Involvement of 4F2 antigen expressed on the MHC-negative target cells in the recognition of murine CD3+CD4-CD8- alpha beta (V alpha 4/V beta 2) T cells.

abstract：:Oral administration of large doses of protein antigen generally induces a state of systemic unresponsiveness currently termed mucosally induced tolerance. In this study, we used human milk protein (HMP) without casein as a multi-protein antigen for the study of mucosally induced tolerance. The HMP utilized in this stu...

journal_title：International immunology

authors： Yuki Y,Fujihashi K,Yamamoto M,McGhee JR,Kiyono H

更新日期：1998-04-01 00:00:00

abstract：:NK cells were first identified in 1975 and represent the prototypical group 1 innate lymphoid cell (ILC). More recently, the discovery of new members of the ILC family has highlighted the complexity of this innate lymphoid lineage. Importantly, it has been recognized that different subsets exist within the group 1 ILC...

journal_title：International immunology

authors： Seillet C,Belz GT

更新日期：2016-01-01 00:00:00

abstract：:Under equilibrium conditions, the affinities of five anti-IgG2a mAb isolated from virus-infected mice were comparable to other high-affinity auto-antibodies. Similar to rheumatoid factors, these anti-IgG2a auto-antibodies bound to aggregated or complexed IgG2a with 50 to 1500-fold higher avidity than their monomeric c...

journal_title：International immunology

authors： Fazekas G,Pálfi G,Wolff-Winiski B,Rosenwirth B,Dukor P,Gergely J,Rajnavölgyi E

更新日期：1995-07-01 00:00:00

abstract：:Previous evidence from several laboratories suggests that CD8+ T suppressor cells may be important regulatory elements governing specific unresponsiveness of lepromatous lepromatous leprosy patients to M.leprae. To analyse the mechanism of suppression, CD8+ Ts clones were established from lesions and peripheral blood ...

journal_title：International immunology

authors： Salgame P,Modlin R,Bloom BR

更新日期：1989-01-01 00:00:00

abstract：:In this study, we report that the release of IL-1 receptor antagonist (IL-1ra) from IL-4-stimulated neutrophils is markedly enhanced in the presence of IL-10. We also show that up-regulation of IL-1ra release by IL-10 in IL-4-stimulated neutrophils takes place through IL-1ra mRNA stabilization and enhancement of IL-1r...

journal_title：International immunology

authors： Crepaldi L,Silveri L,Calzetti F,Pinardi C,Cassatella MA

更新日期：2002-10-01 00:00:00

abstract：:In view of our recent report that T cell receptor (TCR) alpha chain restriction fragment length polymorphism (RFLP) is associated with multiple sclerosis (MS), we have assessed the possibility that HLA-DR2, HLA-DPw4, and TCR alpha chain RFLPs may interact to increase the risk of developing MS. Detection of TCR alpha c...

journal_title：International immunology

authors： Sherritt MA,Oksenberg J,de Rosbo NK,Bernard CC

更新日期：1992-02-01 00:00:00

abstract：:A central tenet of vaccine development is to identify immune correlates of protection. Both plasmid-encoded gD as well as recombinant protein gD can protect mice from lethal herpes simplex virus (HSV) challenge. It is known that different vaccine modalities should induce different immune phenotypes. Yet, paradoxically...

journal_title：International immunology

authors： Sin JI,Ayyavoo V,Boyer J,Kim J,Ciccarelli RB,Weiner DB

更新日期：1999-11-01 00:00:00

abstract：:The thymus leukemia antigens (TL) belong to the MHC class Ib family and can be recognized by CD8-dependent or -independent cytotoxic T lymphocytes (CTL) showing TL, but not H-2, restriction. We previously reported that the CTL epitope is TAP independent and in the present study we further characterize the recognition ...

journal_title：International immunology

authors： Tsujimura K,Obata Y,Kondo E,Nishida K,Matsudaira Y,Akatsuka Y,Kuzushima K,Takahashi T

更新日期：2003-11-01 00:00:00

abstract：:Lymphocyte migration from the blood into specific tissues is directed by their expression of adhesion molecules referred to as homing receptors. The homing receptor L-selectin, for example, directs the migration of lymphocytes into peripheral lymph nodes (PLN). Since bovine gamma delta T cells, a major lymphocyte subs...

journal_title：International immunology

authors： Walcheck B,Jutila MA

更新日期：1994-01-01 00:00:00

abstract：:An alloreactive CTL clone, 27.B2, produced in the mouse strain combination B6.C-H-2bm1 (bm1) against C57BL/6 (B6) and nominally directed against the Kb molecule has been shown to be peptide dependent. The clone recognizes intact B6, but not intact bm1 or bm3 target cells. However, peptides recognized by 27.B2 CTL can ...

