Abstract:
:Ibudilast selectively vasodilates cerebral vessels without reducing blood pressure. We investigated the effect of the drug on retinal circulation in 8 patients with diabetes mellitus, using the video-densitometric image analysis of fluorescein angiography. We compared the build up time, the time constant of washout rate and the mean circulation time (MCT) before and after oral therapy with ibudilast. After 2 weeks of daily administration (30 mg), MCT was shortened significantly (4.2 +/- 2.8 vs. 3.0 +/- 1.6 s, p = 0.0215). Since retinal circulation in patients with diabetes mellitus was improved by ibudilast, the drug may be useful to treat disorders such as diabetic retinopathy.
journal_name
Ophthalmic Resjournal_title
Ophthalmic researchauthors
Suzuki R,Sugihara I,Ishibashi T,Kurimoto Sdoi
10.1159/000267168subject
Has Abstractpub_date
1992-01-01 00:00:00pages
197-202issue
4eissn
0030-3747issn
1423-0259journal_volume
24pub_type
杂志文章abstract:PURPOSE:To evaluate the corneal button of primary penetrating keratoplasty of patients diagnosed with congenital aniridia. The study took place at the Instituto Universitario Barraquer and the Centro de Oftalmología Barraquer. METHODS:A retrospective analysis of cases diagnosed with congenital aniridia was carried out...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000444930
更新日期:2016-01-01 00:00:00
abstract:OBJECTIVE:Acute corneal permeability change after instillation of benzalkonium chloride (BAC) was evaluated using a newly developed in vivo corneal transepithelial electric resistance (TER) measurement method. METHOD:Corneal TER was measured by Ag/AgCl electrodes placed in the anterior aqueous chamber and on the corne...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000109986
更新日期:2007-01-01 00:00:00
abstract::The activities of sialyl-, fucosyl- and galactosyltransferase were measured in membrane preparations from bovine eyes. Radioactive sugars from CMP-N-neuraminic acid, GDP-fucose and UDP-galactose were incorporated into the endogenous and exogenous acceptors. The enzymatic activities of all three glycosyltransferases we...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000267045
更新日期:1990-01-01 00:00:00
abstract:BACKGROUND/AIMS:To evaluate the safety of suramin compared with mitomycin-C (MMC) as an adjunctive agent in trabeculectomy by determining its ciliary body toxicity at predetermined effective dosages in rabbit eyes. METHODS:Thirty-two New Zealand albino rabbits received either suramin (200, 300, 400, or 800 mg/ml) or M...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000187625
更新日期:2009-01-01 00:00:00
abstract::Substance P (SP) immunoreactivity was demonstrated using the indirect immunofluorescence technique in one normal and one retinoblastomatous human retina. In the normal retina SP immunoreaction was located in nerve fibres but not in the neurons in the inner plexiform layer. A similar location was observed in the histol...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000265276
更新日期:1983-01-01 00:00:00
abstract::Two out of three normal eyes tested with frequent instillation of 30 microliters of drops of 0.5% bupranolol, a beta 1 + beta 2 blocking drug with some intrinsic sympathomimetic and local anesthetic activity, showed a miotic effect of the order of a 25% reduction of pupil area, as estimated by an open-loop iris-videor...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000265407
更新日期:1986-01-01 00:00:00
abstract:BACKGROUND/AIMS:It has been suggested that eye makeup could interact with human meibum causing a decrease in the stability of the tear film. The aim of this pilot study was to measure makeup-human meibum interactions in vitro. METHODS:Human meibum-makeup interactions were quantified by measuring order-to-disorder lipi...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000371852
更新日期:2015-01-01 00:00:00
abstract:AIM/BACKGROUND:A 1-bp deletion (1147delA) in the SAG (also known as arrestin or S-antigen) gene is the most frequently seen mutation in Japanese patients suffering from Oguchi disease, a recessively inherited stationary night blindness. We investigated macular function in a patient with Oguchi disease with the 1147delA...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000325024
更新日期:2011-10-01 00:00:00
abstract::L-Timolol (0.4 mg/kg) reduced significantly retinal blood flow (17%), systemic blood pressure (18-20%) and heart rate (28%) in the rabbit. D-Timolol (4.0 mg/kg) increased retinal blood flow slightly (9%) and did not significantly affect systemic blood pressure or heart rate. Since D-timolol is effective in reducing in...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000265470
