On the mechanism of human T cell suppression.


:Previous evidence from several laboratories suggests that CD8+ T suppressor cells may be important regulatory elements governing specific unresponsiveness of lepromatous lepromatous leprosy patients to M.leprae. To analyse the mechanism of suppression, CD8+ Ts clones were established from lesions and peripheral blood of lepromatous patients and tested for ability to suppress antigen-responsive CD4+. Th clones or PBL. Suppression required induction by specific M.leprae antigen, but was effected in an antigen-non-specific fashion. The Ts clones failed to exhibit cytotoxicity of four antigen-exposed MHC-matched target cells: (i) an ori-SV40 transformed macrophage line; (ii) EBV transformed B cell lines; (iii) primary macrophages; and (iv) M.leprae responsive CD4+ cells. The possibility that Ts clones induce functional inactivation of CD4+ clones in vitro was investigated. M.leprae-responsive CD4+ clones were preincubated with Ts CD8+ clones, APC, and antigen for 16 h, after which the CD8+ cells were removed. The CD4+ clones with M.leprae and APC remained unresponsive to restimulation with APC and antigen for at least 10 days, although they responded to IL-2. Addition of IL-2 to the pre- or post-incubation cultures neither prevented the induction of unresponsiveness, nor reversed it. Earlier models of tolerance have suggested that receptor occupancy in the absence of second signals induces tolerance in B and T cells. Under conditions in which antigen responses of Th clones were HLA-DR-restricted, the Ts clones were able to suppress the response of DR mismatched Th clones. Thus, the effect of the Ts cells, like mechanisms requiring antigen presentation without a second signal, appears to be induction of clonal anergy in Th cells, perhaps by a novel mechanism.


Int Immunol


International immunology


Salgame P,Modlin R,Bloom BR




Has Abstract


1989-01-01 00:00:00












  • Expression of I mu-C gamma hybrid germline transcripts subsequent to immunoglobulin heavy chain class switching.

    abstract::Germline CH transcripts initiate from a non-coding I exon and terminate downstream of the associated CH exons. Ig heavy chain class switch recombination from the VDJ-C mu gene to particular downstream CH genes appears to be regulated by a process that involves mitogen and/or cytokine induction of germline CH transcrip...

    journal_title:International immunology

    pub_type: 杂志文章


    authors: Li SC,Rothman PB,Zhang J,Chan C,Hirsh D,Alt FW

    更新日期:1994-04-01 00:00:00

  • Human CD8 co-receptor is strictly involved in MHC-peptide tetramer-TCR binding and T cell activation.

    abstract::Although there has been extensive analysis on the capacity of MHC-peptide tetramers to bind antigen-specific TCR, there have been comparatively few studies regarding the role of the CD4 and CD8 co-receptors in binding and activation by these multimeric molecules. Here, we start from the observation that different anti...

    journal_title:International immunology

    pub_type: 杂志文章


    authors: Campanelli R,Palermo B,Garbelli S,Mantovani S,Lucchi P,Necker A,Lantelme E,Giachino C

    更新日期:2002-01-01 00:00:00

  • Unique and conserved functions of B cell-activating factor of the TNF family (BAFF) in the chicken.

    abstract::The chicken represents the best-characterized animal model for B cell development in the so-called gut-associated lymphoid tissue (GALT) and the molecular processes leading to B cell receptor diversification in this species are well investigated. However, the mechanisms regulating B cell development and homeostasis in...

    journal_title:International immunology

    pub_type: 杂志文章


    authors: Kothlow S,Morgenroth I,Graef Y,Schneider K,Riehl I,Staeheli P,Schneider P,Kaspers B

    更新日期:2007-02-01 00:00:00

  • CD4 T cells inhibit the CD8 T cell response during low-dose virus infection.

    abstract::CD4 T cells are not thought to play a significant role in generating an effective primary CD8 T cell response to most viral infections. We have challenged this view by demonstrating that antigen-specific CD4 T cells can indeed suppress the proliferation of antigen-specific naive CD8 T cells in response to low doses of...

