Abstract:
:Non-obese diabetic (NOD) mice that are genetically deficient in either IFN-gamma or beta chain of the IFN-gammaR develop diabetes with similar kinetics to wild-type NOD mice. In the current study, we demonstrated that treatment of IFN-gamma signaling-deficient NOD mice with cyclophosphamide (CY) not only fails to induce acute diabetes but also confers permanent protection from diabetes. Protection was mediated by the preferential generation of regulatory T cells (Treg cells) that are capable of suppressing the diabetogenic process, with no change in the total number and function of Treg cells. Moreover, CY treatment of IFN-gamma signaling-deficient NOD mice reversed the ongoing pathogenic process and eliminated cellular infiltrates of pancreatic islets. While these results have been derived using a genetically modified mouse model of diabetes, they indicate that knowledge of host genetic factors and environmental factors influencing the development of Type I diabetes mellitus may provide a rational approach to develop a means to reverse the development of Type I diabetes in human.
journal_name
Int Immunoljournal_title
International immunologyauthors
Mori Y,Kato T,Kodaka T,Kanagawa EM,Hori S,Kanagawa Odoi
10.1093/intimm/dxn080subject
Has Abstractpub_date
2008-09-01 00:00:00pages
1231-7issue
9eissn
0953-8178issn
1460-2377pii
dxn080journal_volume
20pub_type
杂志文章abstract::Pathogenic intracellular bacteria often hijack macrophages for their propagation. The infected macrophages release IL-1β and IL-18 and simultaneously commit suicide, which is called pyroptosis; both responses require caspase-1. Here, we found that pyroptotic cells induced by microbial infection were efficiently engulf...
journal_title:International immunology
pub_type: 杂志文章
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abstract::The ileal Peyer's patch (PP) plays a central role in B cell development in young sheep and it is hypothesized that this B cell development occurs independent of extrinsic antigen and T cells. Therefore, it was of interest to examine ileal PP follicular (iPf) B cell responses to CD40 ligand, a molecule integral to T ce...
journal_title:International immunology
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doi:10.1093/intimm/7.3.369
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abstract::Analyses of bone marrow (BM) lymphocytes in C57BL/6 mice homozygous for the lpr mutation (B6.lpr) disclosed low numbers of pre-B and B cells, as compared with age-matched control B6 mice. BM depletion in B6.lpr mice was selective for B-lineage cells, appeared in young adults, and developed markedly with age and diseas...
journal_title:International immunology
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journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/11.2.217
更新日期:1999-02-01 00:00:00
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journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/13.11.1383
更新日期:2001-11-01 00:00:00
abstract::Sphingosine 1-phosphate (S1P) and S1P receptor 1 (S1P1) play an important role in the egress of mature CD4 or CD8 single-positive (SP) thymocytes from the thymus. Fingolimod hydrochloride (FTY720), an S1P1 functional antagonist, induced significant accumulation of CD62L(high)CD69(low) mature SP thymocytes in the thymi...
journal_title:International immunology
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journal_title:International immunology
pub_type: 杂志文章,评审
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更新日期:2020-06-26 00:00:00
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journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/dxs075
更新日期:2012-11-01 00:00:00
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journal_title:International immunology
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更新日期:1993-08-01 00:00:00
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journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/3.7.673
更新日期:1991-07-01 00:00:00
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journal_title:International immunology
pub_type: 杂志文章,评审
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更新日期:2018-03-10 00:00:00
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journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/10.12.1891
更新日期:1998-12-01 00:00:00
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journal_title:International immunology
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doi:10.1093/intimm/dxt061
更新日期:2014-05-01 00:00:00
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journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/7.5.727
更新日期:1995-05-01 00:00:00
abstract::Impaired lymphocyte function is a common feature of human diabetes. Nucleoside transport across the plasma membrane is an essential step during lymphocyte growth and activation. In our study, we evaluated the impact of diabetic conditions on nucleoside transport system in B lymphocytes. Examination of the nucleoside t...
journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/dxh195
更新日期:2005-02-01 00:00:00
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journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/8.3.343
更新日期:1996-03-01 00:00:00
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journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/dxy067
更新日期:2019-02-15 00:00:00
abstract::A recipient who received a renal graft from a living related donor showed good renal function for as long as 15 years after the withdrawal of azathioprine. The patient's creatinine clearance was maintained at 60 ml/min in spite of the administration of only 10 mg of predonisolon per day. Anti-idiotypic antibodies in t...
journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/1.5.503
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journal_title:International immunology
pub_type: 杂志文章
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更新日期:2000-06-01 00:00:00
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doi:10.1093/intimm/6.11.1777
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journal_title:International immunology
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doi:10.1093/intimm/11.7.1169
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journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/8.7.1149
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journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/2.6.521
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pub_type: 杂志文章
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更新日期:1992-02-01 00:00:00
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journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/10.12.1801
更新日期:1998-12-01 00:00:00
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journal_title:International immunology
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doi:10.1093/intimm/dxv061
更新日期:2016-02-01 00:00:00