Signaling events following chemokine receptor ligation in human dendritic cells at different developmental stages.

abstract：:Peyer's patch (PP) organogenesis proceeds through three histologically distinct steps: formation of organizing centers expressing VCAM-1 and ICAM-1 in segregated regions of the intestine at 15.5 days post-coitus (d.p.c.) (step I), accumulation of blood cells expressing different sets of surface markers to this region ...

journal_title：International immunology

authors： Yoshida H,Honda K,Shinkura R,Adachi S,Nishikawa S,Maki K,Ikuta K,Nishikawa SI

更新日期：1999-05-01 00:00:00

abstract：:Blocking T cell co-stimulatory signals by anti-B7-1/B7-2 mAb is an attractive approach to treat autoimmune diseases. However, anti-B7-1/B7-2 mAb treatment is known to exacerbate autoimmune diseases through mechanisms not fully understood. Tumor necrosis factor alpha (TNF-alpha) and reactive oxygen species (ROS) also p...

journal_title：International immunology

authors： Khan N,Ghousunnissa S,Jegadeeswaran SM,Thiagarajan D,Hasnain SE,Mukhopadhyay S

更新日期：2007-04-01 00:00:00

abstract：:Hepatitis C virus (HCV) has the ability to persist in the majority of infected people. Strong, multispecific and sustained T-cell response is correlated with viral clearance. The mechanisms of chronicity by HCV are unclear. HCV could restrain the immune system and establish chronic infection by modulating dendritic ce...

journal_title：International immunology

authors： Krishnadas DK,Ahn JS,Han J,Kumar R,Agrawal B

更新日期：2010-06-01 00:00:00

abstract：:Mice with a targeted deletion of the T-bet gene exhibit spontaneous airway hyperresponsiveness (AHR), airway inflammation, enhanced recovery of T(h)2 cytokines from bronchoalveolar lavage fluid, sub-epithelial collagen deposition and myofibroblast transformation. Here we analyze the mechanisms responsible for the chro...

journal_title：International immunology

authors： Finotto S,Hausding M,Doganci A,Maxeiner JH,Lehr HA,Luft C,Galle PR,Glimcher LH

更新日期：2005-08-01 00:00:00

abstract：:In vaccine development, a major objective is to induce strong, specific T cell responses. This might be obtained by targeting antigen to cell surface molecules that efficiently channel the antigen into endocytic compartments for loading of MHC molecules. Antibodies have been used to deliver antigen; however, it is imp...

journal_title：International immunology

authors： Schjetne KW,Thompson KM,Aarvak T,Fleckenstein B,Sollid LM,Bogen B

更新日期：2002-12-01 00:00:00

abstract：:Toll-like receptors (TLRs) traffic to distinct membranes for signaling. TLR7 and TLR9 recognize viral nucleic acids in the endosomes and induce robust anti-viral program. Signaling from these TLRs bifurcate at the level of distinct endosomal compartments, namely VAMP3(+) and LAMP(+) endosomes, to mediate the induction...

journal_title：International immunology

authors： Hayashi K,Sasai M,Iwasaki A

更新日期：2015-09-01 00:00:00

abstract：:Interleukin 6 (IL-6) is involved both in immune responses and in inflammation, hematopoiesis, bone metabolism and embryonic development. IL-6 plays roles in chronic inflammation (closely related to chronic inflammatory diseases, autoimmune diseases and cancer) and even in the cytokine storm of corona virus disease 201...

journal_title：International immunology

authors： Hirano T

更新日期：2020-12-18 00:00:00

abstract：:The class II trans-activator (CIITA) is a bi- or multi-functional domain protein which plays a critical role in the expression of MHC class II genes. We report that removal of the N-terminal 151 amino acids, encompassing all of the acidic domain but leaving intact the proline/serine/threonine-rich domain, results in a...

journal_title：International immunology

authors： Yun S,Gustafsson K,Fabre JW

更新日期：1997-10-01 00:00:00

abstract：:In humans, the thymus is the primary lymphoid organ able to support the development of T cells through its three-dimensional (3D) organization of the thymic stromal cells. Since a remarkable number of similarities are shared between the thymic epithelial cells (TECs) and skin-derived keratinocytes and fibroblasts, in ...

journal_title：International immunology

authors： Palamaro L,Guarino V,Scalia G,Antonini D,De Falco L,Bianchino G,Fusco A,Romano R,Grieco V,Missero C,Del Vecchio L,Ambrosio L,Pignata C

更新日期：2013-12-01 00:00:00

abstract：:Natural killer (NK) cells are a major FcγRIIIA-expressing lymphocyte population that mediate antibody-dependent cellular cytotoxicity. Although NK cells are critical for immunity against viruses and tumors, they are also activated in the joints of patients with rheumatoid arthritis (RA) and may be involved in disease ...

