Mycobacterium indicus pranii (Mw)-mediated protection against visceral leishmaniasis by reciprocal regulation of host dual-specificity phosphatases.

abstract：:The contribution of the HLA-DRB1, -B3, and -B5 gene products in the recognition of Dermatophagoides spp. (house dust mite) by helper T cells isolated from an atopic individual (HLA-DRw12, DR7; DRw52b) with perennial rhinitis was investigated. Using a panel of histocompatible and histoincompatible accessory cells, the ...

journal_title：International immunology

authors： O'Hehir RE,Mach B,Berte C,Greenlaw R,Tiercy JM,Bal V,Lechler RI,Trowsdale J,Lamb JR

更新日期：1990-01-01 00:00:00

abstract：:1,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)] and the vitamin D receptor (VDR) are important regulators of autoimmunity. The effect of the VDR on the ability of mice to fight a primary or secondary infection has not been determined. Young and old VDR knockout (KO) mice were able to clear both primary and secondary infe...

journal_title：International immunology

authors： Bruce D,Whitcomb JP,August A,McDowell MA,Cantorna MT

更新日期：2009-02-01 00:00:00

abstract：:Induction of mucosal tolerance by inhalation of soluble peptides with defined T cell epitopes is receiving much attention as a means of specifically down-regulating pathogenic T cell reactivities in autoimmune and allergic disorders. Experimental autoimmune encephalomyelitis (EAE) induced in the Lewis rat by immunizat...

journal_title：International immunology

authors： Liu JQ,Bai XF,Shi FD,Xiao BG,Li HL,Levi M,Mustafa M,Wahren B,Link H

更新日期：1998-08-01 00:00:00

abstract：:The origin of anti-DNA antibodies remains speculative. We argue that some of these antibodies may arise inadvertently in nature during the course of a normal immune response due to their induction by antibodies which bear structures (mimotopes) that mimic DNA. These antibodies are not necessarily DNA specific but, lik...

journal_title：International immunology

authors： Wun HL,Leung DT,Wong KC,Chui YL,Lim PL

更新日期：2001-09-01 00:00:00

abstract：:Apoptosis is a major mechanism whereby HIV-1 depletes uninfected CD4+ and CD8+ T cells. We previously showed that resting peripheral blood T cells derived from healthy donors were killed by an apoptotic mechanism after adsorption to gp120-containing, protease-defective HIV-1 (L-2) particles, more effectively than pare...

journal_title：International immunology

authors： Kameoka M,Suzuki S,Kimura T,Fujinaga K,Auwanit W,Luftig RB,Ikuta K

更新日期：1997-10-01 00:00:00

abstract：:The M54 transgenic mouse line, which carries the 17.2.25 Ig mu heavy chain gene, rearranges Ig heavy chains and expresses both transgenic and endogenous mu. B cell lineage development is selectively impaired in these mice and cells that simultaneously express transgenic and endogenous mu ('double-producers') are commo...

journal_title：International immunology

authors： Lam KP,Herzenberg LA,Stall AM

更新日期：1993-09-01 00:00:00

abstract：:Monoclonal non-specific suppressor factor (MNSF), a lymphokine produced by a murine hybridoma, was originally found to inhibit the generation of lipopolysaccharide (LPS)-induced Ig-secreting cells. Most recently, we demonstrated the recombinant form of the ubiquitin-like segment (rUbi-L) or MNSF beta, an isoform of MN...

journal_title：International immunology

authors： Nakamura M,Nagata T,Xavier M,Tanigawa Y

更新日期：1996-11-01 00:00:00

abstract：:A novel system to study the effects of co-cross-linking CD23/FceRII and sIg on murine B lymphocytes utilizes a highly multivalent form of anti-Ig prepared by covalently linking anti-Ig antibodies to a DNP-dextran backbone. CD23-sIg co-cross-linking is accomplished by the addition of DNP-specific monoclonal IgE. Previo...

journal_title：International immunology

authors： Campbell KA,Studer EJ,Kilmon MA,Lees A,Finkelman F,Conrad DH

更新日期：1997-08-01 00:00:00

abstract：:HIV infected T and monocytic cell lines could activate and fix C3 fragments when incubated in human serum under conditions allowing for activation of the alternative complement pathway. Normal T lymphocytes incubated with HIV could also activate and fix C3. This activity was, at least in part, the property of the viru...

journal_title：International immunology

authors： Yefenof E,Asjö B,Klein E

更新日期：1991-04-01 00:00:00

abstract：:Neural stem cells (NSCs) transplantation has been proposed as a means of restoring damaged brain tissue, a possibility rendered more likely by reports of low NSCs immunogenicity in various experimental models because of low expression of MHC class I and II as well as co-stimulatory molecules. We investigated the immun...

journal_title：International immunology

authors： Ubiali F,Nava S,Nessi V,Frigerio S,Parati E,Bernasconi P,Mantegazza R,Baggi F

