TRAF6 is a critical regulator of LMP1 functions in vivo.

abstract：:The Ig heavy chain (IgH) locus is controlled by multiple regulatory sequences mapping both within the IgH transcription unit (E mu) and downstream (3') of IgH coding sequences (hs3a, hs1,2, hs3b and hs4). Enhancer knockout studies in mice have implicated E mu in the control of IgH variable region gene assembly, but si...

journal_title：International immunology

authors： Shi X,Eckhardt LA

更新日期：2001-08-01 00:00:00

abstract：:CD70 and CD80 are co-stimulatory molecules which belong to the tumor necrosis factor family and the B7 family respectively. When they are co-expressed by gene-modified TS/A tumor cells, they provide an efficient protective and long-lasting T-dependent antitumor response. We first showed that when CD70 and CD80 were de...

journal_title：International immunology

authors： Douin-Echinard V,Péron JM,Lauwers-Cancès V,Favre G,Couderc B

更新日期：2003-03-01 00:00:00

abstract：:Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired type hemolytic disorder. Hematopoietic cells of patients with PNH are deficient in glycosylphosphatidylinositol (GPI) anchored membrane proteins. Since some membrane-bound complement inhibitors, such as CD59 and decay accelerating factor (DAF), are GPI anchored ...

journal_title：International immunology

authors： Ueda E,Nishimura J,Kitani T,Nasu K,Kageyama T,Kim YU,Takeda J,Kinoshita T

更新日期：1992-11-01 00:00:00

abstract：:Human dendritic cells (DC) generated from CD34+ hematopoietic progenitors cultured in the presence of granulocyte macrophage colony stimulating factor (GM-CSF) and tumor necrosis factor (TNF)-alpha are related to Langerhans cells (DLC) and have been shown to induce a strong proliferation of allogeneic CD4+ T cells. Th...

journal_title：International immunology

authors： Caux C,Massacrier C,Vanbervliet B,Barthelemy C,Liu YJ,Banchereau J

更新日期：1994-08-01 00:00:00

abstract：:In this study, we analyzed peripheral blood CD4+CD8+ double-positive (DP) lymphocytes in adult cynomolgus monkeys (Macaca fascicularis). Forty of 55 monkeys had > 5% of the peripheral blood DP subpopulation (9.3 +/- 5.9%; mean +/- SD) in peripheral blood lymphocytes (PBL) in contrast to a low percentage of peripheral ...

journal_title：International immunology

authors： Akari H,Terao K,Murayama Y,Nam KH,Yoshikawa Y

更新日期：1997-04-01 00:00:00

abstract：:T cell apoptosis has been proposed as an important contributor to the functional defects and depletion of T cells in HIV-infected individuals. However, the mechanisms involved in this apoptosis have not been elucidated. We recently showed that peripheral blood T cells from HIV-infected individuals are especially susce...

journal_title：International immunology

authors： Katsikis PD,García-Ojeda ME,Wunderlich ES,Smith CA,Yagita H,Okumura K,Kayagaki N,Alderson M,Herzenberg LA,Herzenberg LA

更新日期：1996-08-01 00:00:00

abstract：:Neutrophils and lymphocytes are recruited to sites of inflammation and require the adhesion molecule L-selectin (CD62L) for adherence to endothelial cells. Nucleotides released from activated or dying cells at sites of inflammation can mediate signaling through purinergic receptor family II, resulting in CD62L sheddin...

journal_title：International immunology

authors： Sengstake S,Boneberg EM,Illges H

更新日期：2006-07-01 00:00:00

abstract：:Lymphocyte migration from the blood into specific tissues is directed by their expression of adhesion molecules referred to as homing receptors. The homing receptor L-selectin, for example, directs the migration of lymphocytes into peripheral lymph nodes (PLN). Since bovine gamma delta T cells, a major lymphocyte subs...

journal_title：International immunology

authors： Walcheck B,Jutila MA

更新日期：1994-01-01 00:00:00

abstract：:Regulatory T cells (Tregs), which could be down-regulated by IL-28B, were reported to suppress T-cell-mediated immunity. The aim of this study was to investigate the role of IL-28B on the immune responses and protective efficacy of a tuberculosis (TB) subunit vaccine. First, a recombinant adenoviral vector expressing ...

journal_title：International immunology

authors： Luo Y,Ma X,Liu X,Lu X,Niu H,Yu H,Bai C,Peng J,Xian Q,Wang Y,Zhu B

更新日期：2016-02-01 00:00:00

abstract：:We investigated the role of IL-7 receptor alpha (IL-7Ralpha) signal in the formation of Peyer's patch (PP) anlage. Although pan-lymphopenia is a common phenotype of rag2-/- and il7ralpha-/- mice, a close inspection revealed nodules corresponding to PP in the adult rag2-/- but not in the il7ralpha-/- mouse. In our prev...

