Adjuvant-dependent modulation of Th1 and Th2 responses to immunization with beta-amyloid.

abstract：:Tissue selective traffic of lymphocytes into different lymphoid organs is mediated by adherence of blood borne lymphocytes to specialized endothelial cells lining the high endothelial venules (HEV) in lymphoid organs. Lymphocytes discriminate between HEV in peripheral lymph nodes and in mucosal lymphoid tissues by mea...

journal_title：International immunology

authors： Mebius RE,Brevé J,Kraal G,Streeter PR

更新日期：1993-05-01 00:00:00

abstract：:It is now generally recognized that bone marrow is the survival niche for antigen-specific plasma cells with long-term immunological memory. These cells release antibodies into the circulation, needed to prime effector cells in the secondary immune response. These antibodies participate in the surveillance for antigen...

journal_title：International immunology

authors： Gould HJ,Wu YB

更新日期：2018-08-30 00:00:00

abstract：:The chicken represents the best-characterized animal model for B cell development in the so-called gut-associated lymphoid tissue (GALT) and the molecular processes leading to B cell receptor diversification in this species are well investigated. However, the mechanisms regulating B cell development and homeostasis in...

journal_title：International immunology

authors： Kothlow S,Morgenroth I,Graef Y,Schneider K,Riehl I,Staeheli P,Schneider P,Kaspers B

更新日期：2007-02-01 00:00:00

abstract：:Infection by protozoan parasites of the genus Leishmania results in the development of leishmaniasis, an increasingly prevalent group of diseases affecting over 12 million people worldwide. Leishmaniasis can have very different outcomes ranging from cutaneous lesions, mucosal lesions to visceralization depending on th...

journal_title：International immunology

authors： Rossi M,Fasel N

更新日期：2018-03-10 00:00:00

abstract：:NK cells were first identified in 1975 and represent the prototypical group 1 innate lymphoid cell (ILC). More recently, the discovery of new members of the ILC family has highlighted the complexity of this innate lymphoid lineage. Importantly, it has been recognized that different subsets exist within the group 1 ILC...

journal_title：International immunology

authors： Seillet C,Belz GT

更新日期：2016-01-01 00:00:00

abstract：:We have searched the human genome for genes that predispose to rheumatoid arthritis (RA) using fluorescence-based microsatellite marker analysis and affected sib-pair linkage study. A panel of 41 Japanese families, each with at least two affected siblings, was typed for genome-wide 358 polymorphic microsatellite marke...

journal_title：International immunology

authors： Shiozawa S,Hayashi S,Tsukamoto Y,Goko H,Kawasaki H,Wada T,Shimizu K,Yasuda N,Kamatani N,Takasugi K,Tanaka Y,Shiozawa K,Imura S

更新日期：1998-12-01 00:00:00

abstract：:Transforming growth factor (TGF)-beta has been shown to stimulate isotype switching to IgA in cultures of lipopolysaccharide (LPS)-stimulated B cells. The induction of isotype switching is associated with the appearance of novel germline alpha transcripts that cannot be found in cultures stimulated with LPS alone. TGF...

journal_title：International immunology

authors： Lebman DA,Park MJ,Hansen-Bundy S,Pandya A

更新日期：1994-01-01 00:00:00

abstract：:Tyrosine kinase 2 (Tyk2), a member of the Jak kinase family, mediates signals triggered by various cytokines, which are related to the pathogenesis of psoriasis. In this study, we investigated the role of Tyk2 in IL-23-induced psoriasis-like skin inflammation. Tyk2(-/-) mice when injected with IL-23 showed significant...

journal_title：International immunology

authors： Ishizaki M,Muromoto R,Akimoto T,Sekine Y,Kon S,Diwan M,Maeda H,Togi S,Shimoda K,Oritani K,Matsuda T

更新日期：2014-05-01 00:00:00

abstract：:We have generated a high copy number transgenic mouse line in which expression of mouse IL-7 cDNA is under the control of the mouse MHC class II E alpha promoter. These mice were generated in order to see if IL-7 over-production in the thymus altered either thymocyte differentiation or the process of negative selectio...

journal_title：International immunology

authors： Mertsching E,Burdet C,Ceredig R

更新日期：1995-03-01 00:00:00

abstract：:Fas (CD95) is a cell surface death receptor belonging to the tumor necrosis factor receptor superfamily, which mediates apoptosis-inducing signaling when activated by Fas ligand or its agonistic antibody. lpr mice with a loss of apoptosis-inducing function mutation in the Fas gene develop systemic autoimmune disease a...

journal_title：International immunology

authors： Takahashi S,Futatsugi-Yumikura S,Fukuoka A,Yoshimoto T,Nakanishi K,Yonehara S

更新日期：2013-05-01 00:00:00

abstract：:The mature dendritic cell (DC) is considered to be the most potent antigen-presenting cell. Regulation of the DC, particularly its survival, is therefore critical. Mature DC are markedly more sensitive to HLA-DR-mediated apoptosis than immature DC. To further characterize this key survival difference, we compared the ...