更新日期:1987-01-01 00:00:00
abstract:PURPOSE:Osthole is an agent isolated from Cnidium monnieri (L.) Cusson and has been used to treat several disorders. Corneal neovascularization is a sight-threatening condition associated with several inflammatory or infectious ocular disorders. In this study, we investigated the anti-angiogenic effects of osthole on c...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000505976
更新日期:2020-01-01 00:00:00
abstract::Rat lenses with experimentally induced cataract (either by naphthalene or by streptozotocin) were analyzed biochemically. Both noxae had some effects in common. Water-soluble protein and aldose reductase activity decreased, and glucose-6-phosphate dehydrogenase, phosphofructokinase and glutathione reductase activity i...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000266581
更新日期:1988-01-01 00:00:00
abstract:INTRODUCTION:This study aimed to evaluate the longitudinal changes in retinal layers thickness in patients treated with hydroxychloroquine and no signs of retinal toxicity. METHODS:Longitudinal retrospective study of patients taking hydroxychloroquine followed in a hydroxychloroquine retinal toxicity screening program...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000511592
更新日期:2020-09-15 00:00:00
abstract::In a search for a pharmacologic adjuvant in the management of posttraumatic proliferative vitreoretinopathy (PVR), we investigated the effect of intravitreal injection of prinomastat (AG3340) on an experimental model. Posterior penetrating eye trauma was created in one eye each of 24 New Zealand white rabbits. One wee...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000055636
更新日期:2001-01-01 00:00:00
abstract:PURPOSE:To investigate the effect of vitreomacular adhesion (VMA) on the outcome of antiangiogenic treatment for neovascular age-related macular degeneration (AMD). METHODS:Ninety-nine eyes of 83 patients were used in our cohort study. We prospectively evaluated best corrected visual acuity (BCVA) and central retinal ...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000459626
更新日期:2017-01-01 00:00:00
abstract:OBJECTIVE:To evaluate the sensitivity and specificity of pseudoexfoliation syndrome diagnosis in pseudophakic patients and potential means of improving it. METHODS:This prospective, nonrandomized study comprised 41 consecutive patients (41 eyes) scheduled for cataract surgery at a tertiary medical center during 2016-2...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000508336
更新日期:2020-04-30 00:00:00
abstract::The effect of topical neutral formaldehyde on the blood-aqueous barrier of the rat was studied. Thirty minutes after irritation, the protein concentration of the aqueous humour had increased from the control value of 1.95 +/- 0.25 to 2.95 +/- 0.45 mg/ml (p less than 0.05). Extravasation of Evans blue dye from the iris...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000265442
更新日期:1986-01-01 00:00:00
abstract::Tear hyperosmolarity is known to cause ocular surface inflammation in dry eye syndrome. Benzalkonium chloride (BAK), an eyedrop preservative, is known to induce dry eye in long-term-treated patients. Analyzing the modulation of the proinflammatory potential of hyperosmolarity in the presence of BAK on the conjunctiva ...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000448117
更新日期:2017-01-01 00:00:00
abstract:INTRODUCTION:Retinitis pigmentosa (RP) is an inherited retinal disorder, characterized by photoreceptor degeneration inducing progressive vision loss. This study evaluates its impact on quality of life (QOL) and emotional states of patients affected by RP. METHODS:A cross-sectional study was conducted on 60 RP patient...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000435886
更新日期:2015-01-01 00:00:00
abstract::The effect of large intake of dietary ascorbic acid on heat-induced eye lens protein damage has been studied. Male guinea pigs of the Hartley strain were used. Ascorbic acid was administered to the experimental animals in the drinking water. The mean daily ascorbic acid intakes for the control and experimental animals...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000267008
更新日期:1990-01-01 00:00:00
abstract:PURPOSE:In this investigation the authors studied the effect of dapiprazole, an alpha-adrenergic blocking agent, on aqueous humor dynamics in patients affected with pigmentary glaucoma. METHODS:Dapiprazole 0.5% eye drops were administered 3 times daily as adjunctive therapy to 16 pigmentary glaucoma patients in additi...