journal_title：International immunology

authors： Adachi S,Yoshida H,Honda K,Maki K,Saijo K,Ikuta K,Saito T,Nishikawa SI

更新日期：1998-01-01 00:00:00

abstract：:In this review, we propose that certain modifications in cellular metabolism might function as danger signals triggering inflammasome-mediated immune responses. We propose to call them danger-associated metabolic modifications (DAMMs). As intracellular bacteria can actively modulate macrophage metabolism for their ben...

journal_title：International immunology

authors： Dramé M,Buchrieser C,Escoll P

更新日期：2020-06-26 00:00:00

abstract：:It has previously been described that V gamma 3 cells can proliferate extensively in vitro in the presence of different cytokines. Here, the role of cytokines in the maintenance of V gamma 3 cells in the thymus has been determined. Culture of fetal thymocytes in cell suspension for 24 h showed that, whereas immature T...

journal_title：International immunology

authors： Leclercq G,De Smedt M,Plum J

更新日期：1995-05-01 00:00:00

abstract：:Unlike splenic B cells from normal BALB/c mice, those from autoimmune-prone NZB x NZW (B/W) F1 young mice were hyperresponsive to interleukin 2 (IL2) and proliferated even in the absence of prior stimulation signals. We found that the B cell subpopulation responsible for this event belongs to that with 6B2 (B220)-dull...

journal_title：International immunology

authors： Hasegawa K,Abe M,Okada T,Hirose S,Sato H,Shirai T

更新日期：1989-01-01 00:00:00

abstract：:The third complementarity determining regions of heavy chain variable regions (CDRH3) confer the fine specificities of antibodies. The CDRH3 length distribution of all human or all mouse antibodies appears to be more or less random, with the human distribution having a wider spread. Since the Kabat database of aligned...

journal_title：International immunology

authors： Johnson G,Wu TT

更新日期：1998-12-01 00:00:00

abstract：:Streptococcus suis serotype 2 is an important porcine bacterial pathogen and a zoonotic agent responsible for sudden death, septic shock and meningitis, with exacerbated inflammation being a hallmark of the systemic and central nervous system (CNS) infections. However, S. suis serotype 2 strains are genetically and ph...

journal_title：International immunology

authors： Auger JP,Benoit-Biancamano MO,Bédard C,Segura M,Gottschalk M

更新日期：2019-10-16 00:00:00

abstract：:We have shown that the dominance of CD8+ T cells expressing TCR Vbeta17 in the adult HLA-A*0201-restricted influenza A/M1(58-66)-specific response is acquired following first antigen exposure. Despite the acquired dominance of Vbeta17+ cells, subdominant M1(58-66)-specific clones expressing non-Vbeta17+ TCR persist in...

journal_title：International immunology

authors： Lawson TM,Man S,Wang EC,Williams S,Amos N,Gillespie GM,Moss PA,Borysiewicz LK

更新日期：2001-11-01 00:00:00

abstract：:It has proven difficult to evaluate the functional potential of germinal center (GC) B cells, including those from Peyer's patches (PP), by either in vivo or in vitro methods. Thus, rather than assess secreted Ig product as an indicator of functional potential we have instead sought to detect mRNAs related to the vari...

journal_title：International immunology

authors： Weinstein PD,Schweitzer PA,Cebra-Thomas JA,Cebra JJ

更新日期：1991-12-01 00:00:00

abstract：:The immunomodulator FTY720 inhibits lymph node (LN) and thymic egress, thereby constraining T cell circulation and reducing peripheral T cell numbers. Here, we analyzed in mouse models the as yet scarcely characterized impact of long-term (up to 6 months) FTY720 exposure on T cell homeostasis and possible consequences...

journal_title：International immunology

authors： Metzler B,Gfeller P,Wieczorek G,Li J,Nuesslein-Hildesheim B,Katopodis A,Mueller M,Brinkmann V

更新日期：2008-05-01 00:00:00

abstract：:Although CD4(+) T cells form a major subset of TCRalphabeta T cells, only a small number of TCRgammadelta T cells express CD4. Factors contributing to the down-regulation of CD4(+) TCRgammadelta T cells have not been identified. The CD5 molecule is expressed on most TCRgammadelta T cells in the spleen, whereas only a ...

journal_title：International immunology

authors： Mizoguchi A,Mizoguchi E,de Jong YP,Takedatsu H,Preffer FI,Terhorst C,Bhan AK

更新日期：2003-01-01 00:00:00

abstract：:The anti-CD20 chimeric monoclonal antibody rituximab mediates cytotoxicity in malignant B cells via multiple mechanisms, including complement-dependent cytotoxicity (CDC), antibody-dependent cellular cytotoxicity (ADCC) and direct induction of apoptosis. To optimize treatment of non-Hodgkin's lymphoma, a fuller unders...

journal_title：International immunology

authors： Mishima Y,Terui Y,Mishima Y,Kuniyoshi R,Matsusaka S,Mikuniya M,Kojima K,Hatake K

更新日期：2012-08-01 00:00:00

abstract：:Novel biomarkers of rheumatoid arthritis (RA), in addition to antibodies against cyclic citrullinated peptides, are required. Metabolome analysis is a promising approach to identify metabolite biomarkers for clinical diagnosis. We adopted a comprehensive nontargeted metabolomics approach combining capillary electropho...

