Abstract:
:After activation, populations of antigen-specific T cells flow between sites of antigen expression, local lymphoid structures and other lymphoid and non-lymphoid organs. In this study, we documented the in vivo dynamics of a CD8(+) T cell response to antigen delivered using herpes simplex virus amplicon vectors and revealed several unexpected features. First, the T cells localized to the site of vector injection, as well as the draining lymph node within 24-48 h. Second, the major site to which T cells later redistributed were intra-abdominal lymphoid organs, including milky spots, mesenteric and lumbar lymph nodes. We determined the relationship between bioluminescent signal and antigen-specific T cell numbers in various lymphoid organs, and concluded that bioluminescent signal is a valid surrogate measure of T cell abundance in superficial lymph nodes, but not in deeper structures such as the spleen.
journal_name
Int Immunoljournal_title
International immunologyauthors
Azadniv M,Dugger K,Bowers WJ,Weaver C,Crispe INdoi
10.1093/intimm/dxm086subject
Has Abstractpub_date
2007-10-01 00:00:00pages
1165-73issue
10eissn
0953-8178issn
1460-2377pii
dxm086journal_volume
19pub_type
杂志文章abstract::We report here that different organ grafts are not equally competent to induce tolerance of the host even if they are performed early in development, i.e. before the host's immune system has started to develop. We have grafted the epithelio-mesenchymal rudiment of the bursa of Fabricius between histoincompatible chick...
journal_title:International immunology
pub_type: 杂志文章
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abstract::The adaptive immune response is involved in the development and progression of atherosclerosis and IL-17A(+) cells play a role in this disease. Although elevated number of CD4(+) IL-17A(+) (Th17) and IL-17A(+)TCRγδ(+) T cells are found within murine atherosclerotic aortas and human plaques, the mechanisms governing IL...
journal_title:International immunology
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journal_title:International immunology
pub_type: 杂志文章
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更新日期:2001-10-01 00:00:00
abstract::Intestinal intraepithelial lymphocytes (i-IEL) of aged rats comprise CD4+CD8alphaalpha+ and CD4-CD8alphaalpha+ T cells expressing TCR alphabeta. In the present study, we compared characteristics between CD4+CD8alphaalpha+ and CD4-CD8alphaalpha+ i-IEL, which were purified by a cell sorter from the i-IEL of 6-month-old ...
journal_title:International immunology
pub_type: 杂志文章
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更新日期:1999-01-01 00:00:00
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journal_title:International immunology
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journal_title:International immunology
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journal_title:International immunology
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abstract::The A6H mAb raised primarily against human renal cell carcinoma (RCC) has previously been shown to bind strongly to RCC, to some degree to colon carcinoma but only marginally to a variety of normal tissues. Immunohistochemical analysis or RCC tissues containing tumor-infiltrating lymphocytes revealed that A6H stained ...
journal_title:International immunology
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pub_type: 杂志文章
doi:10.1093/intimm/3.8.827
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journal_title:International immunology
pub_type: 杂志文章
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更新日期:1990-01-01 00:00:00
abstract::Under physiological conditions immune complexes (IC) are efficiently cleared from the circulation and meanwhile provide important feedback signals for the immune system via Fc gamma Rs and complement receptors. Dysregulation of these mechanisms have been implicated in conditions where IC concentrations reach pathologi...
journal_title:International immunology
pub_type: 杂志文章
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更新日期:2008-02-01 00:00:00
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pub_type: 杂志文章
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更新日期:2000-10-01 00:00:00
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journal_title:International immunology
pub_type: 杂志文章,评审
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journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/10.2.131
更新日期:1998-02-01 00:00:00
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abstract::Man has been found to produce highly conserved chitinases. The most prominent is the phagocyte-derived chitotriosidase, the plasma levels of which are markedly elevated in some pathological conditions. Here, we report that both polymorphonuclear neutrophils (PMNs) and macrophages (m) are a source of chitotriosidase. T...
journal_title:International immunology
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更新日期:2005-11-01 00:00:00
abstract::CD4 and CD8 T cell subsets involved in primary allo-MLR responses were re-evaluated in the present study. The slope analysis of B6 allo-MLR responses to MHC class I-disparate bm1 and class II-disparate bm12 revealed the presence of a T-T cell interaction between CD4 and CD8 T cell subsets. The allo-MLR response of B6 ...
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journal_title:International immunology
pub_type: 杂志文章
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journal_title:International immunology
pub_type: 杂志文章
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pub_type: 杂志文章,评审
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journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/8.7.1045
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journal_title:International immunology
pub_type: 杂志文章
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更新日期:2014-05-01 00:00:00
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journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/dxp053
更新日期:2009-07-01 00:00:00