journal_title:Ophthalmic research
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000267920
更新日期:1996-01-01 00:00:00
abstract:PURPOSE:Abnormalities in electroretinograms (ERG), such as reduced amplitudes and delayed implicit times of a- and b-wave and oscillatory potentials (OPs), are one of the earliest features of diabetic retinopathy prior to obvious vascular changes in diabetic retinas. We have previously shown that serum levels of advanc...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000440768
更新日期:2015-01-01 00:00:00
abstract:PURPOSE:This study was performed to examine the location, width, and insertional shape of rectus extraocular muscles (EOMs), and to elucidate the symmetry of the insertional anatomy of rectus EOMs in the left and right eyes. METHODS:EOMs were dissected from their origin to the insertion point in 100 intact orbits of 5...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000272021
更新日期:2010-01-01 00:00:00
abstract::The effects of optical defocusing with convex lenses on the amplitudes of pattern reversal visual-evoked response (PVER) were investigated. With the large check size and high-contrast pattern, PVER amplitudes showed a linear decrease in response to initial defocusing up to +5 to +6 dptr. As the degree of defocus incre...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000267051
更新日期:1990-01-01 00:00:00
abstract:PURPOSE:To investigate the role of integrin-linked kinase (ILK) in endothelial cell migration, proliferation and tube formation in vitro. MATERIALS AND METHODS:Cultured RF/6A cells were knocked down for ILK using small interfering RNA (siRNA). Cellular ILK expression was quantified by real-time quantitative PCR and We...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000232971
更新日期:2009-01-01 00:00:00
abstract:PURPOSE:The traditional medium for storing corneas in European Eye Banks is Gibco's MEM (Eagle's) with Earle's salts and Hepes containing 2% fetal calf serum, glutamine and antimycotics. Although serum-free MegaCell MEM has been reported to be more suitable for this purpose, it contains components of animal origin that...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000246576
更新日期:2010-01-01 00:00:00
abstract:PURPOSE:To investigate the effect of propolis, a natural resin produced by honeybees, in the treatment of alkali-injured rabbit eyes. METHOD:A corneal alkali burn was induced by applying filter paper immersed in 1 N NaOH on the central axis of the right corneas of 24 rabbits for 30 s. The animals were divided into thr...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000055581
更新日期:2000-01-01 00:00:00
abstract:PURPOSE:To assess and describe sequential morphological changes in the choroidal neovascularization (CNV) net using optical coherence tomography angiography (OCTA) in patients undergoing treatment with intravitreal antivascular endothelial growth factor (VEGF). METHODS:Prospective cohort study. OCTA was performed sequ...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000442671
更新日期:2016-01-01 00:00:00
abstract::The eyes of 200 rats (Mol:SPRD, Moellegaard Ltd., Skensvet, Denmark), 8 weeks of age and of both sexes, were examined routinely with a photo-slitlamp microscope (Zeiss) and opthalmoscope (Heine) 3-4 times in the course of four different 12-week toxicity studies. The animals were kept under constant lighting conditions...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000267492
更新日期:1994-01-01 00:00:00
abstract::The refractive indices in various rat retinal layers, based on the total dry mass concentration, ranged from 1.369 to 1.385. The ratios of the refractive indices of neighboring retinal layers were near unity. This finding suggests that light passes through the rat retina without much refraction. ...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000267223
更新日期:1993-01-01 00:00:00
abstract::The possible multiple effect of galactose diet and X-irradiation on cataract development in mice was investigated by scanning electron microscopy. X-ray cataracts were induced by maintaining animals either on a normal or 50% galactose diet. No detectable changes in lens morphology were seen in animals fed galactose al...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000265280
更新日期:1983-01-01 00:00:00