更新日期：2007-09-01 00:00:00

abstract：:Notch2 and Delta-like 1 (Dll1) have been implicated in the development of marginal zone B (MZB) cells. In the present study, we characterized the expression and function of mouse Notch receptors and ligands in the spleen by using newly generated mAbs. Although Notch2 was expressed on both B and T cells in the spleen, ...

journal_title：International immunology

authors： Moriyama Y,Sekine C,Koyanagi A,Koyama N,Ogata H,Chiba S,Hirose S,Okumura K,Yagita H

更新日期：2008-06-01 00:00:00

abstract：:SDF-1 is a member of the CXC chemokines. In contrast to other chemokines that are induced by inflammation, SDF-1 is constitutively produced by stromal cells. In order to investigate the physiological roles of SDF-1, we constructed a fusion protein, SDF-1-Cgamma1, composed from murine SDF-1alpha and the constant region...

journal_title：International immunology

authors： Suzuki G,Nakata Y,Dan Y,Uzawa A,Nakagawa K,Saito T,Mita K,Shirasawa T

更新日期：1998-08-01 00:00:00

abstract：:Previously we observed elevation of the serum concentration of two acute-phase protein (AFP) complement components (C9 and C1-inhibitor) in patients with chronic hepatitis C who responded (R) to IFN-alpha therapy, but not in non-responders (NR). In the present study we investigated the effect of high-dose IFN-alpha th...

journal_title：International immunology

authors： Kalabay L,Nemesánszky E,Csepregi A,Pusztay M,Dávid K,Horváth G,Ibrányi E,Telegdy L,Pár A,Bíró A,Fekete B,Gervain J,Horányi M,Ribiczey P,Csöndes M,Kleiber M,Walentin S,Prohászka Z,Füst G

更新日期：2004-01-01 00:00:00

abstract：:Constitutive expression of p35 and p40 IL-12 mRNA was detected in splenic macrophages isolated from aged mice. Macrophages were also implicated as the cell type responsible for the dysregulated IL-6 and tumor necrosis factor (TNF)-alpha commonly observed to be constitutively produced by lymphoid cells from aged donors...

journal_title：International immunology

authors： Spencer NF,Daynes RA

更新日期：1997-05-01 00:00:00

abstract：:The role of B7 co-stimulatory signaling in in vivo tumor rejection remains incompletely characterized. In particular, the relative competence of B7-1 (CD80) and B7-2 (CD86) to provide effective co-stimulus is not well defined, and the identification of the T cell co-stimulatory receptor that mediates B7 co-stimulation...

journal_title：International immunology

authors： Yu X,Abe R,Hodes RJ

更新日期：1998-06-01 00:00:00

abstract：:A Plasmodium falciparum schizont lysate has been previously described as being a powerful inducer of proliferation for human peripheral T lymphocytes. In this report we study the phenotype of cycling T cells from unexposed donors and examine how the P. falciparum lysate compares with the conventional T cell mitogen ph...

journal_title：International immunology

authors： Behr C,Dubois P

更新日期：1992-03-01 00:00:00

abstract：:Nitric oxide (NO) is formed constitutively in neurons by the constitutive enzyme NO synthase (cNOS) and acts as a neurotransmitter. It has already been shown that cNOS-containing neurons are identical to neurons staining for NADPH diaphorase and vice versa. Effector cells of the immune response produce high NO levels ...

journal_title：International immunology

authors： Flesch IE,Hess JH,Kaufmann SH

更新日期：1994-11-01 00:00:00

abstract：:Intravenous sensitization of C57BL/6 (B6) mice with class II H-2-disparate B6-C-H-2bm12(bm12) resting B cells induced anti-bm12 CD4+ T cell tolerance as shown by hyporesponsiveness in the anti-bm12 mixed lymphocyte reaction (MLR). The present study investigated the mechanism(s) of the failure of bm12 B cells to stimul...

journal_title：International immunology

authors： Toyooka K,Maruo S,Iwahori T,Yamamoto N,Tai XG,Abe R,Takahama Y,Murakami M,Uede T,Hamaoka T,Fujiwara H

更新日期：1996-02-01 00:00:00

abstract：:Immunoglobulin affinity maturation depends on somatic hypermutation (SHM) in immunoglobulin variable (IgV) regions initiated by activation-induced cytidine deaminase (AID). AID induces transition mutations by C→U deamination on both strands, causing C:G→T:A. Error-prone repairs of U by base excision and mismatch repai...

journal_title：International immunology

authors： Eid MMA,Shimoda M,Singh SK,Almofty SA,Pham P,Goodman MF,Maeda K,Sakaguchi N

更新日期：2017-05-01 00:00:00

abstract：:Naturally arising CD25(+)CD4(+) regulatory T (T(R)) cells can be exploited to establish immunologic tolerance to non-self antigens. In vivo exposure of CD25(+)CD4(+) T cells from normal naive mice to alloantigen in a T cell-deficient environment elicited spontaneous expansion of alloantigen-specific CD25(+)CD4(+) T(R)...

