Targeting of integrin-linked kinase with a small interfering RNA inhibits endothelial cell migration, proliferation and tube formation in vitro.

abstract：PURPOSE:To evaluate the long-term outcome of trabeculectomy with intra- and postoperative 5-fluorouracil (5-FU) application in glaucoma. METHODS:Eighty-six patients with glaucoma planned for primary trabeculectomy with 5-FU and a minimum follow-up of 3 years were retrospectively analyzed. Success rates, postsurgical 5...

journal_title：Ophthalmic research

authors： Lindemann F,Plange N,Kuerten D,Schimitzek H,Koutsonas A

更新日期：2017-01-01 00:00:00

abstract：:The component oxygen fluxes that constitute a single recording of corneal oxygen uptake when a polarographic oxygen sensor (POS) is placed in contact with the cornea were determined in the in vivo rabbit eye by removing the epithelium and injecting an air bubble into the anterior chamber. The relative contribution of ...

journal_title：Ophthalmic research

authors： Holden BA,Sulonen J,Vannas A,Sweeney DF,Efron N

更新日期：1985-01-01 00:00:00

abstract：BACKGROUND:To assess the cytotoxic properties of voriconazole and sulfobutylether-β-cyclodextrin (SBECD) on cultured primary human corneal epithelial cells. METHODS:Human corneal epithelial cells were cultured and exposed to various concentrations of SBECD (0.016-32 mg/ml) and voriconazole (0.001-2 mg/ml). Cellular cy...

journal_title：Ophthalmic research

authors： Sobolewska B,Guerel G,Hofmann J,Tarek B,Bartz-Schmidt KU,Yoeruek E

更新日期：2015-01-01 00:00:00

abstract：:We studied lens opacification of rabbit lenses in culture. Opacification was produced by maintaining rabbit lenses in medium containing calcium concentrations as high as 10 mmol/l and the opacity was measured using LASER spectroscopy. Increasing calcium caused significant opacification in lens cortex while the transpa...

journal_title：Ophthalmic research

authors： Clark JI,Danford ME

更新日期：1985-01-01 00:00:00

abstract：:HY-1 genotype chick lenses display epithelial hyperplasia and associated lens opacities. Membrane proteins from HY-1 and normal chick lenses were separated by isoelectric focusing, and 45Ca2+ binding capacities were determined. Markedly higher (congruent to 900-fold) binding of 45Ca2+ was observed in high molecular we...

journal_title：Ophthalmic research

authors： Odeigah PG,Patmore L

更新日期：1985-01-01 00:00:00

abstract：:Soluble dextran polymer derivatives (CMDBSs) are originally synthesized as heparin-like plasma substitutes. Some of them mimic heparin in its interactions and stabilize, protect and facilitate actions of heparin binding growth factors. The wound healing activity of one specific CMDBS was studied in a model of corneal ...

journal_title：Ophthalmic research

authors： Fredj-Reygrobellet D,Hristova DL,Ettaiche M,Meddahi A,Jozefonwicz J,Barritault D

更新日期：1994-01-01 00:00:00

abstract：:The crystalline lens capsules of eye bank eyes, intraocular lens (IOL)-inserted eyes and those of monkey and rabbit eyes were observed in vivo and/or in vitro through a specular microscope or Scheimpflug slit images in combination with new image-processing techniques and scanning electron microscopy. Shagreen patterns...

journal_title：Ophthalmic research

authors： Sasaki K,Kojima M,Hara T

更新日期：1988-01-01 00:00:00

abstract：PURPOSE:To determine whether docosahexaenoic acid (DHA) can reduce the retinal damage induced by transient retinal ischemia. METHODS:Retinal ischemia was induced by increasing intraocular pressure (IOP). Retinal circulation was restored by lowering IOP. An intraperitoneal injection of 1,000 mg/kg of DHA-ester (DHA-E) ...

journal_title：Ophthalmic research

authors： Miyauchi O,Mizota A,Adachi-Usami E,Nishikawa M

更新日期：2001-07-01 00:00:00

abstract：:Tear hyperosmolarity is known to cause ocular surface inflammation in dry eye syndrome. Benzalkonium chloride (BAK), an eyedrop preservative, is known to induce dry eye in long-term-treated patients. Analyzing the modulation of the proinflammatory potential of hyperosmolarity in the presence of BAK on the conjunctiva ...

journal_title：Ophthalmic research

authors： Warcoin E,Clouzeau C,Roubeix C,Raveu AL,Godefroy D,Riancho L,Baudouin C,Brignole-Baudouin F

更新日期：2017-01-01 00:00:00

abstract：:Equine recurrent uveitis (ERU) is an autoimmune disease that occurs with a high prevalence (10%) in horses. ERU represents the only reliable spontaneous model for human autoimmune uveitis. We already identified and characterized novel autoantigens (malate dehydrogenase, recoverin, CRALBP) by analyzing the autoantibody...

