Intestinal epithelial cell-derived IL-15 determines local maintenance and maturation of intra-epithelial lymphocytes in the intestine.

abstract：:Dendritic cells (DCs) act as a first-line recognition system for invading pathogens, such as influenza A. The interaction of DC with influenza A virus results in DC activation via endosomal Toll-like receptors and also leads to presentation of viral peptides on MHC class II molecules. Prior work demonstrated that infl...

journal_title：International immunology

authors： Burster T,Giffon T,Dahl ME,Björck P,Bogyo M,Weber E,Mahmood K,Lewis DB,Mellins ED

更新日期：2007-05-01 00:00:00

abstract：:To understand the nature of long-term Th immune responses, we investigated in the present study the TCRBV gene repertoire of CD4(+) T cells specific for the recall antigen tetanus toxoid (TT) in recipients of an allogeneic bone marrow transplantation (allo-BMT) at several time points after transplantation and in their...

journal_title：International immunology

authors： Godthelp BC,van Tol MJ,Vossen JM,van den Elsen PJ

更新日期：2001-04-01 00:00:00

abstract：:Sphingosine 1-phosphate (S1P) and S1P receptor 1 (S1P1) play an important role in the egress of mature CD4 or CD8 single-positive (SP) thymocytes from the thymus. Fingolimod hydrochloride (FTY720), an S1P1 functional antagonist, induced significant accumulation of CD62L(high)CD69(low) mature SP thymocytes in the thymi...

journal_title：International immunology

authors： Maeda Y,Yagi H,Takemoto K,Utsumi H,Fukunari A,Sugahara K,Masuko T,Chiba K

更新日期：2014-05-01 00:00:00

abstract：:Natural cytotoxicity receptors and NKG2D correspond to major activating receptors involved in triggering of tumor cell lysis by human NK cells. In this report, we investigated the expression of NKG2D ligands (NKG2DLs), MHC class I-related chain (MIC) A, MICB and UL16-binding proteins 1, 2 and 3, on a panel of human no...

journal_title：International immunology

authors： Le Maux Chansac B,Missé D,Richon C,Vergnon I,Kubin M,Soria JC,Moretta A,Chouaib S,Mami-Chouaib F

更新日期：2008-07-01 00:00:00

abstract：:Chemokine receptors (CCRs) are important co-stimulatory molecules found on many blood cells and associated with various diseases. The expression and function of CCRs on mast cells has been quite controversial. In this study, we report for the first time that murine bone marrow-derived mast cells (BMMC) express messeng...

journal_title：International immunology

authors： Fifadara NH,Aye CC,Raghuwanshi SK,Richardson RM,Ono SJ

更新日期：2009-08-01 00:00:00

abstract：:Activated macrophages exert strong arginase (ASE) activity that converts L-arginine into ornithine, the key precursor for putrescine and polyamine biosynthesis. Macrophages were previously also shown to generate nitric oxide that is derived from the guanido group of arginine by the oxidative deiminase (OAD) reaction. ...

journal_title：International immunology

authors： Benninghoff B,Lehmann V,Eck HP,Dröge W

更新日期：1991-05-01 00:00:00

abstract：:To develop a comprehensive catalogue of phenotypic and functional parameters of human CD4(+) T cell differentiation stages, we have performed microarray gene expression profiling on subpopulations of human thymocytes and circulating naive CD4(+) T cells, including CD3(-)CD4(+)CD8(-) intrathymic T progenitor cells, CD3...

journal_title：International immunology

authors： Lee MS,Hanspers K,Barker CS,Korn AP,McCune JM

更新日期：2004-08-01 00:00:00

abstract：:We report the characterization of the Fc epsilon RI gamma chain which associates with the transmembrane form of CD16 to form the low affinity receptor for IgG (Fc gamma RIII) expressed on human natural killer (NK) cells. cDNA cloning and sequence analysis of Fc epsilon RI gamma from a polyclonal CD3-CD16+ NK line esta...

journal_title：International immunology

authors： Moingeon P,Lucich JL,Reinherz EL

更新日期：1992-08-01 00:00:00

abstract：:The product of the LAG-3 gene is a cell surface protein with significant homology to CD4. It has been suggested that it can serve as a functional equivalent of CD4 and account for the MHC class II-restricted responses which persist in CD4-deficient mice. To test this hypothesis, we have created CD4/LAG-3 double-defici...

journal_title：International immunology

authors： Miyazaki T,Dierich A,Benoist C,Mathis D

更新日期：1996-05-01 00:00:00

abstract：:HLA-G, a human MHC class I molecule expressed on the trophoblast during pregnancy, was expressed in transgenic mice by recombining the HLA-G gene with a transcriptional promoter from a murine H-2 MHC class I gene. Skin grafts from HLA-G transgenic mice were rejected by non-transgenic mice showing that HLA-G behaves as...

