Abstract:
:In this review, we propose that certain modifications in cellular metabolism might function as danger signals triggering inflammasome-mediated immune responses. We propose to call them danger-associated metabolic modifications (DAMMs). As intracellular bacteria can actively modulate macrophage metabolism for their benefit, infected host cells might sense bacteria-induced metabolic alterations and activate immune reactions. Here we report the known metabolic interactions that occur during infection of macrophages by intracellular bacteria and discuss the possible emergence of DAMMs upon bacteria-induced alterations of cellular metabolism.
journal_name
Int Immunoljournal_title
International immunologyauthors
Dramé M,Buchrieser C,Escoll Pdoi
10.1093/intimm/dxaa035subject
Has Abstractpub_date
2020-06-26 00:00:00pages
475-483issue
7eissn
0953-8178issn
1460-2377pii
5842096journal_volume
32pub_type
杂志文章,评审abstract::Semaphorin 3A (Sema3A), originally identified as a potent growth cone collapsing factor in developing sensory neurons, is now recognized as a key player in immune, cardiovascular, bone metabolism and neurological systems. Here we established an anti-Sema3A monoclonal antibody that neutralizes the effects of Sema3A bot...
journal_title:International immunology
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journal_title:International immunology
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doi:10.1093/intimm/dxn129
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journal_title:International immunology
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doi:10.1093/intimm/12.6.927
更新日期:2000-06-01 00:00:00
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journal_title:International immunology
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更新日期:2002-05-01 00:00:00
abstract::Human CD83 is a cell surface protein expressed predominantly by dendritic cells (DC) and lymphoid cells. So far, there exists no information on the function and distribution of mCD83. Here we demonstrate that mCD83 is moderately expressed on resting T cells and DC, but strongly increases in its expression on T cells f...
journal_title:International immunology
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pub_type: 杂志文章
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更新日期:2005-01-01 00:00:00
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journal_title:International immunology
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journal_title:International immunology
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更新日期:2002-09-01 00:00:00
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journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/dxf079
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abstract::The lectin complement pathway is initiated by binding of mannose-binding lectin (MBL) and MBL-associated serine protease (MASP) to carbohydrates. In the human lectin pathway, MASP-1 and MASP-2 are involved in the proteolysis of C4, C2 and C3. Here we report that the human MBL-MASP complex contains a new 22 kDa protein...
journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/11.5.859
更新日期:1999-05-01 00:00:00
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journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/dxf058
更新日期:2002-08-01 00:00:00
abstract::The class II transactivator (CIITA) controls both the constitutive and IFN-gamma inducible expression of HLA-D genes. In addition, through the squelching of another transactivator CREB-binding protein, CIITA was more recently shown to have a wider cellular function, including cell cycle control or cellular response to...
journal_title:International immunology
pub_type: 杂志文章
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更新日期:2002-08-01 00:00:00
abstract::NK cells limit the emergence of cancers and viral infections by surveillance of 'missing-self' and 'induced-self' ligands, and by direct recognition of pathogen-associated molecules. We examined individual roles for Toll-like receptors (TLRs)-7 and -8 in human NK-cell activation using synthetic, small molecule agonist...
journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/dxl046
更新日期:2006-07-01 00:00:00
abstract::Nitric oxide (NO) is formed constitutively in neurons by the constitutive enzyme NO synthase (cNOS) and acts as a neurotransmitter. It has already been shown that cNOS-containing neurons are identical to neurons staining for NADPH diaphorase and vice versa. Effector cells of the immune response produce high NO levels ...
journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/6.11.1751
更新日期:1994-11-01 00:00:00
abstract::Secretory IgA (sIgA) antibodies in human tears and milk were found to recognize protein disulfide isomerase (PDI) on a Toxoplasma gondii lysate immunoblot (IB). These antibodies were already detectable in tears of infants. To determine the epitope containing-regions on PDI, we generated truncated versions of recombina...
journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/dxf091
更新日期:2002-11-01 00:00:00
abstract::Hepatitis C virus (HCV) has the ability to persist in the majority of infected people. Strong, multispecific and sustained T-cell response is correlated with viral clearance. The mechanisms of chronicity by HCV are unclear. HCV could restrain the immune system and establish chronic infection by modulating dendritic ce...
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更新日期:2005-11-01 00:00:00
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journal_title:International immunology
pub_type: 杂志文章
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更新日期:1995-08-01 00:00:00
abstract::Neural stem cells (NSCs) transplantation has been proposed as a means of restoring damaged brain tissue, a possibility rendered more likely by reports of low NSCs immunogenicity in various experimental models because of low expression of MHC class I and II as well as co-stimulatory molecules. We investigated the immun...
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pub_type: 杂志文章
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更新日期:2007-09-01 00:00:00
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journal_title:International immunology
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