Abstract:
:The aim of the study was to examine the effects of nonsteroidal anti-inflammatory drugs (NSAIDs)/acetylsalicylic acid (ASA) on human lens epithelial cells (HLECs) during oxidative stress. HLECs were exposed to H2O2 in the absence or presence of indomethacin, diclofenac, celecoxib (NSAIDs) or ASA for 24 h. HLECs were assayed for changes in superoxide and peroxide production and for variations in glutathione. Mitochondrial depolarization was measured using the membrane potential-sensitive dye JC-1. The results of the study include reduction in superoxide and peroxide production as well as reduction in glutathione depletion in oxidatively stressed HLECs incubated with low concentrations of NSAIDs/ASA. However, no protection against H2O2-induced mitochondrial depolarization by NSAIDs/ASA could be seen. In conclusion, NSAIDs/ASA display reactive oxygen species-scavenging properties in H2O2-exposed HLECs in culture.
journal_name
Ophthalmic Resjournal_title
Ophthalmic researchauthors
Petersen A,Carlsson T,Karlsson JO,Zetterberg Mdoi
10.1159/000113885subject
Has Abstractpub_date
2008-01-01 00:00:00pages
77-85issue
2eissn
0030-3747issn
1423-0259pii
000113885journal_volume
40pub_type
杂志文章abstract::Low intensity diffuse white fluorescent light (1,000 lx for 2 h) exclusively induced photoreceptor damage in the inferior retina of albino rats; the temporal retina showed extensive damage, whereas the nasal retina revealed threshold lesions prior to recovery. To expand our morphological data, further experiments were...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000267881
更新日期:1996-01-01 00:00:00
abstract:PURPOSE:In this investigation the authors studied the effect of dapiprazole, an alpha-adrenergic blocking agent, on aqueous humor dynamics in patients affected with pigmentary glaucoma. METHODS:Dapiprazole 0.5% eye drops were administered 3 times daily as adjunctive therapy to 16 pigmentary glaucoma patients in additi...
journal_title:Ophthalmic research
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000267920
更新日期:1996-01-01 00:00:00
abstract::The high cytotoxicity of linoleic acid (LA) to cultured bovine lens epithelial cells is correlated with high uptake rates for the fatty acid (FA). Both, LA uptake and LA cytotoxicity strongly increase with the increasing LA-to-albumin molar ratio in the culture medium. Cellular uptake and cytotoxicity of LA can be com...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000055595
更新日期:2000-03-01 00:00:00
abstract:AIMS:To investigate whether allogeneic limbal mesenchymal stem cell (LMSC) therapy affects corneal healing after a severe chemical burn and whether the route of administration of LMSCs differs in its therapeutic effect in this respect. METHODS:A total of 60 Sprague-Dawley rats with clinically proven alkali injury were...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000368659
更新日期:2015-01-01 00:00:00
abstract::The high-voltage electron microscope (HVEM) permits examination of sections much thicker (up to 1 micron) than those usually used in transmission electron microscopy, which are approximately 70 nm in thickness. Two examples of the utility of the HVEM in research on the ultrastructure of the retinal pigment epithelium ...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000265457
更新日期:1986-01-01 00:00:00
abstract::Animal models are indispensable for pharmaceutical investigations. However, investigators often have difficulty choosing the appropriate modal for their research. To provide a comprehensive and convenient source of information about animal models of proliferative vitreoretinopathy (PVR), the current review sorted and ...
