Regulation of T cell development by c-Cbl: essential role of Lck.

abstract：:Unlike splenic B cells from normal BALB/c mice, those from autoimmune-prone NZB x NZW (B/W) F1 young mice were hyperresponsive to interleukin 2 (IL2) and proliferated even in the absence of prior stimulation signals. We found that the B cell subpopulation responsible for this event belongs to that with 6B2 (B220)-dull...

journal_title：International immunology

authors： Hasegawa K,Abe M,Okada T,Hirose S,Sato H,Shirai T

更新日期：1989-01-01 00:00:00

abstract：:Antigen-coupled antigen-presenting cells (APC) serve as potent tolerogens for inhibiting immune responses in vivo and in vitro, apparently by providing an antigen-specific signal through the TCR in the absence of co-stimulation. Although this approach has been well studied in rodents, little is known about its effects...

journal_title：International immunology

authors： Vandenbark AA,Barnes D,Finn T,Bourdette DN,Whitham R,Robey I,Kaleeba J,Bebo BF Jr,Miller SD,Offner H,Chou YK

更新日期：2000-01-01 00:00:00

abstract：:LPS-binding protein (LBP) can facilitate the transfer of cell wall components of both Gram-negative bacteria (LPS) and Gram-positive bacteria (lipoteichoic acid) to inflammatory cells. Although LBP is predominantly produced in the liver, recent studies have indicated that this protein is also synthesized locally in th...

journal_title：International immunology

authors： Branger J,Florquin S,Knapp S,Leemans JC,Pater JM,Speelman P,Golenbock DT,van der Poll T

更新日期：2004-11-01 00:00:00

abstract：:Macrophages are heterogeneous and plastic, and play several diverse functions in immune responses. Emerging data provide evidence of multiple roles for metabolic pathways in the control of macrophage effector functions. The diverse functions of macrophages are categorized into two main subsets: classical activated mac...

journal_title：International immunology

authors： Kang S,Kumanogoh A

更新日期：2020-06-26 00:00:00

abstract：:Despite intense recent interest, the suppressive mechanisms of regulatory CD25+CD4 T cells remain poorly understood. One deficiency in the field is the lack of in vivo models where the effects of regulatory CD25+CD4 T cells on antigen-specific responder T cells can be measured quantitatively. We describe one such mode...

journal_title：International immunology

authors： Thorstenson KM,Herzovi L,Khoruts A

更新日期：2005-04-01 00:00:00

abstract：:NK cells were first identified in 1975 and represent the prototypical group 1 innate lymphoid cell (ILC). More recently, the discovery of new members of the ILC family has highlighted the complexity of this innate lymphoid lineage. Importantly, it has been recognized that different subsets exist within the group 1 ILC...

journal_title：International immunology

authors： Seillet C,Belz GT

更新日期：2016-01-01 00:00:00

abstract：:A small proportion of the sIg+ B lymphocytes in peripheral lymphoid organs [22% in spleen and 6% in lymph node (LN)] in rat carries the Thy-1 antigen. These Thy-1+ B cells represent newly formed bone marrow (BM) derived (or immature) B cells. In this study we investigated the kinetic behavior of Thy-1+ and Thy-1- B ce...

journal_title：International immunology

authors： Deenen GJ,Kroese FG

更新日期：1993-07-01 00:00:00

abstract：:NK cells are functionally controlled by the killer immunoglobulin-like receptor (KIR) family that comprises inhibitory (iKIR) and activating (aKIR) members. Genetic association studies suggest that donors expressing aKIRs next to iKIRs will be superior donors in the setting of hematopoietic stem cell transplantation o...

journal_title：International immunology

authors： Baltner K,Kübler A,Pal M,Balvociute M,Mezger M,Handgretinger R,André MC

更新日期：2017-11-01 00:00:00

abstract：:T lymphocyte responses to the MHC of an evolutionarily distant species are known to be weak compared with responses against allogeneic MHC products within a species. This fact was used to examine the regions of human MHC class II molecules required for the stimulation of strong primary immune responses against MHC all...

journal_title：International immunology

authors： Ramesh P,Barber L,Batchelor JR,Lechler RI

更新日期：1992-08-01 00:00:00

abstract：:Autoimmune gastritis is a CD4+ T cell-mediated disease induced in genetically susceptible mice by thymectomy on the third day after birth. Previous linkage analysis indicated that Gasa1 and Gasa2, the major susceptibility loci for gastritis, are located on mouse chromosome 4. Here we verified these linkage data by sho...

journal_title：International immunology

authors： Ang DK,Brodnicki TC,Jordan MA,Wilson WE,Silveira P,Gliddon BL,Baxter AG,van Driel IR

