Proinflammatory cytokines induce liver and activation-regulated chemokine/macrophage inflammatory protein-3alpha/CCL20 in mucosal epithelial cells through NF-kappaB [correction of NK-kappaB].

abstract：:The CC chemokine receptor 7 (CCR7) and its two ligands, CCL21 and CCL19, play an important role in migration of immune cells to lymphoid tissue. To analyze the function of CCR7 in T cell immunity to infectious agents in vivo, transgenic (tg) mice expressing CCL21 in an ubiquitous fashion were generated. These mice con...

journal_title：International immunology

authors： Unsoeld H,Mueller K,Schleicher U,Bogdan C,Zwirner J,Voehringer D,Pircher H

更新日期：2007-11-01 00:00:00

abstract：:We have generated a high copy number transgenic mouse line in which expression of mouse IL-7 cDNA is under the control of the mouse MHC class II E alpha promoter. These mice were generated in order to see if IL-7 over-production in the thymus altered either thymocyte differentiation or the process of negative selectio...

journal_title：International immunology

authors： Mertsching E,Burdet C,Ceredig R

更新日期：1995-03-01 00:00:00

abstract：:Peptide-MHC class II complexes (pMHC II) are degraded by MARCH-I-mediated ubiquitination, and the stabilization of pMHC II by loss of its ubiquitination is one phenotype defining the activation of conventional dendritic cells (cDCs). However, the role of such stabilization of pMHC II in the context of T-cell activatio...

journal_title：International immunology

authors： Ishikawa R,Kajikawa M,Ishido S

更新日期：2014-05-01 00:00:00

abstract：:Adhesion molecules of the integrin family are implicated not only in leukocyte migration but also in leukocyte activation. Here we characterize the expression and function of fibronectin receptor integrins on rat mast cells. A rat basophilic leukemia cell line (RBL-2H3) and phorbol ester-stimulated rat peritoneal mast...

journal_title：International immunology

authors： Yasuda M,Hasunuma Y,Adachi H,Sekine C,Sakanishi T,Hashimoto H,Ra C,Yagita H,Okumura K

更新日期：1995-02-01 00:00:00

abstract：:The product of the LAG-3 gene is a cell surface protein with significant homology to CD4. It has been suggested that it can serve as a functional equivalent of CD4 and account for the MHC class II-restricted responses which persist in CD4-deficient mice. To test this hypothesis, we have created CD4/LAG-3 double-defici...

journal_title：International immunology

authors： Miyazaki T,Dierich A,Benoist C,Mathis D

更新日期：1996-05-01 00:00:00

abstract：:BALB/c mice are susceptible to cutaneous leishmaniasis upon infection with Leishmania major while C57BL/6 are not. There is a major promastigote surface protease (PSP or gp63) which is available in both native and recombinant forms, and for which the primary amino acid sequence is known. Immunization with PSP has been...

journal_title：International immunology

authors： Soares LR,Sercarz EE,Miller A

更新日期：1994-05-01 00:00:00

abstract：:Normal human sera contained 10-60 ng/ml of soluble membrane cofactor protein (MCP, CD46) whereas sera of > 50% of the cancer patients contained > 60 ng/ml. MCP purified by immunoaffinity chromatography from both normal and cancer patients' sera consisted of three bands of 56, 47 and 29 kDa on SDS-PAGE/immunoblotting. ...

journal_title：International immunology

authors： Seya T,Hara T,Iwata K,Kuriyama S,Hasegawa T,Nagase Y,Miyagawa S,Matsumoto M,Hatanaka M,Atkinson JP

更新日期：1995-05-01 00:00:00

abstract：:MicroRNAs 125a and 125b are predicted to be able to bind to the B lymphocyte-induced maturation protein-1 (BLIMP-1) and IFN regulatory protein-4 (IRF-4) transcription factors, which are essential for plasma cell differentiation. A computational survey of the human and mouse genomes revealed that miR-125a and miR-125b ...

journal_title：International immunology

authors： Gururajan M,Haga CL,Das S,Leu CM,Hodson D,Josson S,Turner M,Cooper MD

更新日期：2010-07-01 00:00:00

abstract：:The T cell Ig domain and mucin domain (TIM) proteins form a conserved family of transmembrane cell-surface glycoproteins expressed by a variety of tissues. Each TIM protein contains a single V-type Ig domain, a glycosylated mucin-like domain, a transmembrane domain and a cytoplasmic domain. TIM proteins recognize a di...

journal_title：International immunology

authors： Wilker PR,Sedy JR,Grigura V,Murphy TL,Murphy KM

更新日期：2007-06-01 00:00:00

abstract：:Human monocytes isolated from peripheral blood of healthy donors show a time-dependent differentiation into macrophages upon in vitro cultivation, closely mimicking their in vivo migration and maturation into extravascular tissues. The mediator(s) of this maturation process has not been yet defined. We investigated th...

