Molecular genetic features reflecting the preference for isotype switching to IgA expression by Peyer's patch germinal center B cells.

abstract：:NK cells limit the emergence of cancers and viral infections by surveillance of 'missing-self' and 'induced-self' ligands, and by direct recognition of pathogen-associated molecules. We examined individual roles for Toll-like receptors (TLRs)-7 and -8 in human NK-cell activation using synthetic, small molecule agonist...

journal_title：International immunology

authors： Gorski KS,Waller EL,Bjornton-Severson J,Hanten JA,Riter CL,Kieper WC,Gorden KB,Miller JS,Vasilakos JP,Tomai MA,Alkan SS

更新日期：2006-07-01 00:00:00

abstract：:Experiments in transgenic mice have demonstrated that thymocyte differentiation into the mature CD4+ helper or CD8+ cytotoxic T cell lineage is ultimately dependent upon the specificity of the TCR for class II or class I MHC molecules respectively. However, the initial mechanistic events involved in this process remai...

journal_title：International immunology

authors： DeKoning J,Carbone FR,Kaye J

更新日期：1995-04-01 00:00:00

abstract：:Dendritic cells (DC) are potent antigen-presenting cells and understanding their mechanisms of antigen uptake is important for loading DC with antigen for immunotherapy. The multilectin receptors, DEC-205 and macrophage mannose receptor (MMR), are potential antigen-uptake receptors; therefore, we examined their expres...

journal_title：International immunology

authors： Kato M,Neil TK,Fearnley DB,McLellan AD,Vuckovic S,Hart DN

更新日期：2000-11-01 00:00:00

abstract：:A recipient who received a renal graft from a living related donor showed good renal function for as long as 15 years after the withdrawal of azathioprine. The patient's creatinine clearance was maintained at 60 ml/min in spite of the administration of only 10 mg of predonisolon per day. Anti-idiotypic antibodies in t...

journal_title：International immunology

authors： Miyajima T,Shimizu R,Kuzuhara H,Fujimoto S

更新日期：1989-01-01 00:00:00

abstract：:CD100/Sema4D belongs to the semaphorin family, factors known to act as repulsive cues for axons during neuronal development. Mouse CD100 plays a crucial role in both humoral and cellular immunity through ligation of the lymphocyte receptor, CD72. It remains controversial, however, whether human CD100 can function thro...

journal_title：International immunology

authors： Ishida I,Kumanogoh A,Suzuki K,Akahani S,Noda K,Kikutani H

更新日期：2003-08-01 00:00:00

abstract：:Peptide-MHC class II complexes (pMHC II) are degraded by MARCH-I-mediated ubiquitination, and the stabilization of pMHC II by loss of its ubiquitination is one phenotype defining the activation of conventional dendritic cells (cDCs). However, the role of such stabilization of pMHC II in the context of T-cell activatio...

journal_title：International immunology

authors： Ishikawa R,Kajikawa M,Ishido S

更新日期：2014-05-01 00:00:00

abstract：:In this study, we explored the potential of human naive CD4(+) T cells to acquire regulatory properties upon stimulation. We demonstrated that, in vitro, pre-activated naive CD4(+)CD25(-)CD45RA(+) T cells could become anergic and suppressive CD4(+)CD25(+) T cells upon lower intensity TCR stimulation. These CD4(+)CD25(...

journal_title：International immunology

authors： Noël G,Brinster C,Semana G,Bruniquel D

更新日期：2009-09-01 00:00:00

abstract：:In this paper we describe a monoclonal antibody, JR9-318, which was obtained from a wild-derived mouse immunized with the M14T cell line (CD3+CD4-CD8-) in order to describe antigenic molecules expressed during T cell differentiation. This mAb precipitated a protein from the M14T cell line or subclones that migrates li...

journal_title：International immunology

authors： Roland J,Cazenave PA

更新日期：1992-06-01 00:00:00

abstract：:Organs of transgenic pigs that express human complement regulatory proteins are under assessment as an alternative to transplantation. A major barrier to the transplantation of pig organs is the hyperacute rejection caused by pre-existing antibodies and complement. Pig cells are very susceptible to human complement, p...

journal_title：International immunology

authors： Toyomura K,Fujimura T,Murakami H,Natsume T,Shigehisa T,Inoue N,Takeda J,Kinoshita T

更新日期：1997-06-01 00:00:00

abstract：:Cytotoxic T lymphocytes (CTL) confer protection against intracellular pathogens, yet the mechanism by which some escape activation induced cell death (AICD) and give rise to long-lived memory cells is unclear. We studied the differentiation of transgenic TCR CD8(+) cells into CTL and memory cells using a novel system ...

