Modulation of CD4 co-receptor limits spontaneous autoimmunity when high-affinity transgenic TCR specific for self-antigen is expressed on a genetically resistant background.

abstract：:Activation of T cells leads to the induction of many cytokine genes that are required for appropriate immune responses, including IL-2, a key cytokine for T cell proliferation and homeostasis. The activating transcription factors such as nuclear factor of activated T cells, nuclear factor kappaB/Rel and activated prot...

journal_title：International immunology

authors： Wang J,Lee S,Teh CE,Bunting K,Ma L,Shannon MF

更新日期：2009-03-01 00:00:00

abstract：:Immunoglobulin affinity maturation depends on somatic hypermutation (SHM) in immunoglobulin variable (IgV) regions initiated by activation-induced cytidine deaminase (AID). AID induces transition mutations by C→U deamination on both strands, causing C:G→T:A. Error-prone repairs of U by base excision and mismatch repai...

journal_title：International immunology

authors： Eid MMA,Shimoda M,Singh SK,Almofty SA,Pham P,Goodman MF,Maeda K,Sakaguchi N

更新日期：2017-05-01 00:00:00

abstract：:A novel system to study the effects of co-cross-linking CD23/FceRII and sIg on murine B lymphocytes utilizes a highly multivalent form of anti-Ig prepared by covalently linking anti-Ig antibodies to a DNP-dextran backbone. CD23-sIg co-cross-linking is accomplished by the addition of DNP-specific monoclonal IgE. Previo...

journal_title：International immunology

authors： Campbell KA,Studer EJ,Kilmon MA,Lees A,Finkelman F,Conrad DH

更新日期：1997-08-01 00:00:00

abstract：:Earlier studies have demonstrated an over-expression of 9-O-acetylated sialoglycoconjugates (9-OAcSGs) on lymphoblasts, concomitant with high titers of anti-9-OAcSGs in childhood acute lymphoblastic leukemia (ALL). The present study was aimed to evaluate whether this high induction of anti-9-OAcSGs at disease presenta...

journal_title：International immunology

authors： Bandyopadhyay S,Bhattacharyya A,Mallick A,Sen AK,Tripathi G,Das T,Sa G,Bhattacharya DK,Mandal C

更新日期：2005-02-01 00:00:00

abstract：:Chemokine receptors (CCRs) are important co-stimulatory molecules found on many blood cells and associated with various diseases. The expression and function of CCRs on mast cells has been quite controversial. In this study, we report for the first time that murine bone marrow-derived mast cells (BMMC) express messeng...

journal_title：International immunology

authors： Fifadara NH,Aye CC,Raghuwanshi SK,Richardson RM,Ono SJ

更新日期：2009-08-01 00:00:00

abstract：:Amongst CD4-CD8- (double negative) thymocytes there is a sizeable population (variable from strain to strain) of cells expressing surface T cell receptor (TCR). These TCR+ double negatives are predominantly non-cycling, have very little precursor activity, and, unlike the TCR-CD4-CD8- thymocytes, appear not to be part...

journal_title：International immunology

authors： Wu L,Pearse M,Egerton M,Petrie H,Scollay R

更新日期：1990-01-01 00:00:00

abstract：:'Programmed cell death' has been used to describe the death of cells killed by cytotoxic T cells or growth factor deprivation. Although bcl-2 can prevent death of cells deprived of growth factor, it failed to protect cells against T cell killing. In spite of bcl-2 expression, the DNA of targeted cells was degraded int...

journal_title：International immunology

authors： Vaux DL,Aguila HL,Weissman IL

更新日期：1992-07-01 00:00:00

abstract：:Novel biomarkers of rheumatoid arthritis (RA), in addition to antibodies against cyclic citrullinated peptides, are required. Metabolome analysis is a promising approach to identify metabolite biomarkers for clinical diagnosis. We adopted a comprehensive nontargeted metabolomics approach combining capillary electropho...

journal_title：International immunology

authors： Kishikawa T,Maeda Y,Nii T,Arase N,Hirata J,Suzuki K,Yamamoto K,Masuda T,Ogawa K,Tsuji S,Matsushita M,Matsuoka H,Yoshimura M,Tsunoda S,Ohshima S,Narazaki M,Ogata A,Saeki Y,Inohara H,Kumanogoh A,Takeda K,Okada Y

更新日期：2020-08-31 00:00:00

abstract：:Three MHC class II-derived synthetic peptides (I-A beta (g7)1-16, I-A beta (g7)52-77 and I-A alpha (g7)63-82YC) were analyzed for their ability to bind to syngeneic and allogeneic MHC class II molecules using a whole cell, competitive peptide binding assay. These studies demonstrated that the A beta (g7)1-16 peptide w...

journal_title：International immunology

authors： Feili-Hariri M,Kao H,Mietzner TA,Morel PA

更新日期：1996-12-01 00:00:00

abstract：:The signaling lymphocytic activation molecule (SLAM) receptor-associated adaptor Ewing's sarcoma-associated transcript-2 (EAT-2) is primarily expressed in innate immune cells including dendritic cells (DCs), macrophages and NK cells. A recent human HIV vaccine study confirmed that EAT-2 expression was associated with ...