journal_title：International immunology

authors： Falk K,Rötzschke O,Rammensee HG

更新日期：1992-03-01 00:00:00

abstract：:BALB/c mice are susceptible to cutaneous leishmaniasis upon infection with Leishmania major while C57BL/6 are not. There is a major promastigote surface protease (PSP or gp63) which is available in both native and recombinant forms, and for which the primary amino acid sequence is known. Immunization with PSP has been...

journal_title：International immunology

authors： Soares LR,Sercarz EE,Miller A

更新日期：1994-05-01 00:00:00

abstract：:Antibody responses to ingested antigens can be inhibited by a mechanism known as oral tolerance which acts to prevent excessive stimulation from luminal contents. Local IgA responses can be induced in this non-responsive environment and during intestinal inflammation, mucosal IgG responses can also be increased. The p...

journal_title：International immunology

authors： Zettel L,Clark DA,Ernst PB

更新日期：1992-09-01 00:00:00

abstract：:SCID mice are profoundly immunodeficient, resulting from an inability to carry out the V(D)J recombination reaction during both B cell and T cell development. Recently, however, it was revealed that normal rearrangement frequently did occur in the TCR delta and gamma chain loci in the SCID thymus. To evaluate whether ...

journal_title：International immunology

authors： Araki R,Itoh M,Hamatani K,Abe M

更新日期：1996-07-01 00:00:00

abstract：:A small proportion of the sIg+ B lymphocytes in peripheral lymphoid organs [22% in spleen and 6% in lymph node (LN)] in rat carries the Thy-1 antigen. These Thy-1+ B cells represent newly formed bone marrow (BM) derived (or immature) B cells. In this study we investigated the kinetic behavior of Thy-1+ and Thy-1- B ce...

journal_title：International immunology

authors： Deenen GJ,Kroese FG

更新日期：1993-07-01 00:00:00

abstract：:IFN-regulatory factor (IRF)-4 is a member of the IRF family of transcription factors expressed in lymphocytes and macrophages. The previous studies using mice deficient in the IRF-4 gene showed profound defects in function of both B and T cells. To further investigate the role of IRF-4 in CD4(+) T cell function, IRF-4...

journal_title：International immunology

authors： Tominaga N,Ohkusu-Tsukada K,Udono H,Abe R,Matsuyama T,Yui K

更新日期：2003-01-01 00:00:00

abstract：:The efficacy of cytotoxic T lymphocytes (CTL) has been shown to be highly dependent upon their functional avidity (the sensitivity of their cellular response to MHC-peptide complexes). To examine this relationship, we employed target cell lysis as a quantitative measure and established a set of four CTL clones that ex...

journal_title：International immunology

authors： Derby MA,Wang J,Margulies DH,Berzofsky JA

更新日期：2001-06-01 00:00:00

abstract：:Spectroscopic methods have been applied to elucidate conformational differences responsible for the immunological diversity of two synthetic multichain copolymers, Tyr1Tyr2Glu3Glu4-poly-DL-Ala--poly-Lys and Tyr1Glu2Tyr3Glu4-poly-DL-Ala--poly-Lys. Despite their far-reaching structural similarity in the epitope peptide ...

journal_title：International immunology

authors： Muszkat KA,Schechter B,Sela M

更新日期：1993-06-01 00:00:00

abstract：:The regulation of MHC class II expression by the class II transactivator (CIITA) is complex and differs in various cell types depending on the relative activity of three CIITA promoters. Here we show that, in plasma cell tumors, the deacetylase inhibitor trichostatin A (TSA) elicits PIII-CIITA but does not activate th...

journal_title：International immunology

authors： Chou SD,Khan AN,Magner WJ,Tomasi TB

更新日期：2005-11-01 00:00:00

abstract：:To understand the nature of long-term Th immune responses, we investigated in the present study the TCRBV gene repertoire of CD4(+) T cells specific for the recall antigen tetanus toxoid (TT) in recipients of an allogeneic bone marrow transplantation (allo-BMT) at several time points after transplantation and in their...

journal_title：International immunology

authors： Godthelp BC,van Tol MJ,Vossen JM,van den Elsen PJ

更新日期：2001-04-01 00:00:00

abstract：:Mice lacking the IL-2 receptor beta chain (IL-2R beta) exhibit an autoimmune reaction characterized by generalized T cell activation, production of autoantibodies, myeloproliferation and severe anemia. T cells of IL-2R beta-/- mice were examined to elucidate the mechanism responsible for their abnormal activation and ...