journal_title：International immunology

authors： Horuzsko A,Antoniou J,Tomlinson P,Portik-Dobos V,Mellor AL

更新日期：1997-05-01 00:00:00

abstract：:Previous evidence from several laboratories suggests that CD8+ T suppressor cells may be important regulatory elements governing specific unresponsiveness of lepromatous lepromatous leprosy patients to M.leprae. To analyse the mechanism of suppression, CD8+ Ts clones were established from lesions and peripheral blood ...

journal_title：International immunology

authors： Salgame P,Modlin R,Bloom BR

更新日期：1989-01-01 00:00:00

abstract：:T cells of an unique phenotype (CD3+CD4-CD8- alpha beta TCR+) develop in vitro from the hematopoietic progenitors, the majority of which carry homologous alpha beta TCR (V alpha 4J alpha 28/V beta 2D beta 1.1J beta 2.6). In the present study, antigen corresponding to the particular alpha beta TCR was investigated, tak...

journal_title：International immunology

authors： Kubota H,Sato M,Ogawa Y,Iwai K,Hattori M,Yoshida T,Minato N

更新日期：1994-09-01 00:00:00

abstract：:IgG is the major immunoglobulin class produced during an immune response against foreign antigens and efficiently provides protection through its bifunctional nature. While the Fab domains confer highly specific recognition of the antigen, the Fc domain mediates a wide range of effector functions that modulate several...

journal_title：International immunology

authors： Bournazos S,Ravetch JV

更新日期：2017-07-01 00:00:00

abstract：:Constitutive expression of p35 and p40 IL-12 mRNA was detected in splenic macrophages isolated from aged mice. Macrophages were also implicated as the cell type responsible for the dysregulated IL-6 and tumor necrosis factor (TNF)-alpha commonly observed to be constitutively produced by lymphoid cells from aged donors...

journal_title：International immunology

authors： Spencer NF,Daynes RA

更新日期：1997-05-01 00:00:00

abstract：:Neural stem cells (NSCs) transplantation has been proposed as a means of restoring damaged brain tissue, a possibility rendered more likely by reports of low NSCs immunogenicity in various experimental models because of low expression of MHC class I and II as well as co-stimulatory molecules. We investigated the immun...

journal_title：International immunology

authors： Ubiali F,Nava S,Nessi V,Frigerio S,Parati E,Bernasconi P,Mantegazza R,Baggi F

更新日期：2007-09-01 00:00:00

abstract：:Neutrophils and lymphocytes are recruited to sites of inflammation and require the adhesion molecule L-selectin (CD62L) for adherence to endothelial cells. Nucleotides released from activated or dying cells at sites of inflammation can mediate signaling through purinergic receptor family II, resulting in CD62L sheddin...

journal_title：International immunology

authors： Sengstake S,Boneberg EM,Illges H

更新日期：2006-07-01 00:00:00

abstract：:A gelatin sponge model of concomitant tumor immunity was employed in order to examine the clonality of T cells associated with progressing and rejected tumor sites. Here we show that freshly isolated T cells bearing TCR V(beta)1, CDR3 RPGTGN, J(beta)1.1 and TCR V(beta)8, CDR3 GD, J(beta)1.6 predominated progressing an...

journal_title：International immunology

authors： Kurt RA,Park JA,Schluter SF,Marchalonis JJ,Akporiaye ET

更新日期：2000-05-01 00:00:00

abstract：:Hepatitis C virus (HCV) has the ability to persist in the majority of infected people. Strong, multispecific and sustained T-cell response is correlated with viral clearance. The mechanisms of chronicity by HCV are unclear. HCV could restrain the immune system and establish chronic infection by modulating dendritic ce...

journal_title：International immunology

authors： Krishnadas DK,Ahn JS,Han J,Kumar R,Agrawal B

更新日期：2010-06-01 00:00:00

abstract：:We have found that FOXP3 is an oligomeric component of a large supramolecular complex. Certain FOXP3 mutants with single amino acid deletions in the leucine zipper domain of FOXP3 are associated with the X-linked autoimmunity-allergic dysregulation (XLAAD) and immunodysregulation, polyendocrinopathy and enteropathy, X...

journal_title：International immunology

authors： Li B,Samanta A,Song X,Iacono KT,Brennan P,Chatila TA,Roncador G,Banham AH,Riley JL,Wang Q,Shen Y,Saouaf SJ,Greene MI

更新日期：2007-07-01 00:00:00

abstract：:Cyclosporin A (CsA) prevents most immature thymocytes from progressing to a mature phenotype and blocks the deletion of T cells that express self-specific TCR in the small population of cells that achieve maturity. The latter effect may explain the paradoxical observation that this immunosuppressive drug can induce au...