journal_title：International immunology

authors： Shimizu Y,Kohyama M,Yorifuji H,Jin H,Arase N,Suenaga T,Arase H

更新日期：2019-04-26 00:00:00

abstract：:IL-18 is a proinflammatory cytokine that plays an important role in NK cell activation and T(h)1 response. IL-18 has a structural homology to IL-1, particularly IL-1beta. IL-18R, composed of IL-1R-related protein (IL-18Ralpha) and IL-1R accessory protein-like (IL-18Rbeta), belongs to the IL-1R family. Furthermore, IL-...

journal_title：International immunology

authors： Tominaga K,Yoshimoto T,Torigoe K,Kurimoto M,Matsui K,Hada T,Okamura H,Nakanishi K

更新日期：2000-02-01 00:00:00

abstract：:IL-12 has been shown to play a central role in cell-mediated inflammatory reactions through direct activation of T cells and NK cells. IL-12 also strongly influences humoral immunity but these effects have been thought to be indirect and caused by intermediary cytokines. Using flow cytometry, we now show that IL-12 di...

journal_title：International immunology

authors： Vogel LA,Showe LC,Lester TL,McNutt RM,Van Cleave VH,Metzger DW

更新日期：1996-12-01 00:00:00

abstract：:We have used a set of single-chain variable fragment antibodies (sc) genetically fused with an influenza hemagglutinin-derived peptide as a means to investigate the role of CR1 and CR2 in antigen presentation by B cells. When incubated with the B cell lymphoma 2PK3, peptide-containing sc specific for either CR1 or CR1...

journal_title：International immunology

authors： Prechl J,Baiu DC,Horváth A,Erdei A

更新日期：2002-03-01 00:00:00

abstract：:Liver fibrosis is commonly observed in chronic liver disease. However, the immunological mechanisms underlying hepatic fibrosis due to chronic inflammation are not well defined, mainly because suitable experimental models have not been established. We have found that weekly i.v. administration of concanavalin A (Con A...

journal_title：International immunology

authors： Kimura K,Ando K,Ohnishi H,Ishikawa T,Kakumu S,Takemura M,Muto Y,Moriwaki H

更新日期：1999-09-01 00:00:00

abstract：:The TCR is responsible for the specificity of cytotoxic T lymphocytes (CTL) by recognizing peptides presented in the context of MHC. By producing recombinant soluble TCR, it is possible to study this interaction at the molecular level. We generated single-chain TCR (scTCR) from tumor infiltrating lymphocytes (TIL) and...

journal_title：International immunology

authors： Lake DF,Salgaller ML,van der Bruggen P,Bernstein RM,Marchalonis JJ

更新日期：1999-05-01 00:00:00

abstract：:Intradermal inoculation of plasmids expressing antigens that contain MHC class I-restricted epitopes leads to the induction of specific CD8(+) cytotoxic T lymphocytes (CTL). The role of in situ transfected antigen-presenting cells (APC) in the priming of specific CTL subsequent to intradermal DNA immunization was inve...

journal_title：International immunology

authors： Bot A,Stan AC,Inaba K,Steinman R,Bona C

更新日期：2000-06-01 00:00:00

abstract：:We investigated the role of IL-7 receptor alpha (IL-7Ralpha) signal in the formation of Peyer's patch (PP) anlage. Although pan-lymphopenia is a common phenotype of rag2-/- and il7ralpha-/- mice, a close inspection revealed nodules corresponding to PP in the adult rag2-/- but not in the il7ralpha-/- mouse. In our prev...

journal_title：International immunology

authors： Adachi S,Yoshida H,Honda K,Maki K,Saijo K,Ikuta K,Saito T,Nishikawa SI

更新日期：1998-01-01 00:00:00

abstract：:CD40 has been shown to play an important role in the regulation of B cell survival, proliferation and Ig class switching. The natural partner for CD40 is CD40 ligand, gp 39, which is transiently expressed on activated T cells. In vitro, CD40 ligation leads to polyclonal B cell proliferation and, in the presence of app...

journal_title：International immunology

authors： Wohlleben G,Gray D,Schimpl A

更新日期：1996-03-01 00:00:00

abstract：BACKGROUND:Intranasal administration of high amount of allergen was shown to induce tolerance and to reverse the allergic phenotype. However, mechanisms of tolerance induction via the mucosal route are still unclear. OBJECTIVES:To characterize the therapeutic effects of intranasal application of ovalbumin (OVA) in a m...

journal_title：International immunology

authors： Pellaton-Longaretti C,Boudousquié C,Barbier N,Barbey C,Argiroffo CB,Donati Y,Sauty A,Spertini F

更新日期：2011-01-01 00:00:00

abstract：:The immunomodulator FTY720 inhibits lymph node (LN) and thymic egress, thereby constraining T cell circulation and reducing peripheral T cell numbers. Here, we analyzed in mouse models the as yet scarcely characterized impact of long-term (up to 6 months) FTY720 exposure on T cell homeostasis and possible consequences...

