Effect of Gm allotypes on IgG2 antibody responses and IgG2 concentrations in children and adults.

abstract：:Recent studies have shown that tumor cells acquire escape mechanisms to evade host immunity in the tumor microenvironment. Two key immune checkpoint pathways mediated by immunosuppressive co-signaling, the first via programmed cell death 1 (PD-1) and PD-1 ligand 1 (PD-1/PD-L1) and the second via CTLA-4 and B7 (CTLA-4/...

journal_title：International immunology

authors： Hamanishi J,Mandai M,Konishi I

更新日期：2016-07-01 00:00:00

abstract：:The profile of cytokines produced by CD4 T cells is profoundly influenced by the presence of IL-12. Here we demonstrate that during re-stimulation of antigen-specific immune responses in vitro, antigen-primed lymph node cells from DBA/2 mice produced 3- to 30-fold more IL-12 than did cells from BALB/c mice, which are ...

journal_title：International immunology

authors： Gieni RS,Fang Y,Trinchieri G,Umetsu DT,DeKruyff RH

更新日期：1996-10-01 00:00:00

abstract：:The alternative complement pathway (ACP) in vertebrates is known to be important in inflammatory reactions, and to be activated by foreign substances such as bacterial lipopolysaccharide (LPS) and zymosan, although to date no intrinsic activators have been identified except complement receptor type 2. From the point o...

journal_title：International immunology

authors： Oshima H,Soma G,Mizuno D

更新日期：1993-10-01 00:00:00

abstract：:Factors responsible for the predictable generation of Th1 or Th2 immune responses to microorganisms in vivo are not well characterized, although the ability of antigen presenting cells (APC) to provide co-stimulation, the kinetics of MHC-peptide ligand generation as well as the cytokine environment are all considered ...

journal_title：International immunology

authors： Pashine A,John B,Rath S,George A,Bal V

更新日期：1999-04-01 00:00:00

abstract：:The class II transactivator (CIITA) controls both the constitutive and IFN-gamma inducible expression of HLA-D genes. In addition, through the squelching of another transactivator CREB-binding protein, CIITA was more recently shown to have a wider cellular function, including cell cycle control or cellular response to...

journal_title：International immunology

authors： Barbieri G,Deffrennes V,Prod'homme T,Vedrenne J,Baton F,Cortes C,Fischer A,Bono MR,Lisowska-Grospierre B,Charron D,Alcaïde-Loridan C

更新日期：2002-08-01 00:00:00

abstract：:Dendritic cells (DCs) are specialized antigen-presenting cells that play pivotal roles in initiating immune responses. However, DC maturation is usually strongly restricted by the stromal microenvironment, especially in non-lymphoid tissues, such as skin and mucosa. Although suppression of DC maturation by stromal cel...

journal_title：International immunology

authors： Shiraishi H,Yoshida H,Saeki K,Miura Y,Watanabe S,Ishizaki T,Hashimoto M,Takaesu G,Kobayashi T,Yoshimura A

更新日期：2008-09-01 00:00:00

abstract：:IgG is the major immunoglobulin class produced during an immune response against foreign antigens and efficiently provides protection through its bifunctional nature. While the Fab domains confer highly specific recognition of the antigen, the Fc domain mediates a wide range of effector functions that modulate several...

journal_title：International immunology

authors： Bournazos S,Ravetch JV

更新日期：2017-07-01 00:00:00

abstract：:Lymphocyte migration from the blood into specific tissues is directed by their expression of adhesion molecules referred to as homing receptors. The homing receptor L-selectin, for example, directs the migration of lymphocytes into peripheral lymph nodes (PLN). Since bovine gamma delta T cells, a major lymphocyte subs...

journal_title：International immunology

authors： Walcheck B,Jutila MA

更新日期：1994-01-01 00:00:00

abstract：:Previously we examined the ability of the host's immune responses to regulate Ig production in an IgE-secreting murine plasma cell tumor (B53). In the present study we have examined the reverse phenomenon, in that we have investigated the effects of this and other plasma cell tumors on the immune responses of their ho...

journal_title：International immunology

authors： Ruzek MC,Mathur A

更新日期：1995-07-01 00:00:00

abstract：:Structural and functional aspects of the accessory molecule lymphocyte function associated antigen (LFA)-3 (CD58) have been examined following the transfection of DAP.3 and P815 cells with a cDNA clone encoding the glycosyl phosphatidylinositol (GPI)-linked form of human LFA-3. Despite earlier observations that DAP.3 ...

journal_title：International immunology

authors： Greenlaw R,Robinson P,Heaton T,Lombardi G,Lechler R

更新日期：1992-06-01 00:00:00

abstract：:We have shown that the dominance of CD8+ T cells expressing TCR Vbeta17 in the adult HLA-A*0201-restricted influenza A/M1(58-66)-specific response is acquired following first antigen exposure. Despite the acquired dominance of Vbeta17+ cells, subdominant M1(58-66)-specific clones expressing non-Vbeta17+ TCR persist in...

