Normal D-JH rearranged products of the IgH gene in SCID mouse bone marrow.

abstract：:The B cell-activating factor from the tumor necrosis factor family (BAFF) is an important regulator of B cell immunity. Recently, we demonstrated that recombinant BAFF also provides a co-stimulatory signal to T cells. Here, we studied expression of BAFF in peripheral blood leukocytes and correlated this expression wit...

journal_title：International immunology

authors： Huard B,Arlettaz L,Ambrose C,Kindler V,Mauri D,Roosnek E,Tschopp J,Schneider P,French LE

更新日期：2004-03-01 00:00:00

abstract：:Activated macrophages exert strong arginase (ASE) activity that converts L-arginine into ornithine, the key precursor for putrescine and polyamine biosynthesis. Macrophages were previously also shown to generate nitric oxide that is derived from the guanido group of arginine by the oxidative deiminase (OAD) reaction. ...

journal_title：International immunology

authors： Benninghoff B,Lehmann V,Eck HP,Dröge W

更新日期：1991-05-01 00:00:00

abstract：:T cell apoptosis has been proposed as an important contributor to the functional defects and depletion of T cells in HIV-infected individuals. However, the mechanisms involved in this apoptosis have not been elucidated. We recently showed that peripheral blood T cells from HIV-infected individuals are especially susce...

journal_title：International immunology

authors： Katsikis PD,García-Ojeda ME,Wunderlich ES,Smith CA,Yagita H,Okumura K,Kayagaki N,Alderson M,Herzenberg LA,Herzenberg LA

更新日期：1996-08-01 00:00:00

abstract：:Immunopathology and immune responses to Schistosoma mansoni were examined in IL-4 -/- mice. IL-5 and IL-10 production by lymphoid cells stimulated with soluble egg antigen (SEA), peripheral eosinophilia and serum levels of soluble IL-4 receptor but not IgE were all significantly elevated over background normal levels ...

journal_title：International immunology

authors： Pearce EJ,Cheever A,Leonard S,Covalesky M,Fernandez-Botran R,Kohler G,Kopf M

更新日期：1996-04-01 00:00:00

abstract：:The T cell Ig domain and mucin domain (TIM) proteins form a conserved family of transmembrane cell-surface glycoproteins expressed by a variety of tissues. Each TIM protein contains a single V-type Ig domain, a glycosylated mucin-like domain, a transmembrane domain and a cytoplasmic domain. TIM proteins recognize a di...

journal_title：International immunology

authors： Wilker PR,Sedy JR,Grigura V,Murphy TL,Murphy KM

更新日期：2007-06-01 00:00:00

abstract：:Sphingosine 1-phosphate (S1P) and S1P receptor 1 (S1P1) play an important role in the egress of mature CD4 or CD8 single-positive (SP) thymocytes from the thymus. Fingolimod hydrochloride (FTY720), an S1P1 functional antagonist, induced significant accumulation of CD62L(high)CD69(low) mature SP thymocytes in the thymi...

journal_title：International immunology

authors： Maeda Y,Yagi H,Takemoto K,Utsumi H,Fukunari A,Sugahara K,Masuko T,Chiba K

更新日期：2014-05-01 00:00:00

abstract：:An alloreactive CTL clone, 27.B2, produced in the mouse strain combination B6.C-H-2bm1 (bm1) against C57BL/6 (B6) and nominally directed against the Kb molecule has been shown to be peptide dependent. The clone recognizes intact B6, but not intact bm1 or bm3 target cells. However, peptides recognized by 27.B2 CTL can ...

journal_title：International immunology

authors： Falk K,Rötzschke O,Rammensee HG

更新日期：1992-03-01 00:00:00

abstract：:Immune tolerance in the lung is important for preventing hypersensitivity, such as allergic asthma. Maintenance of tolerance in the lung is established by coordinated activities of poorly understood cellular and molecular mechanisms, including participation of dendritic cells (DCs). We have previously identified DC ex...

journal_title：International immunology

authors： Han D,Walsh MC,Kim KS,Hong SW,Lee J,Yi J,Rivas G,Choi Y,Surh CD

更新日期：2017-02-01 00:00:00

abstract：:It has previously been described that V gamma 3 cells can proliferate extensively in vitro in the presence of different cytokines. Here, the role of cytokines in the maintenance of V gamma 3 cells in the thymus has been determined. Culture of fetal thymocytes in cell suspension for 24 h showed that, whereas immature T...

journal_title：International immunology

authors： Leclercq G,De Smedt M,Plum J

更新日期：1995-05-01 00:00:00

abstract：:Taking advantage of the recently demonstrated presence of N-aminopeptidases and the serine protease dipeptidyl aminopeptidase IV (DPP IV) at the surface of human myeloblastic HL-60 cells, the regulation of these protease activities in HL-60 cell differentiation has been assessed using combined spectrophotometric and f...

