Molecular mimicry: anti-DNA antibodies may arise inadvertently as a response to antibodies generated to microorganisms.

abstract：:Naive CD4(+) T cells rapidly proliferate to generate effector cells after encountering an antigen and small numbers survive as memory T cells in preparation for future immunological events. In the present work, adoptive transfer of naive CD4(+) T cells into RAG2(-/-) mice caused the generation of memory-type effector ...

journal_title：International immunology

authors： Noguchi D,Wakita D,Tajima M,Ashino S,Iwakura Y,Zhang Y,Chamoto K,Kitamura H,Nishimura T

更新日期：2007-12-01 00:00:00

abstract：:Recent studies point to glycolipid-enriched membrane (GEM) microdomains as the critical sites for TCR-mediated signal transduction. However, whether the TCR complex is localized in the GEM domain is not well-defined. In the present study, we analyzed localization of the TCR-CD3 complex in the GEM domain by isolating t...

journal_title：International immunology

authors： Kosugi A,Saitoh S,Noda S,Yasuda K,Hayashi F,Ogata M,Hamaoka T

更新日期：1999-09-01 00:00:00

abstract：:The aim of this in vitro study was to evaluate if osteoclasts (OCs) and dendritic cells (DCs), both of monocyte origin, can support the survival of normal human plasma cells (PCs). PCs differentiate from plasmablasts (PBs) arising from activated B cells, essentially memory B cells. To study the survival of both PBs (C...

journal_title：International immunology

authors： Geffroy-Luseau A,Jégo G,Bataille R,Campion L,Pellat-Deceunynck C

更新日期：2008-06-01 00:00:00

abstract：:The regulation of MHC class II expression by the class II transactivator (CIITA) is complex and differs in various cell types depending on the relative activity of three CIITA promoters. Here we show that, in plasma cell tumors, the deacetylase inhibitor trichostatin A (TSA) elicits PIII-CIITA but does not activate th...

journal_title：International immunology

authors： Chou SD,Khan AN,Magner WJ,Tomasi TB

更新日期：2005-11-01 00:00:00

abstract：:Man has been found to produce highly conserved chitinases. The most prominent is the phagocyte-derived chitotriosidase, the plasma levels of which are markedly elevated in some pathological conditions. Here, we report that both polymorphonuclear neutrophils (PMNs) and macrophages (m) are a source of chitotriosidase. T...

journal_title：International immunology

authors： van Eijk M,van Roomen CP,Renkema GH,Bussink AP,Andrews L,Blommaart EF,Sugar A,Verhoeven AJ,Boot RG,Aerts JM

更新日期：2005-11-01 00:00:00

abstract：:Immunoglobulin affinity maturation depends on somatic hypermutation (SHM) in immunoglobulin variable (IgV) regions initiated by activation-induced cytidine deaminase (AID). AID induces transition mutations by C→U deamination on both strands, causing C:G→T:A. Error-prone repairs of U by base excision and mismatch repai...

journal_title：International immunology

authors： Eid MMA,Shimoda M,Singh SK,Almofty SA,Pham P,Goodman MF,Maeda K,Sakaguchi N

更新日期：2017-05-01 00:00:00

abstract：:T cells of an unique phenotype (CD3+CD4-CD8- alpha beta TCR+) develop in vitro from the hematopoietic progenitors, the majority of which carry homologous alpha beta TCR (V alpha 4J alpha 28/V beta 2D beta 1.1J beta 2.6). In the present study, antigen corresponding to the particular alpha beta TCR was investigated, tak...

journal_title：International immunology

authors： Kubota H,Sato M,Ogawa Y,Iwai K,Hattori M,Yoshida T,Minato N

更新日期：1994-09-01 00:00:00

abstract：:To study the paracrine effect of IL-10 on autoimmune insulitis and diabetes, we produced IL-10 transgenic non-obese diabetic (NOD) mice (NOD-IL-10) in which murine IL-10 was expressed in pancreatic islet A cells under the control of a rat glucagon promoter without directly manipulating pancreatic islet B cells. Among ...

journal_title：International immunology

authors： Moritani M,Yoshimoto K,Tashiro F,Hashimoto C,Miyazaki J,Ii S,Kudo E,Iwahana H,Hayashi Y,Sano T

更新日期：1994-12-01 00:00:00

abstract：:Human dendritic cells (DC) generated from CD34+ hematopoietic progenitors cultured in the presence of granulocyte macrophage colony stimulating factor (GM-CSF) and tumor necrosis factor (TNF)-alpha are related to Langerhans cells (DLC) and have been shown to induce a strong proliferation of allogeneic CD4+ T cells. Th...

journal_title：International immunology

authors： Caux C,Massacrier C,Vanbervliet B,Barthelemy C,Liu YJ,Banchereau J

更新日期：1994-08-01 00:00:00

abstract：:CD4 T cells are not thought to play a significant role in generating an effective primary CD8 T cell response to most viral infections. We have challenged this view by demonstrating that antigen-specific CD4 T cells can indeed suppress the proliferation of antigen-specific naive CD8 T cells in response to low doses of...