journal_title：International immunology

authors： Lawson TM,Man S,Wang EC,Williams S,Amos N,Gillespie GM,Moss PA,Borysiewicz LK

更新日期：2001-11-01 00:00:00

abstract：:In vascularized organ transplantation, vascular endothelial cells (EC) confronting recipient T cells are potentially significant APC initiating cellular immune responses that lead to rejection. In the present study, we studied the ability of human EC to stimulate allogeneic T cells and the co-stimulatory molecules inv...

journal_title：International immunology

authors： Seino K,Azuma M,Bashuda H,Fukao K,Yagita H,Okumura K

更新日期：1995-08-01 00:00:00

abstract：:Previously we have described the role of two 14mer peptides in autoimmune uveitis, PDSAg from the retinal autoantigen S-antigen (S-Ag) and B27PD from the sequence of disease-associated HLA-B molecules, which show antigenic mimicry. The retinal peptide gave rise to severe uveitis in the Lewis rat model of experimental ...

journal_title：International immunology

authors： Wildner G,Diedrichs-Möhring M

更新日期：2003-08-01 00:00:00

abstract：:Liver fibrosis is commonly observed in chronic liver disease. However, the immunological mechanisms underlying hepatic fibrosis due to chronic inflammation are not well defined, mainly because suitable experimental models have not been established. We have found that weekly i.v. administration of concanavalin A (Con A...

journal_title：International immunology

authors： Kimura K,Ando K,Ohnishi H,Ishikawa T,Kakumu S,Takemura M,Muto Y,Moriwaki H

更新日期：1999-09-01 00:00:00

abstract：:The ileal Peyer's patch (PP) plays a central role in B cell development in young sheep and it is hypothesized that this B cell development occurs independent of extrinsic antigen and T cells. Therefore, it was of interest to examine ileal PP follicular (iPf) B cell responses to CD40 ligand, a molecule integral to T ce...

journal_title：International immunology

authors： Griebel P,Ferrari G

更新日期：1995-03-01 00:00:00

abstract：:Dendritic cells (DC) are highly potent activators of the immune response. The precise mechanisms that give rise to the DC phenotype are not known. To investigate the mechanisms that contribute to the generation of the DC phenotype, precursor DC were freshly isolated from human blood and allowed to mature in vitro. The...

journal_title：International immunology

authors： Engering AJ,Richters CD,Fluitsma DM,van Pelt AM,Kamperdijk EW,Hoefsmit EC,Pieters J

更新日期：1998-11-01 00:00:00

abstract：:Semaphorin 3A (Sema3A), originally identified as a potent growth cone collapsing factor in developing sensory neurons, is now recognized as a key player in immune, cardiovascular, bone metabolism and neurological systems. Here we established an anti-Sema3A monoclonal antibody that neutralizes the effects of Sema3A bot...

journal_title：International immunology

authors： Yamashita N,Jitsuki-Takahashi A,Ogawara M,Ohkubo W,Araki T,Hotta C,Tamura T,Hashimoto S,Yabuki T,Tsuji T,Sasakura Y,Okumura H,Takaiwa A,Koyama C,Murakami K,Goshima Y

更新日期：2015-09-01 00:00:00

abstract：:Notch2 and Delta-like 1 (Dll1) have been implicated in the development of marginal zone B (MZB) cells. In the present study, we characterized the expression and function of mouse Notch receptors and ligands in the spleen by using newly generated mAbs. Although Notch2 was expressed on both B and T cells in the spleen, ...

journal_title：International immunology

authors： Moriyama Y,Sekine C,Koyanagi A,Koyama N,Ogata H,Chiba S,Hirose S,Okumura K,Yagita H

更新日期：2008-06-01 00:00:00

abstract：:The chicken represents the best-characterized animal model for B cell development in the so-called gut-associated lymphoid tissue (GALT) and the molecular processes leading to B cell receptor diversification in this species are well investigated. However, the mechanisms regulating B cell development and homeostasis in...

journal_title：International immunology

authors： Kothlow S,Morgenroth I,Graef Y,Schneider K,Riehl I,Staeheli P,Schneider P,Kaspers B

更新日期：2007-02-01 00:00:00

abstract：:Myelin proteolipid protein (PLP) 139-151 is an immunodominant peptide that induces experimental autoimmune encephalomyelitis (EAE) in H-2(s) SJL/J mice. While PLP 139-151-specific TCR transgenic (tg) 4E3 mice develop fulminant spontaneous disease on the susceptible SJL/J background, spontaneous EAE is dramatically red...

journal_title：International immunology

authors： Illés Z,Waldner H,Reddy J,Anderson AC,Sobel RA,Kuchroo VK

更新日期：2007-10-01 00:00:00

abstract：:IL-7 is a required factor for T-cell homeostasis. Because of low expression levels and poor reagent availability, the cellular sources of IL-7 have proven challenging to characterize. In this study, we describe a reporter mouse in which enhanced GFP is expressed from the endogenous Il7 locus. We show that IL-7 is prod...

