Truncation of the mu heavy chain alters BCR signalling and allows recruitment of CD5+ B cells.

abstract：:Impaired lymphocyte function is a common feature of human diabetes. Nucleoside transport across the plasma membrane is an essential step during lymphocyte growth and activation. In our study, we evaluated the impact of diabetic conditions on nucleoside transport system in B lymphocytes. Examination of the nucleoside t...

journal_title：International immunology

authors： Sakowicz M,Szutowicz A,Pawelczyk T

更新日期：2005-02-01 00:00:00

abstract：BACKGROUND:Intranasal administration of high amount of allergen was shown to induce tolerance and to reverse the allergic phenotype. However, mechanisms of tolerance induction via the mucosal route are still unclear. OBJECTIVES:To characterize the therapeutic effects of intranasal application of ovalbumin (OVA) in a m...

journal_title：International immunology

authors： Pellaton-Longaretti C,Boudousquié C,Barbier N,Barbey C,Argiroffo CB,Donati Y,Sauty A,Spertini F

更新日期：2011-01-01 00:00:00

abstract：:It was recently shown that paf-acether (paf) synthesized in different cell types remains partly cell-associated. In the present work, we tested the hypothesis that cell-associated paf might in fact remain exposed on the external plasma membrane and be able to exert its biological functions. Human polymorphonuclear neu...

journal_title：International immunology

authors： Ninio E,Leyravaud S,Bidault J,Jurgens P,Benveniste J

更新日期：1991-11-01 00:00:00

abstract：:Toll-like receptors (TLRs) traffic to distinct membranes for signaling. TLR7 and TLR9 recognize viral nucleic acids in the endosomes and induce robust anti-viral program. Signaling from these TLRs bifurcate at the level of distinct endosomal compartments, namely VAMP3(+) and LAMP(+) endosomes, to mediate the induction...

journal_title：International immunology

authors： Hayashi K,Sasai M,Iwasaki A

更新日期：2015-09-01 00:00:00

abstract：:We established an experimental system in vitro to examine the developmental capacity of individual hematopoietic progenitors to generate T, B and myeloid (M) cells. By using this system we analyzed the process of lineage commitment of hematopoietic progenitors in murine fetal liver (FL). It is known that small numbers...

journal_title：International immunology

authors： Kawamoto H,Ohmura K,Katsura Y

更新日期：1997-07-01 00:00:00

abstract：:Interleukin-15 (IL-15) is a cytokine critical for maintenance of intestinal intra-epithelial lymphocytes (IELs), especially CD8αα + IELs (CD8αα IELs). In the intestine, IL-15 is produced by intestinal epithelial cells (IECs), blood vascular endothelial cells (BECs) and hematopoietic cells. However, the precise role of...

journal_title：International immunology

authors： Zhu Y,Cui G,Miyauchi E,Nakanishi Y,Mukohira H,Shimba A,Abe S,Tani-Ichi S,Hara T,Nakase H,Chiba T,Sehara-Fujisawa A,Seno H,Ohno H,Ikuta K

更新日期：2020-05-08 00:00:00

abstract：:SKG mice, a newly established model of rheumatoid arthritis (RA), spontaneously develop autoimmune arthritis accompanying extra-articular manifestations, such as interstitial pneumonitis. To examine possible roles of T cells for mediating this systemic autoimmunity, we generated T cell clones from arthritic joints of ...

journal_title：International immunology

authors： Wakasa-Morimoto C,Toyosaki-Maeda T,Matsutani T,Yoshida R,Nakamura-Kikuoka S,Maeda-Tanimura M,Yoshitomi H,Hirota K,Hashimoto M,Masaki H,Fujii Y,Sakata T,Tsuruta Y,Suzuki R,Sakaguchi N,Sakaguchi S

更新日期：2008-10-01 00:00:00

abstract：:Eye-derived antigen-presenting cells (APCs) are known to contribute to the immune privilege status of the eye by inducing a form of peripheral tolerance that deviates T(h)1 type of pro-inflammatory immune responses. Similar systemic tolerance can also be induced by non-ocular APCs exposed to transforming growth factor...

journal_title：International immunology

authors： Masli S,Turpie B,Streilein JW

更新日期：2006-05-01 00:00:00

abstract：:The ability of cytokines to steer CD4(+) T(h) cell responses toward a T(h)1 or T(h)2 phenotype and enhance the magnitude of both CD8(+) cytotoxic T lymphocytes (CTL) and antibody responses has clearly been demonstrated by our lab and others, but the influence of cytokines on protective immune responses is much less cl...

journal_title：International immunology

authors： Ahlers JD,Belyakov IM,Matsui S,Berzofsky JA

更新日期：2001-07-01 00:00:00

abstract：:The intestinal epithelium not only acts as the physical structure that separates the intestinal lumen from the body but also actively participates in intestinal barrier functions. In the past decade, significant progress has been made in the development of culture technologies to maintain intestinal epithelial cells (...