journal_title：International immunology

authors： Laouar A,Wietzerbin J,Bauvois B

更新日期：1993-08-01 00:00:00

abstract：:The invertebrate pattern-recognition protein named coelomic cytolytic factor (CCF) and the mammalian cytokine tumor necrosis factor (TNF) share functional analogies that are based on a similar saccharide recognition specificity. In particular, CCF and TNF have been shown to interact with ion channels on the surface of...

journal_title：International immunology

authors： Bilej M,Josková R,Van den Bergh R,Procházková P,Silerová M,Ameloot P,De Baetselier P,Beschin A

更新日期：2006-12-01 00:00:00

abstract：:To investigate potential roles of the RAG-1 and RAG-2 gene products in Ig heavy chain class recombination (CSR), we have generated RAG-1(-/-) and RAG-2(-/-) mice which contain both a rearranged Ig HC V(D)J gene (referred to as B1-8) inserted into the endogenous Ig heavy chain (HC) locus in place of the JH segments, an...

journal_title：International immunology

authors： Lansford R,Manis JP,Sonoda E,Rajewsky K,Alt FW

更新日期：1998-03-01 00:00:00

abstract：:Induction of mucosal tolerance by inhalation of soluble peptides with defined T cell epitopes is receiving much attention as a means of specifically down-regulating pathogenic T cell reactivities in autoimmune and allergic disorders. Experimental autoimmune encephalomyelitis (EAE) induced in the Lewis rat by immunizat...

journal_title：International immunology

authors： Liu JQ,Bai XF,Shi FD,Xiao BG,Li HL,Levi M,Mustafa M,Wahren B,Link H

更新日期：1998-08-01 00:00:00

abstract：:Antibody-secreting cells (ASCs) in respiratory tract tissues provide a first line of defense against invading pathogens. These cells often secrete IgA that is efficiently transcytosed across epithelial barriers into the airway lumen where pathogens can be blocked at their point of entry. Previous literature has report...

journal_title：International immunology

authors： Sealy RE,Surman SL,Vogel P,Hurwitz JL

更新日期：2016-11-01 00:00:00

abstract：:We report the characterization of the Fc epsilon RI gamma chain which associates with the transmembrane form of CD16 to form the low affinity receptor for IgG (Fc gamma RIII) expressed on human natural killer (NK) cells. cDNA cloning and sequence analysis of Fc epsilon RI gamma from a polyclonal CD3-CD16+ NK line esta...

journal_title：International immunology

authors： Moingeon P,Lucich JL,Reinherz EL

更新日期：1992-08-01 00:00:00

abstract：:Blocking T cell co-stimulatory signals by anti-B7-1/B7-2 mAb is an attractive approach to treat autoimmune diseases. However, anti-B7-1/B7-2 mAb treatment is known to exacerbate autoimmune diseases through mechanisms not fully understood. Tumor necrosis factor alpha (TNF-alpha) and reactive oxygen species (ROS) also p...

journal_title：International immunology

authors： Khan N,Ghousunnissa S,Jegadeeswaran SM,Thiagarajan D,Hasnain SE,Mukhopadhyay S

更新日期：2007-04-01 00:00:00

abstract：:Whether astrocytes utilize B7:CD28 co-stimulation to activate T cells mediating CNS inflammatory disease is controversial. In this report, primary astrocytes and murine astrocyte lines, generated by immortalization at two different times, day 7 or 45 of culture, were examined for their capability to express B7 co-stim...

journal_title：International immunology

authors： Soos JM,Ashley TA,Morrow J,Patarroyo JC,Szente BE,Zamvil SS

更新日期：1999-07-01 00:00:00

abstract：:Naturally occurring CD4(+)CD25(+) regulatory T cells (nT(R)) comprise a separate lineage of T cells that are essential for maintaining immunological tolerance to self. Here we demonstrate that the level of phosphorylation of the TCR zeta-chain is approximately 1.5- to 4-fold higher in nT(R) as compared with CD4(+)CD25...

journal_title：International immunology

authors： Andersson J,Stefanova I,Stephens GL,Shevach EM

更新日期：2007-04-01 00:00:00

abstract：:Streptococcus suis capsular type 2 is an important swine pathogen and an agent of zoonosis. Although meningitis is the most common form of disease, septicemia and septic shock are also frequently reported. Despite reports that CD14 is involved in the recognition of encapsulated S. suis by host cells, the mechanisms un...

journal_title：International immunology

authors： Graveline R,Segura M,Radzioch D,Gottschalk M

更新日期：2007-04-01 00:00:00

abstract：:Several cytokines and chemokines including chemokine (C-C motif) ligand-2 (CCL2) are induced in HIV-1 infection. However, the impact of HIV-1 viremia on CCL2 regulation is largely unknown. We utilized a DNA oligonucleotide microarray covering 110 inflammatory genes. Five genes were induced by at least 2-fold in PBMCs ...