journal_title：Ophthalmic research

authors： Deeg CA,Hauck SM,Amann B,Pompetzki D,Altmann F,Raith A,Schmalzl T,Stangassinger M,Ueffing M

更新日期：2008-01-01 00:00:00

abstract：:VEGF is considered as an important factor in the pathogenesis of macular edema. VEGF induces the rupture of the blood retinal barrier and may also influence the retinal pigment epithelial (RPE) outer retinal barrier. The aim of this work was to analyze the influence of the VEGF receptor pathways in the modulation of t...

journal_title：Ophthalmic research

authors： Miyamoto N,de Kozak Y,Normand N,Courtois Y,Jeanny JC,Benezra D,Behar-Cohen F

更新日期：2008-01-01 00:00:00

abstract：INTRODUCTION:This study aimed to evaluate the longitudinal changes in retinal layers thickness in patients treated with hydroxychloroquine and no signs of retinal toxicity. METHODS:Longitudinal retrospective study of patients taking hydroxychloroquine followed in a hydroxychloroquine retinal toxicity screening program...

journal_title：Ophthalmic research

authors： Godinho G,Madeira C,Falcão M,Penas S,Dinah-Bragança T,Brandão E,Carneiro Â,Santos-Silva R,Falcão-Reis F,Beato J

更新日期：2020-09-15 00:00:00

abstract：:The aim of the study was to examine the effects of nonsteroidal anti-inflammatory drugs (NSAIDs)/acetylsalicylic acid (ASA) on human lens epithelial cells (HLECs) during oxidative stress. HLECs were exposed to H2O2 in the absence or presence of indomethacin, diclofenac, celecoxib (NSAIDs) or ASA for 24 h. HLECs were a...

journal_title：Ophthalmic research

authors： Petersen A,Carlsson T,Karlsson JO,Zetterberg M

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Genipin (GP) is a safe method for corneal crosslinking, even for very thin corneas. However, there have been no reports on the optimal GP concentration range to use in vivo for corneal crosslinking. OBJECTIVES:To investigate the safety of corneal crosslinking after a 24-h incubation with different concentra...

journal_title：Ophthalmic research

authors： Song W,Tang Y,Qiao J,Li H,Rong B,Yang S,Wu Y,Yan X

更新日期：2019-01-01 00:00:00

abstract：PURPOSE:To analyze a multiflash multifocal electroretinogram in 20 patients with open-angle glaucoma (OAG). METHODS:The stimulation sequence consisted of a binary m-sequence (L(max) 200 cd/m(2), L(min) <1 cd/m(2)). Each m-sequence stimulus was followed by three global flashes (luminance: 400 cd/m(2)) at an interval of...

journal_title：Ophthalmic research

authors： Palmowski AM,Allgayer R,Heinemann-Vernaleken B,Ruprecht KW

更新日期：2002-03-01 00:00:00

abstract：:Epinephrine (1, 3 and 10 micrograms/kg) was found to increase retinal and choroidal blood flow (22, 49 and 67%) when it was administered intravenously. The increase in retinal and choroidal blood flow coincided well with the increase in systemic blood pressure (44, 65 and 96%, respectively). When epinephrine (2%) was ...

journal_title：Ophthalmic research

authors： Chiou GC,Girgis Z,Chiou FY

更新日期：1988-01-01 00:00:00

abstract：:The high-voltage electron microscope (HVEM) permits examination of sections much thicker (up to 1 micron) than those usually used in transmission electron microscopy, which are approximately 70 nm in thickness. Two examples of the utility of the HVEM in research on the ultrastructure of the retinal pigment epithelium ...

journal_title：Ophthalmic research

authors： Korte GE,Heriot W,Pollack A

更新日期：1986-01-01 00:00:00

abstract：PURPOSE:To evaluate diabetic retinopathy (DR) progression in patients with diabetes mellitus type 2 in 2 populations of different ethnicity. METHODS:A prospective observational study was designed to follow eyes/patients with mild nonproliferative DR, for 2 years or until the development of central-involved macular ede...

journal_title：Ophthalmic research

authors： Ribeiro L,Pappuru R,Lobo C,Alves D,Cunha-Vaz J

更新日期：2018-01-01 00:00:00

abstract：PURPOSE:This study was performed to examine the location, width, and insertional shape of rectus extraocular muscles (EOMs), and to elucidate the symmetry of the insertional anatomy of rectus EOMs in the left and right eyes. METHODS:EOMs were dissected from their origin to the insertion point in 100 intact orbits of 5...

journal_title：Ophthalmic research

authors： Cho HK,Shin SY

更新日期：2010-01-01 00:00:00

abstract：AIMS:Experimental retinal research has gained great importance due to the ophthalmic pharmacotherapy era. An increasing number of drugs are constantly released into the market for the treatment of retinal diseases. In this review, animal species, animal models and toxicity assays in retinal research are discussed. MET...