journal_title：International immunology

authors： Metzler B,Gfeller P,Wieczorek G,Li J,Nuesslein-Hildesheim B,Katopodis A,Mueller M,Brinkmann V

更新日期：2008-05-01 00:00:00

abstract：:CD69, an 'activation marker' that is rapidly induced on mature T cells after stimulation through the T cell antigen receptor (TCR) was found to be expressed on approximately 10% of normal thymocytes. All of these CD69+ thymocytes express alpha beta TCR, and they include both TCRlowCD4+CD8+ and TCRhighCD4+CD8- or CD4-C...

journal_title：International immunology

authors： Yamashita I,Nagata T,Tada T,Nakayama T

更新日期：1993-09-01 00:00:00

abstract：:Two major B cell subpopulations were identified in the IgD- compartment of tonsils and subsequently isolated. They displayed the following phenotypes: CD10+CD38+CD44- (CD38+ B cells) and CD10-CD38-CD44+ (CD38- B cells). Of the CD38- B cells, 70% also expressed CD24 and CD39, whereas CD77 was specifically distributed o...

journal_title：International immunology

authors： Lagresle C,Bella C,Defrance T

更新日期：1993-10-01 00:00:00

abstract：:NKT cells are characterized by their expression of an NKT-cell-specific invariant antigen-receptor α chain encoded by Vα14Jα18 gene segments. These NKT cells bridge the innate and acquired immune systems to mediate effective and augmented responses; however, the limited number of NKT cells in vivo hampers their analys...

journal_title：International immunology

authors： Ren Y,Dashtsoodol N,Watarai H,Koseki H,Quan C,Taniguchi M

更新日期：2014-10-01 00:00:00

abstract：:Long-term side effects may represent a relevant burden of antiretroviral treatment (ART) in HIV-infected patients with good CD4 immune reconstitution over extended time spans. CD4-guided treatment interruption (TI) has been evaluated to address this point and may result in a wide spectrum of time off ART in different ...

journal_title：International immunology

authors： Bozzano F,Nasi M,Bertoncelli L,Nemes E,Prati F,Marras F,Mussini C,Moretta L,Cossarizza A,De Maria A

更新日期：2011-02-01 00:00:00

abstract：:B cell development is a complex process involving interactions between B cell precursors, stroma, and known and unknown ligands and cytokines. In order to more fully understand the requirements for Ig in that development we have created transgenic mice that carry a gamma 2b transgene and express it early in B cell dev...

journal_title：International immunology

authors： Kurtz BS,Witte PL,Storb U

更新日期：1997-03-01 00:00:00

abstract：:The third complementarity determining regions of heavy chain variable regions (CDRH3) confer the fine specificities of antibodies. The CDRH3 length distribution of all human or all mouse antibodies appears to be more or less random, with the human distribution having a wider spread. Since the Kabat database of aligned...

journal_title：International immunology

authors： Johnson G,Wu TT

更新日期：1998-12-01 00:00:00

abstract：:Antibody-secreting cells (ASCs) in respiratory tract tissues provide a first line of defense against invading pathogens. These cells often secrete IgA that is efficiently transcytosed across epithelial barriers into the airway lumen where pathogens can be blocked at their point of entry. Previous literature has report...

journal_title：International immunology

authors： Sealy RE,Surman SL,Vogel P,Hurwitz JL

更新日期：2016-11-01 00:00:00

abstract：:Candida albicans is a commensal fungus that predominantly resides on mucosal surfaces and can cause lethal systemic infection when the host defense is compromised. Candidalysin is a cytolytic peptide toxin produced by C. albicans hyphae that is essential for mucosal tissue damage and is believed to contribute to the e...

journal_title：International immunology

authors： Hanaoka M,Domae E

更新日期：2020-10-10 00:00:00

abstract：:The adaptive immune response is involved in the development and progression of atherosclerosis and IL-17A(+) cells play a role in this disease. Although elevated number of CD4(+) IL-17A(+) (Th17) and IL-17A(+)TCRγδ(+) T cells are found within murine atherosclerotic aortas and human plaques, the mechanisms governing IL...

journal_title：International immunology

authors： Butcher MJ,Wu CI,Waseem T,Galkina EV

更新日期：2016-05-01 00:00:00

abstract：:Germline CH transcripts initiate from a non-coding I exon and terminate downstream of the associated CH exons. Ig heavy chain class switch recombination from the VDJ-C mu gene to particular downstream CH genes appears to be regulated by a process that involves mitogen and/or cytokine induction of germline CH transcrip...

journal_title：International immunology

authors： Li SC,Rothman PB,Zhang J,Chan C,Hirsh D,Alt FW

更新日期：1994-04-01 00:00:00