journal_title：International immunology

authors： Bertho N,Blancheteau VM,Setterblad N,Laupeze B,Lord JM,Drénou B,Amiot L,Charron DJ,Fauchet R,Mooney N

更新日期：2002-08-01 00:00:00

abstract：:The utilization of individual VH7183 genes in the autoimmune non-obese diabetic (NOD) mouse and the normal C57BL/6 mouse, both carrying the IgHb haplotype, was investigated. Nucleotide sequence analyses of a large number of VHDJH rearrangements utilizing VH7183 gene segments allowed us to identify 10 individual member...

journal_title：International immunology

authors： Andersson A,Ekstrand-Hammarström B,Eriksson B,Overmo C,Holmberg D

更新日期：1994-04-01 00:00:00

abstract：:Auto-antibodies against heat shock proteins (HSPs) are frequently found in the sera of patients with rheumatic and other autoimmune diseases. However, it is unclear whether these auto-antibodies play a role in the pathophysiology and etiology of these diseases. We found that a murine anti-HSP60 mAb enhanced the produc...

journal_title：International immunology

authors： Yokota S,Minota S,Fujii N

更新日期：2006-04-01 00:00:00

abstract：:Although IL-2 receptor beta chain (IL-2R beta) expressed in various lymphoid cell lines binds IL-2 with an intermediate affinity, IL-2R beta expressed in fibroblasts is unable to bind IL-2, suggesting that IL-2R beta is on its own not sufficient for generating the intermediate-affinity receptor and that lymphoid-speci...

journal_title：International immunology

authors： Kuida K,Tanaka T,Kitamura F,Toyama-Sorimachi N,Miyasaka M

更新日期：1992-10-01 00:00:00

abstract：:Naturally arising CD25(+)CD4(+) regulatory T (T(R)) cells can be exploited to establish immunologic tolerance to non-self antigens. In vivo exposure of CD25(+)CD4(+) T cells from normal naive mice to alloantigen in a T cell-deficient environment elicited spontaneous expansion of alloantigen-specific CD25(+)CD4(+) T(R)...

journal_title：International immunology

authors： Nishimura E,Sakihama T,Setoguchi R,Tanaka K,Sakaguchi S

更新日期：2004-08-01 00:00:00

abstract：:Stroke is one of the major causes of lethality and disability, yet few effective therapies have been established for ischemic stroke. Inflammation in the ischemic brain is induced by the infiltration and subsequent activation of immune cells. Loss of cerebral blood flow and ischemic brain-cell death trigger the activa...

journal_title：International immunology

authors： Nakamura A,Otani K,Shichita T

更新日期：2020-10-20 00:00:00

abstract：:CD161(++)IL-18Rα(+)CD8(+) human T cells have recently been identified as a new subset of memory cells but their exact role remains unclear. CD161(++)IL-18Rα(+)CD8(+), mucosal-associated invariant T cells express a semi-invariant TCR Vα7.2-Jα33, which recognizes the MHC-related protein 1. On the basis of properties inc...

journal_title：International immunology

authors： Havenith SH,Yong SL,Henson SM,Piet B,Idu MM,Koch SD,Jonkers RE,Kragten NA,Akbar AN,van Lier RA,ten Berge IJ

更新日期：2012-10-01 00:00:00

abstract：:The ability of Bcl-2 to inhibit apoptotic cell death is well established. Several homologues of the bcl-2 gene, such as bax, bcl-x or mcl-1, have recently been identified. Like Bcl-2, both Bcl-XL and Mcl-1 appear to function as repressors of apoptotic cell death, whereas Bax facilitates it, indicating possible interac...

journal_title：International immunology

authors： Ohta K,Iwai K,Kasahara Y,Taniguchi N,Krajewski S,Reed JC,Miyawaki T

更新日期：1995-11-01 00:00:00

abstract：:Adhesion molecules of the integrin family are implicated not only in leukocyte migration but also in leukocyte activation. Here we characterize the expression and function of fibronectin receptor integrins on rat mast cells. A rat basophilic leukemia cell line (RBL-2H3) and phorbol ester-stimulated rat peritoneal mast...

journal_title：International immunology

authors： Yasuda M,Hasunuma Y,Adachi H,Sekine C,Sakanishi T,Hashimoto H,Ra C,Yagita H,Okumura K

更新日期：1995-02-01 00:00:00

abstract：:Effective vaccination using in vitro peptide-loaded heat-shock proteins (HSP), tumor-derived HSP and HSP fusion proteins has been shown in viral, parasite and tumor model systems. We demonstrate protective DNA vaccination using gp96-peptide fusion proteins against the intracellular bacterial pathogen Listeria monocyto...

journal_title：International immunology

authors： Rapp UK,Kaufmann SH

更新日期：2004-04-01 00:00:00

abstract：:HLA class II molecules present superantigens more efficiently than their murine counterpart. Therefore, transgenic mice expressing HLA-DQ8 with and without CD28 were used to address the role of CD28 in staphylococcal enterotoxin B (SEB)-driven immune responses. SEB-induced in vitro proliferation of naive DQ8.CD28(-/-)...