journal_title：International immunology

authors： Aldhamen YA,Seregin SS,Aylsworth CF,Godbehere S,Amalfitano A

更新日期：2014-05-01 00:00:00

abstract：:House dust mite (HDM) is a common allergen of allergic asthma. Eosinophils are principal effector cells of allergic inflammation and their adhesion onto human bronchial epithelial cells is mediated by a CD18-intracellular adhesion molecule-1 (ICAM-1)-dependent interaction. We studied the effects of HDM Dermatophagoide...

journal_title：International immunology

authors： Wong CK,Li ML,Wang CB,Ip WK,Tian YP,Lam CW

更新日期：2006-08-01 00:00:00

abstract：:Lipid mediators, such as prostanoids and leukotrienes (LTs), exert a range of actions through their own receptors on cell surfaces in various pathophysiological conditions. It has been reported that the production of prostanoids and LTs is significantly elevated in the skin lesions of some chronic inflammatory skin di...

journal_title：International immunology

authors： Honda T,Kabashima K

更新日期：2019-08-23 00:00:00

abstract：:NOD mice spontaneously develop type I diabetes resulting from autoimmune destruction of their insulin-producing beta cells. Among the self-antigens targeted by NOD autoimmune T cells is a peptide, p277, from the sequence of the 60 kDa heat shock protein (hsp60). Common to the anti-p277 T cell populations of NOD mice i...

journal_title：International immunology

authors： Elias D,Tikochinski Y,Frankel G,Cohen IR

更新日期：1999-06-01 00:00:00

abstract：:Several cis-acting elements regulate the expression of germline transcripts of heavy chain constant region genes and their subsequent switch recombination. To study such elements in the murine gamma1 gene, we have utilized a transgenic approach. In this study we focused on a DNase I hypersensitive site (termed 'Site I...

journal_title：International immunology

authors： Adams K,Ackerly H,Cunningham K,Dunnick W

更新日期：2000-12-01 00:00:00

abstract：:Organs of transgenic pigs that express human complement regulatory proteins are under assessment as an alternative to transplantation. A major barrier to the transplantation of pig organs is the hyperacute rejection caused by pre-existing antibodies and complement. Pig cells are very susceptible to human complement, p...

journal_title：International immunology

authors： Toyomura K,Fujimura T,Murakami H,Natsume T,Shigehisa T,Inoue N,Takeda J,Kinoshita T

更新日期：1997-06-01 00:00:00

abstract：:Schnurri (Shn)-2 is a large zinc finger-containing protein, which plays a critical role in cell growth, signal transduction and lymphocyte development. In Shn-2-deficient (Shn-2(-/-)) CD4 T cells, the activation of nuclear factor-kappaB is up-regulated and their ability to differentiate into Th2 is enhanced. Here, we ...

journal_title：International immunology

authors： Iwamura C,Kimura MY,Shinoda K,Endo Y,Hasegawa A,Yamashita M,Nakayama T

更新日期：2007-06-01 00:00:00

abstract：:Notch2 and Delta-like 1 (Dll1) have been implicated in the development of marginal zone B (MZB) cells. In the present study, we characterized the expression and function of mouse Notch receptors and ligands in the spleen by using newly generated mAbs. Although Notch2 was expressed on both B and T cells in the spleen, ...

journal_title：International immunology

authors： Moriyama Y,Sekine C,Koyanagi A,Koyama N,Ogata H,Chiba S,Hirose S,Okumura K,Yagita H

更新日期：2008-06-01 00:00:00

abstract：:Murine bone marrow-derived macrophages (BMM) are able to inhibit the intracellular growth of Mycobacterium bovis and Mycobacterium tuberculosis H37Rv after activation with recombinant (r) IFN and growth inhibition is mediated by reactive nitrogen intermediates (RNI) derived from L-arginine. We now demonstrate that tum...

journal_title：International immunology

authors： Flesch IE,Hess JH,Oswald IP,Kaufmann SH

更新日期：1994-05-01 00:00:00

abstract：:We investigated the role of IL-7 receptor alpha (IL-7Ralpha) signal in the formation of Peyer's patch (PP) anlage. Although pan-lymphopenia is a common phenotype of rag2-/- and il7ralpha-/- mice, a close inspection revealed nodules corresponding to PP in the adult rag2-/- but not in the il7ralpha-/- mouse. In our prev...

journal_title：International immunology

authors： Adachi S,Yoshida H,Honda K,Maki K,Saijo K,Ikuta K,Saito T,Nishikawa SI

更新日期：1998-01-01 00:00:00

abstract：:A subclone (160b) of the human B cell (Karpas 160) was shown to produce a novel cytotoxic lymphokine [Factor 2 (F2)] in addition to tumour necrosis factor alpha (TNF-alpha) and beta (TNF-beta). F2 was found to have selective toxicity to numerous human tumour cell lines, particularly the erythroleukaemic cell line K562...