    journal_title:International immunology

    pub_type: 杂志文章


    authors: Cose S,Brammer C,Zammit DJ,Blair DA,Lefrançois L

    更新日期:2006-08-01 00:00:00

  • Characterization of dendritic-like cells derived from t(9;22) acute lymphoblastic leukemia blasts.

    abstract::We asked herein whether functional dendritic-like cells could be generated from t(9;22) acute lymphoblastic leukemia (ALL) blasts. We first determined that the combination of interleukin (IL)-1beta, IL-3, IL-7, tumor necrosis factor-alpha, stem cell factor and CD40 ligand was optimal for generating dendritic-like cell...

    journal_title:International immunology

    pub_type: 杂志文章


    authors: Lee J,Sait SN,Wetzler M

    更新日期:2004-10-01 00:00:00

  • Differentiation and diversity of subsets in group 1 innate lymphoid cells.

    abstract::NK cells were first identified in 1975 and represent the prototypical group 1 innate lymphoid cell (ILC). More recently, the discovery of new members of the ILC family has highlighted the complexity of this innate lymphoid lineage. Importantly, it has been recognized that different subsets exist within the group 1 ILC...

    journal_title:International immunology

    pub_type: 杂志文章,评审


    authors: Seillet C,Belz GT

    更新日期:2016-01-01 00:00:00

  • Cloning and sequence analysis of a novel beta 2-related integrin transcript from T lymphocytes: homology of integrin cysteine-rich repeats to domain III of laminin B chains.

    abstract::The integrins have been grouped into three subfamilies based on the utilization of three distinct beta chain subunits, beta 1, beta 2, and beta 3. The recent discovery of beta 4 and beta 5 subunits, and the sharing of alpha subunits between beta subfamilies reflects a greater structural and functional diversity of the...

    journal_title:International immunology

    pub_type: 杂志文章


    authors: Yuan QA,Jiang WM,Krissansen GW,Watson JD

    更新日期:1990-01-01 00:00:00

  • Purification and functional properties of soluble forms of membrane cofactor protein (CD46) of complement: identification of forms increased in cancer patients' sera.

    abstract::Normal human sera contained 10-60 ng/ml of soluble membrane cofactor protein (MCP, CD46) whereas sera of > 50% of the cancer patients contained > 60 ng/ml. MCP purified by immunoaffinity chromatography from both normal and cancer patients' sera consisted of three bands of 56, 47 and 29 kDa on SDS-PAGE/immunoblotting. ...

    journal_title:International immunology

    pub_type: 杂志文章


    authors: Seya T,Hara T,Iwata K,Kuriyama S,Hasegawa T,Nagase Y,Miyagawa S,Matsumoto M,Hatanaka M,Atkinson JP

    更新日期:1995-05-01 00:00:00

  • Distinct gut-derived lactic acid bacteria elicit divergent dendritic cell-mediated NK cell responses.

    abstract::Lactic acid bacteria (LAB) are abundant in the gastrointestinal tract where they continuously regulate the immune system. NK cells are potently activated by dendritic cells (DCs) matured by inflammatory stimuli, and NK cells are present in the gut epithelium and in mesenteric lymph nodes, but it is not known how NK-DC...

    journal_title:International immunology

    pub_type: 杂志文章


    authors: Fink LN,Zeuthen LH,Christensen HR,Morandi B,Frøkiaer H,Ferlazzo G

    更新日期:2007-12-01 00:00:00

  • Rag-1: a topoisomerase?

    abstract::Recombination activating genes Rag-1 and Rag-2 were isolated on the basis of their ability to confer V(D)J recombination activity when co-expressed in fibroblasts. The mode of action of the confer V(D)J recombination activity when co-expressed in fibroblasts. The mode of action of the products of these genes is not kn...

    journal_title:International immunology

    pub_type: 杂志文章


    authors: Kallenbach S,Brinkmann T,Rougeon F

    更新日期:1993-02-01 00:00:00

  • Fas deficiency in mice with the Balb/c background induces blepharitis with allergic inflammation and hyper-IgE production in conjunction with severe autoimmune disease.

