当前位置： SCI文献检索 > INTERNATIONAL IMMUNOLOGY期刊下所有文献 > Class I-restricted cytotoxic T cell recognition of split peptide ligands.

Class I-restricted cytotoxic T cell recognition of split peptide ligands.

Abstract：

:We developed a novel approach to probe the molecular basis of TCR recognition of the MHC class I-peptide complex and to determine how constraints placed on peptide binding by the class I molecule influence T cell recognition. We synthesized peptide pairs derived from the N- and C-terminal regions of class I peptide ligands in which the TCR contacts and dominant binding residues were placed together or were separated. Complementary peptide pairs derived from two well-characterized Ld peptide ligands, tum- (QNHRALDL) and p2Ca (LSPFPFDL), were tested for the ability to sensitize targets for recognition by peptide-specific cytotoxic T lymphocytes (CTL). The tum-derived tetramer QNHR, containing both primary TCR contact residues (H17 and R18), is recognized only when used in combination with ALDL which contains the primary binding residues (A19, D21 and L22). This suggests that both peptides of the pair contribute to positioning of the TCR contacts. Remarkably, CTL clone P24 recognized target cells sensitized with a trimer (QNH) combined with a pentamer (RALDL), demonstrating that TCR recognition can occur when the TCR contacts are separated (placed on separate peptide subunits). For the p2Ca peptide LSPFPFDL, the C-terminal tetramer PFDL, which contains both the primary TCR contact residue (P) and the dominant binding residue (L), is sufficient for recognition. In addition, PFDL was able to bind effectively to Ld and to activate naive antigen-specific T cells. These data suggest that peptide subunits and complementary peptide pairs composed of trimeric, tetrameric or pentameric peptides can bind independently to the Ld molecule in the same register and orientation as they do when contained within the parent peptide.

journal_name

Int Immunol

journal_title

International immunology

authors

Gillanders WE,Hanson HL,Rubocki RJ,Hansen TH,Connolly JM

doi

10.1093/intimm/9.1.81

subject

Has Abstract

pub_date

1997-01-01 00:00:00

pages

81-9

issue

1

eissn

0953-8178

issn

1460-2377

journal_volume

9

pub_type

杂志文章

相关文献

INTERNATIONAL IMMUNOLOGY文献大全
  • Influenza A virus elevates active cathepsin B in primary murine DC.

    abstract：:Dendritic cells (DCs) act as a first-line recognition system for invading pathogens, such as influenza A. The interaction of DC with influenza A virus results in DC activation via endosomal Toll-like receptors and also leads to presentation of viral peptides on MHC class II molecules. Prior work demonstrated that infl...

    journal_title：International immunology

    pub_type： 杂志文章

    doi：10.1093/intimm/dxm030

    authors： Burster T,Giffon T,Dahl ME,Björck P,Bogyo M,Weber E,Mahmood K,Lewis DB,Mellins ED

    更新日期：2007-05-01 00:00:00

  • Kit-independent mast cell adhesion mediated by Notch.

    abstract：:Kit/CD117 plays a crucial role in the cell-cell and cell-matrix adhesion of mammalian mast cells (MCs); however, it is unclear whether other adhesion molecule(s) perform important roles in the adhesion of MCs. In the present study, we show a novel Kit-independent adhesion mechanism of mouse cultured MCs mediated by No...

    journal_title：International immunology

    pub_type： 杂志文章

    doi：10.1093/intimm/dxy067

    authors： Murata A,Hikosaka M,Yoshino M,Zhou L,Hayashi SI

    更新日期：2019-02-15 00:00:00

  • Paradoxical alteration of acute-phase protein levels in patients with chronic hepatitis C treated with IFN-alpha2b.

    abstract：:Previously we observed elevation of the serum concentration of two acute-phase protein (AFP) complement components (C9 and C1-inhibitor) in patients with chronic hepatitis C who responded (R) to IFN-alpha therapy, but not in non-responders (NR). In the present study we investigated the effect of high-dose IFN-alpha th...

