Abstract:
:SKG mice, a newly established model of rheumatoid arthritis (RA), spontaneously develop autoimmune arthritis accompanying extra-articular manifestations, such as interstitial pneumonitis. To examine possible roles of T cells for mediating this systemic autoimmunity, we generated T cell clones from arthritic joints of SKG mice. Two distinct CD8(+) clones were established and both showed in vitro autoreactivity by killing syngeneic synovial cells and a variety of MHC-matched cell lines. Transfer of each clone to histocompatible athymic nude mice elicited joint swelling and histologically evident synovitis accompanying the destruction of adjacent cartilage and bone. Notably, the transfer also produced diffuse severe interstitial pneumonitis. Clone-specific TCR gene messages in the inflamed joints and lungs of the recipients gradually diminished, becoming hardly detectable in 6-11 months; yet, arthritis and pneumonitis continued to progress. Thus, the same CD8(+) T cell clones from arthritic lesions of SKG mice can elicit both synovitis and pneumonitis, which chronically progress and apparently become less T cell dependent in a later phase. The results provide clues to our understanding of how self-reactive T cells cause both articular and extra-articular lesions in RA as a systemic autoimmune disease.
journal_name
Int Immunoljournal_title
International immunologyauthors
Wakasa-Morimoto C,Toyosaki-Maeda T,Matsutani T,Yoshida R,Nakamura-Kikuoka S,Maeda-Tanimura M,Yoshitomi H,Hirota K,Hashimoto M,Masaki H,Fujii Y,Sakata T,Tsuruta Y,Suzuki R,Sakaguchi N,Sakaguchi Sdoi
10.1093/intimm/dxn091subject
Has Abstractpub_date
2008-10-01 00:00:00pages
1331-42issue
10eissn
0953-8178issn
1460-2377pii
dxn091journal_volume
20pub_type
杂志文章abstract::Peyer's patch (PP) organogenesis proceeds through three histologically distinct steps: formation of organizing centers expressing VCAM-1 and ICAM-1 in segregated regions of the intestine at 15.5 days post-coitus (d.p.c.) (step I), accumulation of blood cells expressing different sets of surface markers to this region ...
journal_title:International immunology
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journal_title:International immunology
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更新日期:2002-10-01 00:00:00
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