosis (FPR7, FPR10 and FPR15) for their interacti...

journal_title：International immunology

authors： Alileche A,Han D,Plaisance S,Assier E,Sahraoui Y,Clemanceau C,Metivier D,Brouty-Boyer D,Jasmin C,Azzarone B

更新日期：1994-10-01 00:00:00

abstract：:Protein antigens elicit humoral responses in mice that consist predominantly of IgG1 antibodies. We have now investigated the ability of IL-12, a cytokine reported to augment IgG2a anti-hapten responses through activation of Th1 cells, to alter antibody responses to hen eggwhite lysozyme (HEL). The normal response of ...

journal_title：International immunology

authors： Buchanan JM,Vogel LA,Van Cleave VH,Metzger DW

更新日期：1995-09-01 00:00:00

abstract：:The co-existence of tumor specific immunity with a progressing tumor is observed in a variety of experimental systems and remains one of the major paradoxes of tumor immunology. We now report that a human melanoma cell line (SMC) expressing MHC class II was able to induce clonal anergy in a specific, MHC-restricted CD...

journal_title：International immunology

authors： Becker JC,Brabletz T,Czerny C,Termeer C,Bröcker EB

更新日期：1993-12-01 00:00:00

abstract：:The extravasation of recirculating lymphocytes into lymph nodes, which is crucial for immune system function, occurs constitutively from specialized post-capillary venules in the lymph node paracortex. The migration of lymphocytes between the structurally distinct high endothelial cells which line these blood vessels ...

journal_title：International immunology

authors： Ager A,Humphries MJ

更新日期：1990-01-01 00:00:00

abstract：:The regulation of MHC class II expression by the class II transactivator (CIITA) is complex and differs in various cell types depending on the relative activity of three CIITA promoters. Here we show that, in plasma cell tumors, the deacetylase inhibitor trichostatin A (TSA) elicits PIII-CIITA but does not activate th...

journal_title：International immunology

authors： Chou SD,Khan AN,Magner WJ,Tomasi TB

更新日期：2005-11-01 00:00:00

abstract：:Human intestinal intraepithelial lymphocytes (iIEL) are a unique population of predominantly CD8 alpha beta+, TCR alpha beta+ lymphocytes and, to a lesser extent, TCP gamma delta+ lymphocytes that proliferate poorly to anti-CD3 mitogenic signals but display significant cytolytic activity. Studies in mouse model system...

journal_title：International immunology

authors： Balk SP,Polischuk JE,Probert C,Stevens C,Ebert E,She J,Terhorst C,Blumberg RS

更新日期：1995-08-01 00:00:00

abstract：:NK cells are functionally controlled by the killer immunoglobulin-like receptor (KIR) family that comprises inhibitory (iKIR) and activating (aKIR) members. Genetic association studies suggest that donors expressing aKIRs next to iKIRs will be superior donors in the setting of hematopoietic stem cell transplantation o...

journal_title：International immunology

authors： Baltner K,Kübler A,Pal M,Balvociute M,Mezger M,Handgretinger R,André MC

更新日期：2017-11-01 00:00:00

abstract：:Auto-antibodies against heat shock proteins (HSPs) are frequently found in the sera of patients with rheumatic and other autoimmune diseases. However, it is unclear whether these auto-antibodies play a role in the pathophysiology and etiology of these diseases. We found that a murine anti-HSP60 mAb enhanced the produc...

journal_title：International immunology

authors： Yokota S,Minota S,Fujii N

更新日期：2006-04-01 00:00:00

abstract：:Dendritic cells (DCs) are specialized antigen-presenting cells that play pivotal roles in initiating immune responses. However, DC maturation is usually strongly restricted by the stromal microenvironment, especially in non-lymphoid tissues, such as skin and mucosa. Although suppression of DC maturation by stromal cel...

journal_title：International immunology

authors： Shiraishi H,Yoshida H,Saeki K,Miura Y,Watanabe S,Ishizaki T,Hashimoto M,Takaesu G,Kobayashi T,Yoshimura A

更新日期：2008-09-01 00:00:00

abstract：:CD6, a 130-kDa surface glycoprotein, is expressed primarily on cells of T lineage. A co-stimulatory role for CD6 in mature T cells has been shown, but the function of CD6 during thymocyte development is unknown. Since CD6 ligands are expressed on thymic epithelium, their interactions with CD6 could be important in thy...

journal_title：International immunology

authors： Singer NG,Fox DA,Haqqi TM,Beretta L,Endres JS,Prohaska S,Parnes JR,Bromberg J,Sramkoski RM

更新日期：2002-06-01 00:00:00

abstract：:Signal transducer and activator of transcription-1 (STAT1) signaling mediate most biological functions of IFNalpha, IFNbeta and IFNgamma although recent studies indicate that IFNgamma can alter expression of several genes via a STAT1-independent pathway. STAT1 is critical for immunity against a variety of intracellula...

journal_title：International immunology

authors： Roth KM,Gunn JS,Lafuse W,Satoskar AR

更新日期：2009-01-01 00:00:00

abstract：:Malaria infection induces the production of serum antibodies to a variety of malaria antigens but the prevalence of antibodies to any particular antigen is typically much less than 100%. It has been assumed that non-responsiveness to defined antigens in malaria immune subjects is due to HLS-mediated restriction of the...

journal_title：International immunology

authors： Taylor RR,Egan A,McGuinness D,Jepson A,Adair R,Drakely C,Riley E

更新日期：1996-06-01 00:00:00

abstract：:Dendritic cells (DC) are potent antigen-presenting cells and understanding their mechanisms of antigen uptake is important for loading DC with antigen for immunotherapy. The multilectin receptors, DEC-205 and macrophage mannose receptor (MMR), are potential antigen-uptake receptors; therefore, we examined their expres...