journal_title：International immunology

authors： Coccia EM,Del Russo N,Stellacci E,Testa U,Marziali G,Battistini A

更新日期：1999-07-01 00:00:00

abstract：:Under equilibrium conditions, the affinities of five anti-IgG2a mAb isolated from virus-infected mice were comparable to other high-affinity auto-antibodies. Similar to rheumatoid factors, these anti-IgG2a auto-antibodies bound to aggregated or complexed IgG2a with 50 to 1500-fold higher avidity than their monomeric c...

journal_title：International immunology

authors： Fazekas G,Pálfi G,Wolff-Winiski B,Rosenwirth B,Dukor P,Gergely J,Rajnavölgyi E

更新日期：1995-07-01 00:00:00

abstract：:A Plasmodium falciparum schizont lysate has been previously described as being a powerful inducer of proliferation for human peripheral T lymphocytes. In this report we study the phenotype of cycling T cells from unexposed donors and examine how the P. falciparum lysate compares with the conventional T cell mitogen ph...

journal_title：International immunology

authors： Behr C,Dubois P

更新日期：1992-03-01 00:00:00

abstract：:Absence of transforming growth factor-beta (TGF-beta) signaling to T cells in mice results in an increase in T cell numbers, an activated CD44 high, CD69-, CD25- T cell phenotype and a T cell-mediated injury to many organs. It is not known if such T cell activation in the absence of TGF-beta signaling is spontaneous o...

journal_title：International immunology

authors： Mehal WZ,Sheikh SZ,Gorelik L,Flavell RA

更新日期：2005-05-01 00:00:00

abstract：:Dendritic cells (DC) are potent antigen-presenting cells and understanding their mechanisms of antigen uptake is important for loading DC with antigen for immunotherapy. The multilectin receptors, DEC-205 and macrophage mannose receptor (MMR), are potential antigen-uptake receptors; therefore, we examined their expres...

journal_title：International immunology

authors： Kato M,Neil TK,Fearnley DB,McLellan AD,Vuckovic S,Hart DN

更新日期：2000-11-01 00:00:00

abstract：:Cyclosporin A (CsA) prevents most immature thymocytes from progressing to a mature phenotype and blocks the deletion of T cells that express self-specific TCR in the small population of cells that achieve maturity. The latter effect may explain the paradoxical observation that this immunosuppressive drug can induce au...

journal_title：International immunology

authors： Urdahl KB,Pardoll DM,Jenkins MK

更新日期：1992-12-01 00:00:00

abstract：:In this study, we analyzed peripheral blood CD4+CD8+ double-positive (DP) lymphocytes in adult cynomolgus monkeys (Macaca fascicularis). Forty of 55 monkeys had > 5% of the peripheral blood DP subpopulation (9.3 +/- 5.9%; mean +/- SD) in peripheral blood lymphocytes (PBL) in contrast to a low percentage of peripheral ...

journal_title：International immunology

authors： Akari H,Terao K,Murayama Y,Nam KH,Yoshikawa Y

更新日期：1997-04-01 00:00:00

abstract：:In this paper we describe a monoclonal antibody, JR9-318, which was obtained from a wild-derived mouse immunized with the M14T cell line (CD3+CD4-CD8-) in order to describe antigenic molecules expressed during T cell differentiation. This mAb precipitated a protein from the M14T cell line or subclones that migrates li...

journal_title：International immunology

authors： Roland J,Cazenave PA

更新日期：1992-06-01 00:00:00

abstract：:T cell responses against complex antigens are often directed against a limited set of immunodominant determinants. We have studied this phenomenon at the level of cellularly processed peptides recognized by CTL in the B6 anti-BALB.B minor histocompatibility (H) barrier, comprising at least 29 antigen loci. B6 anti-BAL...

journal_title：International immunology

authors： Wolpert E,Franksson L,Kärre K

更新日期：1995-06-01 00:00:00

abstract：:The interleukin 2 receptor (IL-2R) is composed of at least two polypeptides--a 55 kd protein (the L chain, p55, or alpha chain) and a 75 kd protein (the H chain, p75 or beta chain). The high-affinity binding of IL-2 results in the formation of a ternary complex consisting of IL-2 and the L and H chains. We found that ...

journal_title：International immunology

authors： Saito Y,Ogura T,Kamio M,Sabe H,Uchiyama T,Honjo T

更新日期：1990-01-01 00:00:00

abstract：:CD4 and CD8 T cell subsets involved in primary allo-MLR responses were re-evaluated in the present study. The slope analysis of B6 allo-MLR responses to MHC class I-disparate bm1 and class II-disparate bm12 revealed the presence of a T-T cell interaction between CD4 and CD8 T cell subsets. The allo-MLR response of B6 ...

