Abstract:
:Tissue selective traffic of lymphocytes into different lymphoid organs is mediated by adherence of blood borne lymphocytes to specialized endothelial cells lining the high endothelial venules (HEV) in lymphoid organs. Lymphocytes discriminate between HEV in peripheral lymph nodes and in mucosal lymphoid tissues by means of membrane associated lymphocyte homing receptors adhering to their putative HEV ligands, the vascular addressins. The expression of particular vascular addressins on HEV is site- or tissue-selective and may be directed by factors unique to a specific location or lymph node environment. In this study we investigated the impact of regional environments on lymph node HEV differentiation and function. Experimentally, this problem was approached by the transplantation of lymph nodes from one region to a second region. The sites selected for receipt of tissues were the mesentery, a mucosal site, and the popliteal fossa, a peripheral site. We found that the phenotype of lymph node HEV following transplantation was influenced by both donor age and transplantation site. The transplantation site could influence vascular addressin expression, when tissues were obtained from late fetal or early neonatal donors and not when obtained from adult donors. Transplanted adult tissues retained their pre-transplantation vascular addressin expression phenotype regardless of transplantation site. Thus the endothelium within adult lymph nodes may be committed to expression of a particular addressin or addressins during lymph node development. It is also possible that regulatory cells or structures present within lymph nodes at the time of transplantation direct vascular addressin expression following tissue engraftment.(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
Int Immunoljournal_title
International immunologyauthors
Mebius RE,Brevé J,Kraal G,Streeter PRdoi
10.1093/intimm/5.5.443subject
Has Abstractpub_date
1993-05-01 00:00:00pages
443-9issue
5eissn
0953-8178issn
1460-2377journal_volume
5pub_type
杂志文章abstract::The utilization of individual VH7183 genes in the autoimmune non-obese diabetic (NOD) mouse and the normal C57BL/6 mouse, both carrying the IgHb haplotype, was investigated. Nucleotide sequence analyses of a large number of VHDJH rearrangements utilizing VH7183 gene segments allowed us to identify 10 individual member...
journal_title:International immunology
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journal_title:International immunology
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journal_title:International immunology
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journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/10.11.1713
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journal_title:International immunology
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journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/dxq434
更新日期:2010-10-01 00:00:00
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journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/dxh139
更新日期:2004-10-01 00:00:00
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journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/dxf058
更新日期:2002-08-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2016-01-01 00:00:00
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journal_title:International immunology
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doi:10.1093/intimm/dxq448
更新日期:2010-12-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2019-08-23 00:00:00
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journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/2.10.921
更新日期:1990-01-01 00:00:00
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journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/dxh227
更新日期:2005-04-01 00:00:00
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更新日期:1993-12-01 00:00:00
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doi:10.1093/intimm/7.10.1649
更新日期:1995-10-01 00:00:00
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journal_title:International immunology
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doi:10.1093/intimm/4.8.955
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journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/4.2.177
更新日期:1992-02-01 00:00:00
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journal_title:International immunology
pub_type: 杂志文章
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更新日期:2005-08-01 00:00:00
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journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/6.9.1323
更新日期:1994-09-01 00:00:00
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更新日期:2000-05-01 00:00:00
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journal_title:International immunology
pub_type: 杂志文章
doi:10.1093/intimm/dxp082
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journal_title:International immunology
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doi:10.1093/intimm/10.6.791
更新日期:1998-06-01 00:00:00