    journal_title：International immunology

    pub_type： 杂志文章

    doi：10.1093/intimm/dxh024

    authors： Kalabay L,Nemesánszky E,Csepregi A,Pusztay M,Dávid K,Horváth G,Ibrányi E,Telegdy L,Pár A,Bíró A,Fekete B,Gervain J,Horányi M,Ribiczey P,Csöndes M,Kleiber M,Walentin S,Prohászka Z,Füst G

    更新日期：2004-01-01 00:00:00

  • LPS-binding protein-deficient mice have an impaired defense against Gram-negative but not Gram-positive pneumonia.

    abstract：:LPS-binding protein (LBP) can facilitate the transfer of cell wall components of both Gram-negative bacteria (LPS) and Gram-positive bacteria (lipoteichoic acid) to inflammatory cells. Although LBP is predominantly produced in the liver, recent studies have indicated that this protein is also synthesized locally in th...

    journal_title：International immunology

    pub_type： 杂志文章

    doi：10.1093/intimm/dxh161

    authors： Branger J,Florquin S,Knapp S,Leemans JC,Pater JM,Speelman P,Golenbock DT,van der Poll T

    更新日期：2004-11-01 00:00:00

  • Clonal prevalence of T cells infiltrating into the pancreas of prediabetic non-obese diabetic mice.

    abstract：:The non-obese diabetic (NOD) mouse spontaneously develops T-cell-mediated autoimmune insulitis. We analyzed the clonotypes of T cell infiltrates of the NOD mouse islets using a new method we have developed recently, which consists of RT-PCR amplification of the CDR3 region of the TCR beta chain mRNA and subsequent sin...

    journal_title：International immunology

    pub_type： 杂志文章

    doi：10.1093/intimm/8.6.807

    authors： Komagata Y,Masuko K,Tashiro F,Kato T,Ikuta K,Nishioka K,Ito K,Miyazaki J,Yamamoto K

    更新日期：1996-06-01 00:00:00

  • IL-1α released from oral epithelial cells upon candidalysin exposure initiates an early innate epithelial response.

    abstract：:Candida albicans is a commensal fungus that predominantly resides on mucosal surfaces and can cause lethal systemic infection when the host defense is compromised. Candidalysin is a cytolytic peptide toxin produced by C. albicans hyphae that is essential for mucosal tissue damage and is believed to contribute to the e...

    journal_title：International immunology

    pub_type： 杂志文章

    doi：10.1093/intimm/dxaa070

    authors： Hanaoka M,Domae E

    更新日期：2020-10-10 00:00:00

  • Fas deficiency in mice with the Balb/c background induces blepharitis with allergic inflammation and hyper-IgE production in conjunction with severe autoimmune disease.

    abstract：:Fas (CD95) is a cell surface death receptor belonging to the tumor necrosis factor receptor superfamily, which mediates apoptosis-inducing signaling when activated by Fas ligand or its agonistic antibody. lpr mice with a loss of apoptosis-inducing function mutation in the Fas gene develop systemic autoimmune disease a...

    journal_title：International immunology

    pub_type： 杂志文章

    doi：10.1093/intimm/dxs109

    authors： Takahashi S,Futatsugi-Yumikura S,Fukuoka A,Yoshimoto T,Nakanishi K,Yonehara S

    更新日期：2013-05-01 00:00:00

  • MHC class I antigens regulate CD3-induced tyrosine phosphorylation of proteins in T cells.

    abstract：:The MHC class I antigens enhance the T cell response to various mitogenic stimuli. Class I antigens co-cap and associate with the CD3 structure on these cells. The present work shows that co-aggregation of these MHC antigens with CD3 induces a sustained elevated Ca2+ response in T cells. The duration required for a 50...

    journal_title：International immunology

    pub_type： 杂志文章

    doi：10.1093/intimm/6.3.481

    authors： Dasgupta JD,Granja CB,Yunis EJ,Relias V

    更新日期：1994-03-01 00:00:00

  • Human CD8 co-receptor is strictly involved in MHC-peptide tetramer-TCR binding and T cell activation.

