Abstract:
:We have searched the human genome for genes that predispose to rheumatoid arthritis (RA) using fluorescence-based microsatellite marker analysis and affected sib-pair linkage study. A panel of 41 Japanese families, each with at least two affected siblings, was typed for genome-wide 358 polymorphic microsatellite marker loci. Markers were amplified by the PCR using fluorescence-tagged primers and sized based on the difference of CA repeats on DNA. Linkage analysis was made using maximum lod score (MLS). The MLS for D1S214 and D8S556 was 3.27 and 3.33, while the MLS for the HLA-DRB1 region was <3.0. According to detailed analysis by single-point analysis using MAPMAKER/SIBS, the MLS for D1S253 and D1S214 was 3.77 and 3.58. The MLS by multipoint analysis was 6.13 for D1S253. The MLS for D8S556 by single-point analysis was 4.20. The MLS for DXS1232 was 2.35 by single-point analysis, whereas the MLS for the region 2 cM right to DXS1232 and the region between DXS1227 and DXS1200 was 3.03 and 2.93 by multi-point analysis. Three principal chromosome regions of linkage, D1S253/214, D8S556 and DXS1232, have been identified which we call RA1, RA2 and RA3 for RA disease loci.
journal_name
Int Immunoljournal_title
International immunologyauthors
Shiozawa S,Hayashi S,Tsukamoto Y,Goko H,Kawasaki H,Wada T,Shimizu K,Yasuda N,Kamatani N,Takasugi K,Tanaka Y,Shiozawa K,Imura Sdoi
10.1093/intimm/10.12.1891subject
Has Abstractpub_date
1998-12-01 00:00:00pages
1891-5issue
12eissn
0953-8178issn
1460-2377journal_volume
10pub_type
杂志文章abstract::A gelatin sponge model of concomitant tumor immunity was employed in order to examine the clonality of T cells associated with progressing and rejected tumor sites. Here we show that freshly isolated T cells bearing TCR V(beta)1, CDR3 RPGTGN, J(beta)1.1 and TCR V(beta)8, CDR3 GD, J(beta)1.6 predominated progressing an...
journal_title:International immunology
pub_type: 杂志文章
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journal_title:International immunology
pub_type: 杂志文章
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更新日期:2012-08-01 00:00:00
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journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/6.5.785
更新日期:1994-05-01 00:00:00
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pub_type: 杂志文章
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更新日期:2009-10-01 00:00:00
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pub_type: 杂志文章
doi:10.1093/intimm/4.6.691
更新日期:1992-06-01 00:00:00
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journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/8.9.1421
更新日期:1996-09-01 00:00:00
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journal_title:International immunology
pub_type: 杂志文章
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更新日期:2009-07-01 00:00:00
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pub_type: 杂志文章
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更新日期:1997-09-01 00:00:00
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pub_type: 杂志文章
doi:10.1093/intimm/11.7.1075
更新日期:1999-07-01 00:00:00
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更新日期:2008-02-01 00:00:00
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pub_type: 杂志文章
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更新日期:1996-02-01 00:00:00
abstract::Streptococcus suis serotype 2 is an important porcine bacterial pathogen and a zoonotic agent responsible for sudden death, septic shock and meningitis, with exacerbated inflammation being a hallmark of the systemic and central nervous system (CNS) infections. However, S. suis serotype 2 strains are genetically and ph...
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pub_type: 杂志文章
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更新日期:2019-10-16 00:00:00
abstract::The mucosa is one of the initial sites of group A streptococcal (GAS) infection and salivary IgA (sIgA) is thought to be critical to immunity. However, the target epitopes of sIgA and the function of sIgA in GAS immunity, in particular the role of accessory cells and complement, is largely unknown. We studied the aqui...
journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/11.4.569
更新日期:1999-04-01 00:00:00
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pub_type: 杂志文章
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更新日期:1999-08-01 00:00:00
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更新日期:2004-08-01 00:00:00
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journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/3.2.205
更新日期:1991-02-01 00:00:00
abstract::CD6, a 130-kDa surface glycoprotein, is expressed primarily on cells of T lineage. A co-stimulatory role for CD6 in mature T cells has been shown, but the function of CD6 during thymocyte development is unknown. Since CD6 ligands are expressed on thymic epithelium, their interactions with CD6 could be important in thy...
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pub_type: 杂志文章
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更新日期:2002-06-01 00:00:00