journal_title：International immunology

authors： Kishikawa T,Maeda Y,Nii T,Arase N,Hirata J,Suzuki K,Yamamoto K,Masuda T,Ogawa K,Tsuji S,Matsushita M,Matsuoka H,Yoshimura M,Tsunoda S,Ohshima S,Narazaki M,Ogata A,Saeki Y,Inohara H,Kumanogoh A,Takeda K,Okada Y

更新日期：2020-08-31 00:00:00

abstract：:Intradermal inoculation of plasmids expressing antigens that contain MHC class I-restricted epitopes leads to the induction of specific CD8(+) cytotoxic T lymphocytes (CTL). The role of in situ transfected antigen-presenting cells (APC) in the priming of specific CTL subsequent to intradermal DNA immunization was inve...

journal_title：International immunology

authors： Bot A,Stan AC,Inaba K,Steinman R,Bona C

更新日期：2000-06-01 00:00:00

abstract：:Recent studies have shown that tumor cells acquire escape mechanisms to evade host immunity in the tumor microenvironment. Two key immune checkpoint pathways mediated by immunosuppressive co-signaling, the first via programmed cell death 1 (PD-1) and PD-1 ligand 1 (PD-1/PD-L1) and the second via CTLA-4 and B7 (CTLA-4/...

journal_title：International immunology

authors： Hamanishi J,Mandai M,Konishi I

更新日期：2016-07-01 00:00:00

abstract：:Insulitis develops in non-obese diabetic (NOD) mice as a multicentric and asynchronous process. In an effort to understand how this T cell mediated process expands within each islet and propagates between the islets of the same pancreas, we have analyzed the junctional diversity of TCR V beta 6 and V beta 8.2 transcri...

journal_title：International immunology

authors： Sarukhan A,Bedossa P,Garchon HJ,Bach JF,Carnaud C

更新日期：1995-01-01 00:00:00

abstract：:The kinetics of kappa light (kappa L) chain gene rearrangement and expression on mRNA and protein level has been studied with four stromal cell/IL-7 reactive, long-term in vitro proliferating pre-B cell lines and clones, two from fetal liver of normal mice and two from fetal liver of E microH-bcl-2 transgenic (bcl-2-t...

journal_title：International immunology

authors： Grawunder U,Haasner D,Melchers F,Rolink A

更新日期：1993-12-01 00:00:00

abstract：:We have found that FOXP3 is an oligomeric component of a large supramolecular complex. Certain FOXP3 mutants with single amino acid deletions in the leucine zipper domain of FOXP3 are associated with the X-linked autoimmunity-allergic dysregulation (XLAAD) and immunodysregulation, polyendocrinopathy and enteropathy, X...

journal_title：International immunology

authors： Li B,Samanta A,Song X,Iacono KT,Brennan P,Chatila TA,Roncador G,Banham AH,Riley JL,Wang Q,Shen Y,Saouaf SJ,Greene MI

更新日期：2007-07-01 00:00:00

abstract：:The interleukin 2 receptor (IL-2R) is composed of at least two polypeptides--a 55 kd protein (the L chain, p55, or alpha chain) and a 75 kd protein (the H chain, p75 or beta chain). The high-affinity binding of IL-2 results in the formation of a ternary complex consisting of IL-2 and the L and H chains. We found that ...

journal_title：International immunology

authors： Saito Y,Ogura T,Kamio M,Sabe H,Uchiyama T,Honjo T

更新日期：1990-01-01 00:00:00

abstract：:Two major B cell subpopulations were identified in the IgD- compartment of tonsils and subsequently isolated. They displayed the following phenotypes: CD10+CD38+CD44- (CD38+ B cells) and CD10-CD38-CD44+ (CD38- B cells). Of the CD38- B cells, 70% also expressed CD24 and CD39, whereas CD77 was specifically distributed o...

journal_title：International immunology

authors： Lagresle C,Bella C,Defrance T

更新日期：1993-10-01 00:00:00

abstract：:T cells of an unique phenotype (CD3+CD4-CD8- alpha beta TCR+) develop in vitro from the hematopoietic progenitors, the majority of which carry homologous alpha beta TCR (V alpha 4J alpha 28/V beta 2D beta 1.1J beta 2.6). In the present study, antigen corresponding to the particular alpha beta TCR was investigated, tak...

journal_title：International immunology

authors： Kubota H,Sato M,Ogawa Y,Iwai K,Hattori M,Yoshida T,Minato N

更新日期：1994-09-01 00:00:00

abstract：:Amongst CD4-CD8- (double negative) thymocytes there is a sizeable population (variable from strain to strain) of cells expressing surface T cell receptor (TCR). These TCR+ double negatives are predominantly non-cycling, have very little precursor activity, and, unlike the TCR-CD4-CD8- thymocytes, appear not to be part...

journal_title：International immunology

authors： Wu L,Pearse M,Egerton M,Petrie H,Scollay R

更新日期：1990-01-01 00:00:00