    abstract::Fas (CD95) is a cell surface death receptor belonging to the tumor necrosis factor receptor superfamily, which mediates apoptosis-inducing signaling when activated by Fas ligand or its agonistic antibody. lpr mice with a loss of apoptosis-inducing function mutation in the Fas gene develop systemic autoimmune disease a...

    journal_title:International immunology

    pub_type: 杂志文章


    authors: Takahashi S,Futatsugi-Yumikura S,Fukuoka A,Yoshimoto T,Nakanishi K,Yonehara S

    更新日期:2013-05-01 00:00:00

  • Distinct indirect pathways govern human NK-cell activation by TLR-7 and TLR-8 agonists.

    abstract::NK cells limit the emergence of cancers and viral infections by surveillance of 'missing-self' and 'induced-self' ligands, and by direct recognition of pathogen-associated molecules. We examined individual roles for Toll-like receptors (TLRs)-7 and -8 in human NK-cell activation using synthetic, small molecule agonist...

    journal_title:International immunology

    pub_type: 杂志文章


    authors: Gorski KS,Waller EL,Bjornton-Severson J,Hanten JA,Riter CL,Kieper WC,Gorden KB,Miller JS,Vasilakos JP,Tomai MA,Alkan SS

    更新日期:2006-07-01 00:00:00

  • Unique biomarkers for B-cell function predict the serum response to pandemic H1N1 influenza vaccine.

    abstract::In order to develop predictive markers for a beneficial humoral immune response, we evaluated the in vivo and in vitro response to the pandemic (p)H1N1 vaccine in young and elderly individuals. We measured serum antibody response and associated this with the in vitro B-cell response to the vaccine, measured by activat...

    journal_title:International immunology

    pub_type: 杂志文章


    authors: Frasca D,Diaz A,Romero M,Phillips M,Mendez NV,Landin AM,Blomberg BB

    更新日期:2012-03-01 00:00:00

  • MHC class II and invariant chain biosynthesis and transport during maturation of human precursor dendritic cells.

    abstract::Dendritic cells (DC) are highly potent activators of the immune response. The precise mechanisms that give rise to the DC phenotype are not known. To investigate the mechanisms that contribute to the generation of the DC phenotype, precursor DC were freshly isolated from human blood and allowed to mature in vitro. The...

    journal_title:International immunology

    pub_type: 杂志文章


    authors: Engering AJ,Richters CD,Fluitsma DM,van Pelt AM,Kamperdijk EW,Hoefsmit EC,Pieters J

    更新日期:1998-11-01 00:00:00

  • Role of the CD5 molecule on TCR gammadelta T cell-mediated immune functions: development of germinal centers and chronic intestinal inflammation.

    abstract::Although CD4(+) T cells form a major subset of TCRalphabeta T cells, only a small number of TCRgammadelta T cells express CD4. Factors contributing to the down-regulation of CD4(+) TCRgammadelta T cells have not been identified. The CD5 molecule is expressed on most TCRgammadelta T cells in the spleen, whereas only a ...

    journal_title:International immunology

    pub_type: 杂志文章


    authors: Mizoguchi A,Mizoguchi E,de Jong YP,Takedatsu H,Preffer FI,Terhorst C,Bhan AK

    更新日期:2003-01-01 00:00:00

  • Truncation of the mu heavy chain alters BCR signalling and allows recruitment of CD5+ B cells.

    abstract::Ig are multifunctional molecules with distinct properties assigned to individual domains. To assess the importance of IgM domain assembly in B cell development we generated two transgenic mouse lines with truncated muH chains by homologous integration of the neomycin resistance gene (neo(r)) into exons C(mu)1 and C(mu...

    journal_title:International immunology

    pub_type: 杂志文章


    authors: Zou X,Ayling C,Xian J,Piper TA,Barker PJ,Brüggemann M

    更新日期:2001-12-01 00:00:00

  • Transforming growth factor-beta 1 enhances IgG and IgA sheep red blood cell responses.

    abstract::Antibody responses to ingested antigens can be inhibited by a mechanism known as oral tolerance which acts to prevent excessive stimulation from luminal contents. Local IgA responses can be induced in this non-responsive environment and during intestinal inflammation, mucosal IgG responses can also be increased. The p...