journal_title：International immunology

authors： Suzuki H,Hayakawa A,Bouchard D,Nakashima I,Mak TW

更新日期：1997-09-01 00:00:00

abstract：:The third complementarity determining regions of heavy chain variable regions (CDRH3) confer the fine specificities of antibodies. The CDRH3 length distribution of all human or all mouse antibodies appears to be more or less random, with the human distribution having a wider spread. Since the Kabat database of aligned...

journal_title：International immunology

authors： Johnson G,Wu TT

更新日期：1998-12-01 00:00:00

abstract：:Immune tolerance in the lung is important for preventing hypersensitivity, such as allergic asthma. Maintenance of tolerance in the lung is established by coordinated activities of poorly understood cellular and molecular mechanisms, including participation of dendritic cells (DCs). We have previously identified DC ex...

journal_title：International immunology

authors： Han D,Walsh MC,Kim KS,Hong SW,Lee J,Yi J,Rivas G,Choi Y,Surh CD

更新日期：2017-02-01 00:00:00

abstract：:In this study, we analyzed peripheral blood CD4+CD8+ double-positive (DP) lymphocytes in adult cynomolgus monkeys (Macaca fascicularis). Forty of 55 monkeys had > 5% of the peripheral blood DP subpopulation (9.3 +/- 5.9%; mean +/- SD) in peripheral blood lymphocytes (PBL) in contrast to a low percentage of peripheral ...

journal_title：International immunology

authors： Akari H,Terao K,Murayama Y,Nam KH,Yoshikawa Y

更新日期：1997-04-01 00:00:00

abstract：:Lymphokine activity in seven myelin basic protein (MBP)-specific T cell clones was examined. All of the clones recognize MBP peptide 1-9 in the context of I-Au. A strong positive correlation was found between levels of lymphotoxin (LT) and tumor necrosis factor alpha (TNF-alpha) mRNA and biological activity on L929 ce...

journal_title：International immunology

authors： Powell MB,Mitchell D,Lederman J,Buckmeier J,Zamvil SS,Graham M,Ruddle NH,Steinman L

更新日期：1990-01-01 00:00:00

abstract：:Plasmid DNA vectors have been constructed with minigenes encoding a single cytotoxic T lymphocyte (CTL) epitope from either the M2 protein of respiratory syncytial virus (RSV) or from the nucleoprotein of measles virus (MV) with or without a signal sequence (also called secretory or leader sequence). Following intrade...

journal_title：International immunology

authors： Hsu SC,Obeid OE,Collins M,Iqbal M,Chargelegue D,Steward MW

更新日期：1998-10-01 00:00:00

abstract：:Cells bearing the gamma delta form of the TCR make up only 1-3% of T cells in the adult murine thymus and peripheral lymphoid organs. Evidence from studies of nude mice suggests that the development of at least some gamma delta T cells is thymus dependent; however, until now it has not been directly demonstrated that ...

journal_title：International immunology

authors： Kelly KA,Pearse M,Lefrancois L,Scollay R

更新日期：1993-04-01 00:00:00

abstract：:We have used a set of single-chain variable fragment antibodies (sc) genetically fused with an influenza hemagglutinin-derived peptide as a means to investigate the role of CR1 and CR2 in antigen presentation by B cells. When incubated with the B cell lymphoma 2PK3, peptide-containing sc specific for either CR1 or CR1...

journal_title：International immunology

authors： Prechl J,Baiu DC,Horváth A,Erdei A

更新日期：2002-03-01 00:00:00

abstract：:The alternative complement pathway (ACP) in vertebrates is known to be important in inflammatory reactions, and to be activated by foreign substances such as bacterial lipopolysaccharide (LPS) and zymosan, although to date no intrinsic activators have been identified except complement receptor type 2. From the point o...

journal_title：International immunology

authors： Oshima H,Soma G,Mizuno D

更新日期：1993-10-01 00:00:00

abstract：:Members of protein kinase D (PKD) family serine/threonine kinases (PKD1, PKD2 and PKD3) are expressed in wide range of cells and regulate various cellular responses including immune responses. We have previously shown that PKD is involved in the signaling pathways of a human CD4(+) T cell clone stimulated with its cog...

journal_title：International immunology

authors： Irie A,Harada K,Tsukamoto H,Kim JR,Araki N,Nishimura Y

更新日期：2006-12-01 00:00:00

abstract：:Human CD83 is a cell surface protein expressed predominantly by dendritic cells (DC) and lymphoid cells. So far, there exists no information on the function and distribution of mCD83. Here we demonstrate that mCD83 is moderately expressed on resting T cells and DC, but strongly increases in its expression on T cells f...

journal_title：International immunology

authors： Cramer SO,Trumpfheller C,Mehlhoop U,Moré S,Fleischer B,von Bonin A

更新日期：2000-09-01 00:00:00