journal_title：Ophthalmic research

authors： Penha FM,Rodrigues EB,Maia M,Dib E,Fiod Costa E,Furlani BA,Nunes Moraes Filho M,Dreyfuss JL,Bottós J,Farah ME

更新日期：2010-01-01 00:00:00

abstract：:A technique for chronic implantation of a device for long-term continuous, quantitative monitoring of intraocular pressure (IOP) in experimental animals is presented. The methodology employed is straight forward and should be easily duplicated for experimental investigations where such monitoring might be useful. Cont...

journal_title：Ophthalmic research

authors： Flower RW,Maumenee AE,Michelson EA

更新日期：1982-01-01 00:00:00

abstract：:Photodocumented measurements of the lens thickness using an EAS-1000 Scheimpflug camera were performed in 261 cataract eyes (162 pure type) compared with 52 control eyes. The lens thickness in normal eyes usually increased with age by 0.015 mm annually. The cataractous lens, especially in the anterior subcapsular type...

journal_title：Ophthalmic research

authors： Shyn KH,Kim HC,Kim JC

更新日期：1992-01-01 00:00:00

abstract：:To determine the conditions under which anesthetized pigs can be used in acute noninvasive investigations of ocular hydro- and hemodynamics, the intraocular pressure (IOP) of adult pigs was recorded under the following conditions: (1) after intravenous injection of propofol plus ketamine; (2) during inhalation of isof...

journal_title：Ophthalmic research

authors： Buehner E,Pietsch UC,Bringmann A,Foja C,Wiedemann P,Uhlmann S

更新日期：2011-01-01 00:00:00

abstract：:To determine the effect of interleukin-10 (IL-10) and transforming growth factor-beta (TGF-beta) on the down-regulation of MHC class II antigens, bovine retinal pigment epithelial (RPE) cells were incubated with interferon-gamma (IFN-gamma) in different concentrations. Subsequently, the IFN-gamma pretreated RPE cells ...

journal_title：Ophthalmic research

authors： Enzmann V,Stadler M,Wiedemann P,Kohen L

更新日期：1999-01-01 00:00:00

abstract：AIMS:Mutations in the PAX6 are the major cause of congenital aniridia. The objective of this study was to analyze genetic mutations in PAX6 in Chinese patients with congenital aniridia. METHODS:Total genomic DNA was isolated from the peripheral blood of the aniridia patients, all healthy family members and 100 healthy...

journal_title：Ophthalmic research

authors： Luo F,Zhou L,Ma X,He Y,Zou L,Jie Y,Liu J,Pan Z

更新日期：2012-01-01 00:00:00

abstract：AIM:To develop a local approach to study rabbit lacrimal secretion in situ by administering specific secretagogues directly onto the lacrimal gland (LG). METHODS:After the rabbit has been anesthetized, the inferior bulbar conjunctiva and underlying connective tissue are blunt dissected. A polyethylene tube, for drug d...

journal_title：Ophthalmic research

authors： Ding C,Rife L,Nakamura T,Wang YW,Kopp K,Schechter JE

更新日期：2008-01-01 00:00:00

abstract：:Toxoplasma gondii is an extremely successful opportunistic parasite which infects approximately one third of the human population worldwide. The impact of this parasite on human health becomes particularly manifest in congenital damage with infection and subsequent inflammation of neuronal tissues including the retina...

journal_title：Ophthalmic research

authors： Pleyer U,Schlüter D,Mänz M

更新日期：2014-01-01 00:00:00

abstract：INTRODUCTION:The aim of this work was to describe the optical coherence tomography (OCT) angiography (OCTA) features in paediatric Leber-Coats disease. METHODS:Three children presenting with unilateral, clinically active Leber-Coats disease were evaluated using spectral domain OCT and OCTA. OCT angiograms were analyse...

journal_title：Ophthalmic research

authors： Fortunato M,Turtoro A,Cennamo G

更新日期：2017-01-01 00:00:00

abstract：PURPOSE:To evaluate the effect of transpupillary thermotherapy (TTT) on foveal thickness and macular function in eyes with choroidal neovascularization (CNV) associated with age-related macular degeneration. METHODS:Sixteen eyes with occult CNV and 6 eyes with classic CNV were treated with TTT. Optical coherence tomog...

journal_title：Ophthalmic research

authors： Ishikawa K,Terasaki H,Kobayashi C,Niwa Y,Piao CH,Ito Y,Kondo M,Miyake Y

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:The lens is the ocular structure most susceptible to oxidative damage. Antioxidants, micronutrients and phytochemicals have been extensively studied for their possible effects to prevent or delay the progression of various eye diseases. OBJECTIVES:A brief overview of the updated literature on the role of an...

journal_title：Ophthalmic research

authors： Agte V,Tarwadi K

更新日期：2010-01-01 00:00:00