    journal_title:International immunology

    pub_type: 杂志文章


    authors: Zettel L,Clark DA,Ernst PB

    更新日期:1992-09-01 00:00:00

  • IL-7 transgenic mice: analysis of the role of IL-7 in the differentiation of thymocytes in vivo and in vitro.

    abstract::We have generated a high copy number transgenic mouse line in which expression of mouse IL-7 cDNA is under the control of the mouse MHC class II E alpha promoter. These mice were generated in order to see if IL-7 over-production in the thymus altered either thymocyte differentiation or the process of negative selectio...

    journal_title:International immunology

    pub_type: 杂志文章


    authors: Mertsching E,Burdet C,Ceredig R

    更新日期:1995-03-01 00:00:00

  • Blocking of IL-6 signaling pathway prevents CD4+ T cell-mediated colitis in a T(h)17-independent manner.

    abstract::Naive CD4(+) T cells rapidly proliferate to generate effector cells after encountering an antigen and small numbers survive as memory T cells in preparation for future immunological events. In the present work, adoptive transfer of naive CD4(+) T cells into RAG2(-/-) mice caused the generation of memory-type effector ...

    journal_title:International immunology

    pub_type: 杂志文章


    authors: Noguchi D,Wakita D,Tajima M,Ashino S,Iwakura Y,Zhang Y,Chamoto K,Kitamura H,Nishimura T

    更新日期:2007-12-01 00:00:00

  • Differential production of IL-12 in BALB/c and DBA/2 mice controls IL-4 versus IFN-gamma synthesis in primed CD4 lymphocytes.

    abstract::The profile of cytokines produced by CD4 T cells is profoundly influenced by the presence of IL-12. Here we demonstrate that during re-stimulation of antigen-specific immune responses in vitro, antigen-primed lymph node cells from DBA/2 mice produced 3- to 30-fold more IL-12 than did cells from BALB/c mice, which are ...

    journal_title:International immunology

    pub_type: 杂志文章


    authors: Gieni RS,Fang Y,Trinchieri G,Umetsu DT,DeKruyff RH

    更新日期:1996-10-01 00:00:00

  • Activation of mast cells by incorporation of cholesterol into rafts.

    abstract::IgE plus antigen-stimulated mast cells degranulate, synthesize leukotrienes and secrete cytokines. According to the coalescence model this process is initiated in specific membrane compartments termed rafts. There, enhanced levels of glycosphingolipids and cholesterol stabilize the interaction of FcepsilonRI and Lyn, ...

    journal_title:International immunology

    pub_type: 杂志文章


    authors: Baumruker T,Csonga R,Pursch E,Pfeffer A,Urtz N,Sutton S,Bofill-Cardona E,Cooke M,Prieschl E

    更新日期:2003-10-01 00:00:00

  • Isoforms of the class II transactivator protein.

    abstract::The class II transactivator (CIITA) controls both the constitutive and IFN-gamma inducible expression of HLA-D genes. In addition, through the squelching of another transactivator CREB-binding protein, CIITA was more recently shown to have a wider cellular function, including cell cycle control or cellular response to...

    journal_title:International immunology

    pub_type: 杂志文章


    authors: Barbieri G,Deffrennes V,Prod'homme T,Vedrenne J,Baton F,Cortes C,Fischer A,Bono MR,Lisowska-Grospierre B,Charron D,Alcaïde-Loridan C

    更新日期:2002-08-01 00:00:00

  • Involvement of CD100, a lymphocyte semaphorin, in the activation of the human immune system via CD72: implications for the regulation of immune and inflammatory responses.

    abstract::CD100/Sema4D belongs to the semaphorin family, factors known to act as repulsive cues for axons during neuronal development. Mouse CD100 plays a crucial role in both humoral and cellular immunity through ligation of the lymphocyte receptor, CD72. It remains controversial, however, whether human CD100 can function thro...

    journal_title:International immunology

    pub_type: 杂志文章


    authors: Ishida I,Kumanogoh A,Suzuki K,Akahani S,Noda K,Kikutani H

    更新日期:2003-08-01 00:00:00

  • HLA-G functions as a restriction element and a transplantation antigen in mice.