    abstract：:Although there has been extensive analysis on the capacity of MHC-peptide tetramers to bind antigen-specific TCR, there have been comparatively few studies regarding the role of the CD4 and CD8 co-receptors in binding and activation by these multimeric molecules. Here, we start from the observation that different anti...

    journal_title：International immunology

    pub_type： 杂志文章

    doi：10.1093/intimm/14.1.39

    authors： Campanelli R,Palermo B,Garbelli S,Mantovani S,Lucchi P,Necker A,Lantelme E,Giachino C

    更新日期：2002-01-01 00:00:00

  • Anti-Semaphorin 3A neutralization monoclonal antibody prevents sepsis development in lipopolysaccharide-treated mice.

    abstract：:Semaphorin 3A (Sema3A), originally identified as a potent growth cone collapsing factor in developing sensory neurons, is now recognized as a key player in immune, cardiovascular, bone metabolism and neurological systems. Here we established an anti-Sema3A monoclonal antibody that neutralizes the effects of Sema3A bot...

    journal_title：International immunology

    pub_type： 杂志文章

    doi：10.1093/intimm/dxv014

    authors： Yamashita N,Jitsuki-Takahashi A,Ogawara M,Ohkubo W,Araki T,Hotta C,Tamura T,Hashimoto S,Yabuki T,Tsuji T,Sasakura Y,Okumura H,Takaiwa A,Koyama C,Murakami K,Goshima Y

    更新日期：2015-09-01 00:00:00

  • mAb against hen egg-white lysozyme regulate its presentation to CD4(+) T cells.

    abstract：:Specific antibodies increase antigen uptake and presentation by antigen-presenting cells via the B cell receptor in B cells or FcgammaR in dendritic cells. To determine whether the interaction between antibody and antigen could influence the set of peptides presented by MHC II molecules, we analyzed the presentation o...

    journal_title：International immunology

    pub_type： 杂志文章

    doi：10.1093/intimm/11.11.1863

    authors： Guermonprez P,Lo-Man R,Sedlik C,Rojas MJ,Poljak RJ,Leclerc C

    更新日期：1999-11-01 00:00:00

  • Involvement of CD100, a lymphocyte semaphorin, in the activation of the human immune system via CD72: implications for the regulation of immune and inflammatory responses.

    abstract：:CD100/Sema4D belongs to the semaphorin family, factors known to act as repulsive cues for axons during neuronal development. Mouse CD100 plays a crucial role in both humoral and cellular immunity through ligation of the lymphocyte receptor, CD72. It remains controversial, however, whether human CD100 can function thro...

    journal_title：International immunology

    pub_type： 杂志文章

    doi：10.1093/intimm/dxg098

    authors： Ishida I,Kumanogoh A,Suzuki K,Akahani S,Noda K,Kikutani H

    更新日期：2003-08-01 00:00:00

  • Peripheral blood CD4+CD8+ lymphocytes in cynomolgus monkeys are of resting memory T lineage.

    abstract：:In this study, we analyzed peripheral blood CD4+CD8+ double-positive (DP) lymphocytes in adult cynomolgus monkeys (Macaca fascicularis). Forty of 55 monkeys had > 5% of the peripheral blood DP subpopulation (9.3 +/- 5.9%; mean +/- SD) in peripheral blood lymphocytes (PBL) in contrast to a low percentage of peripheral ...

    journal_title：International immunology

    pub_type： 杂志文章

    doi：10.1093/intimm/9.4.591

    authors： Akari H,Terao K,Murayama Y,Nam KH,Yoshikawa Y

    更新日期：1997-04-01 00:00:00

  • Sulfates are main targets of immune responses to cruzipain and are involved in heart damage in BALB/c immunized mice.