更新日期：2007-09-01 00:00:00

abstract：:During brain development, the generation of neurons and glial cells is rigorously regulated by diverse mechanisms including the immune system. Dysfunction of the developing system results in the onset of neurodevelopmental disorders and psychological disorders. Recent studies have demonstrated that the immune system i...

journal_title：International immunology

authors： Tanabe S,Yamashita T

更新日期：2018-09-25 00:00:00

abstract：:IL-18 is a proinflammatory cytokine that plays an important role in NK cell activation and T(h)1 response. IL-18 has a structural homology to IL-1, particularly IL-1beta. IL-18R, composed of IL-1R-related protein (IL-18Ralpha) and IL-1R accessory protein-like (IL-18Rbeta), belongs to the IL-1R family. Furthermore, IL-...

journal_title：International immunology

authors： Tominaga K,Yoshimoto T,Torigoe K,Kurimoto M,Matsui K,Hada T,Okamura H,Nakanishi K

更新日期：2000-02-01 00:00:00

abstract：:Secretory IgA (sIgA) antibodies in human tears and milk were found to recognize protein disulfide isomerase (PDI) on a Toxoplasma gondii lysate immunoblot (IB). These antibodies were already detectable in tears of infants. To determine the epitope containing-regions on PDI, we generated truncated versions of recombina...

journal_title：International immunology

authors： Meek B,Back JW,Klaren VN,Speijer D,Peek R

更新日期：2002-11-01 00:00:00

abstract：:The dynamic behaviour of isolated populations of peritoneal LPS-reactive (LPSr) B lymphocytes was studied upon transfer of peritoneal cells (PerC) from C57BL/6 LPS responder into C57BL/10ScCr LPS non-responder mice. We have followed the persistence and life-span of the transferred LPSr donor B cells in the spleen and ...

journal_title：International immunology

authors： Thomas-Vaslin V,Feitas AA

更新日期：1990-01-01 00:00:00

abstract：:Intradermal inoculation of plasmids expressing antigens that contain MHC class I-restricted epitopes leads to the induction of specific CD8(+) cytotoxic T lymphocytes (CTL). The role of in situ transfected antigen-presenting cells (APC) in the priming of specific CTL subsequent to intradermal DNA immunization was inve...

journal_title：International immunology

authors： Bot A,Stan AC,Inaba K,Steinman R,Bona C

更新日期：2000-06-01 00:00:00

abstract：:Exosomes are small vesicles (60-100 nm) secreted by various cell types upon the fusion of endosomal compartments with the plasma membrane. Exosomes from antigen-presenting cells (APC), such as B lymphocytes and dendritic cells (DC), bear MHC class II molecules. In addition, the injection of DC-derived exosomes was rep...

journal_title：International immunology

authors： Vincent-Schneider H,Stumptner-Cuvelette P,Lankar D,Pain S,Raposo G,Benaroch P,Bonnerot C

更新日期：2002-07-01 00:00:00

abstract：:We have used a set of single-chain variable fragment antibodies (sc) genetically fused with an influenza hemagglutinin-derived peptide as a means to investigate the role of CR1 and CR2 in antigen presentation by B cells. When incubated with the B cell lymphoma 2PK3, peptide-containing sc specific for either CR1 or CR1...

journal_title：International immunology

authors： Prechl J,Baiu DC,Horváth A,Erdei A

更新日期：2002-03-01 00:00:00

abstract：:The contribution of the HLA-DRB1, -B3, and -B5 gene products in the recognition of Dermatophagoides spp. (house dust mite) by helper T cells isolated from an atopic individual (HLA-DRw12, DR7; DRw52b) with perennial rhinitis was investigated. Using a panel of histocompatible and histoincompatible accessory cells, the ...

journal_title：International immunology

authors： O'Hehir RE,Mach B,Berte C,Greenlaw R,Tiercy JM,Bal V,Lechler RI,Trowsdale J,Lamb JR

更新日期：1990-01-01 00:00:00

abstract：:In order to further understand the developmental aspects of B-1 cells, we characterized the ontogeny of this B cell population in the spleen and peritoneal cavity of BALB/c mice. Although there are B-1 cells in the spleen within the first 1-3 weeks after birth, they do not at any stage represent the majority of spleni...

journal_title：International immunology

authors： Hamilton AM,Lehuen A,Kearney JF

更新日期：1994-03-01 00:00:00

abstract：:We have shown that the dominance of CD8+ T cells expressing TCR Vbeta17 in the adult HLA-A*0201-restricted influenza A/M1(58-66)-specific response is acquired following first antigen exposure. Despite the acquired dominance of Vbeta17+ cells, subdominant M1(58-66)-specific clones expressing non-Vbeta17+ TCR persist in...

journal_title：International immunology

authors： Lawson TM,Man S,Wang EC,Williams S,Amos N,Gillespie GM,Moss PA,Borysiewicz LK