journal_title：International immunology

authors： Nakamura T

更新日期：2019-02-06 00:00:00

abstract：:Epitope spreading has been best characterized as an exacerbating factor in CD4(+) T cell-dependent autoimmune disease models and is believed to occur via presentation of antigens liberated by tissue destruction initiated by CD4(+) T cells specific for a primary epitope. The growing evidence that exogenous antigens can...

journal_title：International immunology

authors： Markiewicz MA,Fallarino F,Ashikari A,Gajewski TF

更新日期：2001-05-01 00:00:00

abstract：:MicroRNAs 125a and 125b are predicted to be able to bind to the B lymphocyte-induced maturation protein-1 (BLIMP-1) and IFN regulatory protein-4 (IRF-4) transcription factors, which are essential for plasma cell differentiation. A computational survey of the human and mouse genomes revealed that miR-125a and miR-125b ...

journal_title：International immunology

authors： Gururajan M,Haga CL,Das S,Leu CM,Hodson D,Josson S,Turner M,Cooper MD

更新日期：2010-07-01 00:00:00

abstract：:Intestinal intraepithelial lymphocytes (i-IEL) of aged rats comprise CD4+CD8alphaalpha+ and CD4-CD8alphaalpha+ T cells expressing TCR alphabeta. In the present study, we compared characteristics between CD4+CD8alphaalpha+ and CD4-CD8alphaalpha+ i-IEL, which were purified by a cell sorter from the i-IEL of 6-month-old ...

journal_title：International immunology

authors： Yamada K,Kimura Y,Nishimura H,Namii Y,Murase M,Yoshikai Y

更新日期：1999-01-01 00:00:00

abstract：:Peyer's patch (PP) organogenesis proceeds through three histologically distinct steps: formation of organizing centers expressing VCAM-1 and ICAM-1 in segregated regions of the intestine at 15.5 days post-coitus (d.p.c.) (step I), accumulation of blood cells expressing different sets of surface markers to this region ...

journal_title：International immunology

authors： Yoshida H,Honda K,Shinkura R,Adachi S,Nishikawa S,Maki K,Ikuta K,Nishikawa SI

更新日期：1999-05-01 00:00:00

abstract：:An alloreactive CTL clone, 27.B2, produced in the mouse strain combination B6.C-H-2bm1 (bm1) against C57BL/6 (B6) and nominally directed against the Kb molecule has been shown to be peptide dependent. The clone recognizes intact B6, but not intact bm1 or bm3 target cells. However, peptides recognized by 27.B2 CTL can ...

journal_title：International immunology

authors： Falk K,Rötzschke O,Rammensee HG

更新日期：1992-03-01 00:00:00

abstract：:P-selectin is a Ca(2+)-dependent lectin that participates in leukocyte adhesion to vascular endothelium and platelets. Myeloid cells and a subset of T lymphocytes express carbohydrate ligands at the cell surface. Previously, we suggested that heat stable antigen (HSA/mouse CD24), an extensively glycosylated cell surfa...

journal_title：International immunology

authors： Aigner S,Ruppert M,Hubbe M,Sammar M,Sthoeger Z,Butcher EC,Vestweber D,Altevogt P

更新日期：1995-10-01 00:00:00

abstract：:The immunomodulator FTY720 inhibits lymph node (LN) and thymic egress, thereby constraining T cell circulation and reducing peripheral T cell numbers. Here, we analyzed in mouse models the as yet scarcely characterized impact of long-term (up to 6 months) FTY720 exposure on T cell homeostasis and possible consequences...

journal_title：International immunology

authors： Metzler B,Gfeller P,Wieczorek G,Li J,Nuesslein-Hildesheim B,Katopodis A,Mueller M,Brinkmann V

更新日期：2008-05-01 00:00:00

abstract：:'Programmed cell death' has been used to describe the death of cells killed by cytotoxic T cells or growth factor deprivation. Although bcl-2 can prevent death of cells deprived of growth factor, it failed to protect cells against T cell killing. In spite of bcl-2 expression, the DNA of targeted cells was degraded int...

journal_title：International immunology

authors： Vaux DL,Aguila HL,Weissman IL

更新日期：1992-07-01 00:00:00

abstract：:We have used a set of single-chain variable fragment antibodies (sc) genetically fused with an influenza hemagglutinin-derived peptide as a means to investigate the role of CR1 and CR2 in antigen presentation by B cells. When incubated with the B cell lymphoma 2PK3, peptide-containing sc specific for either CR1 or CR1...

journal_title：International immunology

authors： Prechl J,Baiu DC,Horváth A,Erdei A

更新日期：2002-03-01 00:00:00

abstract：:Soluble recombinant (r) P-selectin and rP-selectin immobilized on plastic surfaces were tested for their capacity to activate neutrophils to produce superoxide anion. Soluble rP-selectin was incapable of activating leukocytes, whereas immobilized rP-selectin was able to induce leukocyte activation. When neutrophils we...