journal_title：International immunology

authors： Asano Y,Komuro T,Tada T

更新日期：1990-01-01 00:00:00

abstract：:Signal transducer and activator of transcription-1 (STAT1) signaling mediate most biological functions of IFNalpha, IFNbeta and IFNgamma although recent studies indicate that IFNgamma can alter expression of several genes via a STAT1-independent pathway. STAT1 is critical for immunity against a variety of intracellula...

journal_title：International immunology

authors： Roth KM,Gunn JS,Lafuse W,Satoskar AR

更新日期：2009-01-01 00:00:00

abstract：:Lipid mediators, such as prostanoids and leukotrienes (LTs), exert a range of actions through their own receptors on cell surfaces in various pathophysiological conditions. It has been reported that the production of prostanoids and LTs is significantly elevated in the skin lesions of some chronic inflammatory skin di...

journal_title：International immunology

authors： Honda T,Kabashima K

更新日期：2019-08-23 00:00:00

abstract：:NK cells are functionally controlled by the killer immunoglobulin-like receptor (KIR) family that comprises inhibitory (iKIR) and activating (aKIR) members. Genetic association studies suggest that donors expressing aKIRs next to iKIRs will be superior donors in the setting of hematopoietic stem cell transplantation o...

journal_title：International immunology

authors： Baltner K,Kübler A,Pal M,Balvociute M,Mezger M,Handgretinger R,André MC

更新日期：2017-11-01 00:00:00

abstract：:Cytotoxic T lymphocytes (CTL) confer protection against intracellular pathogens, yet the mechanism by which some escape activation induced cell death (AICD) and give rise to long-lived memory cells is unclear. We studied the differentiation of transgenic TCR CD8(+) cells into CTL and memory cells using a novel system ...

journal_title：International immunology

authors： Opferman JT,Ober BT,Narayanan R,Ashton-Rickardt PG

更新日期：2001-04-01 00:00:00

abstract：:Acute graft-versus-host disease (GvHD) is a serious complication after allogeneic bone marrow transplantation. Donor-derived T cells infiltrate recipient target organs and cause severe tissue damage, often leading to death of the affected patient. Tissue destruction is a direct result of donor CD8+ T cell activation a...

journal_title：International immunology

authors： Arnold D,Wasem C,Juillard P,Graber P,Cima I,Frutschi C,Herren S,Jakob S,Alouani S,Mueller C,Chvatchko Y,Brunner T

更新日期：2002-05-01 00:00:00

abstract：:We developed a novel approach to probe the molecular basis of TCR recognition of the MHC class I-peptide complex and to determine how constraints placed on peptide binding by the class I molecule influence T cell recognition. We synthesized peptide pairs derived from the N- and C-terminal regions of class I peptide li...

journal_title：International immunology

authors： Gillanders WE,Hanson HL,Rubocki RJ,Hansen TH,Connolly JM

更新日期：1997-01-01 00:00:00

abstract：:The origin of anti-DNA antibodies remains speculative. We argue that some of these antibodies may arise inadvertently in nature during the course of a normal immune response due to their induction by antibodies which bear structures (mimotopes) that mimic DNA. These antibodies are not necessarily DNA specific but, lik...

journal_title：International immunology

authors： Wun HL,Leung DT,Wong KC,Chui YL,Lim PL

更新日期：2001-09-01 00:00:00

abstract：:Taking advantage of the recently demonstrated presence of N-aminopeptidases and the serine protease dipeptidyl aminopeptidase IV (DPP IV) at the surface of human myeloblastic HL-60 cells, the regulation of these protease activities in HL-60 cell differentiation has been assessed using combined spectrophotometric and f...

journal_title：International immunology

authors： Laouar A,Wietzerbin J,Bauvois B

更新日期：1993-08-01 00:00:00

abstract：:Specific antibodies increase antigen uptake and presentation by antigen-presenting cells via the B cell receptor in B cells or FcgammaR in dendritic cells. To determine whether the interaction between antibody and antigen could influence the set of peptides presented by MHC II molecules, we analyzed the presentation o...

journal_title：International immunology

authors： Guermonprez P,Lo-Man R,Sedlik C,Rojas MJ,Poljak RJ,Leclerc C

更新日期：1999-11-01 00:00:00

abstract：:It was recently shown that paf-acether (paf) synthesized in different cell types remains partly cell-associated. In the present work, we tested the hypothesis that cell-associated paf might in fact remain exposed on the external plasma membrane and be able to exert its biological functions. Human polymorphonuclear neu...

journal_title：International immunology

authors： Ninio E,Leyravaud S,Bidault J,Jurgens P,Benveniste J

更新日期：1991-11-01 00:00:00