Abstract:
:The B cell-activating factor from the tumor necrosis factor family (BAFF) is an important regulator of B cell immunity. Recently, we demonstrated that recombinant BAFF also provides a co-stimulatory signal to T cells. Here, we studied expression of BAFF in peripheral blood leukocytes and correlated this expression with BAFF T cell co-stimulatory function. BAFF is produced by antigen-presenting cells (APC). Blood dendritic cells (DC) as well as DC differentiated in vitro from monocytes or CD34+ stem cells express BAFF mRNA. Exposure to bacterial products further up-regulates BAFF production in these cells. A low level of BAFF transcription, up-regulated upon TCR stimulation, was also detected in T cells. Functionally, blockade of endogenous BAFF produced by APC and, to a lesser extent, by T cells inhibits T cell activation. Altogether, this indicates that BAFF may regulate T cell immunity during APC-T cell interactions and as an autocrine factor once T cells have detached from the APC.
journal_name
Int Immunoljournal_title
International immunologyauthors
Huard B,Arlettaz L,Ambrose C,Kindler V,Mauri D,Roosnek E,Tschopp J,Schneider P,French LEdoi
10.1093/intimm/dxh043subject
Has Abstractpub_date
2004-03-01 00:00:00pages
467-75issue
3eissn
0953-8178issn
1460-2377journal_volume
16pub_type
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