journal_title：International immunology

authors： Opferman JT,Ober BT,Narayanan R,Ashton-Rickardt PG

更新日期：2001-04-01 00:00:00

abstract：:One of the characteristic features of asthma is chronic airway inflammation typically with eosinophil infiltration. Most asthmatics can be treated successfully with conventional treatment appropriate for their severity, but in some severe cases, asthma cannot be well controlled even with thorough treatment and this co...

journal_title：International immunology

authors： Ohta K,Nagase H,Suzukawa M,Ohta S

更新日期：2017-07-01 00:00:00

abstract：:We have shown that the dominance of CD8+ T cells expressing TCR Vbeta17 in the adult HLA-A*0201-restricted influenza A/M1(58-66)-specific response is acquired following first antigen exposure. Despite the acquired dominance of Vbeta17+ cells, subdominant M1(58-66)-specific clones expressing non-Vbeta17+ TCR persist in...

journal_title：International immunology

authors： Lawson TM,Man S,Wang EC,Williams S,Amos N,Gillespie GM,Moss PA,Borysiewicz LK

更新日期：2001-11-01 00:00:00

abstract：:Antigen-coupled antigen-presenting cells (APC) serve as potent tolerogens for inhibiting immune responses in vivo and in vitro, apparently by providing an antigen-specific signal through the TCR in the absence of co-stimulation. Although this approach has been well studied in rodents, little is known about its effects...

journal_title：International immunology

authors： Vandenbark AA,Barnes D,Finn T,Bourdette DN,Whitham R,Robey I,Kaleeba J,Bebo BF Jr,Miller SD,Offner H,Chou YK

更新日期：2000-01-01 00:00:00

abstract：:In the final analysis, the self (S)-non-self (NS) discrimination is regulated by the sufficiency or insufficiency of effector T(h) (eT(h)) specific for the given antigen. We have described a model (Th genesis) for the origin of eT(h) based on an antigen-independent pathway from initial state T(h) (iT(h)) to eT(h), and...

journal_title：International immunology

authors： Langman RE,Mata JJ,Cohn M

更新日期：2003-05-01 00:00:00

abstract：:We have previously cloned the murine homolog of cDNA for the human myelomonocytic differentiation antigen, CD14. We synthesized three hydrophilic peptides derived from the predicted amino acid sequence of murine CD14 (mCD14), designated MS7.1, MS7.2, and MS7.3, respectively, and raised antisera against them. Each anti...

journal_title：International immunology

authors： Nasu N,Yoshida S,Akizuki S,Higuchi Y,Setoguchi M,Yamamoto S

更新日期：1991-02-01 00:00:00

abstract：:The efficacy of cytotoxic T lymphocytes (CTL) has been shown to be highly dependent upon their functional avidity (the sensitivity of their cellular response to MHC-peptide complexes). To examine this relationship, we employed target cell lysis as a quantitative measure and established a set of four CTL clones that ex...

journal_title：International immunology

authors： Derby MA,Wang J,Margulies DH,Berzofsky JA

更新日期：2001-06-01 00:00:00

abstract：:T cells of an unique phenotype (CD3+CD4-CD8- alpha beta TCR+) develop in vitro from the hematopoietic progenitors, the majority of which carry homologous alpha beta TCR (V alpha 4J alpha 28/V beta 2D beta 1.1J beta 2.6). In the present study, antigen corresponding to the particular alpha beta TCR was investigated, tak...

journal_title：International immunology

authors： Kubota H,Sato M,Ogawa Y,Iwai K,Hattori M,Yoshida T,Minato N

更新日期：1994-09-01 00:00:00

abstract：:We have isolated two cDNA clones encoding the guinea pig receptor for the Fc portion of IgG2 (Fc gamma 2R) from a guinea pig peritoneal macrophage cDNA library. Analysis of the predicted amino acid sequence of the one cDNA clone indicated that the guinea pig Fc gamma 2R is a type I transmembrane protein and has approx...

journal_title：International immunology

authors： Isashi Y,Yamashita T,Nagasawa S,Murakami M,Uede T

更新日期：1996-09-01 00:00:00

abstract：:In order to further understand the developmental aspects of B-1 cells, we characterized the ontogeny of this B cell population in the spleen and peritoneal cavity of BALB/c mice. Although there are B-1 cells in the spleen within the first 1-3 weeks after birth, they do not at any stage represent the majority of spleni...

journal_title：International immunology

authors： Hamilton AM,Lehuen A,Kearney JF

更新日期：1994-03-01 00:00:00

abstract：:Defects of early complement components (C1, C4 and C2) are associated with the development of systemic lupus erythematosus (SLE). The availability of complement knockout mice has increased our knowledge on the role of complement in the regulation of adaptive immunity. An impaired removal of apoptotic bodies, a disturb...