journal_title:Ophthalmic research
pub_type: 杂志文章,评审
doi:10.1159/000488492
更新日期:2018-01-01 00:00:00
abstract::Autofluorescence and transmission values of the lens for blue-green light were determined at two locations with the use of identical fluorophotometers: in Coimbra, Portugal, in 44 healthy controls, 15 haemodialysis and 11 renal failure patients, and in Leiden, The Netherlands, in 57 healthy controls, 23 haemodialysis ...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000266736
更新日期:1988-01-01 00:00:00
abstract::Extracellular recordings were performed on electrophysiologically identified achromatic neurons of the photosensitive pineal organ of the frog. The effects of iontophoretically applied aspartate and glutamate as well as one aspartate antagonist (D-alpha-aminoadipate) were observed on spontaneous activity and light-evo...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000265304
更新日期:1984-01-01 00:00:00
abstract::A system for isolation of capillaries from the retina has been adapted to biochemical studies in vitro. Insulin receptors were identified in human and calf retinal blood vessels. Binding of 125I insulin by calf retinal blood vessels takes place through high affinity (low capacity) and low affinity (high capacity) rece...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000265234
更新日期:1983-01-01 00:00:00
abstract:PURPOSE:Abnormalities in electroretinograms (ERG), such as reduced amplitudes and delayed implicit times of a- and b-wave and oscillatory potentials (OPs), are one of the earliest features of diabetic retinopathy prior to obvious vascular changes in diabetic retinas. We have previously shown that serum levels of advanc...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000440768
更新日期:2015-01-01 00:00:00
abstract::This study developed a modified monolayer culture technique for expansion of retinal progenitor cells in vitro. Using this method, spheres collected by low centrifugation from free floating cultures were re-seeded onto poly-D-lysine pre-coated flasks, and cultured in the retinal progenitor cells medium (including fibr...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000134927
更新日期:2008-10-01 00:00:00
abstract::The purpose of this study was to determine the expression of metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) in the aqueous humour of patients with exfoliation syndrome (XFS). XFS and control samples were analysed for their MMP content by zymography and for their tissue inhibitors by ELISA. In XFS eyes, ...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000063661
更新日期:2002-05-01 00:00:00
abstract::Dragomirescu et al. [1983] described a 2-chamber flow system for the incubation of lenses with an inserted photometer to measure changes in lens transparency. Mester et al. [1984] applied the method to simulate conditions occurring during vitrectomy, which occasionally leads to reversible lens opacification. Using Sch...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000265357
更新日期:1985-01-01 00:00:00
abstract::To determine the conditions under which anesthetized pigs can be used in acute noninvasive investigations of ocular hydro- and hemodynamics, the intraocular pressure (IOP) of adult pigs was recorded under the following conditions: (1) after intravenous injection of propofol plus ketamine; (2) during inhalation of isof...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000317060
更新日期:2011-01-01 00:00:00
abstract::To evaluate the possible role of nitric oxide in the pathogenesis of exogenous prostaglandin (PG) induced aqueous flare elevation, we examined the effect of NG-nitro-L-arginine methyl ester (L-NAME), an L-arginine analogue acting as a specific inhibitor of nitric oxide synthase, on the elevation of aqueous flare in pi...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000267912
更新日期:1996-01-01 00:00:00
abstract::The tear levels of cholesterol of 17 patients with chronic blepharitis and 17 healthy subjects were determined by the photometric method. The mean cholesterol level of the patients was determined to be 56.1 +/- 8.9 (SEM) mg/dl. No statistically significant difference between the tear cholesterol levels of the two grou...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000267034
更新日期:1990-01-01 00:00:00
abstract::Photodocumented measurements of the lens thickness using an EAS-1000 Scheimpflug camera were performed in 261 cataract eyes (162 pure type) compared with 52 control eyes. The lens thickness in normal eyes usually increased with age by 0.015 mm annually. The cataractous lens, especially in the anterior subcapsular type...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000267205
更新日期:1992-01-01 00:00:00
abstract:PURPOSE:To determine whether docosahexaenoic acid (DHA) can reduce the retinal damage induced by transient retinal ischemia. METHODS:Retinal ischemia was induced by increasing intraocular pressure (IOP). Retinal circulation was restored by lowering IOP. An intraperitoneal injection of 1,000 mg/kg of DHA-ester (DHA-E) ...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000055669