journal_title：International immunology

authors： Cose S,Brammer C,Zammit DJ,Blair DA,Lefrançois L

更新日期：2006-08-01 00:00:00

abstract：:At least three B cell subsets, B-1a, B-1b and B-2, or conventional B cells are present in the mouse periphery. Here we demonstrate that B-1 cells spontaneously proliferate in stationary cultures of normal adherent mouse peritoneal cells. B-1 cells were characterized by morphology, immunohistochemistry and flow cytomet...

journal_title：International immunology

authors： Almeida SR,Aroeira LS,Frymuller E,Dias MA,Bogsan CS,Lopes JD,Mariano M

更新日期：2001-09-01 00:00:00

abstract：:The product of the LAG-3 gene is a cell surface protein with significant homology to CD4. It has been suggested that it can serve as a functional equivalent of CD4 and account for the MHC class II-restricted responses which persist in CD4-deficient mice. To test this hypothesis, we have created CD4/LAG-3 double-defici...

journal_title：International immunology

authors： Miyazaki T,Dierich A,Benoist C,Mathis D

更新日期：1996-05-01 00:00:00

abstract：:Murine complement receptor type 2 (MCR2) is homologous to human CR2, whereas murine CR1 (MCR1) is structurally and evolutionary different from human CR1. Since ligand specificities of MCR1 and MCR2 are not completely clarified, we analyzed their functional characteristics to correlate them with structural information ...

journal_title：International immunology

authors： Pramoonjago P,Takeda J,Kim YU,Inoue K,Kinoshita T

更新日期：1993-04-01 00:00:00

abstract：:Stroke is one of the major causes of lethality and disability, yet few effective therapies have been established for ischemic stroke. Inflammation in the ischemic brain is induced by the infiltration and subsequent activation of immune cells. Loss of cerebral blood flow and ischemic brain-cell death trigger the activa...

journal_title：International immunology

authors： Nakamura A,Otani K,Shichita T

更新日期：2020-10-20 00:00:00

abstract：:Mice lacking the IL-2 receptor beta chain (IL-2R beta) exhibit an autoimmune reaction characterized by generalized T cell activation, production of autoantibodies, myeloproliferation and severe anemia. T cells of IL-2R beta-/- mice were examined to elucidate the mechanism responsible for their abnormal activation and ...

journal_title：International immunology

authors： Suzuki H,Hayakawa A,Bouchard D,Nakashima I,Mak TW

更新日期：1997-09-01 00:00:00

abstract：:Incompatibility of human minor histocompatibility (hmH) antigens induces rejection of grafts in organ transplantation and graft versus host disease in bone marrow transplantation if donor and recipient are matched for human leukocyte antigen (HLA) genes. These antigens are recognized only by T cells. We describe here ...

journal_title：International immunology

authors： Sekimata M,Griem P,Egawa K,Rammensee HG,Takiguchi M

更新日期：1992-02-01 00:00:00

abstract：:Src homology region 2-domain-containing phosphatase-1 (SHP-1) plays an important role in the regulation of signaling from various receptors in hematopoietic cells. In mast cells, SHP-1 has been shown to negatively regulate the initial signaling triggered by high-affinity receptor for IgE (FcepsilonRI) and positively r...

journal_title：International immunology

authors： Ozawa T,Nakata K,Mizuno K,Yakura H

更新日期：2007-09-01 00:00:00

abstract：:The class II trans-activator (CIITA) is a bi- or multi-functional domain protein which plays a critical role in the expression of MHC class II genes. We report that removal of the N-terminal 151 amino acids, encompassing all of the acidic domain but leaving intact the proline/serine/threonine-rich domain, results in a...

journal_title：International immunology

authors： Yun S,Gustafsson K,Fabre JW

更新日期：1997-10-01 00:00:00

abstract：:BALB/c mice are susceptible to cutaneous leishmaniasis upon infection with Leishmania major while C57BL/6 are not. There is a major promastigote surface protease (PSP or gp63) which is available in both native and recombinant forms, and for which the primary amino acid sequence is known. Immunization with PSP has been...

journal_title：International immunology

authors： Soares LR,Sercarz EE,Miller A

更新日期：1994-05-01 00:00:00

abstract：:A human neoplastic B cell line SSK41 that expresses IgM on its surface switches spontaneously to IgG-producing cells. The SSK41 line contains a single immunoglobulin heavy-chain locus, the constant region (C) genes of which retain the germline configuration. The IgG-producing SSK41 line was purified by sorting, and sh...

journal_title：International immunology

authors： Sideras P,Mizuta TR,Kanamori H,Suzuki N,Okamoto M,Kuze K,Ohno H,Doi S,Fukuhara S,Hassan MS