journal_title：International immunology

authors： Zachrau B,Finke D,Kropf K,Gosink HJ,Kirchner H,Goerg S

更新日期：2004-12-01 00:00:00

abstract：:The signaling lymphocytic activation molecule (SLAM) receptor-associated adaptor Ewing's sarcoma-associated transcript-2 (EAT-2) is primarily expressed in innate immune cells including dendritic cells (DCs), macrophages and NK cells. A recent human HIV vaccine study confirmed that EAT-2 expression was associated with ...

journal_title：International immunology

authors： Aldhamen YA,Seregin SS,Aylsworth CF,Godbehere S,Amalfitano A

更新日期：2014-05-01 00:00:00

abstract：:Specific antibodies increase antigen uptake and presentation by antigen-presenting cells via the B cell receptor in B cells or FcgammaR in dendritic cells. To determine whether the interaction between antibody and antigen could influence the set of peptides presented by MHC II molecules, we analyzed the presentation o...

journal_title：International immunology

authors： Guermonprez P,Lo-Man R,Sedlik C,Rojas MJ,Poljak RJ,Leclerc C

更新日期：1999-11-01 00:00:00

abstract：:Oral administration of large doses of protein antigen generally induces a state of systemic unresponsiveness currently termed mucosally induced tolerance. In this study, we used human milk protein (HMP) without casein as a multi-protein antigen for the study of mucosally induced tolerance. The HMP utilized in this stu...

journal_title：International immunology

authors： Yuki Y,Fujihashi K,Yamamoto M,McGhee JR,Kiyono H

更新日期：1998-04-01 00:00:00

abstract：:Dendritic cells (DC) sense saprophytic yeast and pathogenic, filamentous forms of Candida albicans in a specific way, resulting in disparate patterns of DC and T(h) cell activation. Using human and murine DC, such disparate patterns could be traced to the exploitation of distinct recognition receptors. Although usage ...

journal_title：International immunology

authors： Romani L,Montagnoli C,Bozza S,Perruccio K,Spreca A,Allavena P,Verbeek S,Calderone RA,Bistoni F,Puccetti P

更新日期：2004-01-01 00:00:00

abstract：:Regulatory T cells (Tregs), which could be down-regulated by IL-28B, were reported to suppress T-cell-mediated immunity. The aim of this study was to investigate the role of IL-28B on the immune responses and protective efficacy of a tuberculosis (TB) subunit vaccine. First, a recombinant adenoviral vector expressing ...

journal_title：International immunology

authors： Luo Y,Ma X,Liu X,Lu X,Niu H,Yu H,Bai C,Peng J,Xian Q,Wang Y,Zhu B

更新日期：2016-02-01 00:00:00

abstract：:Interleukin-15 (IL-15) is a cytokine critical for maintenance of intestinal intra-epithelial lymphocytes (IELs), especially CD8αα + IELs (CD8αα IELs). In the intestine, IL-15 is produced by intestinal epithelial cells (IECs), blood vascular endothelial cells (BECs) and hematopoietic cells. However, the precise role of...

journal_title：International immunology

authors： Zhu Y,Cui G,Miyauchi E,Nakanishi Y,Mukohira H,Shimba A,Abe S,Tani-Ichi S,Hara T,Nakase H,Chiba T,Sehara-Fujisawa A,Seno H,Ohno H,Ikuta K

更新日期：2020-05-08 00:00:00

abstract：:It has previously been described that V gamma 3 cells can proliferate extensively in vitro in the presence of different cytokines. Here, the role of cytokines in the maintenance of V gamma 3 cells in the thymus has been determined. Culture of fetal thymocytes in cell suspension for 24 h showed that, whereas immature T...

journal_title：International immunology

authors： Leclercq G,De Smedt M,Plum J

更新日期：1995-05-01 00:00:00

abstract：:Streptococcus suis serotype 2 is an important porcine bacterial pathogen and a zoonotic agent responsible for sudden death, septic shock and meningitis, with exacerbated inflammation being a hallmark of the systemic and central nervous system (CNS) infections. However, S. suis serotype 2 strains are genetically and ph...

journal_title：International immunology

authors： Auger JP,Benoit-Biancamano MO,Bédard C,Segura M,Gottschalk M

更新日期：2019-10-16 00:00:00

abstract：:Infection by protozoan parasites of the genus Leishmania results in the development of leishmaniasis, an increasingly prevalent group of diseases affecting over 12 million people worldwide. Leishmaniasis can have very different outcomes ranging from cutaneous lesions, mucosal lesions to visceralization depending on th...

journal_title：International immunology

authors： Rossi M,Fasel N

更新日期：2018-03-10 00:00:00

abstract：:Investigation of the process of Peyer's patch (PP) formation has been hampered by difficulties in identifying its initial step in the embryo. In this study, we overcame this problem by means of whole-mount immunohistochemistry using mAb against the molecules which were expressed in the cells accumulated at the site of...

journal_title：International immunology

authors： Adachi S,Yoshida H,Kataoka H,Nishikawa S

更新日期：1997-04-01 00:00:00