journal_title：International immunology

authors： Nishimura E,Sakihama T,Setoguchi R,Tanaka K,Sakaguchi S

更新日期：2004-08-01 00:00:00

abstract：:Non-obese diabetic mice spontaneously develop a type 1 diabetes. The entry of leukocytes in the islets of Langerhans was studied in untreated and in irradiated mice. FITC-labeled cells from spleen, lymph nodes or bone marrow of healthy or diabetic donors did home to the inflamed islets of unmanipulated recipients. B a...

journal_title：International immunology

authors： Faveeuw C,Gagnerault MC,Kraal G,Lepault F

更新日期：1995-12-01 00:00:00

abstract：:Pathogenic intracellular bacteria often hijack macrophages for their propagation. The infected macrophages release IL-1β and IL-18 and simultaneously commit suicide, which is called pyroptosis; both responses require caspase-1. Here, we found that pyroptotic cells induced by microbial infection were efficiently engulf...

journal_title：International immunology

authors： Wang Q,Imamura R,Motani K,Kushiyama H,Nagata S,Suda T

更新日期：2013-06-01 00:00:00

abstract：:Induction of alphaEbeta7 expression on T cells by transforming growth factor (TGF)-beta is thought to be important for intestinal intraepithelial T lymphocyte (IEL) entry into the epithelial compartment. However, there has been no in vivo evidence that up-regulation of alphaEbeta7 expression on T cells by TGF-beta is ...

journal_title：International immunology

authors： Suzuki R,Nakao A,Kanamaru Y,Okumura K,Ogawa H,Ra C

更新日期：2002-04-01 00:00:00

abstract：:Acute graft-versus-host disease (GvHD) is a serious complication after allogeneic bone marrow transplantation. Donor-derived T cells infiltrate recipient target organs and cause severe tissue damage, often leading to death of the affected patient. Tissue destruction is a direct result of donor CD8+ T cell activation a...

journal_title：International immunology

authors： Arnold D,Wasem C,Juillard P,Graber P,Cima I,Frutschi C,Herren S,Jakob S,Alouani S,Mueller C,Chvatchko Y,Brunner T

更新日期：2002-05-01 00:00:00

abstract：:We established an experimental system in vitro to examine the developmental capacity of individual hematopoietic progenitors to generate T, B and myeloid (M) cells. By using this system we analyzed the process of lineage commitment of hematopoietic progenitors in murine fetal liver (FL). It is known that small numbers...

journal_title：International immunology

authors： Kawamoto H,Ohmura K,Katsura Y

更新日期：1997-07-01 00:00:00

abstract：:Intradermal inoculation of plasmids expressing antigens that contain MHC class I-restricted epitopes leads to the induction of specific CD8(+) cytotoxic T lymphocytes (CTL). The role of in situ transfected antigen-presenting cells (APC) in the priming of specific CTL subsequent to intradermal DNA immunization was inve...

journal_title：International immunology

authors： Bot A,Stan AC,Inaba K,Steinman R,Bona C

更新日期：2000-06-01 00:00:00

abstract：:Using Ia antigen-containing lipid vesicles, we investigated by stopped-flow fluorometry the requirements for helper T cell recognition and activation. When azobenzenearsonate-L-tyrosine (ABA-L-Tyr)-specific, I-Ak-restricted helper T cell hybridomas 2-45-12 were mixed with ABA-L-Tyr and purified I-Ak molecules on lipid...

journal_title：International immunology

authors： Odaka C,Utsunomiya N,Nakanishi M,Arata Y,Manabe S,Yasuda T,Tadakuma T

更新日期：1990-01-01 00:00:00

abstract：:T-cell immune responses are critical for protection of the host and for disease pathogenesis during infection with Plasmodium species. We examined the regulation of CD4(+) T-cell cytokine responses during infection with Plasmodium berghei ANKA (PbA). CD4(+) T cells from PbA-infected mice produced IFN-γ, IL-4 and IL-10...

journal_title：International immunology

authors： Kimura D,Miyakoda M,Honma K,Shibata Y,Yuda M,Chinzei Y,Yui K

更新日期：2010-12-01 00:00:00

abstract：:The intestinal epithelium not only acts as the physical structure that separates the intestinal lumen from the body but also actively participates in intestinal barrier functions. In the past decade, significant progress has been made in the development of culture technologies to maintain intestinal epithelial cells (...

journal_title：International immunology

authors： Nakamura T

更新日期：2019-02-06 00:00:00

abstract：:In the final analysis, the self (S)-non-self (NS) discrimination is regulated by the sufficiency or insufficiency of effector T(h) (eT(h)) specific for the given antigen. We have described a model (Th genesis) for the origin of eT(h) based on an antigen-independent pathway from initial state T(h) (iT(h)) to eT(h), and...

journal_title：International immunology

authors： Langman RE,Mata JJ,Cohn M

更新日期：2003-05-01 00:00:00