    abstract：:Trypanosoma cruzi, the agent of Chagas disease contains a major cysteine proteinase, cruzipain (Cz), with an unusual carboxyl-terminal extension (C-T). We have previously reported the presence of sulfate groups in the N-linked oligosaccharide chains of this domain. In order to evaluate the immune responses to sulfated...

    journal_title：International immunology

    pub_type： 杂志文章

    doi：10.1093/intimm/dxm149

    authors： Acosta DM,Arnaiz MR,Esteva MI,Barboza M,Stivale D,Orlando UD,Torres S,Laucella SA,Couto AS,Duschak VG

    更新日期：2008-04-01 00:00:00

  • CCR6hiCD11c(int) B cells promote M-cell differentiation in Peyer's patch.

    abstract：:M cells are responsible for uptake of mucosal antigens in Peyer's patches (PPs). Differentiation of M cells is thought to be induced by interactions between follicle-associated epithelium and PP cells; however, it remains elusive what types of immune cells function as M-cell inducers. Here, we attempted to identify th...

    journal_title：International immunology

    pub_type： 杂志文章

    doi：10.1093/intimm/dxq478

    authors： Ebisawa M,Hase K,Takahashi D,Kitamura H,Knoop KA,Williams IR,Ohno H

    更新日期：2011-04-01 00:00:00

  • Histone acetylation regulates the cell type specific CIITA promoters, MHC class II expression and antigen presentation in tumor cells.

    abstract：:The regulation of MHC class II expression by the class II transactivator (CIITA) is complex and differs in various cell types depending on the relative activity of three CIITA promoters. Here we show that, in plasma cell tumors, the deacetylase inhibitor trichostatin A (TSA) elicits PIII-CIITA but does not activate th...

    journal_title：International immunology

    pub_type： 杂志文章

    doi：10.1093/intimm/dxh326

    authors： Chou SD,Khan AN,Magner WJ,Tomasi TB

    更新日期：2005-11-01 00:00:00

  • Osteoclasts support the survival of human plasma cells in vitro.

    abstract：:The aim of this in vitro study was to evaluate if osteoclasts (OCs) and dendritic cells (DCs), both of monocyte origin, can support the survival of normal human plasma cells (PCs). PCs differentiate from plasmablasts (PBs) arising from activated B cells, essentially memory B cells. To study the survival of both PBs (C...

    journal_title：International immunology

    pub_type： 杂志文章

    doi：10.1093/intimm/dxn035

    authors： Geffroy-Luseau A,Jégo G,Bataille R,Campion L,Pellat-Deceunynck C

    更新日期：2008-06-01 00:00:00

  • Vaccination of the Leishmania major susceptible BALB/c mouse. I. The precise selection of peptide determinant influences CD4+ T cell subset expression.

    abstract：:BALB/c mice are susceptible to cutaneous leishmaniasis upon infection with Leishmania major while C57BL/6 are not. There is a major promastigote surface protease (PSP or gp63) which is available in both native and recombinant forms, and for which the primary amino acid sequence is known. Immunization with PSP has been...

    journal_title：International immunology

    pub_type： 杂志文章

    doi：10.1093/intimm/6.5.785

    authors： Soares LR,Sercarz EE,Miller A

    更新日期：1994-05-01 00:00:00

  • The role of B7-CD28 co-stimulation in tumor rejection.

    abstract：:The role of B7 co-stimulatory signaling in in vivo tumor rejection remains incompletely characterized. In particular, the relative competence of B7-1 (CD80) and B7-2 (CD86) to provide effective co-stimulus is not well defined, and the identification of the T cell co-stimulatory receptor that mediates B7 co-stimulation...

    journal_title：International immunology

    pub_type： 杂志文章

    doi：10.1093/intimm/10.6.791

    authors： Yu X,Abe R,Hodes RJ

    更新日期：1998-06-01 00:00:00

  • CD69 cell surface expression identifies developing thymocytes which audition for T cell antigen receptor-mediated positive selection.