    abstract::HLA-G, a human MHC class I molecule expressed on the trophoblast during pregnancy, was expressed in transgenic mice by recombining the HLA-G gene with a transcriptional promoter from a murine H-2 MHC class I gene. Skin grafts from HLA-G transgenic mice were rejected by non-transgenic mice showing that HLA-G behaves as...

    journal_title:International immunology

    pub_type: 杂志文章


    authors: Horuzsko A,Antoniou J,Tomlinson P,Portik-Dobos V,Mellor AL

    更新日期:1997-05-01 00:00:00

  • Characterization of constitutive and strain-dependent subsets of CD45RA+ cells in the thymus.

    abstract::We have previously shown that the occurrence of CD45RA+ adult mouse thymocytes is strain-dependent, e.g. constituting approximately 0.6% in C57BL/Icrf and approximately 2.5% in BALB/c (Huby, R. and Goff, L., 1992. Eur. J. Immunol. 22:1659). Here we show that irrespective of strain, the thymus contains approximately 0....

    journal_title:International immunology

    pub_type: 杂志文章


    authors: Goff LK,Huby RD

    更新日期:1992-11-01 00:00:00

  • CD154-CD40-independent up-regulation of B7-2 on splenic antigen-presenting cells and efficient T cell priming by staphylococcal enterotoxin A.

    abstract::It has been demonstrated that in vivo T cell priming requires CD154-CD40 interaction, which is suggested to be critical in the induction of co-stimulatory activities on antigen-presenting cells (APC). In the current study, we demonstrate that in vivo administration of a high dose of a superantigen, staphylococcal ente...

    journal_title:International immunology

    pub_type: 杂志文章


    authors: Eshima K,Choi Y,Flavell RA

    更新日期:2003-07-01 00:00:00

  • Targeting CD45RB alters T cell migration and delays viral clearance.

    abstract::CD45 is a receptor tyrosine phosphatase essential for TCR signaling. One isoform, CD45RB, is down-regulated in memory cells and targeting CD45RB with a specific antibody has been shown to inhibit graft rejection. Its role in immunity to infection, however, has not been tested. Here, we report the effect of anti-CD45RB...

    journal_title:International immunology

    pub_type: 杂志文章


    authors: Lim B,Sutherland RM,Zhan Y,Deliyannis G,Brown LE,Lew AM

    更新日期:2006-02-01 00:00:00

  • The cytoplasmic 'linker region' in Toll-like receptor 3 controls receptor localization and signaling.

    abstract::Toll-like receptor 3 (TLR3) recognizes double-stranded RNA and transmits signals to activate NF-kappaB and the interferon (IFN)-beta promoter via the newly identified adaptor, TICAM-1. The extracellular LRR domain of TLR3 is engaged in the ligand recognition, while the intracellular TIR domain is crucial for the adapt...

    journal_title:International immunology

    pub_type: 杂志文章


    authors: Funami K,Matsumoto M,Oshiumi H,Akazawa T,Yamamoto A,Seya T

    更新日期:2004-08-01 00:00:00

  • Phenotype of B cells responding to the thymus-independent type-2 antigen polyvinyl pyrrolidinone.

    abstract::We have determined the origin and cell surface phenotype of B cells producing antibody in response to immunization with the non-self TI-2 antigen polyvinyl pyrrolidinone (PVP). We report that the responding cells are derived from precursors in adult bone marrow and display the phenotype characteristic of B-1 cells. By...

    journal_title:International immunology

    pub_type: 杂志文章


    authors: Whitmore AC,Haughton G,Arnold LW

    更新日期:1996-04-01 00:00:00

  • Immune regulatory effects of central nervous system antigens in culture.

    abstract::Evidence from several different experimental systems suggests that regulatory cells specific for self-antigens exist in the normal immune repertoire, and that these cells are necessary for maintenance of self-tolerance and prevention of autoimmune disease. We attempted to demonstrate the existence of regulatory cells ...

    journal_title:International immunology

    pub_type: 杂志文章


    authors: Lindsey JW,Jin R

    更新日期:2000-11-01 00:00:00