journal_title：International immunology

authors： Ansari AW,Bhatnagar N,Dittrich-Breiholz O,Kracht M,Schmidt RE,Heiken H

更新日期：2006-10-01 00:00:00

abstract：:The Ig heavy chain (IgH) locus is controlled by multiple regulatory sequences mapping both within the IgH transcription unit (E mu) and downstream (3') of IgH coding sequences (hs3a, hs1,2, hs3b and hs4). Enhancer knockout studies in mice have implicated E mu in the control of IgH variable region gene assembly, but si...

journal_title：International immunology

authors： Shi X,Eckhardt LA

更新日期：2001-08-01 00:00:00

abstract：:Dendritic cells (DC) sense saprophytic yeast and pathogenic, filamentous forms of Candida albicans in a specific way, resulting in disparate patterns of DC and T(h) cell activation. Using human and murine DC, such disparate patterns could be traced to the exploitation of distinct recognition receptors. Although usage ...

journal_title：International immunology

authors： Romani L,Montagnoli C,Bozza S,Perruccio K,Spreca A,Allavena P,Verbeek S,Calderone RA,Bistoni F,Puccetti P

更新日期：2004-01-01 00:00:00

abstract：:One of the characteristic features of asthma is chronic airway inflammation typically with eosinophil infiltration. Most asthmatics can be treated successfully with conventional treatment appropriate for their severity, but in some severe cases, asthma cannot be well controlled even with thorough treatment and this co...

journal_title：International immunology

authors： Ohta K,Nagase H,Suzukawa M,Ohta S

更新日期：2017-07-01 00:00:00

abstract：:Dendritic cells (DC) are key players in the initiation and modulation of adaptive immune responses due to their ability to acquire and present antigen and stimulate T cells. For the induction of effector T cell functions, antigen must be presented by activated DC. In this study, we have compared uptake of antigen by m...

journal_title：International immunology

authors： Tirapu I,Giquel B,Alexopoulou L,Uematsu S,Flavell R,Akira S,Diebold SS

更新日期：2009-07-01 00:00:00

abstract：:T(h)17 cells, an inflammatory T helper cell subset, are involved in the pathogenesis of various inflammatory, autoimmune and allergic diseases. Recent evidence supports the idea that immune cell functions and the inflammatory response are finely regulated by various physiological substances. Calcitonin gene-related pe...

journal_title：International immunology

authors： Mikami N,Watanabe K,Hashimoto N,Miyagi Y,Sueda K,Fukada S,Yamamoto H,Tsujikawa K

更新日期：2012-11-01 00:00:00

abstract：:The chicken represents the best-characterized animal model for B cell development in the so-called gut-associated lymphoid tissue (GALT) and the molecular processes leading to B cell receptor diversification in this species are well investigated. However, the mechanisms regulating B cell development and homeostasis in...

journal_title：International immunology

authors： Kothlow S,Morgenroth I,Graef Y,Schneider K,Riehl I,Staeheli P,Schneider P,Kaspers B

更新日期：2007-02-01 00:00:00

abstract：:Mice with a targeted deletion of the T-bet gene exhibit spontaneous airway hyperresponsiveness (AHR), airway inflammation, enhanced recovery of T(h)2 cytokines from bronchoalveolar lavage fluid, sub-epithelial collagen deposition and myofibroblast transformation. Here we analyze the mechanisms responsible for the chro...

journal_title：International immunology

authors： Finotto S,Hausding M,Doganci A,Maxeiner JH,Lehr HA,Luft C,Galle PR,Glimcher LH

更新日期：2005-08-01 00:00:00

abstract：:Despite intense recent interest, the suppressive mechanisms of regulatory CD25+CD4 T cells remain poorly understood. One deficiency in the field is the lack of in vivo models where the effects of regulatory CD25+CD4 T cells on antigen-specific responder T cells can be measured quantitatively. We describe one such mode...

journal_title：International immunology

authors： Thorstenson KM,Herzovi L,Khoruts A

更新日期：2005-04-01 00:00:00

abstract：:House dust mite (HDM) is a common allergen of allergic asthma. Eosinophils are principal effector cells of allergic inflammation and their adhesion onto human bronchial epithelial cells is mediated by a CD18-intracellular adhesion molecule-1 (ICAM-1)-dependent interaction. We studied the effects of HDM Dermatophagoide...

journal_title：International immunology

authors： Wong CK,Li ML,Wang CB,Ip WK,Tian YP,Lam CW

更新日期：2006-08-01 00:00:00

abstract：:Lymphocyte homing to lymph nodes is regulated by transient but specific interactions between lymphocytes and high endothelial venules (HEVs), the initial phase of which is mainly governed by the leukocyte adhesion molecule L-selectin, which recognizes sulfated and sialylated O-linked oligosaccharides displayed on sial...

journal_title：International immunology

authors： Kanda H,Tanaka T,Matsumoto M,Umemoto E,Ebisuno Y,Kinoshita M,Noda M,Kannagi R,Hirata T,Murai T,Fukuda M,Miyasaka M

更新日期：2004-09-01 00:00:00