更新日期：1989-01-01 00:00:00

abstract：:Previous evidence from several laboratories suggests that CD8+ T suppressor cells may be important regulatory elements governing specific unresponsiveness of lepromatous lepromatous leprosy patients to M.leprae. To analyse the mechanism of suppression, CD8+ Ts clones were established from lesions and peripheral blood ...

journal_title：International immunology

authors： Salgame P,Modlin R,Bloom BR

更新日期：1989-01-01 00:00:00

abstract：:Our aim was to investigate the quantitative relationship between inoculation doses and physiological responses to infection by Salmonella enterica serovar Enteritidis. Rats were orally inoculated with 10-10(9) c.f.u. of S. Enteritidis and monitored for 6 days. Neutrophil and delayed-type hypersensitivity (DTH) respons...

journal_title：International immunology

authors： Takumi K,Garssen J,Havelaar A

更新日期：2002-02-01 00:00:00

abstract：:In this study, a B cell growth stimulatory factor, constitutively secreted by a human CD4+ T cell hybridoma clone, MP6, has been purified and characterized. Serum-free 24 h culture media from MP6 cells were collected, concentrated by ultrafiltration and separated by gel chromatography. Fractions were analyzed for stim...

journal_title：International immunology

authors： Rosen A,Lundman P,Carlsson M,Bhavani K,Srinivasa BR,Kjellström G,Nilsson K,Holmgren A

更新日期：1995-04-01 00:00:00

abstract：:The two-signal model states that activation of naive T cells requires a signal 1 stimulus through the TCR and a co-stimulatory signal 2. By contrast, signal 1 alone is sufficient for pre-activated T cells. Recently, however, it has been shown that under certain conditions T cells can bypass the requirement for co-stim...

journal_title：International immunology

authors： Pardigon N,Bercovici N,Calbo S,Santos-Lima EC,Liblau R,Kourilsky P,Abastado JP

更新日期：1998-05-01 00:00:00

abstract：:Sphingosine 1-phosphate (S1P) and S1P receptor 1 (S1P1) play an important role in the egress of mature CD4 or CD8 single-positive (SP) thymocytes from the thymus. Fingolimod hydrochloride (FTY720), an S1P1 functional antagonist, induced significant accumulation of CD62L(high)CD69(low) mature SP thymocytes in the thymi...

journal_title：International immunology

authors： Maeda Y,Yagi H,Takemoto K,Utsumi H,Fukunari A,Sugahara K,Masuko T,Chiba K

更新日期：2014-05-01 00:00:00

abstract：:Unlike splenic B cells from normal BALB/c mice, those from autoimmune-prone NZB x NZW (B/W) F1 young mice were hyperresponsive to interleukin 2 (IL2) and proliferated even in the absence of prior stimulation signals. We found that the B cell subpopulation responsible for this event belongs to that with 6B2 (B220)-dull...

journal_title：International immunology

authors： Hasegawa K,Abe M,Okada T,Hirose S,Sato H,Shirai T

更新日期：1989-01-01 00:00:00

abstract：:The TCR complex transduces the antigen recognition signal through common activation motifs present in both CD3 gamma delta epsilon chains and zeta dimers within the complex. We have investigated functional roles of the cytoplasmic domain in zeta and CD3 gamma delta epsilon for T cell activation in early and late respo...

journal_title：International immunology

authors： Aoe T,Goto S,Ohno H,Saito T

更新日期：1994-11-01 00:00:00

abstract：:Dendritic cells (DCs) act as a first-line recognition system for invading pathogens, such as influenza A. The interaction of DC with influenza A virus results in DC activation via endosomal Toll-like receptors and also leads to presentation of viral peptides on MHC class II molecules. Prior work demonstrated that infl...

journal_title：International immunology

authors： Burster T,Giffon T,Dahl ME,Björck P,Bogyo M,Weber E,Mahmood K,Lewis DB,Mellins ED

更新日期：2007-05-01 00:00:00

abstract：:The A6H mAb raised primarily against human renal cell carcinoma (RCC) has previously been shown to bind strongly to RCC, to some degree to colon carcinoma but only marginally to a variety of normal tissues. Immunohistochemical analysis or RCC tissues containing tumor-infiltrating lymphocytes revealed that A6H stained ...

journal_title：International immunology

authors： Labuda T,Lando P,Björkdahl O,Kalland T,Vessella R,Hedlund G,Eriksson H,Sjögren HO,Dohlsten M

更新日期：1995-09-01 00:00:00

abstract：:SDF-1 is a member of the CXC chemokines. In contrast to other chemokines that are induced by inflammation, SDF-1 is constitutively produced by stromal cells. In order to investigate the physiological roles of SDF-1, we constructed a fusion protein, SDF-1-Cgamma1, composed from murine SDF-1alpha and the constant region...

journal_title：International immunology

authors： Suzuki G,Nakata Y,Dan Y,Uzawa A,Nakagawa K,Saito T,Mita K,Shirasawa T

更新日期：1998-08-01 00:00:00