    abstract：:CD69, an 'activation marker' that is rapidly induced on mature T cells after stimulation through the T cell antigen receptor (TCR) was found to be expressed on approximately 10% of normal thymocytes. All of these CD69+ thymocytes express alpha beta TCR, and they include both TCRlowCD4+CD8+ and TCRhighCD4+CD8- or CD4-C...

    journal_title：International immunology

    pub_type： 杂志文章

    doi：10.1093/intimm/5.9.1139

    authors： Yamashita I,Nagata T,Tada T,Nakayama T

    更新日期：1993-09-01 00:00:00

  • IL-3 facilitates lymphocyte hexose transport by enhancing the intrinsic activity of the transport system.

    abstract：:Interleukin 3 (IL-3) promotes the survival and proliferation of hematopoietic cells of various lineages in culture. Like most other hematopoietic colony stimulating factors, its mode of action is unknown. However, binding of the lymphokine induces protein tyrosine phosphorylation and enhanced glucose transport in some...

    journal_title：International immunology

    pub_type： 杂志文章

    doi：10.1093/intimm/3.8.827

    authors： Nefesh I,Bauskin AR,Alkalay I,Golembo M,Ben-Neriah Y

    更新日期：1991-08-01 00:00:00

  • Novel NLRP3/cryopyrin mutations and pro-inflammatory cytokine profiles in Behçet's syndrome patients.

    abstract：:Behçet's syndrome (BS) is a systemic inflammatory disorder with unknown etiology. Features of both innate and adaptive immunity have been claimed in the pathogenesis of BS. To test the possible dysregulation of the NLRP3/cryopyrin (Nod-like receptor with a pyrin domain 3) inflammasome, as a result of mutation(s), we p...

    journal_title：International immunology

    pub_type： 杂志文章

    doi：10.1093/intimm/dxt046

    authors： Yüksel Ş,Eren E,Hatemi G,Sahillioğlu AC,Gültekin Y,Demiröz D,Akdiş C,Fresko İ,Özören N

    更新日期：2014-02-01 00:00:00

  • Reconstitution of conformationally dependent epitopes on the N-terminal extracellular domain of the human muscle acetylcholine receptor alpha subunit expressed in Escherichia coli: implications for myasthenia gravis therapeutic approaches.

    abstract：:Myasthenia gravis (MG) is an autoimmune disease, caused by autoantibodies against the muscle acetylcholine receptor (AChR), an oligomeric transmembrane glycoprotein composed of alpha(2)beta gamma delta subunits. The alpha subunit carries in its N-terminal extracellular domain the main immunogenic region (MIR), a group...

    journal_title：International immunology

    pub_type： 杂志文章

    doi：10.1093/intimm/12.9.1255

    authors： Tsouloufis T,Mamalaki A,Remoundos M,Tzartos SJ

    更新日期：2000-09-01 00:00:00

  • Differential expression of B7 co-stimulatory molecules by astrocytes correlates with T cell activation and cytokine production.

    abstract：:Whether astrocytes utilize B7:CD28 co-stimulation to activate T cells mediating CNS inflammatory disease is controversial. In this report, primary astrocytes and murine astrocyte lines, generated by immortalization at two different times, day 7 or 45 of culture, were examined for their capability to express B7 co-stim...

    journal_title：International immunology

    pub_type： 杂志文章

    doi：10.1093/intimm/11.7.1169

    authors： Soos JM,Ashley TA,Morrow J,Patarroyo JC,Szente BE,Zamvil SS

    更新日期：1999-07-01 00:00:00

  • TGF-beta signaling regulates CD8+ T cell responses to high- and low-affinity TCR interactions.

    abstract：:Absence of transforming growth factor-beta (TGF-beta) signaling to T cells in mice results in an increase in T cell numbers, an activated CD44 high, CD69-, CD25- T cell phenotype and a T cell-mediated injury to many organs. It is not known if such T cell activation in the absence of TGF-beta signaling is spontaneous o...