journal_title：International immunology

authors： Ni J,Meager A,Karpas A

更新日期：1992-04-01 00:00:00

abstract：:Analysis of immunoglobulin expression in mice transgenic for either a kappa light chain (driven by the kappa enhancer) or lambda light chain (driven by the IgH enhancer) revealed that the transgenic light chains are expressed by the majority of B lymphocytes in the neonatal mice. However, the proportion of B cells tha...

journal_title：International immunology

authors： Pettersson S,Sharpe MJ,Gilmore DR,Surani MA,Neuberger MS

更新日期：1989-01-01 00:00:00

abstract：:Myasthenia gravis (MG) is an autoimmune disease, caused by autoantibodies against the muscle acetylcholine receptor (AChR), an oligomeric transmembrane glycoprotein composed of alpha(2)beta gamma delta subunits. The alpha subunit carries in its N-terminal extracellular domain the main immunogenic region (MIR), a group...

journal_title：International immunology

authors： Tsouloufis T,Mamalaki A,Remoundos M,Tzartos SJ

更新日期：2000-09-01 00:00:00

abstract：:We report here that different organ grafts are not equally competent to induce tolerance of the host even if they are performed early in development, i.e. before the host's immune system has started to develop. We have grafted the epithelio-mesenchymal rudiment of the bursa of Fabricius between histoincompatible chick...

journal_title：International immunology

authors： Martin C,Belo M,Le Douarin NM,Corbel C

更新日期：1994-06-01 00:00:00

abstract：:Pathogenic intracellular bacteria often hijack macrophages for their propagation. The infected macrophages release IL-1β and IL-18 and simultaneously commit suicide, which is called pyroptosis; both responses require caspase-1. Here, we found that pyroptotic cells induced by microbial infection were efficiently engulf...

journal_title：International immunology

authors： Wang Q,Imamura R,Motani K,Kushiyama H,Nagata S,Suda T

更新日期：2013-06-01 00:00:00

abstract：:CD9 is a member of the tetraspanin superfamily which is characterized by four transmembrane (TM) domains and associates with other surface molecules. This tetraspanin was recently found to be expressed on mature T cells. Here, we investigated which molecules associate with CD9 on T cells and which CD9 domains are requ...

journal_title：International immunology

authors： Toyo-oka K,Yashiro-Ohtani Y,Park CS,Tai XG,Miyake K,Hamaoka T,Fujiwara H

更新日期：1999-12-01 00:00:00

abstract：:Intracellular signaling triggered by the antigen receptor of primary B-1 (CD5+ B) lymphocytes is insufficient to bring about cell cycle progression to S phase; this appears to result from a block in signal propagation prior to the activation of protein kinase C. The present studies were undertaken to evaluate specific...

journal_title：International immunology

authors： Morris DL,Rothstein TL

更新日期：1994-07-01 00:00:00

abstract：:Autoimmune gastritis is a CD4+ T cell-mediated disease induced in genetically susceptible mice by thymectomy on the third day after birth. Previous linkage analysis indicated that Gasa1 and Gasa2, the major susceptibility loci for gastritis, are located on mouse chromosome 4. Here we verified these linkage data by sho...

journal_title：International immunology

authors： Ang DK,Brodnicki TC,Jordan MA,Wilson WE,Silveira P,Gliddon BL,Baxter AG,van Driel IR

更新日期：2007-09-01 00:00:00

abstract：:Natural cytotoxicity receptors and NKG2D correspond to major activating receptors involved in triggering of tumor cell lysis by human NK cells. In this report, we investigated the expression of NKG2D ligands (NKG2DLs), MHC class I-related chain (MIC) A, MICB and UL16-binding proteins 1, 2 and 3, on a panel of human no...

journal_title：International immunology

authors： Le Maux Chansac B,Missé D,Richon C,Vergnon I,Kubin M,Soria JC,Moretta A,Chouaib S,Mami-Chouaib F

更新日期：2008-07-01 00:00:00

abstract：:The two-signal model states that activation of naive T cells requires a signal 1 stimulus through the TCR and a co-stimulatory signal 2. By contrast, signal 1 alone is sufficient for pre-activated T cells. Recently, however, it has been shown that under certain conditions T cells can bypass the requirement for co-stim...

journal_title：International immunology

authors： Pardigon N,Bercovici N,Calbo S,Santos-Lima EC,Liblau R,Kourilsky P,Abastado JP

更新日期：1998-05-01 00:00:00

abstract：:The chaperone glucose-regulated protein 94 (GRP94) has long been used to augment peptide presentation to T cells. This chaperone binds antigenic peptides, binds to receptors on professional antigen-presenting cells (APCs), activates these cells and after internalization, transfers the peptides to MHC class I for activ...

journal_title：International immunology

authors： Biswas C,Sriram U,Ciric B,Ostrovsky O,Gallucci S,Argon Y

更新日期：2006-07-01 00:00:00