journal_title：International immunology

authors： Rajagopalan G,Smart MK,Marietta EV,David CS

更新日期：2002-07-01 00:00:00

abstract：:CD9 is a member of the tetraspanin superfamily which is characterized by four transmembrane (TM) domains and associates with other surface molecules. This tetraspanin was recently found to be expressed on mature T cells. Here, we investigated which molecules associate with CD9 on T cells and which CD9 domains are requ...

journal_title：International immunology

authors： Toyo-oka K,Yashiro-Ohtani Y,Park CS,Tai XG,Miyake K,Hamaoka T,Fujiwara H

更新日期：1999-12-01 00:00:00

abstract：:Using anti-Tac (anti-alpha chain) and 2R-B (anti-beta chain) antibodies, we studied the roles of IL-2 receptor subunits (alpha and beta chains) in the formation of IL-2 and high-affinity IL-2 receptor complex, which is the initial event of IL-2 induced T cell growth. High-affinity IL-2 binding which was undetectable i...

journal_title：International immunology

authors： Kamio M,Uchiyama T,Arima N,Itoh K,Ishikawa T,Hori T,Uchino H

更新日期：1990-01-01 00:00:00

abstract：:Tyrosine kinase-2 (Tyk2) participates in the signaling pathways of multiple cytokines in innate and acquired immunity. In the present study, we investigated the in vivo involvement of Tyk2 in anti-type II collagen antibody-induced arthritis (CAIA) using Tyk2-deficient mice. Hind paws of wild-type mice showed massive s...

journal_title：International immunology

authors： Ishizaki M,Muromoto R,Akimoto T,Ohshiro Y,Takahashi M,Sekine Y,Maeda H,Shimoda K,Oritani K,Matsuda T

更新日期：2011-09-01 00:00:00

abstract：:A subclone (160b) of the human B cell (Karpas 160) was shown to produce a novel cytotoxic lymphokine [Factor 2 (F2)] in addition to tumour necrosis factor alpha (TNF-alpha) and beta (TNF-beta). F2 was found to have selective toxicity to numerous human tumour cell lines, particularly the erythroleukaemic cell line K562...

journal_title：International immunology

authors： Ni J,Meager A,Karpas A

更新日期：1992-04-01 00:00:00

abstract：:Human CD83 is a cell surface protein expressed predominantly by dendritic cells (DC) and lymphoid cells. So far, there exists no information on the function and distribution of mCD83. Here we demonstrate that mCD83 is moderately expressed on resting T cells and DC, but strongly increases in its expression on T cells f...

journal_title：International immunology

authors： Cramer SO,Trumpfheller C,Mehlhoop U,Moré S,Fleischer B,von Bonin A

更新日期：2000-09-01 00:00:00

abstract：:CD100/Sema4D belongs to the semaphorin family, factors known to act as repulsive cues for axons during neuronal development. Mouse CD100 plays a crucial role in both humoral and cellular immunity through ligation of the lymphocyte receptor, CD72. It remains controversial, however, whether human CD100 can function thro...

journal_title：International immunology

authors： Ishida I,Kumanogoh A,Suzuki K,Akahani S,Noda K,Kikutani H

更新日期：2003-08-01 00:00:00

abstract：:Man has been found to produce highly conserved chitinases. The most prominent is the phagocyte-derived chitotriosidase, the plasma levels of which are markedly elevated in some pathological conditions. Here, we report that both polymorphonuclear neutrophils (PMNs) and macrophages (m) are a source of chitotriosidase. T...

journal_title：International immunology

authors： van Eijk M,van Roomen CP,Renkema GH,Bussink AP,Andrews L,Blommaart EF,Sugar A,Verhoeven AJ,Boot RG,Aerts JM

更新日期：2005-11-01 00:00:00

abstract：:The functional maturation process of medullary-type CD4(-)CD8(+) [CD8 single-positive (SP)] thymocytes remains largely uncharacterized. We describe a phenotypic analysis of CD8 SP medullary-type thymocytes and find a remarkable heterogeneity within this thymic cell population. While mature CD8(+) T cells in the periph...

journal_title：International immunology

authors： Tian T,Zhang J,Gao L,Qian XP,Chen WF

更新日期：2001-03-01 00:00:00

abstract：:We have evaluated the capacity of a novel, nanoparticle-based tumor vaccine to eradicate established tumors in mice. C57BL/6 mice were intradermally (i.d.) inoculated with ovalbumin (OVA)-expressing EG-7 tumor cells. When the tumor size reached 7-8 mm, the tumor-bearing mice were i.d. injected near the tumor-draining ...

journal_title：International immunology

authors： Wakita D,Chamoto K,Zhang Y,Narita Y,Noguchi D,Ohnishi H,Iguchi T,Sakai T,Ikeda H,Nishimura T

更新日期：2006-03-01 00:00:00