    journal_title：International immunology

    pub_type： 杂志文章

    doi：10.1093/intimm/dxh233

    authors： Mehal WZ,Sheikh SZ,Gorelik L,Flavell RA

    更新日期：2005-05-01 00:00:00

  • Structure of celiac disease-associated HLA-DQ8 and non-associated HLA-DQ9 alleles in complex with two disease-specific epitopes.

    abstract：:The association of celiac disease (CD) with HLA-DQ2 and HLA-DQ8 is indicative of preferential mucosal T cell recognition of gluten fragments bound to either DQ allele. We have recently identified two gluten-derived, HLA-DQ8-restricted T cell stimulatory peptides, one each from gliadin and glutenin, recognized by speci...

    journal_title：International immunology

    pub_type： 杂志文章

    doi：10.1093/intimm/12.8.1157

    authors： Moustakas AK,van de Wal Y,Routsias J,Kooy YM,van Veelen P,Drijfhout JW,Koning F,Papadopoulos GK

    更新日期：2000-08-01 00:00:00

  • Heat stable antigen (mouse CD24) supports myeloid cell binding to endothelial and platelet P-selectin.

    abstract：:P-selectin is a Ca(2+)-dependent lectin that participates in leukocyte adhesion to vascular endothelium and platelets. Myeloid cells and a subset of T lymphocytes express carbohydrate ligands at the cell surface. Previously, we suggested that heat stable antigen (HSA/mouse CD24), an extensively glycosylated cell surfa...

    journal_title：International immunology

    pub_type： 杂志文章

    doi：10.1093/intimm/7.10.1557

    authors： Aigner S,Ruppert M,Hubbe M,Sammar M,Sthoeger Z,Butcher EC,Vestweber D,Altevogt P

    更新日期：1995-10-01 00:00:00

  • IL-7 reverses NK1+ T cell-defective IL-4 production in the non-obese diabetic mouse.

    abstract：:Converging data suggest an important role for IL-7 in T lymphocyte maturation as illustrated by the severe T lymphopenia observed in IL-7-deficient mice. We recently reported that IL-7 preferentially promotes the in vitro expansion of a discrete MHC class I-dependent lymphocyte subset comprising both CD4+ and CD4-CD8-...

    journal_title：International immunology

    pub_type： 杂志文章

    doi：10.1093/intimm/8.11.1751

    authors： Gombert JM,Tancrède-Bohin E,Hameg A,Leite-de-Moraes MC,Vicari A,Bach JF,Herbelin A

    更新日期：1996-11-01 00:00:00

  • Potentiation of NK cell-mediated cytotoxicity in human lung adenocarcinoma: role of NKG2D-dependent pathway.

    abstract：:Natural cytotoxicity receptors and NKG2D correspond to major activating receptors involved in triggering of tumor cell lysis by human NK cells. In this report, we investigated the expression of NKG2D ligands (NKG2DLs), MHC class I-related chain (MIC) A, MICB and UL16-binding proteins 1, 2 and 3, on a panel of human no...

    journal_title：International immunology

    pub_type： 杂志文章

    doi：10.1093/intimm/dxn038

    authors： Le Maux Chansac B,Missé D,Richon C,Vergnon I,Kubin M,Soria JC,Moretta A,Chouaib S,Mami-Chouaib F

    更新日期：2008-07-01 00:00:00

  • Dendritic cells at a DNA vaccination site express the encoded influenza nucleoprotein and prime MHC class I-restricted cytolytic lymphocytes upon adoptive transfer.

    abstract：:Intradermal inoculation of plasmids expressing antigens that contain MHC class I-restricted epitopes leads to the induction of specific CD8(+) cytotoxic T lymphocytes (CTL). The role of in situ transfected antigen-presenting cells (APC) in the priming of specific CTL subsequent to intradermal DNA immunization was inve...

    journal_title：International immunology

    pub_type： 杂志文章

    doi：10.1093/intimm/12.6.825

    authors： Bot A,Stan AC,Inaba K,Steinman R,Bona C

    更新日期：2000-06-01 00:00:00