journal_title：International immunology

authors： Nagata K,Tsuji T,Matsushima K,Hanai N,Irimura T

更新日期：2000-04-01 00:00:00

abstract：:Fc receptors play important roles for a wide array of immune responses. In contrast to the well-defined Fcγ and Fcε receptors, the molecular and functional characteristics of Fc receptors for IgA and IgM have remained incompletely understood for years. Recent progress has unveiled the characteristics of Fc receptors f...

journal_title：International immunology

authors： Shibuya A,Honda SI,Shibuya K

更新日期：2017-12-30 00:00:00

abstract：:Previously we observed elevation of the serum concentration of two acute-phase protein (AFP) complement components (C9 and C1-inhibitor) in patients with chronic hepatitis C who responded (R) to IFN-alpha therapy, but not in non-responders (NR). In the present study we investigated the effect of high-dose IFN-alpha th...

journal_title：International immunology

authors： Kalabay L,Nemesánszky E,Csepregi A,Pusztay M,Dávid K,Horváth G,Ibrányi E,Telegdy L,Pár A,Bíró A,Fekete B,Gervain J,Horányi M,Ribiczey P,Csöndes M,Kleiber M,Walentin S,Prohászka Z,Füst G

更新日期：2004-01-01 00:00:00

abstract：:Mutagenic analyses have identified structural motifs important for TCR-mediated signaling in the antigen-binding chains, CD3 and zeta subunits of the TCR complex. In this study, we altered selected residues in the transmembrane and extracellular constant regions of the TCR beta chain and expressed the mutants in a T h...

journal_title：International immunology

authors： Fuller-Espie S,Hoffman Towler P,Wiest DL,Tietjen I,Spain LM

更新日期：1998-07-01 00:00:00

abstract：:Human intestinal intraepithelial lymphocytes (iIEL) are a unique population of predominantly CD8 alpha beta+, TCR alpha beta+ lymphocytes and, to a lesser extent, TCP gamma delta+ lymphocytes that proliferate poorly to anti-CD3 mitogenic signals but display significant cytolytic activity. Studies in mouse model system...

journal_title：International immunology

authors： Balk SP,Polischuk JE,Probert C,Stevens C,Ebert E,She J,Terhorst C,Blumberg RS

更新日期：1995-08-01 00:00:00

abstract：:O-acetyl GD3 ganglioside is a cell surface molecule of some neural, neural crest and renal cells. Here we show, by using mAbs specific for O-acetyl GD3 (clone 27A) and flow-cytometric, biochemical or immunological techniques, that it is also expressed at high intensity level on the surface of 49.6% (median) of the CD3...

journal_title：International immunology

authors： Reivinen J,Holthöfer H,Miettinen A

更新日期：1994-09-01 00:00:00

abstract：:Synovial tissues are frequent sites of inflammatory disorders in which dendritic cells (DCs) may play an important role. This study examines potential antigen-presenting cells obtained from synovium-rich tissues (SRTs) by vascular perfusion of rat hind limbs with collagenase and further enzymatic digestion of the disa...

journal_title：International immunology

authors： Moghaddami M,Cleland LG,Mayrhofer G

更新日期：2005-08-01 00:00:00

abstract：:The two-signal model states that activation of naive T cells requires a signal 1 stimulus through the TCR and a co-stimulatory signal 2. By contrast, signal 1 alone is sufficient for pre-activated T cells. Recently, however, it has been shown that under certain conditions T cells can bypass the requirement for co-stim...

journal_title：International immunology

authors： Pardigon N,Bercovici N,Calbo S,Santos-Lima EC,Liblau R,Kourilsky P,Abastado JP

更新日期：1998-05-01 00:00:00

abstract：:Experiments in transgenic mice have demonstrated that thymocyte differentiation into the mature CD4+ helper or CD8+ cytotoxic T cell lineage is ultimately dependent upon the specificity of the TCR for class II or class I MHC molecules respectively. However, the initial mechanistic events involved in this process remai...

journal_title：International immunology

authors： DeKoning J,Carbone FR,Kaye J

更新日期：1995-04-01 00:00:00

abstract：:Acute graft-versus-host disease (GvHD) is a serious complication after allogeneic bone marrow transplantation. Donor-derived T cells infiltrate recipient target organs and cause severe tissue damage, often leading to death of the affected patient. Tissue destruction is a direct result of donor CD8+ T cell activation a...

journal_title：International immunology

authors： Arnold D,Wasem C,Juillard P,Graber P,Cima I,Frutschi C,Herren S,Jakob S,Alouani S,Mueller C,Chvatchko Y,Brunner T

更新日期：2002-05-01 00:00:00

abstract：:Whether astrocytes utilize B7:CD28 co-stimulation to activate T cells mediating CNS inflammatory disease is controversial. In this report, primary astrocytes and murine astrocyte lines, generated by immortalization at two different times, day 7 or 45 of culture, were examined for their capability to express B7 co-stim...

journal_title：International immunology

authors： Soos JM,Ashley TA,Morrow J,Patarroyo JC,Szente BE,Zamvil SS

更新日期：1999-07-01 00:00:00