更新日期:2001-07-01 00:00:00
abstract::Lipid peroxidation was induced with porcine retinal homogenates using ferric iron or UV light. A number of lipid and aqueous-soluble antioxidants were tested and their protective effects measured after 60 min of exposure. The iron system produced up to 5 times more lipid hydroperoxides as quantified by the fluorescenc...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000267103
更新日期:1991-01-01 00:00:00
abstract:PURPOSE:Primary open-angle glaucoma (POAG) is a chronic progressive optic neuropathy, leading to degeneration of retinal ganglion cells and characteristic morphological changes at the optic disc. In advanced stages of the disease, functional tests, such as standard automated perimetry (SAP), are the main diagnostic too...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000501693
更新日期:2020-01-01 00:00:00
abstract::Statistically significant differences were found to exist in the frequencies of abnormal cell types in cultured lenses depending on the composition of the nutrient media (Eagle's and Dulbecco's modified essential medium with fetal calf serum FCS) they were cultured on. Abnormal cell growth (epithelioid, fibroblast-lik...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000266786
更新日期:1989-01-01 00:00:00
abstract:BACKGROUND:The aim of this work was to evaluate the narrow anterior chamber angle (ACA) in Chinese patients by anterior segment optical coherence tomography (As-OCT). METHODS:Eighty right eyes of 80 consecutive patients with a shallow peripheral anterior chamber but no peripheral anterior synechia were enrolled in thi...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000448523
更新日期:2017-01-01 00:00:00
abstract::Metabolic changes in the rabbit lens have been studied by means of nuclear magnetic resonance spectroscopy. These changes have been induced by prolonged topical treatment with dexamethasone. Our results demonstrate an increase in sorbitol, sorbitol-3-phosphate, fructose-3-phosphate, glycerol-3-phosphate and glucose-6-...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000055646
更新日期:2001-03-01 00:00:00
abstract:PURPOSE:To establish a retinal blood flow database in normal human eyes using the Canon Laser Blood Flowmeter (CLBF). METHOD:Fourteen healthy subjects (7 males, 7 females) between the ages of 24 and 33 underwent birectional laser Doppler velocimetry (BLDV) in one eye using the CLBF. Measurements consisting of blood ve...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000065600
更新日期:2002-09-01 00:00:00
abstract::Cataract is the leading cause of blindness worldwide. It is a multifactorial disease primarily associated with oxidative stress produced by free radicals. The protection offered by various antioxidants in cataract development is well established. Polyphenolic compounds present in green tea (Camellia sinensis) are repo...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000063881
更新日期:2002-07-01 00:00:00
abstract::Given the propensity of a large number of melanogenic pathways that can be modulated by cellular redox status, a causal role of the deficiency of ocular pigments such as melanin in the pathogenesis of age-related macular degeneration and evidence that melanin production does occur in the adult eye, it seems not improb...
journal_title:Ophthalmic research
pub_type: 杂志文章,评审
doi:10.1159/000081632
更新日期:2004-11-01 00:00:00
abstract::The development and extension of fibrovascular or fibroglial membranes onto the retinal surface are a major cause of visual loss in diabetic patients with proliferative retinopathy and in patients suffering from retinal detachment with proliferative vitreoretinopathy. The pathogenesis of these proliferative diseases, ...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000267115
更新日期:1991-01-01 00:00:00
abstract::L-Timolol (0.4 mg/kg) reduced significantly retinal blood flow (17%), systemic blood pressure (18-20%) and heart rate (28%) in the rabbit. D-Timolol (4.0 mg/kg) increased retinal blood flow slightly (9%) and did not significantly affect systemic blood pressure or heart rate. Since D-timolol is effective in reducing in...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000265470
更新日期:1987-01-01 00:00:00
abstract:PURPOSE:To investigate therapeutic ocular surface medium (TOSM), a potential physiological tear replacement therapy, for persistent epithelial defect (PED). METHODS:11 eyes of 10 patients with PED for ≥ 2 weeks without improvement despite conventional treatment were enrolled in a prospective pilot study of TOSM over 1...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000355065
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND/AIMS:It has been suggested that eye makeup could interact with human meibum causing a decrease in the stability of the tear film. The aim of this pilot study was to measure makeup-human meibum interactions in vitro. METHODS:Human meibum-makeup interactions were quantified by measuring order-to-disorder lipi...
journal_title:Ophthalmic research
pub_type: 杂志文章
doi:10.1159/000371852
更新日期:2015-01-01 00:00:00