journal_title：International immunology

authors： Urdahl KB,Pardoll DM,Jenkins MK

更新日期：1992-12-01 00:00:00

abstract：:In vascularized organ transplantation, vascular endothelial cells (EC) confronting recipient T cells are potentially significant APC initiating cellular immune responses that lead to rejection. In the present study, we studied the ability of human EC to stimulate allogeneic T cells and the co-stimulatory molecules inv...

journal_title：International immunology

authors： Seino K,Azuma M,Bashuda H,Fukao K,Yagita H,Okumura K

更新日期：1995-08-01 00:00:00

abstract：:The extracellular signal-regulated kinase (ERK) signaling pathway is strongly activated in response to TCR stimulation in normal T cells. However, the extent to which activation of the ERK pathway is necessary for TCR-stimulated cytokine production is not clear. We have addressed this question by use of two separate m...

journal_title：International immunology

authors： Egerton M,Fitzpatrick DR,Kelso A

更新日期：1998-02-01 00:00:00

abstract：:In the final analysis, the self (S)-non-self (NS) discrimination is regulated by the sufficiency or insufficiency of effector T(h) (eT(h)) specific for the given antigen. We have described a model (Th genesis) for the origin of eT(h) based on an antigen-independent pathway from initial state T(h) (iT(h)) to eT(h), and...

journal_title：International immunology

authors： Langman RE,Mata JJ,Cohn M

更新日期：2003-05-01 00:00:00

abstract：:Interleukin 6 (IL-6) is involved both in immune responses and in inflammation, hematopoiesis, bone metabolism and embryonic development. IL-6 plays roles in chronic inflammation (closely related to chronic inflammatory diseases, autoimmune diseases and cancer) and even in the cytokine storm of corona virus disease 201...

journal_title：International immunology

authors： Hirano T

更新日期：2020-12-18 00:00:00

abstract：:In this study, we report that the release of IL-1 receptor antagonist (IL-1ra) from IL-4-stimulated neutrophils is markedly enhanced in the presence of IL-10. We also show that up-regulation of IL-1ra release by IL-10 in IL-4-stimulated neutrophils takes place through IL-1ra mRNA stabilization and enhancement of IL-1r...

journal_title：International immunology

authors： Crepaldi L,Silveri L,Calzetti F,Pinardi C,Cassatella MA

更新日期：2002-10-01 00:00:00

abstract：:NKT cells are characterized by their expression of an NKT-cell-specific invariant antigen-receptor α chain encoded by Vα14Jα18 gene segments. These NKT cells bridge the innate and acquired immune systems to mediate effective and augmented responses; however, the limited number of NKT cells in vivo hampers their analys...

journal_title：International immunology

authors： Ren Y,Dashtsoodol N,Watarai H,Koseki H,Quan C,Taniguchi M

更新日期：2014-10-01 00:00:00

abstract：:Mouse CD4+ T cells were subdivided into two subpopulations, naive (CD44low CD45RBhigh) and memory (CD44high CD45RBlow) T cells, by flow cytometric analysis. Examination of spleen and peripheral blood of C57BL/6 mice of various ages revealed that there was a reciprocal age-associated change in these two subpopulations,...

journal_title：International immunology

authors： Kurashima C,Utsuyama M,Kasai M,Ishijima SA,Konno A,Hirokawa K

更新日期：1995-01-01 00:00:00

abstract：:Although IL-2 receptor beta chain (IL-2R beta) expressed in various lymphoid cell lines binds IL-2 with an intermediate affinity, IL-2R beta expressed in fibroblasts is unable to bind IL-2, suggesting that IL-2R beta is on its own not sufficient for generating the intermediate-affinity receptor and that lymphoid-speci...

journal_title：International immunology

authors： Kuida K,Tanaka T,Kitamura F,Toyama-Sorimachi N,Miyasaka M

更新日期：1992-10-01 00:00:00

abstract：:The endocytic and phagocytic activities of a population of MHC IIhi CD11c+ dendritic cell (DC)-like cells in synovium-rich tissues (SRTs) of normal rat paws were compared with CD163+ cells (putative macrophages) from the same tissues and pseudo-afferent lymph DCs, peritoneal macrophages and blood monocytes. Fifty perc...

journal_title：International immunology

authors： Moghaddami M,Mayrhofer G,Cleland LG

更新日期：2005-08-01 00:00:00

abstract：:Man has been found to produce highly conserved chitinases. The most prominent is the phagocyte-derived chitotriosidase, the plasma levels of which are markedly elevated in some pathological conditions. Here, we report that both polymorphonuclear neutrophils (PMNs) and macrophages (m) are a source of chitotriosidase. T...

journal_title：International immunology

authors： van Eijk M,van Roomen CP,Renkema GH,Bussink AP,Andrews L,Blommaart EF,Sugar A,Verhoeven AJ,Boot RG,Aerts JM

更新日期：2005-11-01 00:00:00