更新日期：2001-11-01 00:00:00

abstract：:Under equilibrium conditions, the affinities of five anti-IgG2a mAb isolated from virus-infected mice were comparable to other high-affinity auto-antibodies. Similar to rheumatoid factors, these anti-IgG2a auto-antibodies bound to aggregated or complexed IgG2a with 50 to 1500-fold higher avidity than their monomeric c...

journal_title：International immunology

authors： Fazekas G,Pálfi G,Wolff-Winiski B,Rosenwirth B,Dukor P,Gergely J,Rajnavölgyi E

更新日期：1995-07-01 00:00:00

abstract：:The transcription factor interferon regulatory factor-5 (IRF5) plays an important role in innate immune responses via the TLR-MyD88 (Toll-like receptor - myeloid differentiation primary response 88) pathway. IRF5 is also involved in the pathogenesis of the autoimmune disease systemic lupus erythematosus (SLE). Recent ...

journal_title：International immunology

authors： Ban T,Sato GR,Tamura T

更新日期：2018-10-29 00:00:00

abstract：:BALB/c mice injected at birth with 10(8) semi-allogeneic (C57BL/6 x BALB.IgHb)F1 spleen cells develop a lupus-like syndrome in which autoantibodies bear exclusively the donor allotype. We have analyzed the evolution of donor B cell chimerism and the autoimmune manifestations during the first year of life in these mice...

journal_title：International immunology

authors： de la Hera M,de la Hera A,Ramos A,Buelta L,Alonso JL,Rodriguez-Valverde V,Merino J

更新日期：1992-01-01 00:00:00

abstract：:Recent studies have shown that tumor cells acquire escape mechanisms to evade host immunity in the tumor microenvironment. Two key immune checkpoint pathways mediated by immunosuppressive co-signaling, the first via programmed cell death 1 (PD-1) and PD-1 ligand 1 (PD-1/PD-L1) and the second via CTLA-4 and B7 (CTLA-4/...

journal_title：International immunology

authors： Hamanishi J,Mandai M,Konishi I

更新日期：2016-07-01 00:00:00

abstract：:HLA class II molecules present superantigens more efficiently than their murine counterpart. Therefore, transgenic mice expressing HLA-DQ8 with and without CD28 were used to address the role of CD28 in staphylococcal enterotoxin B (SEB)-driven immune responses. SEB-induced in vitro proliferation of naive DQ8.CD28(-/-)...

journal_title：International immunology

authors： Rajagopalan G,Smart MK,Marietta EV,David CS

更新日期：2002-07-01 00:00:00

abstract：:The invertebrate pattern-recognition protein named coelomic cytolytic factor (CCF) and the mammalian cytokine tumor necrosis factor (TNF) share functional analogies that are based on a similar saccharide recognition specificity. In particular, CCF and TNF have been shown to interact with ion channels on the surface of...

journal_title：International immunology

authors： Bilej M,Josková R,Van den Bergh R,Procházková P,Silerová M,Ameloot P,De Baetselier P,Beschin A

更新日期：2006-12-01 00:00:00

abstract：:Hepatitis C virus (HCV) has the ability to persist in the majority of infected people. Strong, multispecific and sustained T-cell response is correlated with viral clearance. The mechanisms of chronicity by HCV are unclear. HCV could restrain the immune system and establish chronic infection by modulating dendritic ce...

journal_title：International immunology

authors： Krishnadas DK,Ahn JS,Han J,Kumar R,Agrawal B

更新日期：2010-06-01 00:00:00

abstract：:Recent studies have revealed a role for basophils as antigen-presenting cells that preferentially induce T(h)2 cells in response to complexes of antigen plus antigen-specific IgE, to protease allergens or to helminthic parasites in vitro and in vivo through the production of 'early IL-4' and the presentation to CD4(+)...

journal_title：International immunology

authors： Yoshimoto T

更新日期：2010-07-01 00:00:00

abstract：:Cytotoxic T lymphocytes (CTL) confer protection against intracellular pathogens, yet the mechanism by which some escape activation induced cell death (AICD) and give rise to long-lived memory cells is unclear. We studied the differentiation of transgenic TCR CD8(+) cells into CTL and memory cells using a novel system ...

journal_title：International immunology

authors： Opferman JT,Ober BT,Narayanan R,Ashton-Rickardt PG

更新日期：2001-04-01 00:00:00

abstract：:Neutrophils and lymphocytes are recruited to sites of inflammation and require the adhesion molecule L-selectin (CD62L) for adherence to endothelial cells. Nucleotides released from activated or dying cells at sites of inflammation can mediate signaling through purinergic receptor family II, resulting in CD62L sheddin...

journal_title：International immunology

authors： Sengstake S,Boneberg EM,Illges H

更新日期：2006-07-01 00:00:00