journal_title：International immunology

authors： Miller CN,Hartigan-O'Connor DJ,Lee MS,Laidlaw G,Cornelissen IP,Matloubian M,Coughlin SR,McDonald DM,McCune JM

更新日期：2013-08-01 00:00:00

abstract：:In the final analysis, the self (S)-non-self (NS) discrimination is regulated by the sufficiency or insufficiency of effector T(h) (eT(h)) specific for the given antigen. We have described a model (Th genesis) for the origin of eT(h) based on an antigen-independent pathway from initial state T(h) (iT(h)) to eT(h), and...

journal_title：International immunology

authors： Langman RE,Mata JJ,Cohn M

更新日期：2003-05-01 00:00:00

abstract：:We have previously reported that tumor necrosis factor receptor-associated factor 1 (TRAF1), an intracellular protein, which binds to a range of molecules, including tumor necrosis factor (TNF) receptor family members, regulates TNF-induced NF-kappaB and AP-1 signaling as well as TCR-triggered proliferative responses ...

journal_title：International immunology

authors： Bryce PJ,Oyoshi MK,Kawamoto S,Oettgen HC,Tsitsikov EN

更新日期：2006-01-01 00:00:00

abstract：:Dendritic cells (DC) are key players in the initiation and modulation of adaptive immune responses due to their ability to acquire and present antigen and stimulate T cells. For the induction of effector T cell functions, antigen must be presented by activated DC. In this study, we have compared uptake of antigen by m...

journal_title：International immunology

authors： Tirapu I,Giquel B,Alexopoulou L,Uematsu S,Flavell R,Akira S,Diebold SS

更新日期：2009-07-01 00:00:00

abstract：:Long-term side effects may represent a relevant burden of antiretroviral treatment (ART) in HIV-infected patients with good CD4 immune reconstitution over extended time spans. CD4-guided treatment interruption (TI) has been evaluated to address this point and may result in a wide spectrum of time off ART in different ...

journal_title：International immunology

authors： Bozzano F,Nasi M,Bertoncelli L,Nemes E,Prati F,Marras F,Mussini C,Moretta L,Cossarizza A,De Maria A

更新日期：2011-02-01 00:00:00

abstract：:Southern blot analysis of genomic DNA of normal mouse thymocytes with a JH4 probe, a probe for JH4 of Igh genes, consistently showed a second band in addition to a germline band. The same band was also observed in analysis with a 5' DQ probe, a 5'-flanking sequence of DQ52, thus suggesting the use of DQ52. By analyzin...

journal_title：International immunology

authors： Suzuki H,Abe M,Nishikawa S,Nakayama E,Shiku H

更新日期：1989-01-01 00:00:00

abstract：:Natural cytotoxicity receptors and NKG2D correspond to major activating receptors involved in triggering of tumor cell lysis by human NK cells. In this report, we investigated the expression of NKG2D ligands (NKG2DLs), MHC class I-related chain (MIC) A, MICB and UL16-binding proteins 1, 2 and 3, on a panel of human no...

journal_title：International immunology

authors： Le Maux Chansac B,Missé D,Richon C,Vergnon I,Kubin M,Soria JC,Moretta A,Chouaib S,Mami-Chouaib F

更新日期：2008-07-01 00:00:00

abstract：:The course and severity of lupus in spontaneous murine lupus models varies among laboratories, which may be due to variations in diet, housing and/or local environmental conditions. In this study, we investigated the influence of common rodent diets while keeping other factors constant. Female lupus-prone MRL/lpr (MRL...

journal_title：International immunology

authors： Edwards MR,Dai R,Heid B,Cecere TE,Khan D,Mu Q,Cowan C,Luo XM,Ahmed SA

更新日期：2017-06-01 00:00:00

abstract：:AbstractImmune homeostasis is critically regulated by the balance between activating and inhibitory receptors expressed on various immune cells such as T and B lymphocytes, and myeloid cells. The inhibitory receptors play a fundamental role in the immune checkpoint pathway, thus maintaining peripheral tolerance. We re...

journal_title：International immunology

authors： Wong YL,Su MT,Sugahara-Tobinai A,Itoi S,Kezuka D,Endo S,Inui M,Takai T

更新日期：2019-05-21 00:00:00

abstract：:We have searched the human genome for genes that predispose to rheumatoid arthritis (RA) using fluorescence-based microsatellite marker analysis and affected sib-pair linkage study. A panel of 41 Japanese families, each with at least two affected siblings, was typed for genome-wide 358 polymorphic microsatellite marke...

journal_title：International immunology

authors： Shiozawa S,Hayashi S,Tsukamoto Y,Goko H,Kawasaki H,Wada T,Shimizu K,Yasuda N,Kamatani N,Takasugi K,Tanaka Y,Shiozawa K,Imura S

更新日期：1998-12-01 00:00:00