journal_title：International immunology

authors： Kato M,Neil TK,Fearnley DB,McLellan AD,Vuckovic S,Hart DN

更新日期：2000-11-01 00:00:00

abstract：:Defects of early complement components (C1, C4 and C2) are associated with the development of systemic lupus erythematosus (SLE). The availability of complement knockout mice has increased our knowledge on the role of complement in the regulation of adaptive immunity. An impaired removal of apoptotic bodies, a disturb...

journal_title：International immunology

authors： Zachrau B,Finke D,Kropf K,Gosink HJ,Kirchner H,Goerg S

更新日期：2004-12-01 00:00:00

abstract：:Our aim was to investigate the quantitative relationship between inoculation doses and physiological responses to infection by Salmonella enterica serovar Enteritidis. Rats were orally inoculated with 10-10(9) c.f.u. of S. Enteritidis and monitored for 6 days. Neutrophil and delayed-type hypersensitivity (DTH) respons...

journal_title：International immunology

authors： Takumi K,Garssen J,Havelaar A

更新日期：2002-02-01 00:00:00

abstract：:In this study, we explored the potential of human naive CD4(+) T cells to acquire regulatory properties upon stimulation. We demonstrated that, in vitro, pre-activated naive CD4(+)CD25(-)CD45RA(+) T cells could become anergic and suppressive CD4(+)CD25(+) T cells upon lower intensity TCR stimulation. These CD4(+)CD25(...

journal_title：International immunology

authors： Noël G,Brinster C,Semana G,Bruniquel D

更新日期：2009-09-01 00:00:00

abstract：:Intravenous sensitization of C57BL/6 (B6) mice with class II H-2-disparate B6-C-H-2bm12(bm12) resting B cells induced anti-bm12 CD4+ T cell tolerance as shown by hyporesponsiveness in the anti-bm12 mixed lymphocyte reaction (MLR). The present study investigated the mechanism(s) of the failure of bm12 B cells to stimul...

journal_title：International immunology

authors： Toyooka K,Maruo S,Iwahori T,Yamamoto N,Tai XG,Abe R,Takahama Y,Murakami M,Uede T,Hamaoka T,Fujiwara H

更新日期：1996-02-01 00:00:00

abstract：:Pathogenic intracellular bacteria often hijack macrophages for their propagation. The infected macrophages release IL-1β and IL-18 and simultaneously commit suicide, which is called pyroptosis; both responses require caspase-1. Here, we found that pyroptotic cells induced by microbial infection were efficiently engulf...

journal_title：International immunology

authors： Wang Q,Imamura R,Motani K,Kushiyama H,Nagata S,Suda T

更新日期：2013-06-01 00:00:00

abstract：:HLA-B*0702 transgenic mice (expressing a chimeric heavy chain with a murine alpha 3 domain: HLA-B7(m alpha 3)) in which the H-2K(b) and H-2D(b) class I-a (Cl I-a(-/-)) genes have been inactivated were compared with H-2K(b)D(b) Cl I-a(+/+) positive controls. Expression of the HLA-B7(m alpha 3) molecules resulted in a 3...

journal_title：International immunology

authors： Rohrlich PS,Cardinaud S,Firat H,Lamari M,Briand P,Escriou N,Lemonnier FA

更新日期：2003-06-01 00:00:00

abstract：:The extracellular signal-regulated kinase (ERK) signaling pathway is strongly activated in response to TCR stimulation in normal T cells. However, the extent to which activation of the ERK pathway is necessary for TCR-stimulated cytokine production is not clear. We have addressed this question by use of two separate m...

journal_title：International immunology

authors： Egerton M,Fitzpatrick DR,Kelso A

更新日期：1998-02-01 00:00:00

abstract：:Dendritic cells (DCs) are responsible for the initiation of immune responses. Our study demonstrates a new pathway for generating a large quantity of stimulatory monocyte-derived DCs (Mo-DCs) from human monocytes using anti-4-1BB ligand (4-1BBL) mAb to trigger reverse signaling. The anti-4-1BBL-driven Mo-DCs (DCs(alph...

journal_title：International immunology

authors： Ju S,Ju S,Ge Y,Qiu H,Lu B,Qiu Y,Fu J,Liu G,Wang Q,Hu Y,Shu Y,Zhang X

更新日期：2009-10-01 00:00:00

abstract：:We have recently described the novel A6H antigen expressed on human peripheral blood T cells and on renal cell carcinoma cells. Cross-linking of the A6H antigen results in co-stimulation of human CD4(+) T cells, characterized by induction of the transcription factor activator protein-1 (AP-1), proliferation and promin...

journal_title：International immunology

authors： Labuda T,Sundstedt A,Dohlsten M

更新日期：2000-03-01 00:00:00

abstract：:HLA class II molecules present superantigens more efficiently than their murine counterpart. Therefore, transgenic mice expressing HLA-DQ8 with and without CD28 were used to address the role of CD28 in staphylococcal enterotoxin B (SEB)-driven immune responses. SEB-induced in vitro proliferation of naive DQ8.CD28(-/-)...

journal_title：International immunology

authors： Rajagopalan G,Smart MK,Marietta EV,David CS

更新日期：2002-07-01 00:00:00

abstract：:The endocytic and phagocytic activities of a population of MHC IIhi CD11c+ dendritic cell (DC)-like cells in synovium-rich tissues (SRTs) of normal rat paws were compared with CD163+ cells (putative macrophages) from the same tissues and pseudo-afferent lymph DCs, peritoneal macrophages and blood monocytes. Fifty perc...

journal_title：International immunology

authors： Moghaddami M,Mayrhofer G,Cleland LG

更新日期：2005-08-01 00:00:00